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International Journal of Hematology

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15.03.2016 | Letter to the Editor

“Imatinib-induced gastric antral vascular ectasia” in a reporting system of the Japanese Adverse Drug Event Report database

verfasst von: Yasuo Oshima, Koichiro Yuji, Arinobu Tojo

Erschienen in: International Journal of Hematology | Ausgabe 5/2016

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Ong and colleagues (Nov. issue) [1] presented three cases with chronic myeloid leukemia treated with imatinib who developed gastric antral vascular ectasia (GAVE). In all three cases GAVE resolved when imatinib was discontinued and two recurred when imatinib was re-started, thus suggesting causality between imatinib and GAVE. However, the latencies from start of imatinib to onset of GAVE in the reported cases were 7, 13 months, and 6 years. The long latencies with wide variation may make their causality less likely, as a long observation period would increase the chances of capturing adventitious events independent of a suspected drug. We thus conducted a prompt data analysis. …

Ong J, Yeung D, Hughes TP, Nandurkar H. Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia. Int J Hematol. 2015;102:639–42.CrossRefPubMed

Oshima Y, Tojo A. Attractive tools for systematic case accumulation. Int J Hematol. 2011;94:413–4.CrossRefPubMed

Brewer T, Colditz GA. Postmarketing surveillance and adverse drug reactions: current perspectives and future needs. JAMA. 1999;281:824–9.CrossRefPubMed

Titel: “Imatinib-induced gastric antral vascular ectasia” in a reporting system of the Japanese Adverse Drug Event Report database
verfasst von: Yasuo Oshima
Koichiro Yuji
Arinobu Tojo
Publikationsdatum: 15.03.2016
Verlag: Springer Japan
Erschienen in: International Journal of Hematology / Ausgabe 5/2016
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-016-1980-8

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“Imatinib-induced gastric antral vascular ectasia” in a reporting system of the Japanese Adverse Drug Event Report database

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