Background
Methods
Patients and data collection
Statistical analysis
Results
Patient data and characteristics
Age (years) | 60.6 ± 13.9 | Serum albumin (g/dl) | 3.5 ± 0.5 |
Male gender (n [%]) | 78 [77%] | Blood urea nitrogen (mg/dl) | 52.1 ± 14.7 |
Cause of ESRD (n [%]) | Serum creatinine (mg/dl) | 6.6 ± 2.5 | |
Diabetes | 35 [34%] | Serum corrected calcium (mg/dl) | 8.9 ± 1.1 |
Glomerulonephritis | 34 [33%] | Serum phosphate (mg/dl) | 4.6 ± 1.1 |
Nephrosclerosis | 15 [15%] | C-reactive protein (mg/dl) | 0.43 ± 0.68 |
Others | 18 [18%] | Total cholesterol (mg/dl) | 198 ± 39 |
Diabetes mellitus (n [%]) | 35 [34%] | Triglyceride (mg/dl) | 173 ± 129 |
CVD before PD initiation (n [%]) | 25 [25%] | Renal weekly Kt/V | 1.14 ± 0.62 |
Automated PD (n [%]) | 91 [89%] | Total weekly Kt/V | 2.23 ± 0.58 |
Body mass index (kg/m2) | 22.1 ± 3.4 | D/Pcre | 0.59 ± 0.12 |
Systolic blood pressure (mmHg) | 131 ± 18 | PET category | |
Diastolic blood pressure (mmHg) | 77 ± 12 | L | 19 [19%] |
Urine volume (ml/day) | 1182 ± 612 | LA | 59 [58%] |
UF volume (ml/day) | 446 ± 658 | HA + H | 24 [24%] |
Hemoglobin (g/dl) | 10.7 ± 1.6 | P-PrCl (ml/day) | 58.9 ± 26.9 |
Occurrence of CV event and death after PD initiation
Variables | Cardiovascular event (mean ± SD) |
pvalue | |
---|---|---|---|
(−) N = 84 | (+) N = 18 | ||
Age (years) | 59.1 ± 14.3 | 67.4 ± 9.7 | < 0.01 |
Male gender | 75% | 83% | 0.45 |
Cause of ESRD | 0.67 | ||
Diabetes | 31% | 50% | |
Glomerulonephritis | 36% | 22% | |
Nephrosclerosis | 15% | 11% | |
Others | 18% | 17% | |
Diabetes mellitus | 31% | 50% | 0.13 |
CVD before PD initiation | 20% | 44% | 0.03 |
Automated PD | 88% | 94% | 0.43 |
Body mass index (kg/m2) | 22.1 ± 3.4 | 21.7 ± 3.3 | 0.73 |
Systolic blood pressure (mmHg) | 130 ± 18 | 140 ± 18 | 0.07 |
Diastolic blood pressure (mmHg) | 77 ± 12 | 75 ± 12 | 0.24 |
Urine volume (ml/day) | 1166 ± 579 | 1258 ± 763 | 0.57 |
UF volume (ml/day) | 477 ± 640 | 286 ± 745 | 0.31 |
Hemoglobin (g/dl) | 10.8 ± 1.7 | 10.2 ± 1.1 | 0.03 |
Serum albumin (g/dl) | 3.6 ± 0.5 | 3.3 ± 0.5 | 0.01 |
Blood urea nitrogen (mg/dl) | 52.5 ± 14.1 | 50.1 ± 17.2 | 0.49 |
Serum creatinine (mg/dl) | 7.0 ± 2.6 | 5.7 ± 2.3 | 0.08 |
Serum corrected calcium (mg/dl) | 8.9 ± 1.2 | 9.0 ± 0.7 | 0.90 |
Serum phosphate (mg/dl) | 4.7 ± 1.1 | 4.3 ± 1.3 | 0.10 |
C-reactive protein (mg/dl) | 0.39 ± 0.65 | 0.63 ± 0.83 | 0.05 |
