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Erschienen in: Immunologic Research 1-3/2010

01.07.2010

Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University

verfasst von: Gang Jee Ko, Asif Zakaria, Karl L. Womer, Hamid Rabb

Erschienen in: Immunologic Research | Ausgabe 1-3/2010

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Abstracts

Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches.
Literatur
2.
Zurück zum Zitat Palevsky PM, Zhang JH, O’Connor TZ, Chertow GM, Crowley ST, Choudhury D, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008;359:7–20.CrossRefPubMed Palevsky PM, Zhang JH, O’Connor TZ, Chertow GM, Crowley ST, Choudhury D, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008;359:7–20.CrossRefPubMed
3.
Zurück zum Zitat Xue JL, Daniels F, Star RA, Kimmel PL, Eggers PW, Molitoris BA, et al. Incidence and mortality of acute renal failure in medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol. 2006;17:1135–42.CrossRefPubMed Xue JL, Daniels F, Star RA, Kimmel PL, Eggers PW, Molitoris BA, et al. Incidence and mortality of acute renal failure in medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol. 2006;17:1135–42.CrossRefPubMed
4.
Zurück zum Zitat Tilney NL, Guttmann RD. Effects of initial ischemia/reperfusion injury on the transplanted kidney. Transplantation. 1997;64:945–7.CrossRefPubMed Tilney NL, Guttmann RD. Effects of initial ischemia/reperfusion injury on the transplanted kidney. Transplantation. 1997;64:945–7.CrossRefPubMed
5.
Zurück zum Zitat Rabb H, Bonventre J. Therapy in nephrology and hypertension: a companion to Brenner and Rector’s ‘the Kidney’. Philadelphia: WB Saunders; 1998. Rabb H, Bonventre J. Therapy in nephrology and hypertension: a companion to Brenner and Rector’s ‘the Kidney’. Philadelphia: WB Saunders; 1998.
6.
Zurück zum Zitat Rabb H, Star R. Inflammatory response and its consequences in acute renal failure. In: Molitoris B, Finn W, editors. Acute renal failure: a companion to Brenner and Rector’s ‘the Kidney’. Philadelphia: WB Saunders; 2001. p. 89–100. Rabb H, Star R. Inflammatory response and its consequences in acute renal failure. In: Molitoris B, Finn W, editors. Acute renal failure: a companion to Brenner and Rector’s ‘the Kidney’. Philadelphia: WB Saunders; 2001. p. 89–100.
7.
Zurück zum Zitat Rabb H. Role of leukocytes and leukocyte adhesion molecules in renal ischemic-reperfusion injury. Front Biosci. 1996;1:e9–14.PubMed Rabb H. Role of leukocytes and leukocyte adhesion molecules in renal ischemic-reperfusion injury. Front Biosci. 1996;1:e9–14.PubMed
8.
Zurück zum Zitat Rabb H, O’Meara YM, Maderna P, Coleman P, Brady HR. Leukocytes, cell adhesion molecules and ischemic acute renal failure. Kidney Int. 1997;51:1463–8.CrossRefPubMed Rabb H, O’Meara YM, Maderna P, Coleman P, Brady HR. Leukocytes, cell adhesion molecules and ischemic acute renal failure. Kidney Int. 1997;51:1463–8.CrossRefPubMed
9.
Zurück zum Zitat Rabb H, Michishita M, Sharma CP, Brown D, Arnaout MA. Cytoplasmic tails of human complement receptor type 3 (CR3, CD11b/CD18) regulate ligand avidity and the internalization of occupied receptors. J Immunol. 1993;151:990–1002.PubMed Rabb H, Michishita M, Sharma CP, Brown D, Arnaout MA. Cytoplasmic tails of human complement receptor type 3 (CR3, CD11b/CD18) regulate ligand avidity and the internalization of occupied receptors. J Immunol. 1993;151:990–1002.PubMed
10.
Zurück zum Zitat Rabb H, Mendiola CC, Dietz J, Saba SR, Issekutz TB, Abanilla F, et al. Role of CD11a and CD11b in ischemic acute renal failure in rats. Am J Physiol. 1994;267:F1052–8.PubMed Rabb H, Mendiola CC, Dietz J, Saba SR, Issekutz TB, Abanilla F, et al. Role of CD11a and CD11b in ischemic acute renal failure in rats. Am J Physiol. 1994;267:F1052–8.PubMed
11.
