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Rheumatology International

Erschienen in:

01.02.2006 | Original Article

In vivo expression of inflammatory cytokine receptors in the joint compartments of patients with arthritis

verfasst von: Tania Silvestri, Lia Pulsatelli, Paolo Dolzani, Luigi Frizziero, Andrea Facchini, Riccardo Meliconi

Erschienen in: Rheumatology International | Ausgabe 4/2006

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Abstract

To test a hypothesis of compartmentalized pathogenesis of different types of arthritis, namely inflammatory arthritis (IA) and osteoarthritis (OA), synovial and cartilage biopsies were examined for the expression of TNF and IL-1 receptors. In cartilage, we found constitutive expression of all receptors in normal tissues, and decreased expression of signal-transducing receptors in pathological chondrocytes. In synovium, there was a lower expression of signal-transducing receptors in cases of OA compared to those of IA. In OA, the three signal-transducing receptors were more abundantly expressed in cartilage, while in IA they were mainly present in synovial tissue (TNFRp75 being expressed more than p55). IL-1 decoy receptor type II was low or absent in synovial tissues, but present in cartilage. The increased expression of TNFRp75 and IL-1RI in OA cartilage, compared to IA, in addition to the abundant local cytokine production, strengthens the hypothesis of autocrine/paracrine action by inflammatory cytokines in the pathogenesis of cartilage damage.

Harris ED (1990) Rheumatoid arthritis: pathophysiology and implications for therapy. N Engl J Med 322:1277–1289PubMed

Bullough PG (1994) Osteoarthritis: pathology. In: Klippel JH, Dieppe PA (eds) Rheumatology. Mosby-Year Book Europe Ltd., London, pp 7.1–7.8

Kane D, Jensen LE, Grehan S, Whitehead AS, Bresnihan B, Fitzgerald O (2004) Quantitation of metalloproteinase gene expression in rheumatoid and psoriatic arthritis synovial tissue distal and proximal to the cartilage-pannus junction. J Rheumatol 31(7):1274–1280

Pelletier J-P, Roughley PJ, DiBattista JA, McCollum R, Martel-Pelletier J (1991) Are cytokines involved in osteoarthritic pathophysiology? Semin Arthritis Rheum 20:12–25

Linblad S, Hedfors E (1987) Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis. Arthritis Rheum 30:1081–1088PubMed

Myers SL, Brandt KD, Ehlich JW, Braunstein EM, Shelbourne KD, Heck DA et al (1990) Synovial inflammation in patients with early osteoarthritis of the knee. J Rheumatol 17:1662–1669PubMed

Shinmei M, Masuda K, Kikuchi T, Shimomura Y, Okada Y (1991) Production of cytokines by chondrocytes and its role in proteoglycan degradation. J Rheumatol 18:89–91

Melchiorri C, Meliconi R, Frizziero L, Silvestri T, Pulsatelli L, Mazzetti I et al (1998) Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. Arthritis Rheum 41:2165–2174

Büttner FH, Chubinskaya S, Margerie D, Huch K, Flechtenmacher J, Cole AA et al (1997) Expression of membrane type 1 matrix metalloproteinase in human articular cartilage. Arthritis Rheum 40:704–709

10.

Warnock MG, Sharif M, Elson CJ (1994) IL-1β at physiological concentration stimulates degradation of human articular cartilage. Bone 25:S36

11.

Vandenabeele P, Declercq W, Beyaert R, Fiers W (1995) Two tumour necrosis factor receptors: structure and function. Trends Cell Biol 5:392–399

12.

Grell M, Wajant H, Zimmermann G, Scheurich P (1998) The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc Natl Acad Sci USA 95:570–575

13.

Tartaglia LA, Goeddel DV (1992) Two TNF receptors. Immunol Today 13:151–153CrossRefPubMed

14.

Higuchi M, Aggarwall BB (1994) TNF induces internalisation of the p60 receptor and shedding of the p80 receptor. J Immunol 152:3550–3558

15.

Porteu F, Hieblot C (1994) Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils. J Biol Chem 269:2834–2840

16.

Martin MU, Falk W (1997) The interleukin-1 receptor complex and interleukin-1 signal transduction. Eur Cytokine Netw 8:5–17

17.

Malinowsky D, Lundkvist J, Laye S, Bartfai T (1998) Interleukin-1 receptor accessory protein interacts with the type II interleukin-1 receptor. FEBS Lett 429:299–302

18.

Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D et al (1998) The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. J Immunol 161:6871–6877

19.

Saha N, Moldovan F, Tardif G, Pelletier J-P, Cloutier JM, Martel-Pelletier J (1999) Interleukin-1beta-converting enzyme/caspase-1 in human osteoarthritic tissues: localization and role in the maturation of interleukin-1beta and interleukin-18. Arthritis Rheum 42:1577–1587

20.

Amin AR (1999) Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis. Osteoarthritis Cartilage 7:392–394

21.

Smith MD, Triantafillou S, Parker A, Youssef PP, Coleman M (1997) Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol 24:365–371PubMed

22.

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324PubMed

23.

Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K et al (1986) Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 29:1039–1049PubMed

24.

Pasquali-Ronchetti I, Frizziero L, Guerra D, Baccarini-Contri M, Focherini MC, Georgountzos A et al (1992) Aging of the human synovium: an in vivo and ex vivo morphological study. Semin Arthritis Rheum 21:400–414

25.

Wang J, Elewaut D, Veys EM, Verbruggen G (2003) Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage. Arthritis Rheum 48(5):1281–1291

26.

