Impact of autologous platelet rich plasma use on postoperative acute kidney injury in type A acute aortic dissection repair: a retrospective cohort analysis
verfasst von:
Jiaqi Tong, Liang Cao, Liwei Liu, Mu Jin
Perioperative coagulopathy and blood transfusion are common in patients undergoing Stanford type A acute aortic dissection (AAD) repair. The autologous platelet-rich plasmapheresis (aPRP) technique is a blood conservation approach to reduce blood transfusions and morbidity in patients at high risk of bleeding. The purpose of this study was to analyze the effect of aPRP on outcomes, especially in postoperative acute kidney injury (post-AKI), in patients undergoing AAD surgery.
Methods
Six hundred sixty patients were divided into aPRP and non-aPRP groups according to aPRP use. The primary endpoint was the difference in the incidence of post-AKI between two groups. The secondary endpoints were risk factors for post-AKI and to assess clinical outcomes. The risk factors associated with post-AKI were calculated, and all outcomes were adjusted by propensity-score matching analysis.
Results
A total of 272 patients (41.2%) received aPRP, whereas 388 were in the non-aPRP group. Compared to non-aPRP group, the occurrence of post-AKI increased by 14.1% (p = 0.002) and 11.1% (p = 0.010) with and without propensity adjustment in the aPRP group, respectively. The aPRP group required fewer intraoperative transfusions (p < 0.05) and shortened the duration of mechanical ventilation (p < 0.05) than those in the non-aPRP group. Multiple regression analyses showed that aPRP (odds ratio: 1.729, 95% confidence interval: 1.225–2.440; p < 0.001) was one of the independent risk factors for post-AKI.
Conclusions
The use of aPRP significantly reduced intraoperative blood transfusions and decreased postoperative mortality-adjusted mechanical ventilation. However, aPRP use was independently associated with an increased hazard of post-AKI after adjusting for confounding factors.
Hinweise
Jiaqi Tong, Liang Cao and Liwei Liu contributed equally to this work.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Abkürzungen
AAD
Stanford type A acute aortic dissection
aPRP
Autologous platelet-rich plasmapheresis
post-AKI
Postoperative acute kidney injury
CPB
Cardiopulmonary bypass
KDIGO
AKI based on Kidney Disease Improving Global Outcomes
Scr
Serum creatinine
BMI
Body mass index
DM
Diabetes mellitus
LVEF
Left ventricular ejection fraction
LVEDD
Left ventricular end diastolic diameter
EuroSCORE
European system for cardiac operative risk evaluation
MBP
Mean blood pressure
PLC
Platelet count
Hb
Hemoglobin
WBC
White blood cells
Glu
Glucose
LAC
Lactic acid
FIB
Fibrinogen
FDP
Ibrinogen degradation product
APTT
Active part thrombin time
PT
Prothrombin time
APTT
Activated partial thromboplastin time
PTA
Prothrombin activityprothrombin time
ICU
Intensive care unit
CRRT
Continuous renal replacement therapy
AKI
Acute kidney injury
GI
Gastrointestinal
OR
Odds ratio
CI
Confidence interval
Introduction
Stanford type A acute aortic dissection (AAD) is characterized by the rapid development of an intimal flap separating the false and true lumen, blood flow through the nonendothelialized false lumen, and turbulence, which triggers activation of the platelet and coagulation/fibrinolytic system [1, 2]. Moreover, surgery and cardiopulmonary bypass (CPB)-induced coagulation factor consumption and excessive fibrinolysis and platelet activation promote perioperative blood loss and blood product transfusion [3, 4]. Thus, various blood conservation approaches have been applied to improve blood conservation [5‐7]. The use of aPRP in cardiac surgery is beneficial for those at high risk of bleeding and reduces blood transfusions during AAD surgery in those undergoing CPB and hypothermic circulatory arrest [8‐10]. However, volume replacement and unstable hemodynamics are always along with aPRP harvest process, which is potential risk factors of postoperative acute kidney injury [11]. The purpose of this study was to analyze the effect of aPRP on post-AKI in patients undergoing AAD surgery.
Materials and methods
Patient population
This study was approved by the Ethics Committee of the Beijing Anzhen Hospital Clinical Research (Beijing, China), and consent was waived because of the retrospective data collection. Patients with Stanford type A AAD were eligible if they were between 18 and 75 years of age and were suitable for emergency surgery. A total of 1013 consecutive patients’ records were collected between January 2013 and June 2017. Patients who had severe cardiac tamponade, cardiogenic shock, cardiac arrest, or severe systolic hypotension were excluded from the analysis for both groups. Exclusion criteria are shown as a flow diagram (Fig. 1). Patients were divided into two groups: aPRP group and non-aPRP group.
