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Journal of Interventional Cardiac Electrophysiology
Erschienen in: Journal of Interventional Cardiac Electrophysiology 3/2013

01.12.2013

Immediate and medium-term outcomes of cryoballoon-based pulmonary vein isolation in patients with paroxysmal and persistent atrial fibrillation: single-centre experience

verfasst von: Kudret Aytemir, Ali Oto, Uğur Canpolat, Hamza Sunman, Hikmet Yorgun, Levent Şahiner, Ergün Barış Kaya

Erschienen in: Journal of Interventional Cardiac Electrophysiology | Ausgabe 3/2013

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Abstract

Background

Pulmonary vein (PV) isolation with cryoballoon is a recently developed technique for the treatment of atrial fibrillation (AF) with acceptable mid-term results in terms of the success and safety. The purpose of our study is to identify the periprocedural complications, mid-term success rates and predictors of recurrence after AF ablation with cryoballoon.

Method

A total of 236 patients (54 % male, mean age 54.6 ± 10.45 years and 79.6 % paroxysmal AF) with symptomatic AF underwent PV isolation with cryoballoon due to failure with ≥1 antiarrhythmic drug previously. Procedural success, complications and follow-up data were defined according to recent guidelines.

Results

Acute procedural success rate was 99.5 %. Mean procedural and fluoroscopy times were 72.5 ± 5.3 and 14 ± 3.5 min. At a median of 18 (6–27) months follow-up, 80.8 % of paroxysmal AF patients and 50.0 % of persistent AF patients were free from AF recurrence. In multivariate regression analysis, body mass index (BMI) (hazard ratio (HR), 1.35; 95 % confidence interval (CI), 1.18–2.93, p = 0.001), smoking (HR, 2.12; 95 % CI, 1.36–6.67, p < 0.001), non-paroxysmal AF (HR, 1.26; 95 % CI, 1.12–2.56, p = 0.024), duration of AF (HR, 1.42; 95 % CI, 1.18–2.61, p = 0.015), left atrium (LA) diameter (HR, 2.42; 95 % CI, 1.64–5.88, p < 0.001) and early AF recurrence (HR, 4.88; 95 % CI, 2.86–35.6, p < 0.001) were independent predictors of AF recurrence following cryoablation.

Conclusion

Our results showed that AF ablation with cryoballoon is effective and safe. Non-paroxysmal AF, duration of AF, smoking, BMI, LA diameter and early recurrence were found to be the most powerful predictors and could be helpful to select patients for appropriate therapeutic strategy.
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Metadaten
Titel
Immediate and medium-term outcomes of cryoballoon-based pulmonary vein isolation in patients with paroxysmal and persistent atrial fibrillation: single-centre experience
verfasst von
Kudret Aytemir
Ali Oto
Uğur Canpolat
Hamza Sunman
Hikmet Yorgun
Levent Şahiner
Ergün Barış Kaya
Publikationsdatum
01.12.2013
Verlag
Springer US
Erschienen in
Journal of Interventional Cardiac Electrophysiology / Ausgabe 3/2013
Print ISSN: 1383-875X
Elektronische ISSN: 1572-8595
DOI
https://doi.org/10.1007/s10840-013-9834-2

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