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12.01.2021 | Original Article

Influence of different carrier materials on biphasic calcium phosphate induced bone regeneration

verfasst von: Lara Schorn, Tim Fienitz, Maximilian F. Gerstenberg, Anja Sterner-Kock, Alexandra C. Maul, Julian Lommen, Henrik Holtmann, Daniel Rothamel

Erschienen in: Clinical Oral Investigations | Ausgabe 6/2021

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Abstract

Objectives

Biphasic calcium phosphate (BCP) is a bioceramic material successfully used in alloplastic bone augmentation. Despite many advantages, a disadvantage of BCP seems to be a difficult application and position instability. The aim of this study was to determine how different carrier materials influence BCP-induced quantitative and qualitative bone regeneration.

Materials and methods

A total of 70 critical size defects were set in the frontal bone of 14 domestic pigs (5 each) and filled randomly with either BCP alone (BCP), BCP in combination with nano-hydroxyapatite (BCP + NHA), BCP embedded in native porcine type I/III collagen blocks (BCP + C), autologous bone (AB), or were left empty (ED). Specimens were harvested after 4 and 8 weeks and were evaluated histologically as well as histomorphometrically.

Results

Significantly lowest rate of new bone formation was found in ED (p = < 0.001) and BCP + NHA groups (p = 0.05). After 8 weeks, the highest percentage of new bone formation was observed in the BCP + C group. Fibrous matrix was detected highest in BCP alone. The lowest residual bone substitute material was found in BCP + C after 8 weeks.

Conclusions

BCP-induced bone regeneration is indeed affected by different carrier types. Surface morphology and bioactive characteristics influence osseointegration and new bone formation in vivo. The combination of type I/III collagen seems most suitable for qualitative and quantitative bone regeneration.

Clinical relevance

Stabilization of granular bone substitutes using type I/III collagen might be an alternative to granulates alone, indicating excellent volume stability, satisfactory plasticity, and easy application.

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Titel: Influence of different carrier materials on biphasic calcium phosphate induced bone regeneration
verfasst von: Lara Schorn
Tim Fienitz
Maximilian F. Gerstenberg
Anja Sterner-Kock
Alexandra C. Maul
Julian Lommen
Henrik Holtmann
Daniel Rothamel
Publikationsdatum: 12.01.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 6/2021
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-020-03700-y

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Influence of different carrier materials on biphasic calcium phosphate induced bone regeneration