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02.11.2017 | Original Contribution | Ausgabe 8/2018 Open Access

European Journal of Nutrition 8/2018

Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects

Zeitschrift:
European Journal of Nutrition > Ausgabe 8/2018
Autoren:
Nittaya Marungruang, Juscelino Tovar, Inger Björck, Frida Fåk Hållenius
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00394-017-1563-3) contains supplementary material, which is available to authorized users.

Abstract

Purpose

A multifunctional diet (MFD) targeting subclinical inflammation was developed as a tool to decrease risk factors for cardiometabolic disease in healthy “at-risk” individuals (BMI 25–33 kg/m2). MFD contains several components that are degraded in the colon by the microbiota, such as dietary fibers from rye, barley, oats and berries. It also contains soy beans, oily fish and plant stanols. In previous studies, we have observed improved cardiometabolic markers in healthy at-risk individuals after 4–8 week intake of MFD. However, whether these improvements can be associated with changes in the gut microbiota composition has not been investigated. In the present study, we analyzed the gut microbiota before and after an 8-week dietary intervention with MFD.

Methods

Cardiometabolic at-risk individuals (n = 47), between 51 and 72 years old and with a BMI of 25–33 kg/m2, were given either the MFD or a control diet lacking the functional (“active”) components for 8 weeks in a parallel, randomized design. Next-generation sequencing of bacterial 16S rRNA genes was used to analyze the gut microbiota composition.

Results

The 8-week intervention with MFD did not significantly alter the gut microbiota composition at phylum or genus taxonomic levels, while LEfSE analysis identified increased abundance of Prevotella copri in the MFD group as compared to the control group. Treponema correlated positively with blood pressure. In contrast, Faecalibacterium showed a negative association with blood pressure, while Bilophila appeared to associate with a negative blood lipid profile.

Conclusions

Taken together, results from the present study may be used in the further development of effective dietary concepts capable of reducing cardiometabolic risk markers in humans through a targeted modulation of the gut microbial community.

Trial registration number

Clinical Trials.gov NCT02148653.

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Zusatzmaterial
Supplementary material 1 (DOCX 17 KB)
394_2017_1563_MOESM1_ESM.docx
Figure S1. Relative abundance of P. copri in MFD and control diet groups. Data shown are mean and standard deviation. (TIF 173 KB)
394_2017_1563_MOESM2_ESM.tif
Figure S2. Loading (big panel) and score scatter (small) PLS plots illustrating correlations between gut microbiota from de novo OTU picking dataset and cardiometabolic risk markers in MFD and control diet groups. Bacterial genera significantly correlated with the risk markers are shown in big green squares. Uncl, unclassified. (TIF 4374 KB)
394_2017_1563_MOESM3_ESM.tif
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