nach oben

Erschienen in:

01.08.2019 | Original Article

Impact of renin–angiotensin–aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters

verfasst von: George Angelidis, MD, Maria Samara, PhD, Maria Papathanassiou, MSc, Maria Satra, PhD, Varvara Valotassiou, MD, PhD, Ioannis Tsougos, MSc, PhD, Dimitrios Psimadas, MSc, PhD, Chara Tzavara, MSc, PhD, Sotiria Alexiou, MD, PhD, John Koutsikos, MD, PhD, Nikolaos Demakopoulos, MD, PhD, Gregory Giamouzis, MD, PhD, Filippos Triposkiadis, MD, PhD, John Skoularigis, MD, PhD, Panagoula Kollia, PhD, Panagiotis Georgoulias, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 4/2019

Einloggen, um Zugang zu erhalten

Abstract

Background

Renin–angiotensin–aldosterone system (RAAS) has an important role in atherosclerosis. We investigated the effects of six RAAS gene polymorphisms on myocardial perfusion.

Methods and Results

We examined 810 patients with known or suspected coronary artery disease (CAD) using stress–rest myocardial single-photon emission computed tomography. Summed stress score (SSS), summed rest score (SRS), summed difference score (SDS), transient ischemic dilation (TID), and lung/heart ratio (LHR) were recorded. The following gene polymorphisms were investigated: angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensinogen (AGT) M235T and T174M, angiotensin II type 1 receptor (AT1R) A1166C, renin (REN) C5312T, and angiotensin II type 2 receptor (AT2R) C3123A. The heterozygotes or homozygotes on ACE D allele were 7.54 times more likely to have abnormal SSS, while the AGT (T174M) heterozygotes were 5.19 times more likely to have abnormal SSS. The homozygotes of ACE D had significantly higher values on TID and LHR, while the AGT (T174M) heterozygotes had higher values on TID. The AT1R heterozygotes had greater odds for having SSS ≥ 3. The patients carried AT1R homozygosity of C allele had significantly higher values on TID, while heterozygotes of AT1R had significantly higher values on LHR.

Conclusions

Among the polymorphisms investigated, ACE D allele had the strongest association with abnormal myocardial perfusion.

Nur mit Berechtigung zugänglich

Zhao Y, Malik S, Wong ND. Evidence for coronary artery calcification screening in the early detection of coronary artery disease and implications of screening in developing countries. Glob Heart 2014;9:399-407.PubMedCrossRef

Puymirat É. Epidemiology of coronary artery disease. Rev Prat 2015;65:317-20.PubMed

Hartiala J, Schwartzman WS, Gabbay J, Ghazalpour A, Bennett BJ, Allayee H. The genetic architecture of coronary artery disease: current knowledge and future opportunities. Curr Atheroscler Rep 2017;19:6.PubMedPubMedCentralCrossRef

Girelli D, Piubelli C, Martinelli N, Corrocher R, Olivieri O. A decade of progress on the genetic basis of coronary artery disease. Practical insights for the internist. Eur J Intern Med 2017;41:10-17.PubMedCrossRef

Gluba A, Banach M, Mikhailidis DP, Rysz J. Genetic determinants of cardiovascular disease: the renin-angiotensin-aldosterone system, paraoxonases, endothelin-1, nitric oxide synthase and adrenergic receptors. In Vivo 2009;23:797-812.PubMed

Durante A, Peretto G, Laricchia A, Ancona F, Spartera M, Mangieri A, Cianflone D. Role of the renin-angiotensin-aldosterone system in the pathogenesis of atherosclerosis. Curr Pharm Des 2012;18:981-1004.PubMedCrossRef

Benigni A, Cassis P, Remuzzi G. Angiotensin II revisited: new roles in inflammation, immunology and aging. EMBO Mol Med 2010;2:247-57.PubMedPubMedCentralCrossRef

Wang YJ, Pan Y. Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: a meta-analysis. Mol Med Rep 2012;6(4):884-88.PubMedCrossRef

Makino Y, Konoshita T, Omori A, Maegawa N, Nakaya T, Ichikawa M, et al. A genetic variant in the distal enhancer region of the human renin gene affects renin expression. PLoS ONE 2015;10:e0137469.PubMedPubMedCentralCrossRef

10.

Fuchs S, Philippe J, Germain S, Mathieu F, Jeunemaitre X, Corvol P, et al. Functionality of two new polymorphisms in the human renin gene enhancer region. J Hypertens 2002;20:2391-98.PubMedCrossRef

11.

You FJ, Shen DM. Association between angiotensin-converting enzyme insertion/deletion polymorphisms and the risk of heart disease: an updated meta-analysis. Genet Mol Res 2016;15:15017194.PubMedCrossRef

12.

Bonnardeaux A, Davies E, Jeunemaitre X, Féry I, Charru A, Clauser E, et al. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994;24:63-69.PubMedCrossRef

13.

