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Erschienen in: Digestive Diseases and Sciences 10/2007

01.10.2007 | Original Paper

Impact of Nocturnal Heartburn on Quality of Life, Sleep, and Productivity: The SINERGE Study

verfasst von: José Luis Calleja, M. Bixquert, J. Maldonado, for the SINERGE Study Group

Erschienen in: Digestive Diseases and Sciences | Ausgabe 10/2007

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Abstract

The aim of the SINERGE study was to assess the impact of nocturnal heartburn on quality of life, sleep, and productivity. Ambulatory patients ≥18 years old and classified as defined cases of nocturnal heartburn (n=337), nonnocturnal heartburn (n=139), uncontrolled hypertension (n=198), and symptomatic depression (n=104) were included in this cross-sectional study. Information on age, gender, body mass index, and comorbidity was collected and the following validated questionnaires were applied: SF-12, Pittsburgh Sleep Quality Index, and Work Productivity and Activity Impairment questionnaire. The prevalence of primary care consultation for heartburn and nocturnal heartburn was 4.7% and 1.9%, respectively. Health-related quality of life, sleep, and productivity were significantly impaired in patients with frequent nocturnal heartburn symptoms as compared with those of the patients without nocturnal symptoms or patients with hypertension. Nocturnal heartburn poses a considerable burden for the sufferer because of the impact on quality of life, sleep, and daily activities.
Literatur
1.
Zurück zum Zitat Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, Whitehead WE, Janssens J, Funch-Jensen P, Corazziari E, Richter JE, Koch GG (1993) U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci 38:1569–1580PubMedCrossRef Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, Whitehead WE, Janssens J, Funch-Jensen P, Corazziari E, Richter JE, Koch GG (1993) U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci 38:1569–1580PubMedCrossRef
2.
Zurück zum Zitat Heading RC (1999) Prevalence of upper gastrointestinal symptoms in the general population: a systematic review. Scand J Gastroenterol Suppl 231:3–8PubMedCrossRef Heading RC (1999) Prevalence of upper gastrointestinal symptoms in the general population: a systematic review. Scand J Gastroenterol Suppl 231:3–8PubMedCrossRef
3.
Zurück zum Zitat Farup C, Kleinman L, Sloan S, Ganoczy D, Chee E, Lee C, Revicki D (2001) The impact of nocturnal symptoms associated with gastroesophageal reflux disease on health-related quality of life. Arch Intern Med 161:45–52PubMedCrossRef Farup C, Kleinman L, Sloan S, Ganoczy D, Chee E, Lee C, Revicki D (2001) The impact of nocturnal symptoms associated with gastroesophageal reflux disease on health-related quality of life. Arch Intern Med 161:45–52PubMedCrossRef
4.
Zurück zum Zitat Shaker R, Castell DO, Schoenfeld PS, Spechler SJ (2003) Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association. Am J Gastroenterol 98:1487–1493PubMedCrossRef Shaker R, Castell DO, Schoenfeld PS, Spechler SJ (2003) Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association. Am J Gastroenterol 98:1487–1493PubMedCrossRef
5.
Zurück zum Zitat Fass R, Quan SF, O’Connor GT, Ervin A, Iber C (2005) Predictors of heartburn during sleep in a large prospective cohort study. Chest 127:1658–1666PubMedCrossRef Fass R, Quan SF, O’Connor GT, Ervin A, Iber C (2005) Predictors of heartburn during sleep in a large prospective cohort study. Chest 127:1658–1666PubMedCrossRef
6.
Zurück zum Zitat Orr WC, Allen ML, Robinson M (1994) The pattern of nocturnal and diurnal esophageal acid exposure in the pathogenesis of erosive mucosal damage. Am J Gastroenterol 89:509–512PubMed Orr WC, Allen ML, Robinson M (1994) The pattern of nocturnal and diurnal esophageal acid exposure in the pathogenesis of erosive mucosal damage. Am J Gastroenterol 89:509–512PubMed
7.
