Increasing the dose of acute rehabilitation: is there a benefit?

Peiris and colleagues [4] conducted an assessor-blinded RCT including 996 patients in two Australian metropolitan rehabilitation facilities from July 2010 to June 2011. Patients were assigned to one hour each of PT and OT either Monday through Friday (five days/week usual care group) or Monday through Saturday (six days/week intervention group). The extra rehabilitation therapy provided on Saturdays was administered by the patient’s weekday therapist or by another routine care therapist (rather than a research therapist), and in the latter case, the Saturday therapy was based on written handover instructions from the weekday therapist. Non-English speaking patients and those with reduced cognition were included in the study, thus enhancing the generalizability of the results. In addition to evaluating functional independence (measured via the Functional Independence Measure (FIM)), quality of life (via EQ-5D questionnaire) and length of stay (LOS) at discharge, functional independence and quality of life were also assessed at 6- and 12-month follow-up.

While Peiris and colleagues [4] aimed to provide the intervention group with an additional two hours of rehabilitation services on Saturdays, an average of 53 additional minutes of rehabilitation were actually administered during the RCT, with missed therapy sessions resulting from patients feeling unwell, having day leave, or being admitted too late to permit randomization prior to the start of weekend rehabilitation sessions. LOS was non-significantly reduced in the intervention versus usual care group, with a mean LOS of 21 versus 23 days. At discharge, the intervention versus usual care group had greater functional independence and quality of life, with intervention patients being more likely to achieve clinically significant improvements from admission. There were no serious adverse events in either group and no significant difference between groups with respect to any adverse events. At the 6-month follow-up, improvement in patients’ functional independence and quality of life from their status upon admission to the rehabilitation facility still favored the intervention group, but the magnitude of this improvement was smaller, with no significant differences remaining by the 12-month follow-up.

This RCT has important implications for the delivery of patient care in facilities where rehabilitation services are currently restricted to weekdays. Given the variability in dose and delivery of existing rehabilitation interventions [2, 5‐8], the study results and their generalizability must be considered in the context of the usual care control group at the study sites, that is, delivering PT and OT for two hours per day, five days per week [9]. This RCT by Peiris and colleagues, when combined with a prior meta-analysis [2], demonstrates that increasing the standard dose of rehabilitation from five to six days/week broadly improves outcomes for a wide range of patients. The potential benefits of seven versus six days/week rehabilitation or increased duration of weekday sessions is an important area of future research.

This study also raises interesting questions regarding how additional PT and OT improve patient outcomes. One compelling mechanism may be a change in patient motivation induced by weekend therapy. To explore this issue, a separate qualitative analysis of a subgroup of patients from this RCT [10] investigated how patients’ experience of rehabilitation differed whether they received five versus six days/week rehabilitation. While patients in both groups perceived their therapists as providing motivation to participate in rehabilitation, those in the intervention group were more likely to view Saturday as a day to work toward improved function rather than a day of rest. Hence, patients in the intervention group may have realized more of their rehabilitation potential due to a greater sense of motivation to achieve rehabilitation goals imparted by the increased presence of PTs and OTs on weekends.

This increase in motivation among patients in the intervention group may have translated to an increase in habitual activity extending beyond the formal additional Saturday sessions to Sunday as well, when no PT and OT interventions were provided for either group. A second, separate analysis of another sub-group of patients revealed that patients in the intervention versus usual care group took significantly more steps and spent more time upright on Sunday as well as Saturday [11]. Thus, the additional rehabilitation may have led to improved functional independence and quality of life through motivating an increase in habitual activity and creating an expectation that patients should be working toward their rehabilitation goals every day. It is uncertain whether a different intervention that focused on this motivational component, such as an educational intervention promoting physical activity seven days per week, would similarly motivate patients and lead to the demonstrated benefit of PT and OT delivered six days/week.