Katsuya T, Morishita R. Gene polymorphism of angiotensin II type 1 and type 2 receptors. Curr Pharm Des 2013;19:2996-3001.PubMedCrossRef

14.

Georgoulias P, Wozniak G, Samara M, Chiotoglou I, Kontos A, Tzavara C, et al. Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging. J Hum Genet 2009;54:595-602.PubMedCrossRef

15.

Georgoulias P, Tsougos I, Valotassiou V, Samara M, Kollia P. Darwinian molecular imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging 2010;37:829-30.PubMedCrossRef

16.

Satra M, Samara M, Wozniak G, Tzavara C, Kontos A, Valotassiou V, et al. Sequence variations in the FII, FV, F13A1, FGB and PAI-1 genes are associated with differences in myocardial perfusion. Pharmacogenomics 2011;12:195-203.PubMedCrossRef

17.

Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, et al. EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision. Eur J Nucl Med Mol Imaging 2015;42:1929-40.PubMedPubMedCentralCrossRef

18.

Georgoulias P, Tsougos I, Valotassiou V, Tzavara C, Xaplanteris P, Demakopoulos N. Long-term prognostic value of early poststress (99m)Tc-tetrofosmin lung uptake during exercise (SPECT) myocardial perfusion imaging. Eur J Nucl Med Mol Imaging 2010;37:789-98.PubMedCrossRef

19.

Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P, et al. Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med 1994;330:1629-33.PubMedCrossRef

20.

Konoshita T, Kato N, Fuchs S, Mizuno S, Aoyama C, Motomura M, et al. Genetic variant of the Renin-Angiotensin system and diabetes influences blood pressure response to Angiotensin receptor blockers. Diabetes Care 2009;32:1485-90.PubMedPubMedCentralCrossRef

21.

Solari V, Puri P. Genetic polymorphisms of angiotensin system genes in congenital diaphragmatic hernia associated with persistent pulmonary hypertension. J Pediatr Surg 2004;39:302-6.PubMedCrossRef

22.

Katsuya T, Horiuchi M, Minami S, Koike G, Santoro NF, Hsueh AJ, et al. Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome. Mol Cell Endocrinol 1997;127:221-8.PubMedCrossRef

23.

Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 1992;20:1433.PubMedPubMedCentralCrossRef

24.

Shanmugam V, Sell KW, Saha BK. Mistyping ACE heterozygotes. PCR Method Appl 1993;3:120-1.CrossRef

25.

Hesse B, Tägil K, Cuocolo A, Anagnostopoulos C, Bardiés M, Bax J, et al. EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging 2005;32:855-97.PubMedCrossRef

26.

Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. J Nucl Cardiol 2002;9:240-5.PubMedCrossRef

27.

Kapur A, Latus KA, Davies G, Dhawan RT, Eastick S, Jarritt PH, et al. A comparison of three radionuclide myocardial perfusion tracers in clinical practice: the ROBUST study. Eur J Nucl Med Mol Imaging 2002;29:1608-16.PubMedCrossRef

28.

Georgoulias P, Demakopoulos N, Orfanakis A, Xydis K, Xaplanteris P, Vardas P, et al. Evaluation of abnormal heart-rate recovery after exercise testing in patients with diabetes mellitus: correlation with myocardial SPECT and chronotropic parameters. Nucl Med Commun 2007;28:165-71.PubMedCrossRef

29.

Abidov A, Hachamovitch R, Hayes SW, Friedman JD, Cohen I, Kang X, et al. Are shades of gray prognostically useful in reporting myocardial perfusion single-photon emission computed tomography? Circ Cardiovasc Imaging 2009;2:290-8.PubMedCrossRef

30.

McPherson R, Tybjaerg-Hansen A. Genetics of coronary artery disease. Circ Res 2016;118:564-78.PubMedCrossRef

31.

Hamrefors V. Common genetic risk factors for coronary artery disease: new opportunities for prevention? Clin Physiol Funct Imaging 2017;37:243-54.PubMedCrossRef

32.

Hendel RC, Berman DS, Di Carli MF, Heidenreich PA, Henkin RE, Pellikka PA, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the Society of Cardiovascular Computed Tomography, the Society for Cardiovascular Magnetic Resonance, and the Society of Nuclear Medicine. Circulation 2009;119:e561-87.PubMed

33.

Ronan G, Wolk MJ, Bailey SR, Doherty JU, Douglas PS, Hendel RC, et al. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Nucl Cardiol 2014;21:192-220.PubMedCrossRef

34.

Ellis KL, Palmer BR, Frampton CM, Troughton RW, Doughty RN, Whalley GA, et al. Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease. J Hum Hypertens 2013;27:237-44.PubMedCrossRef

35.