Zurück zum Zitat Gerson LB, Edson R, Lavori PW, Triadafilopoulos G (2001) Use of a simple symptom questionnaire to predict Barrett's esophagus in patients with symptoms of gastroesophageal reflux. Am J Gastroenterol 96:2005–2012PubMedCrossRef Gerson LB, Edson R, Lavori PW, Triadafilopoulos G (2001) Use of a simple symptom questionnaire to predict Barrett's esophagus in patients with symptoms of gastroesophageal reflux. Am J Gastroenterol 96:2005–2012PubMedCrossRef
8.
Zurück zum Zitat Lagergren J, Bergstrom R, Lindgren A, Nyren O (1999) Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 340:825–831PubMedCrossRef Lagergren J, Bergstrom R, Lindgren A, Nyren O (1999) Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 340:825–831PubMedCrossRef
9.
Zurück zum Zitat Gislason T, Janson C, Vermeire P, Plaschke P, Bjornsson E, Gislason D, Boman G (2002) Respiratory symptoms and nocturnal gastroesophageal reflux: a population-based study of young adults in three European countries. Chest 121:158–163PubMedCrossRef Gislason T, Janson C, Vermeire P, Plaschke P, Bjornsson E, Gislason D, Boman G (2002) Respiratory symptoms and nocturnal gastroesophageal reflux: a population-based study of young adults in three European countries. Chest 121:158–163PubMedCrossRef
10.
Zurück zum Zitat Dean BB, Crawley JA, Schmitt CM, Wong J, Ofman JJ (2003) The burden of illness of gastro-oesophageal reflux disease: impact on work productivity. Aliment Pharmacol Ther 17:1309–1317PubMedCrossRef Dean BB, Crawley JA, Schmitt CM, Wong J, Ofman JJ (2003) The burden of illness of gastro-oesophageal reflux disease: impact on work productivity. Aliment Pharmacol Ther 17:1309–1317PubMedCrossRef
11.
Zurück zum Zitat Ho KY, Kang JY, Seow A (1999) Patterns of consultation and treatment for heartburn: findings from a Singaporean community survey. Aliment Pharmacol Ther 13:1029–1033PubMedCrossRef Ho KY, Kang JY, Seow A (1999) Patterns of consultation and treatment for heartburn: findings from a Singaporean community survey. Aliment Pharmacol Ther 13:1029–1033PubMedCrossRef
12.
Zurück zum Zitat Rey E, Moreno-Elola-Olaso C, Rodriguez-Artalejo F, Diaz-Rubio M (2004) Medical consultation for gastro-oesophageal reflux symptoms: reasons and associated factors. Digestion 70:173–177PubMedCrossRef Rey E, Moreno-Elola-Olaso C, Rodriguez-Artalejo F, Diaz-Rubio M (2004) Medical consultation for gastro-oesophageal reflux symptoms: reasons and associated factors. Digestion 70:173–177PubMedCrossRef
13.
Zurück zum Zitat Ware JE Jr, Kosinski M, Keller S (1996) A 12-item short-form health survey. Med Care 34:220–233PubMedCrossRef Ware JE Jr, Kosinski M, Keller S (1996) A 12-item short-form health survey. Med Care 34:220–233PubMedCrossRef
14.
Zurück zum Zitat Ware JE, Kosinski M, Keller SD (1998) SF-12: How to scores the SF-12 Physical and Mental Health Summary Scales. QualityMetric Inc, Lincoln, RI Ware JE, Kosinski M, Keller SD (1998) SF-12: How to scores the SF-12 Physical and Mental Health Summary Scales. QualityMetric Inc, Lincoln, RI
15.
Zurück zum Zitat Institut Municipal d’Investigació Mèdica. Cuestionarios de Calidad de Vida relacionada con la Salud. Cuestionario de Salud SF-12. www.imim.es/qqv/esp.htm. Cited 7 April 2005 Institut Municipal d’Investigació Mèdica. Cuestionarios de Calidad de Vida relacionada con la Salud. Cuestionario de Salud SF-12. www.imim.es/qqv/esp.htm. Cited 7 April 2005
16.
Zurück zum Zitat Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193–213PubMedCrossRef Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193–213PubMedCrossRef
17.
Zurück zum Zitat Macías JA, Royuela A (1996) La versión española del índice de calidad de sueño de Pittsburg. Informaciones Psiquiátricas 146:465–472 Macías JA, Royuela A (1996) La versión española del índice de calidad de sueño de Pittsburg. Informaciones Psiquiátricas 146:465–472
18.
Zurück zum Zitat Royuela A, Macías JA (1997) Propiedades clinimétricas de la versión castellana del cuestionario de Pittsburg. Vigilia-Sueño 9:81–94 Royuela A, Macías JA (1997) Propiedades clinimétricas de la versión castellana del cuestionario de Pittsburg. Vigilia-Sueño 9:81–94
