Erschienen in:
01.12.2009 | Original Article
Ileal Mucosal and Fecal Pancreatitis Associated Protein Levels Reflect Severity of Salmonella Infection in Rats
verfasst von:
Marleen T. J. van Ampting, Wendy Rodenburg, Carolien Vink, Evelien Kramer, Arjan J. Schonewille, Jaap Keijer, Roelof van der Meer, Ingeborg M. J. Bovee-Oudenhoven
Erschienen in:
Digestive Diseases and Sciences
|
Ausgabe 12/2009
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Abstract
Background Microbial infections induce ileal pancreatitis-associated protein/regenerating gene III (PAP/RegIII) mRNA expression. Despite increasing interest, little is known about the PAP/RegIII protein. Therefore, ileal mucosal PAP/RegIII protein expression, localization, and fecal excretion were studied in rats upon Salmonella infection. Results
Salmonella infection increased ileal mucosal PAP/RegIII protein levels in enterocytes located at the crypt-villus junction. Increased colonization and translocation of Salmonella was associated with higher ileal mucosal PAP/RegIII levels and secretion of this protein in feces. Conclusions PAP/RegIII protein is increased in enterocytes of the ileal mucosa during Salmonella infection and is associated with infection severity. PAP/RegIII is excreted in feces and might be used as a new and non-invasive infection marker.