Fig. 1
Flow diagram
×
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Study endpoint
The primary endpoint of this study was the difference in the incidence of post-AKI after Stanford type A AAD surgery between aPRP group and non-aPRP group. The secondary endpoints were risk factors for post-AKI and to assess clinical outcomes. Clinical outcomes included perioperative blood product transfusions, in-hospital mortality, time to mechanical ventilation, intensive care unit length of stay, and gastrointestinal tract bleeding. Post-AKI was defined as AKI within postoperative 48 h based on Kidney Disease Improving Global Outcomes (KDIGO) criteria [12].
Surgical technique
After routine anesthesia and intubation, general anesthesia was maintained with intravenous sufentanil, propofol, and neuromuscular blockade drugs. Sun’s surgical technique has been previously detailed [13, 14]. In brief, right axillary artery cannulation was used for cardiopulmonary bypass (CPB) and unilateral selective antegrade cerebral perfusion under moderate hypothermic circulatory arrest at 25 °C. The surgical procedure involved the deployment of a frozen elephant trunk, Cronus (MicroPort Medical, Shanghai, China), into the descending aorta, followed by total arch replacement with a 4-branched vascular graft (Maquet Cardiovascular, Wayne, NJ). Aortic valve or root procedures and concomitant surgeries, such as coronary artery bypass grafting (CABG), were performed during the cooling phase. Blood products were transfused to maintain hemoglobin level > 7 g/L at weaning from CPB, and to correct coagulopathy by thromboelastogram and clinical parameters.
aPRP harvest technique
aPRP was collected from a large-bore central venous access by gravity drainage and an autologous transfusion system (Sorin-Xtra, Milan, Italy) before the administration of heparin and reinfused after the reversal of heparin. Approximately 15 mL/kg of whole blood was collected. A balanced salt solution (Ringer’s lactate) were used to maintain intravascular volume and hemodynamic stability during the aPRP harvest, as well as continuous IV infusion noradrenaline or dopamine. No cases of hemodynamic instability were noted during aPRP collection.
Statistical analysis
All data analyses were performed with SPSS 24.0 (IBM, Armonk, NY, USA). Quantitative variables are presented as the mean ± standard deviation or median (interquartile range), and categorical variables are presented as frequencies or percentages. Multiple regression analyses were used to determine the independent factors of post-AKI. Propensity-score matching was performed by logistic regression for variable adjustment, and the variables of age, body mass index (BMI), preoperative SCr, and duration of surgery were used as covariates. Then patients were matched 1:1 based on their propensity scores, with a fixed caliper width of 0.1. All statistical tests were two-sided, and p < 0.05 was considered statistically significant.
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Results
Baseline characteristics
According to the inclusion and exclusion criteria, a total of 660 patients undergoing Stanford type A AAD surgery were ultimately included in this study. The flow diagram is presented in Fig. 1. In the aPRP group, 272 patients (41.2%) received aPRP, whereas 388 patients were in the non-aPRP group. The mean amount of aPRP collected was 594 ± 331 mL, and the mean amount of red blood cells was 428 ± 243 ml. The aPRP and non-aPRP groups demonstrated the differences of age, BMI, history of smoking, preoperative mean blood pressure, hemoglobin, PLC and preoperative SCr (p < 0.005) (Table 1).