19.
Zurück zum Zitat Reilly MC, Zbrozek AS, Dukes EM (1993) The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 4:353–365PubMed Reilly MC, Zbrozek AS, Dukes EM (1993) The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 4:353–365PubMed
20.
Zurück zum Zitat Reilly Associates. WPAI:SHP V2.0. www.reillyassociates. net/WPAI_SHP.html. Cited 7 April 2005 Reilly Associates. WPAI:SHP V2.0. www.reillyassociates. net/WPAI_SHP.html. Cited 7 April 2005
21.
Zurück zum Zitat Isolauri J, Laippala P (1995) Prevalence of symptoms suggestive of gastro-oesophageal reflux disease in an adult population. Ann Med 27:67–70PubMed Isolauri J, Laippala P (1995) Prevalence of symptoms suggestive of gastro-oesophageal reflux disease in an adult population. Ann Med 27:67–70PubMed
22.
Zurück zum Zitat Locke GR 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd (1997) Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 112:1448–1456PubMedCrossRef Locke GR 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd (1997) Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 112:1448–1456PubMedCrossRef
23.
Zurück zum Zitat Kennedy T, Jones R (2000) The prevalence of gastro-oesophageal reflux symptoms in a UK population and the consultation behaviour of patients with these symptoms. Aliment Pharmacol Ther 14:1589–1594PubMedCrossRef Kennedy T, Jones R (2000) The prevalence of gastro-oesophageal reflux symptoms in a UK population and the consultation behaviour of patients with these symptoms. Aliment Pharmacol Ther 14:1589–1594PubMedCrossRef
24.
Zurück zum Zitat Knill-Jones RP (1991) Geographical differences in the prevalence of dyspepsia. Scand J Gastroenterol Suppl 182:17–24PubMed Knill-Jones RP (1991) Geographical differences in the prevalence of dyspepsia. Scand J Gastroenterol Suppl 182:17–24PubMed
25.
Zurück zum Zitat Revicki DA, Wood M, Maton PN, Sorensen S (1998) The impact of gastroesophageal reflux disease on health-related quality of life. Am J Med 104:252–258PubMedCrossRef Revicki DA, Wood M, Maton PN, Sorensen S (1998) The impact of gastroesophageal reflux disease on health-related quality of life. Am J Med 104:252–258PubMedCrossRef
26.
Zurück zum Zitat Kaplan-Machlis B, Spiegler GE, Revicki DA (1999) Health-related quality of life in primary care patients with gastroesophageal reflux disease. Ann Pharmacother 33:1032–1036PubMedCrossRef Kaplan-Machlis B, Spiegler GE, Revicki DA (1999) Health-related quality of life in primary care patients with gastroesophageal reflux disease. Ann Pharmacother 33:1032–1036PubMedCrossRef
27.
Zurück zum Zitat Wahlqvist P (2001) Symptoms of gastroesophageal reflux disease, perceived productivity, and health-related quality of life. Am J Gastroenterol 96(8 Suppl):S57–61PubMedCrossRef Wahlqvist P (2001) Symptoms of gastroesophageal reflux disease, perceived productivity, and health-related quality of life. Am J Gastroenterol 96(8 Suppl):S57–61PubMedCrossRef
28.
Zurück zum Zitat Royuela A, Macías JA (1997) Calidad del sueño en pacientes ansiosos y depresivos. Psiquiatría Biológica 4:225–230 Royuela A, Macías JA (1997) Calidad del sueño en pacientes ansiosos y depresivos. Psiquiatría Biológica 4:225–230
29.
Zurück zum Zitat Royuela A, Macías JA, Conde VJM (2000) Calidad del sueño en ancianos. Psiquis 21:32–39 Royuela A, Macías JA, Conde VJM (2000) Calidad del sueño en ancianos. Psiquis 21:32–39
30.
Zurück zum Zitat Orr WC, Duke JC, Imes NK, Mellow MH (1994) Comparative effects of H2-receptor antagonists on subjective and objective assessments of sleep. Aliment Pharmacol Ther 8:203–207PubMedCrossRef Orr WC, Duke JC, Imes NK, Mellow MH (1994) Comparative effects of H2-receptor antagonists on subjective and objective assessments of sleep. Aliment Pharmacol Ther 8:203–207PubMedCrossRef
31.
