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Clinical Reviews in Allergy & Immunology

Erschienen in:

10.06.2019

Innate B Cells: the Archetype of Protective Immune Cells

verfasst von: Alexis Grasseau, Marina Boudigou, Laëtitia Le Pottier, Nedra Chriti, Divi Cornec, Jacques-Olivier Pers, Yves Renaudineau, Sophie Hillion

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 1/2020

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Abstract

The innate B cell (IBC) population is heterogeneous and involved in the primary immune response. IBC functions include a high ability to produce natural antibodies with IgM isotype, the elimination of apoptotic cells, and a capacity to be cognate help to T cells. Among IBC subsets, B-1 cells and marginal zone B cells are the main producers of IgM, act as rapid immune responders that may relocate to follicular lymphoid and differentiate to cytokine and antibody-secreting cells shortly after infection. IBCs functions are highly dependent on their localization site and the nature of their B cell receptor repertoire, suggesting a high plasticity range of different immune responses. In this review, we will describe the nature and functions of the different innate-like B cell subsets, first in mice and then in humans. Besides this, we will emphasize the strong ability of these cells to undertake different protective functions from the first line of defense against pathogens to the regulatory role of the broader immune response.

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Titel: Innate B Cells: the Archetype of Protective Immune Cells
verfasst von: Alexis Grasseau
Marina Boudigou
Laëtitia Le Pottier
Nedra Chriti
Divi Cornec
Jacques-Olivier Pers
Yves Renaudineau
Sophie Hillion
Publikationsdatum: 10.06.2019
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 1/2020
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-019-08748-7

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Springer Medizin

Innate B Cells: the Archetype of Protective Immune Cells

Abstract

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