Table 1
Perioperative variables in the non-aPRP group and aPRP group
Clinical variables
Non-aPRP Group(n = 388)
aPRP Group(n = 272)
P Value
Age (year)
49.29 ± 10.60
47.52 ± 9.77
0.030
Males, n (%)
305 (78.4)
230 (84.6)
0.067
Height (cm)
172.05 ± 7.51
171.49 ± 8.02
0.359
Weight (kg)
77.02 ± 13.16
78.8 ± 13.20
0.073
BMI (kg/M2)
25.97 ± 3.75
26.75 ± 3.70
0.009
History of smoking, n (%)
137 (35.2)
120 (44.1)
0.023
History of hypertension, n (%)
294 (75.8)
199 (73.2)
0.448
History of DM, n (%)
18 (4.6)
13 (4.8)
0.933
Time from onset of symptoms to surgery (d)
2 (1,4)
2 (1, 4)
0.768
preoperative
LVEF (%)
60.22 ± 6.52
60.58 ± 6.302
0.490
LVEDd (mm)
50.76 ± 8.71
49.888 ± 7.8517
0.195
EuroSCORE
5 (4.5,5)
5 (5,5)
0.408
HR (beats/min)
80 ± 15
80 ± 15
0.334
MBP (mm Hg)
89 ± 18
85 ± 22
0.014
Hb(g/L)
12.68 ± 2.63
13.91 ± 4.14
0.001
WBC (109/L)
10.91 ± 4.11
11.38 ± 3.72
0.135
PLC(109 /L)
151 ± 76
171 ± 64
0.001
LAC (mmol/L)
1.52 ± 0.95
1.56 ± 0.87
0.549
SCr (umol/L)
102.9 ± 53.1
82.6 ± 37.6
< 0.001
PT (second)
12.74 ± 2.29
12.81 ± 2.06
0.727
PTA(100%)
87.03 ± 14.44
84.67 ± 14.67
0.128
APTT (second)
32.83 ± 11.51
31.70 ± 6.76
0.211
FIB(g/L)
3.30 ± 1.49
3.21 ± 1.56
0.571
FDP (mg/L)
18.65 (9.01,31.45)
19.2 (10.2,35.65)
0.329
D-D (ug/L)
1581 (850, 2976)
1836 (808, 2719)
0.660
INR
1.09 (1.03,1.18)
1.11 (1.04,1.19)
0.192
Intraoperative
With CABG
13 (5.2)
16 (6.5)
0.537
Duration of surgery (min)
465 ± 99
492 ± 105
0.001
Duration of CPB (min)
271.49 ± 172.64
281.27 ± 152.09
0.453
Duration of Aortic cross-clamping (min)
92.97 ± 56.01
86.95 ± 54.77
0.171
Lowest rectal temperature (°C)
25.21 ± 2.13
25.21 ± 1.79
0.966
Lowest nasopharyngeal temperature (°C)
22.46 ± 6.02
22.91 ± 6.60
0.363
Intravenous crystalloid (mL)
2153 ± 887
2354 ± 1133
0.015
Allogeneic Red blood cells (units)
0 (0, 4)
0 (0, 3)
0.012
Allogeneic blood Plasma (mL)
200 (0, 600)
0 (0,400)
0.001
aBlood product transfused (ml)
520 (0,1040)
375 (0,975)
0.014
Urine volume during surgery (mL)
1591 ± 1073
1643 ± 863
0.503
Postoperative
LVEF (%)
59.68 ± 7.04
59.59 ± 6.57
0.870
HR (beats/min)
93 ± 17
94 ± 16
0.384
MBP (mmHg)
88 ± 19
86 ± 20
0.20
Hb(g/L)
10.23 ± 1.86
10.42 ± 1.57
0.545
WBC (109/L)
11.48 ± 4.86
12.15 ± 4.57
0.20
PLC(109 /L)
106 ± 51
97 ± 62
0.14
LAC (mmol/L)
2.79 ± 3.12
3.97 ± 3.93
<0.001
PT (second)
13.77 ± 4.45
13.18 ± 2.39
0.080
PTA(100%)
82.81 ± 15.72
81.56 ± 14.86
0.442
APTT (second)
32.63 ± 7.13
33.10 ± 12.04
0.628
FIB(g/L)
3.34 ± 1.43
3.39 ± 1.97
0.731
FDP (mg/L)
19 (9.17,32.4)
17.56 (9.52,35.67)
0.929
D-D (ug/L)
1963 (855,3046)
1619 (815,2841)
0.510
INR
1.12 (1.04,1.24)
1.14 (1.06,1.24)
0.323
SCr (umol/L)
118.58 ± 72.59
105.89 ± 51.50
0.011
Postoperative 24 h
SCr (umol/L)
133.1 ± 91.8
115.2 ± 66.6
0.005
Seroma volume of drainage (mL)
1472 ± 667
1539 ± 820
0.263
Postoperative 48 h
SCr (umol/L)
136.1 ± 106.3
122.3 ± 98.2
0.102
Postoperative 72 h
SCr (umol/L)
113.4 ± 93.7
110.1 ± 77.5
0.737
Data are given as numbers, percentage, mean ± standard deviation or median (interquartile range, IQR). BMI Body mass index, DM Diabetes mellitus, LVEF Left ventricular ejection fraction, LVEDD Left ventricular end diastolic diameter, EuroSCORE European system for cardiac operative risk evaluation, MBP Mean blood pressure, PLC Platelet count, Hb Hemoglobin, WBC White blood cells, LAC Lactic acid, FIB Fibrinogen, FDP Fibrinogen degradation product, APTT Active part thrombin time, PT Prothrombin time, APTT Activated partial thromboplastin time, PTA Prothrombin activityprothrombin time activity, INR International normalized ratio, D-D D-Dimer, SCr Serum creatine, CABG Coronary artery bypass grafting, CPB Cardiopulmonary bypass. aNumber of blood products transfused perioperatively was defined as total units of red blood cells (1 unit = 160 ml), fresh-frozen plasma and apheresis platelet units (1 unit = 260 ml) administered
Intraoperative
Duration of surgery was more longer in the aPRP group than in the non-aPRP group. The aPRP group required fewer intraoperative transfusions (p < 0.001) and more intravenous crystalloid (p < 0.05) than the non-aPRP group. Adjustment for propensity score did not materially alter the clinical effects and statistical differences for these intraoperative blood products and intravenous solution.