Zurück zum Zitat Chand N, Jonson DA, Tabangin M, Ware JC (2004) Sleep dysfunction in patients with gastro-oesophageal reflux disease: prevalence and response to GERD therapy, a pilot study. Aliment Pharmacol Ther 20:969–974PubMedCrossRef Chand N, Jonson DA, Tabangin M, Ware JC (2004) Sleep dysfunction in patients with gastro-oesophageal reflux disease: prevalence and response to GERD therapy, a pilot study. Aliment Pharmacol Ther 20:969–974PubMedCrossRef
32.
Zurück zum Zitat Orr WC, Goodrich S, Robert J (2005) The effect of acid suppression on sleep patterns and sleep-related gastro-oesophageal reflux. Aliment Pharmacol Ther 21:103–108PubMedCrossRef Orr WC, Goodrich S, Robert J (2005) The effect of acid suppression on sleep patterns and sleep-related gastro-oesophageal reflux. Aliment Pharmacol Ther 21:103–108PubMedCrossRef
33.
Zurück zum Zitat Guda N, Partington S, Vakil N (2004) Symptomatic gastro-oesophageal reflux, arousals and sleep quality in patients undergoing polysomnography for possible obstructive sleep apnoea. Aliment Pharmacol Ther 20:1153–1159PubMedCrossRef Guda N, Partington S, Vakil N (2004) Symptomatic gastro-oesophageal reflux, arousals and sleep quality in patients undergoing polysomnography for possible obstructive sleep apnoea. Aliment Pharmacol Ther 20:1153–1159PubMedCrossRef
34.
Zurück zum Zitat Cohen JA, Arain A, Harris PA, Byrne DW, Holzman MD, Sharp KW, Richards WO (2003) Surgical trial investigating nocturnal gastroesophageal reflux and sleep (STINGERS). Surg Endosc 17:394–400PubMedCrossRef Cohen JA, Arain A, Harris PA, Byrne DW, Holzman MD, Sharp KW, Richards WO (2003) Surgical trial investigating nocturnal gastroesophageal reflux and sleep (STINGERS). Surg Endosc 17:394–400PubMedCrossRef
35.
Zurück zum Zitat Freidin N, Fisher MJ, Taylor W, Boyd D, Surratt P, McCallum RW, Mittal RK (1991) Sleep and nocturnal acid reflux in normal subjects and patients with reflux oesophagitis. Gut 32:1275–1279PubMed Freidin N, Fisher MJ, Taylor W, Boyd D, Surratt P, McCallum RW, Mittal RK (1991) Sleep and nocturnal acid reflux in normal subjects and patients with reflux oesophagitis. Gut 32:1275–1279PubMed
36.
Zurück zum Zitat Orr WC, Harnish MJ (1998) Sleep-related gastro-oesophageal reflux: provocation with a late evening meal and treatment with acid suppression. Aliment Pharmacol Ther 12:1033–1038PubMedCrossRef Orr WC, Harnish MJ (1998) Sleep-related gastro-oesophageal reflux: provocation with a late evening meal and treatment with acid suppression. Aliment Pharmacol Ther 12:1033–1038PubMedCrossRef
37.
Zurück zum Zitat Manocchia M, Keller S, Ware JE (2001) Sleep problems, health-related quality of life, work functioning and health care utilization among the chronically ill. Qual Life Res 10:331–345PubMedCrossRef Manocchia M, Keller S, Ware JE (2001) Sleep problems, health-related quality of life, work functioning and health care utilization among the chronically ill. Qual Life Res 10:331–345PubMedCrossRef
38.
Zurück zum Zitat Fletcher AE, Chester PC, Hawkins CM, Latham AN, Pike LA, Bulpitt CJ (1989) The effects of verapamil and propranolol on quality of life in hypertension. J Hum Hypertens 3:125–130PubMed Fletcher AE, Chester PC, Hawkins CM, Latham AN, Pike LA, Bulpitt CJ (1989) The effects of verapamil and propranolol on quality of life in hypertension. J Hum Hypertens 3:125–130PubMed
39.
Zurück zum Zitat Hill JF, Bulpitt CJ, Fletcher AE (1985) Angiotensin converting enzyme inhibitors and quality of life: the European trial. J Hypertens Suppl 3:S91–94PubMed Hill JF, Bulpitt CJ, Fletcher AE (1985) Angiotensin converting enzyme inhibitors and quality of life: the European trial. J Hypertens Suppl 3:S91–94PubMed
Metadaten
Titel
Impact of Nocturnal Heartburn on Quality of Life, Sleep, and Productivity: The SINERGE Study
verfasst von
José Luis Calleja
M. Bixquert
J. Maldonado
for the SINERGE Study Group
Publikationsdatum
01.10.2007
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 10/2007
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-006-9196-z

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