Zurück zum Zitat Rabb H, Mendiola CC, Saba SR, Dietz JR, Smith CW, Bonventre JV, et al. Antibodies to ICAM-1 protect kidneys in severe ischemic reperfusion injury. Biochem Biophys Res Commun. 1995;211:67–73.CrossRefPubMed Rabb H, Mendiola CC, Saba SR, Dietz JR, Smith CW, Bonventre JV, et al. Antibodies to ICAM-1 protect kidneys in severe ischemic reperfusion injury. Biochem Biophys Res Commun. 1995;211:67–73.CrossRefPubMed
12.
Zurück zum Zitat Rabb H, Ramirez G, Saba SR, Reynolds D, Xu J, Flavell R, et al. Renal ischemic-reperfusion injury in L-selectin-deficient mice. Am J Physiol. 1996;271:F408–13.PubMed Rabb H, Ramirez G, Saba SR, Reynolds D, Xu J, Flavell R, et al. Renal ischemic-reperfusion injury in L-selectin-deficient mice. Am J Physiol. 1996;271:F408–13.PubMed
13.
Zurück zum Zitat Nemoto T, Burne MJ, Daniels F, O’Donnell MP, Crosson J, Berens K, et al. Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure. Kidney Int. 2001;60:2205–14.CrossRefPubMed Nemoto T, Burne MJ, Daniels F, O’Donnell MP, Crosson J, Berens K, et al. Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure. Kidney Int. 2001;60:2205–14.CrossRefPubMed
14.
Zurück zum Zitat Burne MJ, Rabb H. Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury. J Immunol. 2002;169:2648–52.PubMed Burne MJ, Rabb H. Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury. J Immunol. 2002;169:2648–52.PubMed
15.
Zurück zum Zitat Rabb H. The T cell as a bridge between innate and adaptive immune systems: implications for the kidney. Kidney Int. 2002;61:1935–46.CrossRefPubMed Rabb H. The T cell as a bridge between innate and adaptive immune systems: implications for the kidney. Kidney Int. 2002;61:1935–46.CrossRefPubMed
16.
Zurück zum Zitat Rabb H, Daniels F, O’Donnell M, Haq M, Saba SR, Keane W, et al. Pathophysiological role of T lymphocytes in renal ischemia–reperfusion injury in mice. Am J Physiol Renal Physiol. 2000;279:F525–31.PubMed Rabb H, Daniels F, O’Donnell M, Haq M, Saba SR, Keane W, et al. Pathophysiological role of T lymphocytes in renal ischemia–reperfusion injury in mice. Am J Physiol Renal Physiol. 2000;279:F525–31.PubMed
17.
Zurück zum Zitat Burne MJ, Daniels F, El Ghandour A, Mauiyyedi S, Colvin RB, O’Donnell MP, et al. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest. 2001;108:1283–90.PubMed Burne MJ, Daniels F, El Ghandour A, Mauiyyedi S, Colvin RB, O’Donnell MP, et al. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest. 2001;108:1283–90.PubMed
18.
Zurück zum Zitat Yokota N, Daniels F, Crosson J, Rabb H. Protective effect of T cell depletion in murine renal ischemia–reperfusion injury. Transplantation. 2002;74:759–63.CrossRefPubMed Yokota N, Daniels F, Crosson J, Rabb H. Protective effect of T cell depletion in murine renal ischemia–reperfusion injury. Transplantation. 2002;74:759–63.CrossRefPubMed
19.
Zurück zum Zitat Yokota N, Burne-Taney M, Racusen L, Rabb H. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia–reperfusion injury. Am J Physiol Renal Physiol. 2003;285:F319–25.PubMed Yokota N, Burne-Taney M, Racusen L, Rabb H. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia–reperfusion injury. Am J Physiol Renal Physiol. 2003;285:F319–25.PubMed
20.
Zurück zum Zitat Shen XD, Ke B, Zhai Y, Gao F, Anselmo D, Lassman CR, et al. STAT4 and STAT6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of STAT4 disruption-mediated cytoprotection. Hepatology. 2003;37:296–303.CrossRefPubMed Shen XD, Ke B, Zhai Y, Gao F, Anselmo D, Lassman CR, et al. STAT4 and STAT6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of STAT4 disruption-mediated cytoprotection. Hepatology. 2003;37:296–303.CrossRefPubMed
21.