Total cholesterol (mg/dl) | 198 ± 40 | 201 ± 38 | 0.87 |
Triglyceride (mg/dl) | 175 ± 138 | 164 ± 74 | 0.49 |
Renal weekly Kt/V | 1.16 ± 0.65 | 1.12 ± 0.52 | 0.99 |
Total weekly Kt/V | 2.23 ± 0.60 | 2.19 ± 0.50 | 0.88 |
D/Pcre | 0.58 ± 0.12 | 0.65 ± 0.11 | < 0.01 |
PET category | < 0.01 | ||
L | 23% | 0% | |
LA | 60% | 50% | |
HA + H | 18% | 50% | |
P-PrCl (ml/day) | 54.7 ± 24.2 | 72.7 ± 34.1 | 0.03 |
Variables | Death (mean ± SD) |
pvalue | |
---|---|---|---|
(−) N = 87 | (+) N = 15 | ||
Age (years) | 58.0 ± 12.8 | 75.3 ± 11.0 | < 0.01 |
Male gender | 78% | 67% | 0.33 |
Cause of ESRD | 0.05 | ||
Diabetes | 33% | 40% | |
Glomerulonephritis | 39% | 0% | |
Nephrosclerosis | 11% | 33% | |
Others | 16% | 27% | |
Diabetes mellitus | 34% | 40% | 0.62 |
CVD before PD initiation | 24% | 27% | 0.85 |
Automated PD | 91% | 80% | 0.22 |
Body mass index (kg/m2) | 22.2 ± 3.3 | 21.3 ± 3.8 | 0.36 |
Systolic blood pressure (mmHg) | 130 ± 17 | 134 ± 24 | 0.48 |
Diastolic blood pressure (mmHg) | 78 ± 11 | 67 ± 14 | < 0.01 |
Urine volume (ml/day) | 1222 ± 619 | 948 ± 530 | 0.11 |
UF volume (ml/day) | 484 ± 649 | 249 ± 693 | 0.21 |
Hemoglobin (g/dl) | 10.8 ± 1.7 | 10.2 ± 1.2 | 0.04 |
Serum albumin (g/dl) | 3.6 ± 0.4 | 3.1 ± 0.5 | < 0.01 |
Blood urea nitrogen (mg/dl) | 53.0 ± 14.4 | 46.6 ± 15.4 | 0.11 |
Serum creatinine (mg/dl) | 6.9 ± 2.5 | 4.5 ± 1.9 | < 0.01 |
Serum corrected calcium (mg/dl) | 8.9 ± 1.2 | 9.1 ± 0.7 | 0.55 |
Serum phosphate (mg/dl) | 4.8 ± 1.1 | 3.9 ± 0.8 | < 0.01 |
C-reactive protein (mg/dl) | 0.40 ± 0.69 | 0.61 ± 0.60 | < 0.01 |
Total cholesterol (mg/dl) | 199 ± 39 | 193 ± 41 | 0.58 |
Triglyceride (mg/dl) | 178 ± 136 | 147 ± 73 | 0.86 |
Renal weekly Kt/V | 1.13 ± 0.63 | 1.23 ± 0.58 | 0.57 |
Total weekly Kt/V | 2.21 ± 0.56 | 2.30 ± 0.73 | 0.61 |
D/Pcre | 0.58 ± 0.11 | 0.67 ± 0.15 | 0.03 |
PET category | < 0.01 | ||
L | 21% | 7% | |
LA | 61% | 40% | |
HA + H | 18% | 53% | |
P-PrCl (ml/day) | 56.3 ± 27.9 | 67.5 ± 17.3 | 0.02 |
Impact of PET category classification at PD initiation on the prognosis of PD patients
Variables | PET category (mean ± SD) |
pvalue | ||
---|---|---|---|---|
L | LA | HA + H | ||
N= 19 |
N = 59 |
N = 24 | ||
Age (years) | 60.4 ± 15.5 | 58.9 ± 13.7 | 64.9 ± 13.0 | 0.24 |
Male gender | 68% | 78% | 79% | 0.66 |
Cause of ESRD | 0.74 | |||
Diabetes | 26% | 32% | 46% | |
Glomerulonephritis | 52% | 32% | 21% | |