Alsalameh S, Mattka B, Al-Ward R, Lorenz HM, Manger B, Pfizenmaier K, Grell M, Kalden JR (1999) Preferential expression of tumor necrosis factor receptor 55 (TNF-R55) on human articular chondrocytes: selective transcriptional upregulation of TNF-R75 by proinflammatory cytokines interleukin 1beta, tumor necrosis factor-alpha, and basis fibroblast growth factor. J Rheumatol 26(3):645–653

27.

Fukui N, Zhu Y, Maloney WJ, Clohisy J, Sandell LJ (2003) Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes. J Bone Joint Surg Am 85-A (Suppl 3):59–66

28.

Merrihew C, Soeder S, Rueger DC, Kuettner KE, Chubinskaya S (2003) Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage. J Bone Joint Surg Am 85-A (Suppl 3):67–74

29.

Colotta F, Orlando S, Fadlon EJ, Sozzani S, Matteucci C, Mantovani A (1995) Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells. J Exp Med 181:2181–2186

30.

Curtis BM, Widmer MB, deRoos P, Qwarnstrom EE (1990) IL-1 and its receptor are translocated to the nucleus. J Immunol 144(4):1295–1303

31.

Silvestri T, Meliconi R, Pulsatelli L, Dolzani P, Zizzi F, Frizziero L, Borzi RM, Facchini A (2003) Down-modulation of chemokine receptor cartilage expression in inflammatory arthritis. Rheumatology (Oxford) 42(1):14–18

32.

Martel-Pelletier J, McCollum R, DiBattista J, Faure M-P, Chin JA, Fournier S et al (1992) The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function. Arthritis Rheum 35:530–540

33.

Attur MG, Dave M, Cipolletta C, Kang P, Goldring MB, Patel IR et al (2000) Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention. J Biol Chem 275:40307–40315

34.

Colotta F, Saccani S, Giri JG, Dower SK, Sims JE, Introna M et al (1996) Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes. J Immunol 156:2534–2541

35.

Verschure PJ, Marle JV, Joosten LA, Helsen MM, Lafeber FP, Berg WB (1996) Localization of insulin-like growth factor-1 receptor in human normal and osteoarthritic cartilage in relation to proteoglycan synthesis and content. Br J Rheumatol 35:1044–1055

36.

Lafeber FP, van Roy HL, van der Kraan PM, van den Berg WB, Bijlsma JW (1997) Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage. J Rheumatol 24:536–542

37.

Deleuran BW, Chu CQ, Field M, Brennan FM, Katsikis P, Feldmann M et al (1992) Localization of interleukin-1 α, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritis. Br J Rheumatol 31:801–809

38.

Deleuran BW, Chu CQ, Field M, Brennan FM, Mitchell T, Feldmann M et al (1992) Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor α. Arthritis Rheum 35:1170–1178

39.

Butler DM, Feldmann M, Di Padova F, Brennan FM (1994) p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts. Eur Cytokine Netw 5:441–448

40.

Grom AA, Murray KJ, Luyrink L, Emery H, Passo MH, Glass DN et al (1996) Patterns of expression of tumor necrosis factor α, tumor necrosis factor β, and their receptors in synovium of patients with juvenile rheumatoid arthritis and juvenile spondyloarthropathy. Arthritis Rheum 39:1703–1710

41.

Alsalameh S, Winter K, Al-Ward R, Wendler J, Kalden JR, Kinne RW (1999) Distribution of TNF-α, TNF-R55 and TNF-R75 in the rheumatoid synovial membrane: TNF receptors are localized preferentially in the lining layer; TNF-α is distributed mainly in the vicinity of TNF receptors in the deeper layers. Scand J Immunol 49:278–285

42.

Shlopov BV, Gumanovskaya ML, Hasty KA (2000) Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis. Arthritis Rheum 43:195–205

43.

Webb GR, Westacott CI, Elson CJ (1997) Chondrocyte tumor necrosis factor receptors and focal loss of cartilage in osteoarthritis. Osteoarthritis Cartilage 5:427–437

44.

Westacott CI, Atkins RM, Dieppe PA, Elson CJ (1994) Tumor necrosis factor-α receptor expression on chondrocytes isolated from human articular cartilage. J Rheumatol 21:1710–1715

45.

Westacott CI, Barakat AF, Wood L, Perry MJ, Neison P, Bisbinas I et al (2000) Tumor necrosis factor alpha can contribute to focal loss of cartilage in osteoarthritis. Osteoarthritis Cartilage 8:213–221

46.

Alsalameh S, Amin RJ, Kunisch E, Jasin HE, Kinne RW (2003) Preferential induction of prodestructive matrix metalloproteinase-1 and proinflammatory interleukin 6 and prostaglandin E2 in rheumatoid arthritis synovial fibroblasts via tumor necrosis factor receptor-55. J Rheumatol 30:1680–1690

47.

Daigle JL, Hong JH, Chiang CS, McBride WH (2001) The role of tumor necrosis factor signalling pathways in the response of murine brain to irradiation. Cancer Res 61:8859–8865

48.

Price JS, Chambers MG, Poole AR, Fradin A, Mason RM (2002) Comparison of collagenase-cleaved articular cartilage collagen in mice in the naturally occurring STR/ort model of osteoarthritis and in collagen-induced arthritis. Osteoarthritis Cartilage 10:172–179

Titel: In vivo expression of inflammatory cytokine receptors in the joint compartments of patients with arthritis
verfasst von: Tania Silvestri
Lia Pulsatelli
Paolo Dolzani
Luigi Frizziero
Andrea Facchini
Riccardo Meliconi
Publikationsdatum: 01.02.2006
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 4/2006
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-005-0586-x

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