Postoperative outcomes
Postoperative outcomes are shown in Table 2. The primary association of aPRP with unadjusted postoperative complications involved less mortality-adjusted mechanical ventilation (p = 0.029) and in-hospital mortality (p = 0.001). Upon propensity score adjustment, in-hospital mortality was similar in both groups (p = 0.904). The occurrence of post-AKI was greater in the aPRP group, both without and with propensity adjustment (14.1% (p = 0.002) and 11.1% (p = 0.010), respectively). Multiple regression analyses of these variables showed that aPRP (odds ratio [OR]: 1.729, 95% confidence interval [CI]: 1.225–2.440; p < 0.001), postoperative Scr (OR: 1.010, 95% CI: 1.006–1.014; p < 0.001) and postoperative LAC (OR: 1.104, 95% CI: 1.047–1.164; p < 0.001) were significantly associated with post-AKI with adjustment for factors (Table 3). The AUROC (receiver operating characteristic) of this multivariable binary logistic regression analysis was 0.790 (95% CI, 0.754–0.825).
Table 2
Postoperative complications compared between non-aPRP and aPRP groups
Variables
Unmatched
Propensity score-matched
Non-aPRP Group (n = 388)
aPRP Group (n = 272)
P Value
Non-aPRP Group (n = 272)
aPRP Group (n = 272)
P Value
Mortality-adjusted Mechanical ventilation (h)a
40 (17,95)
28 (16,67)
0.029
40 (17,92)
28 (16,67)
0.043
ICU length of stay(h)a
45 (23,90)
43.5 (21.5,95.5)
0.439
40 (22,82)
43.5 (21.5,95.5)
0.368
Post-AKI, n (%)
152 (39.2)
145 (53.3)
0.002
115 (42.2)
145 (53.3)
0.010
CRRT, n (%)
11 (2.8)
25 (9.2)
0.013
10 (3.8)
25 (9.2)
0.015
GI tract bleeding, n (%)
39 (10.1)
34 (12.5)
0.324
34 (12.8)
34 (12.5)
0.922
In-hospital mortality, n (%)
37 (9.5)
16 (5.9)
0.001
15 (5.6)
16 (5.9)
0.904
a In-hospital Survivors; ICU Intensive care unit, CRRT Continuous renal replacement therapy, post-AKI Acute kidney injury within postoperative 48 h, GI Gastrointestinal; Other abbreviations are presented in Table 1
Table 3
Risk factors for postoperative differences stage acute kidney injury after repair of acute Type A aortic dissection in the multivariate-adjusted model a (n = 660)
Variables
Post-AKI
OR
95% (CI)
P Value
aPRP
1.729
1.225–2.440
0.002
postoperative serum creatine (umol/L)
1.010
1.006–1.014
< 0.001
Postoperative LAC (mmol/L)
1.104
1.047–1.164
< 0.001
OR odds ratio, CI confidence interval
a adjusted for male, age, BMI, Intravenous crystalloid, Blood product transfused, Duration of surgery, and History of smoking
Figure 2 depicts perioperative SCr continuously increasing from preoperative to postoperative 3-day time points in the two groups (p < 0.001). We repeated measurements of perioperative SCr at each follow-up visit to characterize the changes in post-AKI over time in both groups. SCr levels increased and peaked at 2 days after surgery and then decreased until 3 days after surgery in all patients. There was no significant differences in treatment-time effects for perioperative SCr levels between both groups. However, in the first period (from preoperative to postoperative), there was a mean maximal increase in SCr of 15.6 and 28.1% in the non-aPRP and aPRP groups, respectively; in the last period (postoperative 2–3 days), there was a mean maximal decrease in SCr of 16.9 and 9.8% in the non-aPRP and aPRP groups, respectively.
Fig. 2
Perioperative SCr changes from preoperative to postoperative 3-day time points in both groups. 0, preoperative; 1, postoperative; 2, postoperative 1 day; 3, postoperative 2 days; 4, postoperative 3 days
×
Discussion
Theoretically, aPRP is less exposure of coagulation factors and platelets to the extra-circulation system to achieve blood conservation from the deleterious effects of CPB. The centrifugation device and autologous transfusion system can be used to harvest and separate whole blood into red cell concentrate and aPRP fraction. The collected red cell is reinfused depended on hemoglobin concentration, and aPRP fraction is reinfusion after separation from CPB and reversal of anticoagulation.
