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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

01.03.2013

Impaired Mitochondrial Metabolism and Mammary Carcinogenesis

verfasst von: Nagendra Yadava, Sallie S. Schneider, D. Joseph Jerry, Chul Kim

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 1/2013

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Abstract

Mitochondrial oxidative metabolism plays a key role in meeting energetic demands of cells by oxidative phosphorylation (OxPhos). Here, we have briefly discussed (a) the dynamic relationship that exists among glycolysis, the tricarboxylic acid (TCA) cycle, and OxPhos; (b) the evidence of impaired OxPhos (i.e. mitochondrial dysfunction) in breast cancer; (c) the mechanisms by which mitochondrial dysfunction can predispose to cancer; and (d) the effects of host and environmental factors that can negatively affect mitochondrial function. We propose that impaired OxPhos could increase susceptibility to breast cancer via suppression of the p53 pathway, which plays a critical role in preventing tumorigenesis. OxPhos is sensitive to a large number of factors intrinsic to the host (e.g. inflammation) as well as environmental exposures (e.g. pesticides, herbicides and other compounds). Polymorphisms in over 143 genes can also influence the OxPhos system. Therefore, declining mitochondrial oxidative metabolism with age due to host and environmental exposures could be a common mechanism predisposing to cancer.

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Titel: Impaired Mitochondrial Metabolism and Mammary Carcinogenesis
verfasst von: Nagendra Yadava
Sallie S. Schneider
D. Joseph Jerry
Chul Kim
Publikationsdatum: 01.03.2013
Verlag: Springer US
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 1/2013
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-012-9271-3

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Impaired Mitochondrial Metabolism and Mammary Carcinogenesis

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