Zurück zum Zitat Bacon KB, Premack BA, Gardner P, Schall TJ. Activation of dual T cell signaling pathways by the chemokine RANTES. Science. 1995;269:1727–30.CrossRefPubMed Bacon KB, Premack BA, Gardner P, Schall TJ. Activation of dual T cell signaling pathways by the chemokine RANTES. Science. 1995;269:1727–30.CrossRefPubMed
22.
Zurück zum Zitat Noiri E, Doi K, Inagi R, Nangaku M, Fujita T. Contribution of T lymphocytes to rat renal ischemia/reperfusion injury. Clin Exp Nephrol. 2009;13:25–32.CrossRefPubMed Noiri E, Doi K, Inagi R, Nangaku M, Fujita T. Contribution of T lymphocytes to rat renal ischemia/reperfusion injury. Clin Exp Nephrol. 2009;13:25–32.CrossRefPubMed
23.
Zurück zum Zitat Ascon DB, Lopez-Briones S, Liu M, Ascon M, Savransky V, Colvin RB, et al. Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury. J Immunol. 2006;177:3380–7.PubMed Ascon DB, Lopez-Briones S, Liu M, Ascon M, Savransky V, Colvin RB, et al. Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury. J Immunol. 2006;177:3380–7.PubMed
24.
Zurück zum Zitat Saito H, Kitamoto M, Kato K, Liu N, Kitamura H, Uemura K, et al. Tissue factor and factor V involvement in rat peritoneal fibrosis. Perit Dial Int. 2009;29:340–51.PubMed Saito H, Kitamoto M, Kato K, Liu N, Kitamura H, Uemura K, et al. Tissue factor and factor V involvement in rat peritoneal fibrosis. Perit Dial Int. 2009;29:340–51.PubMed
25.
Zurück zum Zitat Savransky V, Molls RR, Burne-Taney M, Chien CC, Racusen L, Rabb H. Role of the T-cell receptor in kidney ischemia–reperfusion injury. Kidney Int. 2006;69:233–8.CrossRefPubMed Savransky V, Molls RR, Burne-Taney M, Chien CC, Racusen L, Rabb H. Role of the T-cell receptor in kidney ischemia–reperfusion injury. Kidney Int. 2006;69:233–8.CrossRefPubMed
26.
Zurück zum Zitat Satpute SR, Park JM, Jang HR, Agreda P, Liu M, Gandolfo MT, et al. The role for T cell repertoire/antigen-specific interactions in experimental kidney ischemia reperfusion injury. J Immunol. 2009;183:984–92.CrossRefPubMed Satpute SR, Park JM, Jang HR, Agreda P, Liu M, Gandolfo MT, et al. The role for T cell repertoire/antigen-specific interactions in experimental kidney ischemia reperfusion injury. J Immunol. 2009;183:984–92.CrossRefPubMed
27.
Zurück zum Zitat Liu M, Chien CC, Burne-Taney M, Molls RR, Racusen LC, Colvin RB, et al. A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity. J Am Soc Nephrol. 2006;17:765–74.CrossRefPubMed Liu M, Chien CC, Burne-Taney M, Molls RR, Racusen LC, Colvin RB, et al. A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity. J Am Soc Nephrol. 2006;17:765–74.CrossRefPubMed
28.
Zurück zum Zitat Burne-Taney MJ, Yokota N, Rabb H. Persistent renal and extrarenal immune changes after severe ischemic injury. Kidney Int. 2005;67:1002–9.CrossRefPubMed Burne-Taney MJ, Yokota N, Rabb H. Persistent renal and extrarenal immune changes after severe ischemic injury. Kidney Int. 2005;67:1002–9.CrossRefPubMed
29.
Zurück zum Zitat Ascon M, Ascon DB, Liu M, Cheadle C, Sarkar C, Racusen L, et al. Renal ischemia–reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes. Kidney Int. 2009;75:526–35.CrossRefPubMed Ascon M, Ascon DB, Liu M, Cheadle C, Sarkar C, Racusen L, et al. Renal ischemia–reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes. Kidney Int. 2009;75:526–35.CrossRefPubMed
30.
Zurück zum Zitat Burne-Taney MJ, Liu M, Ascon D, Molls RR, Racusen L, Rabb H. Transfer of lymphocytes from mice with renal ischemia can induce albuminuria in naive mice: a possible mechanism linking early injury and progressive renal disease? Am J Physiol Renal Physiol. 2006;291:F981–6.CrossRefPubMed Burne-Taney MJ, Liu M, Ascon D, Molls RR, Racusen L, Rabb H. Transfer of lymphocytes from mice with renal ischemia can induce albuminuria in naive mice: a possible mechanism linking early injury and progressive renal disease? Am J Physiol Renal Physiol. 2006;291:F981–6.CrossRefPubMed
31.
