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Molecular Imaging and Biology

Erschienen in:

01.06.2018 | Review Article

Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery

verfasst von: Stephanie J. Blocker, Anthony F. Shields

Erschienen in: Molecular Imaging and Biology | Ausgabe 3/2018

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Abstract

Molecular imaging is a vital tool to non-invasively measure nanoparticle delivery to solid tumors. Despite the myriad of nanoparticles studied for cancer, successful applications of nanoparticles in humans is limited by inconsistent and ineffective delivery. Successful nanoparticle delivery in preclinical models is often attributed to enhanced permeability and retention (EPR)—a set of conditions that is heterogeneous and transient in patients. Thus, researchers are evaluating therapeutic strategies to modify nanoparticle delivery, particularly treatments which have demonstrated effects on EPR conditions. Imaging nanoparticle distribution provides a means to measure the effects of therapeutic intervention on nanoparticle delivery to solid tumors. This review focuses on the utility of imaging to measure treatment-induced changes in nanoparticle delivery to tumors and provides preclinical examples studying a broad range of therapeutic interventions.

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Titel: Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery
verfasst von: Stephanie J. Blocker
Anthony F. Shields
Publikationsdatum: 01.06.2018
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 3/2018
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-017-1142-2

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Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery

Abstract

Neu im Fachgebiet Radiologie

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

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