Similar to prior reports [8, 10, 15], we found the aPRP technique markedly reduced intraoperative allogeneic blood transfusion and shortened the duration of mechanical ventilation. For whole blood exposed to the CPB circuit, the patient’s platelets were activated, and coagulation factors were consumed during CPB. The use of aPRP can maintain normal platelet function, preserve plasma volume, and ultimately reduce transfusion. In previous studies, Zhou [8] and Han [15] presumed that the use of aPRP could ameliorate postoperative lung injury and shorten mechanical ventilation, possibly related to fewer allogeneic transfusions.
AKI is frequent as a severe complication following an operation for Type A AAD. According to KDIGO criteria, the reported incidence of post-AKI after thoracic aortic surgery is 53% [16] and 77.6% [17] in China. In this study, we found that there was a significantly lower incidence of post-AKI (45%) compared with the results reported previously. In the present study, we defined post-AKI as AKI occurred within 48 h after surgery, which reduced the incidence of post-AKI and avoided other postoperative complications to confounding the effect of aRPR on renal function.
In this study, the use of aPRP was independently associated with an increased hazard of post-AKI. The main risk with aPRP harvest was hemodynamic fluctuation and hemodilution induced by acute hypovolemia and alternate fluid therapy. In the aPRP group, rapid fluid replacement therapy were required to maintain hemodynamic stability during aPRP collection. Total fluid volume for transfusion was higher in the aPRP group than in the non-aPRP group, which not related to post-AKI by Logistic analysis.
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In this study, post-AKI development after type A acute aortic dissection repair was associated mainly with postoperative variables, such as postoperative serum creatinine and lactate. Although novel biomarkers, such as neutrophil gelatinase-associated lipocalin and cystatin C, have been identified as independent predictors of AKI and are superior to conventional biomarkers, sCr continues to be a more valuable and accepted tool for AKI diagnosis [18]. During surgery and CPB, the kidneys may suffer from an imbalance between oxygen supply and oxygen needs that is associated with lactate production [19]. Higher serum lactate values, which are a surrogate marker of tissue hypoperfusion and imbalance of renal oxygen metabolism, were associated with the occurrence of postoperative AKI. In addition, lower hemoglobin induced by hemodilution during aPRP collection decreased oxygen delivery and was also associated with postoperative AKI [20].
The precise mechanism of aPRP on post-AKI has not been clarified. Thus, careful monitoring and management of hemodynamic and maintaining fluid balance by experienced anesthesiologists during aPRP harvest play a vital role in improving postoperative kidney function. In addition, there still are some questions to be addressed for the application of aPRP in future studies.
Limitations
This retrospective study has several limitations. The most important limitation was the difference in preoperative variables between groups and the possibility of selection bias due to the nonrandomized design. The preoperative characteristics of patients in the aPRP group were younger age, higher BMI values, lower levels of preoperative SCr, and longer duration of surgery patients than those in the non-PRP group. The characteristics between the two groups could be adjusted to partially correct for these differences by propensity-adjusted matching analysis. Additionally, preoperative renal malperfusion is an independent predictor for postoperative AKI [21]. Preoperative renal malperfusion also induced an increase in preoperative SCr values, which possibly led to bias and adverse effects on the results. In this study, preoperative SCr values were higher in 160 (160/660, 24.2%) patients than after surgery, and only 25 (25/160, 15.6%) of these patients had post-AKI. Thus, instead of focusing on preoperative SCr, postoperative SCr was selected in our model of risk factors associated with post-AKI. Ultimately, most patients with severe ischemia or malperfusion were not enrolled in this study. The results were appropriate for patients classified as Penn class Aa but are not a guideline to those who are Penn class Ab and Ac [22].
Conclusion
The use of aPRP significantly reduced intraoperative blood transfusions, as well as decreased postoperative mortality-adjusted mechanical ventilation in patients undergoing open repair of acute Type AAD. However, aPRP was independently associated with an increased hazard of post-AKI after adjusting for confounding factors.
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Acknowledgements
We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.
Ethics approval and consent to participate
This study was approved by the Ethics Committee of the Beijing Anzhen Hospital Clinical Research (Beijing, China), and consent was waived because of the retrospective data collection.
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
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Impact of autologous platelet rich plasma use on postoperative acute kidney injury in type A acute aortic dissection repair: a retrospective cohort analysis
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