Zurück zum Zitat Shevach EM. From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity. 2006;25:195–201.CrossRefPubMed Shevach EM. From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity. 2006;25:195–201.CrossRefPubMed
32.
Zurück zum Zitat Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151–64.PubMed Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151–64.PubMed
33.
Zurück zum Zitat Taylor PA, Noelle RJ, Blazar BR. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med. 2001;193:1311–8.CrossRefPubMed Taylor PA, Noelle RJ, Blazar BR. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med. 2001;193:1311–8.CrossRefPubMed
34.
Zurück zum Zitat Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, et al. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med. 2009;15:192–9.CrossRefPubMed Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, et al. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med. 2009;15:192–9.CrossRefPubMed
35.
Zurück zum Zitat Ascon DB, Ascon M, Satpute S, Lopez-Briones S, Racusen L, Colvin RB, et al. Normal mouse kidneys contain activated and CD3+ CD4− CD8− double-negative T lymphocytes with a distinct TCR repertoire. J Leukoc Biol. 2008;84:1400–9.CrossRefPubMed Ascon DB, Ascon M, Satpute S, Lopez-Briones S, Racusen L, Colvin RB, et al. Normal mouse kidneys contain activated and CD3+ CD4 CD8 double-negative T lymphocytes with a distinct TCR repertoire. J Leukoc Biol. 2008;84:1400–9.CrossRefPubMed
36.
Zurück zum Zitat Gandolfo MT, Jang HR, Bagnasco SM, Ko GJ, Agreda P, Satpute SR, et al. Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury. Kidney Int. 2009;76:717–29.CrossRefPubMed Gandolfo MT, Jang HR, Bagnasco SM, Ko GJ, Agreda P, Satpute SR, et al. Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury. Kidney Int. 2009;76:717–29.CrossRefPubMed
37.
Zurück zum Zitat Kinsey GR, Sharma R, Huang L, Li L, Vergis AL, Ye H, et al. Regulatory T cells suppress innate immunity in kidney ischemia–reperfusion injury. J Am Soc Nephrol. 2009;20:1744–53.CrossRefPubMed Kinsey GR, Sharma R, Huang L, Li L, Vergis AL, Ye H, et al. Regulatory T cells suppress innate immunity in kidney ischemia–reperfusion injury. J Am Soc Nephrol. 2009;20:1744–53.CrossRefPubMed
38.
Zurück zum Zitat Gandolfo MT, Jang HR, Bagnasco SM, Agreda P, Soloski MJ, Crow MT et al.: Mycophenolate mofetil retards repair from ischemic acute kidney injury by a T lymphocyte-mediated mechanism. ASN renal week 2009, San diego; 2009. Gandolfo MT, Jang HR, Bagnasco SM, Agreda P, Soloski MJ, Crow MT et al.: Mycophenolate mofetil retards repair from ischemic acute kidney injury by a T lymphocyte-mediated mechanism. ASN renal week 2009, San diego; 2009.
39.
Zurück zum Zitat Chertow GM, Levy EM, Hammermeister KE, Grover F, Daley J. Independent association between acute renal failure and mortality following cardiac surgery. Am J Med. 1998;104:343–8.CrossRefPubMed Chertow GM, Levy EM, Hammermeister KE, Grover F, Daley J. Independent association between acute renal failure and mortality following cardiac surgery. Am J Med. 1998;104:343–8.CrossRefPubMed
40.
Zurück zum Zitat Kramer AA, Postler G, Salhab KF, Mendez C, Carey LC, Rabb H. Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. Kidney Int. 1999;55:2362–7.CrossRefPubMed Kramer AA, Postler G, Salhab KF, Mendez C, Carey LC, Rabb H. Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. Kidney Int. 1999;55:2362–7.CrossRefPubMed
41.
Zurück zum Zitat Rabb H, Wang Z, Nemoto T, Hotchkiss J, Yokota N, Soleimani M. Acute renal failure leads to dysregulation of lung salt and water channels. Kidney Int. 2003;63:600–6.CrossRefPubMed Rabb H, Wang Z, Nemoto T, Hotchkiss J, Yokota N, Soleimani M. Acute renal failure leads to dysregulation of lung salt and water channels. Kidney Int. 2003;63:600–6.CrossRefPubMed
42.
