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Medical Microbiology and Immunology

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01.11.2012 | Review

Innate immunity regulates adaptive immune response: lessons learned from studying the interplay between NK and CD8⁺ T cells during MCMV infection

verfasst von: Maja Mitrović, Jurica Arapović, Luka Traven, Astrid Krmpotić, Stipan Jonjić

Erschienen in: Medical Microbiology and Immunology | Ausgabe 4/2012

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Abstract

Natural killer (NK) cells play a crucial role in early immune response against cytomegalovirus infection. A large and mounting body of data indicate that these cells are involved in the regulation of the adaptive immune response as well. By using mouse cytomegalovirus (MCMV) as a model, several groups provided novel insights into the role of NK cells in the development and kinetics of antiviral CD8⁺ T cell response. Depending on infection conditions, virus strain and the genetic background of mice used, NK cells are either positive or negative regulators of the CD8⁺ T cell response. At present, there is no unique explanation for the observed differences between various experimental systems used. In this review we discuss the mechanisms involved in the interplay between NK and CD8⁺ T cells in the early control of MCMV infection.

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Titel: Innate immunity regulates adaptive immune response: lessons learned from studying the interplay between NK and CD8+ T cells during MCMV infection
verfasst von: Maja Mitrović
Jurica Arapović
Luka Traven
Astrid Krmpotić
Stipan Jonjić
Publikationsdatum: 01.11.2012
Verlag: Springer-Verlag
Erschienen in: Medical Microbiology and Immunology / Ausgabe 4/2012
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-012-0263-0

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Innate immunity regulates adaptive immune response: lessons learned from studying the interplay between NK and CD8⁺ T cells during MCMV infection

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