Nephrosclerosis | 11% | 15% | 17% | |
Others | 11% | 20% | 17% | |
Diabetes mellitus | 26% | 32% | 46% | 0.54 |
CVD before PD initiation | 16% | 24% | 33% | 0.62 |
Automated PD | 90% | 88% | 92% | 0.99 |
Body mass index (kg/m2) | 20.9 ± 2.8 | 22.6 ± 3.5 | 21.8 ± 3.5 | 0.18 |
Systolic blood pressure (mmHg) | 126 ± 14 | 132 ± 18 | 134 ± 22 | 0.31 |
Diastolic blood pressure (mmHg) | 75 ± 12 | 78 ± 11 | 75 ± 15 | 0.54 |
Urine volume (ml/day) | 1155 ± 401 | 1260 ± 684 | 1012 ± 543 | 0.49 |
UF volume (ml/day) | 654 ± 440 | 437 ± 616 | 300 ± 868 | 0.24 |
Hemoglobin (g/dl) | 11.2 ± 1.2 | 10.6 ± 1.9 | 10.6 ± 1.2 | 0.28 |
Serum albumin (g/dl) | 3.8 ± 0.4 | 3.6 ± 0.4 | 3.3 ± 0.5*,**
| < 0.01 |
Blood urea nitrogen (mg/dl) | 50.8 ± 15.8 | 54.2 ± 13.8 | 47.9 ± 15.3 | 0.26 |
Serum creatinine (mg/dl) | 6.5 ± 2.0 | 6.9 ± 2.6 | 5.9 ± 2.7 | 0.28 |
Serum corrected calcium (mg/dl) | 9.1 ± 0.8 | 8.8 ± 1.3 | 9.0 ± 0.7 | 0.66 |
Serum phosphate (mg/dl) | 4.7 ± 1.4 | 4.9 ± 1.0 | 4.1 ± 1.0**
| < 0.01 |
C-reactive protein (mg/dl) | 0.38 ± 0.83 | 0.41 ± 0.62 | 0.54 ± 0.73 | 0.09 |
Total cholesterol (mg/dl) | 197 ± 27 | 195 ± 44 | 207 ± 37 | 0.35 |
Triglyceride (mg/dl) | 227 ± 215 | 161 ± 105 | 160 ± 69 | 0.39 |
Renal weekly Kt/V | 1.26 ± 0.56 | 1.14 ± 0.60 | 1.09 ± 0.74 | 0.58 |
Total weekly Kt/V | 2.21 ± 0.53 | 2.20 ± 0.54 | 2.32 ± 0.73 | 0.95 |
D/Pcre | 0.45 ± 0.05 | 0.57 ± 0.05*
| 0.75 ± 0.10*,**
| < 0.01 |
P-PrCl (ml/day) | 44.2 ± 23.4 | 56.0 ± 24.9 | 74.1 ± 27.8*,**
| < 0.01 |
Unadjusted | Adjusted | ||||
---|---|---|---|---|---|
Variable | Hazard ratio [95% CI] |
pvalue | Hazard ratio [95% CI] |
pvalue | |
Model 1 | Age | 1.03 [0.99–1.06] | 0.09 | 1.03 [0.99–1.06] | 0.09 |
PET category | 3.70 [1.62–8.43] | < 0.01 | 3.70 [1.62–8.43] | < 0.01 | |
Model 2 | Age | 1.01 [0.98-.1.05] | 0.40 | – | – |
Serum albumin | 0.29 [0.08-1.02] | 0.05 | 0.24 [0.08-0.77] | 0.02 | |
PET category | 3.21 [1.37-7.52] | < 0.01 | 3.49 [1.49-8.15] | < 0.01 | |
Model 3 | Age | 1.03 [0.99–1.08] | 0.13 | 1.03 [0.99–1.07] | 0.11 |
CVD before PD initiation | 1.82 [0.58–5.69] | 0.31 | – | – | |
Hemoglobin | 0.91 [0.66–1.26] | 0.57 | – | – | |
Serum albumin | 0.40 [0.09–1.83] | 0.24 | 0.31 [0.09–1.11] | 0.07 | |
C-reactive protein | 1.19 [0.55–2.61] | 0.65 | – | – | |
PET category | 4.65 [1.78–12.16] | < 0.01 | 4.25 [1.79–10.10] | < 0.01 | |
P-PrCl | 0.99 [0.97–1.01] | 0.54 | – | – |