Zurück zum Zitat Hassoun HT, Grigoryev DN, Lie ML, Liu M, Cheadle C, Tuder RM, et al. Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy. Am J Physiol Renal Physiol. 2007;293:F30–40.CrossRefPubMed Hassoun HT, Grigoryev DN, Lie ML, Liu M, Cheadle C, Tuder RM, et al. Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy. Am J Physiol Renal Physiol. 2007;293:F30–40.CrossRefPubMed
43.
Zurück zum Zitat Grigoryev DN, Liu M, Hassoun HT, Cheadle C, Barnes KC, Rabb H. The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol. 2008;19:547–58.CrossRefPubMed Grigoryev DN, Liu M, Hassoun HT, Cheadle C, Barnes KC, Rabb H. The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol. 2008;19:547–58.CrossRefPubMed
44.
Zurück zum Zitat Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia–reperfusion injury induces caspase-dependent pulmonary apoptosis. Am J Physiol Renal Physiol. 2009;297:F125–37.CrossRefPubMed Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia–reperfusion injury induces caspase-dependent pulmonary apoptosis. Am J Physiol Renal Physiol. 2009;297:F125–37.CrossRefPubMed
45.
Zurück zum Zitat Feltes C, Rabb H: Acute kidney injury leads to pulmonary endothelial cell transcriptional, cytoskeletal and apoptotic changes. ASN renal week 2009, San Diego; 2009. Feltes C, Rabb H: Acute kidney injury leads to pulmonary endothelial cell transcriptional, cytoskeletal and apoptotic changes. ASN renal week 2009, San Diego; 2009.
46.
Zurück zum Zitat Liu M, Stins M, Saleem S, Dore S, Rabb H: Acute kidney injury disrupts blood brain barrier and increases susceptibility to stroke. ASN renal week 2009, San Diego; 2009. Liu M, Stins M, Saleem S, Dore S, Rabb H: Acute kidney injury disrupts blood brain barrier and increases susceptibility to stroke. ASN renal week 2009, San Diego; 2009.
47.
Zurück zum Zitat Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, et al. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007;18:155–64.CrossRefPubMed Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, et al. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007;18:155–64.CrossRefPubMed
48.
Zurück zum Zitat Kelly KJ. Distant effects of experimental renal ischemia/reperfusion injury. J Am Soc Nephrol. 2003;14:1549–58.CrossRefPubMed Kelly KJ. Distant effects of experimental renal ischemia/reperfusion injury. J Am Soc Nephrol. 2003;14:1549–58.CrossRefPubMed
49.
Zurück zum Zitat Liu M, Liang Y, Chigurupati S, Lathia JD, Pletnikov M, Sun Z, et al. Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol. 2008;19:1360–70.CrossRefPubMed Liu M, Liang Y, Chigurupati S, Lathia JD, Pletnikov M, Sun Z, et al. Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol. 2008;19:1360–70.CrossRefPubMed
50.
Zurück zum Zitat Kuiper JW, Groeneveld AB, Slutsky AS, Plotz FB. Mechanical ventilation and acute renal failure. Crit Care Med. 2005;33:1408–15.CrossRefPubMed Kuiper JW, Groeneveld AB, Slutsky AS, Plotz FB. Mechanical ventilation and acute renal failure. Crit Care Med. 2005;33:1408–15.CrossRefPubMed
51.
Zurück zum Zitat Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA. 1999;282:54–61.CrossRefPubMed Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA. 1999;282:54–61.CrossRefPubMed
52.
Zurück zum Zitat Jang HR, Rabb H. The innate immune response in ischemic acute kidney injury. Clin Immunol. 2009;130:41–50.CrossRefPubMed Jang HR, Rabb H. The innate immune response in ischemic acute kidney injury. Clin Immunol. 2009;130:41–50.CrossRefPubMed
53.
Zurück zum Zitat Scheel PJ, Liu M, Rabb H. Uremic lung: new insights into a forgotten condition. Kidney Int. 2008;74:849–51.CrossRefPubMed Scheel PJ, Liu M, Rabb H. Uremic lung: new insights into a forgotten condition. Kidney Int. 2008;74:849–51.CrossRefPubMed
Metadaten
Titel
Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University
verfasst von
Gang Jee Ko
Asif Zakaria
Karl L. Womer
Hamid Rabb
Publikationsdatum
01.07.2010
Verlag
Humana Press Inc
Erschienen in
Immunologic Research / Ausgabe 1-3/2010
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-009-8140-7

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