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01.09.2004 | Regular Paper

Induction of nerve growth factor mRNA in a rat dorsal root ganglion after application of a tourniquet

verfasst von: Sumiko Abe, Ikubumi Mizusawa, Katsuyuki Kanno, Atsuko Yabashi, Miwako Suto, Mikio Kuraya, Takashi Honda, Kouichi Hiraiwa

Erschienen in: Acta Neuropathologica | Ausgabe 3/2004

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Abstract

We investigated the mRNA levels of neurotrophins and neurotrophin receptors in a rat dorsal root ganglion (DRG), after tourniquet application to a hind limb, to identify the nerve-protective molecules that are induced immediately after peripheral nerve crush and play a part in the process leading to secondary events. No significant expression of nerve growth factor (NGF) mRNA or protein was observed in the control or contralateral DRG. NGF mRNA expression started within 2 h and NGF protein expression was observed in Schwann cells at 4 h after application of the tourniquet, due to termination of the neurotrophin supply from peripheral nerves. The levels of neurotrophin 3 mRNA were significantly increased in the DRGs on both sides at 1 and 2 h after tourniquet application, but no significant changes in brain-derived neurotrophic factor and neurotrophin 4/5 expression levels were observed in either the contralateral or ipsilateral DRG. The expression levels of neurotrophin receptors in the DRGs on both the contralateral and ipsilateral sides had decreased at 1 to 2 h after application of the tourniquet and had returned to the control levels at 4 h after tourniquet application.

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Titel: Induction of nerve growth factor mRNA in a rat dorsal root ganglion after application of a tourniquet
verfasst von: Sumiko Abe
Ikubumi Mizusawa
Katsuyuki Kanno
Atsuko Yabashi
Miwako Suto
Mikio Kuraya
Takashi Honda
Kouichi Hiraiwa
Publikationsdatum: 01.09.2004
Verlag: Springer-Verlag
Erschienen in: Acta Neuropathologica / Ausgabe 3/2004
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-004-0870-y

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