Guney AI, Ergec D, Kirac D, Ozturhan H, Caner M, Koc G, et al. Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease. Genet Mol Res 2013;12:6895-906.PubMedCrossRef

36.

Moradzadegan A, Vaisi-Raygani A, Nikzamir A, Rahimi Z. Angiotensin converting enzyme insertion/deletion (I/D) (rs4646994) and Vegf polymorphism (+405G/C; rs2010963) in type II diabetic patients: association with the risk of coronary artery disease. J Renin Angiotensin Aldosterone Syst 2015;16:672-80.PubMedCrossRef

37.

Al-Hazzani A, Daoud MS, Ataya FS, Fouad D, Al-Jafari AA. Renin-angiotensin system gene polymorphisms among Saudi patients with coronary artery disease. J Biol Res (Thessalon) 2014;21:8.CrossRef

38.

Pandey U, Kumari R, Nath B, Ganesh S, Banerjee I, Hasan OM, et al. Association of angiotensin-converting enzyme, methylene tetrahydrofolate reductase and paraoxonase gene polymorphism and coronary artery disease in an Indian population. Cardiol J 2011;18:385-94.PubMed

39.

Tsai CT, Hwang JJ, Ritchie MD, Moore JH, Chiang FT, Lai LP, et al. Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis 2007;195:172-80.PubMedCrossRef

40.

Ragia G, Nikolaidis E, Tavridou A, Arvanitidis KI, Kanoni S, Dedoussis GV, et al. Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients. J Renin Angiotensin Aldosterone Syst 2010;11:136-45.PubMedCrossRef

41.

Bonfim-Silva R, Guimarães LO, Souza Santos J, Pereira JF, Leal Barbosa AA, Souza Rios DL. Case-control association study of polymorphisms in the angiotensinogen and angiotensin-converting enzyme genes and coronary artery disease and systemic artery hypertension in African-Brazilians and Caucasian-Brazilians. J Genet 2016;95:63-9.PubMedCrossRef

42.

Araújo MA, Menezes BS, Lourenço C, Cordeiro ER, Gatti RR, Goulart LR (2004). The A1166C polymorphism of the angiotensin II type-1 receptor in acute myocardial infarction. Arq Bras Cardiol 83:409-13, 404-8

43.

Tsai CT, Hwang JJ, Lai LP, Wang YC, Lin JL, Chiang FT. Interaction of gender, hypertension, and the angiotensinogen gene haplotypes on the risk of coronary artery disease in a large angiographic cohort. Atherosclerosis 2009;203:249-56.PubMedCrossRef

44.

Gardemann A, Stricker J, Humme J, Nguyen QD, Katz N, Philipp M, et al. Angiotensinogen T174 M and M235T gene polymorphisms are associated with the extent of coronary atherosclerosis. Atherosclerosis 1999;145:309-14.PubMedCrossRef

45.

Jeunemaitre X, Ledru F, Battaglia S, Guillanneuf MT, Courbon D, Dumont C, et al. Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study. Hum Genet 1997;99:66-73.PubMedCrossRef

46.

Ko YL, Ko YS, Wang SM, Chu PH, Teng MS, Cheng NJ, et al. Angiotensinogen and angiotensin-I converting enzyme gene polymorphisms and the risk of coronary artery disease in Chinese. Hum Genet 1997;100:210-4.PubMedCrossRef

47.

Renner W, Nauck M, Winkelmann BR, Hoffmann MM, Scharnagl H, Mayer V, et al. Association of angiotensinogen haplotypes with angiotensinogen levels but not with blood pressure or coronary artery disease: the ludwigshafen risk and cardiovascular health study. J Mol Med (Berl) 2005;83:235-9.CrossRef

48.

Underwood SR, Anagnostopoulos C, Cerqueira M, Ell PJ, Flint EJ, Harbinson M, et al. Myocardial perfusion scintigraphy: the evidence. Eur J Nucl Med Mol Imaging 2004;31:261-91.PubMedCrossRef

Titel: Impact of renin–angiotensin–aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters
verfasst von: George Angelidis, MD
Maria Samara, PhD
Maria Papathanassiou, MSc
Maria Satra, PhD
Varvara Valotassiou, MD, PhD
Ioannis Tsougos, MSc, PhD
Dimitrios Psimadas, MSc, PhD
Chara Tzavara, MSc, PhD
Sotiria Alexiou, MD, PhD
John Koutsikos, MD, PhD
Nikolaos Demakopoulos, MD, PhD
Gregory Giamouzis, MD, PhD
Filippos Triposkiadis, MD, PhD
John Skoularigis, MD, PhD
Panagoula Kollia, PhD
Panagiotis Georgoulias, MD, PhD
Publikationsdatum: 01.08.2019
Verlag: Springer International Publishing
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 4/2019
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-017-1181-8

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Impact of renin–angiotensin–aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters