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Current Fungal Infection Reports
Erschienen in: Current Fungal Infection Reports 3/2020

06.06.2020 | Clinical Mycology Lab Issues (S Cordoba, Section Editor)

Innovative Approaches for Histoplasma Detection

verfasst von: Diego H. Caceres, Norma B. Fernandez, Shawn R. Lockhart

Erschienen in: Current Fungal Infection Reports | Ausgabe 3/2020

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Abstract

Purpose of Review

This review highlights innovative approaches for histoplasmosis detection using laboratory technologies published in the past 6 years.

Recent Findings

Microscopy and culture are the gold standards for confirming the diagnosis of histoplasmosis, but these can be slow, and their sensitivity and specificity can vary. It is well known that rapid diagnosis is necessary to save lives. Newer technologies based on detection of antibodies, antigens, and DNA can enable rapid and accurate clinical diagnosis.

Summary

Based on a systematic review of the literature and evaluation of methodologies in five areas, assay accuracy, rapid testing, point of care testing, commercial availability, and use in animal diagnosis and environmental detection, we describe innovative approaches for detection of Histoplasma/histoplasmosis.
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Literatur
1.
2.
3.
Deepe Jr GS, Dolin R, Blaser MJ. 265 - Histoplasma capsulatum (Histoplasmosis) A2 - Bennett, John E. Mandell, Douglas, and Bennett's principles and practice of infectious diseases (Eighth Edition). Philadelphia: Content Repository Only!; 2015. p. 2949–62.e1.
4.
Bahr NC, Antinori S, Wheat LJ, Sarosi GA. Histoplasmosis infections worldwide: thinking outside of the Ohio River valley. Curr Trop Med Rep. 2015;2(2):70–80.PubMedPubMedCentral
5.
Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: up-to-date evidence-based approach to diagnosis and management. Semin Respir Crit Care Med. 2015;36(5):729–45.PubMed
6.
Caceres DH, Zuluaga A, Arango-Bustamante K, de Bedout C, Tobon AM, Restrepo A, et al. Implementation of a training course increased the diagnosis of histoplasmosis in Colombia. Am J Trop Med Hyg. 2015;93(3):662–7.PubMedPubMedCentral
7.
Bansal N, Sethuraman N, Gopalakrishnan R, Ramasubramanian V, Kumar DS, Nambi PS, et al. Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region? Mycoses. 2019;62(6):502–507. https://​doi.​org/​10.​1111/​myc.​12902.
8.
Falci DR, Monteiro AA, Braz Caurio CF, Magalhaes TCO, Xavier MO, Basso RP, et al. Histoplasmosis, an underdiagnosed disease affecting people living with HIV/AIDS in Brazil: results of a multicenter prospective cohort study using both classical mycology tests and histoplasma urine antigen detection. Open Forum Infect Dis. 2019;6(4):ofz073.PubMedPubMedCentral
9.
Samayoa B, Roy M, Cleveland AA, Medina N, Lau-Bonilla D, Scheel CM, et al. High mortality and Coinfection in a prospective cohort of human immunodeficiency virus/acquired immune deficiency syndrome patients with histoplasmosis in Guatemala. Am J Trop Med Hyg. 2017;97(1):42–8.PubMedPubMedCentral
10.
Haynes RB, Wilczynski NL. Optimal search strategies for retrieving scientifically strong studies of diagnosis from Medline: analytical survey. Bmj. 2004;328(7447):1040.PubMedPubMedCentral
11.
• Rothenburg L, Hanzlicek AS, Payton ME. A monoclonal antibody-based urine Histoplasma antigen enzyme immunoassay (IMMY(R)) for the diagnosis of histoplasmosis in cats. J Vet Intern Med. 2019;33(2):603–10 Validation of an antigen detection assay for the diagnosis of histoplasmosis in animal.PubMed
12.
• Cunningham L, Cook A, Hanzlicek A, Harkin K, Wheat J, Goad C, et al. Sensitivity and specificity of Histoplasma antigen detection by enzyme immunoassay. J Am Anim Hosp Assoc. 2015;51(5):306–10 Validation of an antigen detection assay for the diagnosis of histoplasmosis in animal.PubMed
13.
•• Caceres DH, Gomez BL, Tobon AM, Chiller TM, Lindsley MD. Evaluation of a Histoplasma antigen lateral flow assay for the rapid diagnosis of progressive disseminated histoplasmosis in Colombian patients with AIDS. Mycoses. 2020;63(2):139–44 Validation of a point of care assay for the diagnosis of histoplasmosis.PubMed
14.
Caceres DH, Samayoa BE, Medina NG, Tobon AM, Guzman BJ, Mercado D, et al. Multicenter validation of commercial aReagents to diagnose progressive disseminated histoplasmosis in people living with HIV/AIDS in two Latin American countries. J Clin Microbiol. 2018;56(6):e01959–17. https://​doi.​org/​10.​1128/​JCM.​01959-17.
15.
Hoffmann ER, Daboit TC, Paskulin DD, Monteiro AA, Falci DR, Linhares T, et al. Disseminated histoplasmosis and AIDS: a prospective and multicentre study to evaluate the performance of different diagnostic tests. Mycoses. 2017;60(1):20–4.PubMed
16.
Torres-Gonzalez P, Niembro-Ortega MD, Martinez-Gamboa A, Ahumada-Topete VH, Andrade-Villanueva J, Araujo-Melendez J, et al. Diagnostic accuracy cohort study and clinical value of the Histoplasma urine antigen (ALPHA Histoplasma EIA) for disseminated histoplasmosis among HIV infected patients: a multicenter study. PLoS Negl Trop Dis. 2018;12(11):e0006872.PubMedPubMedCentral
17.
Zhang C, Lei GS, Lee CH, Hage CA. Evaluation of two new enzyme immunoassay reagents for diagnosis of histoplasmosis in a cohort of clinically characterized patients. Med Mycol. 2015;53(8):868–73.PubMed
18.
Richer SM, Smedema ML, Durkin MM, Herman KM, Hage CA, Fuller D, et al. Improved diagnosis of acute pulmonary Histoplasmosis by combining antigen and antibody detection. Clin Infect Dis. 2016;62(7):896–902.PubMedPubMedCentral
19.
Bloch KC, Myint T, Raymond-Guillen L, Hage CA, Davis TE, Wright PW, et al. Improvement in diagnosis of Histoplasma meningitis by combined testing for Histoplasma antigen and immunoglobulin G and immunoglobulin M anti-Histoplasma antibody in cerebrospinal fluid. Clin Infect Dis. 2018;66(1):89–94.PubMed
20.
Theel ES, Harring JA, Dababneh AS, Rollins LO, Bestrom JE, Jespersen DJ. Reevaluation of commercial reagents for detection of Histoplasma capsulatum antigen in urine. J Clin Microbiol. 2015;53(4):1198–203.PubMedPubMedCentral
21.
• Almeida MA, Damasceno LS, Pizzini CV, Muniz MM, Almeida-Paes R, Zancope-Oliveira RM. Role of western blot assay for the diagnosis of histoplasmosis in AIDS patients from a National Institute of Infectious Diseases in Rio de Janeiro, Brazil. Mycoses. 2019;62(3):261–7 Validation of a high sensitive antibody detection assay for the diagnosis of histoplasmosis in people living with HIV.PubMed
22.
Almeida Mde A, Pizzini CV, Damasceno LS, Muniz Mde M, Almeida-Paes R, Peralta RH, et al. Validation of western blot for Histoplasma capsulatum antibody detection assay. BMC Infect Dis. 2016;16:87.PubMed
23.
•• Gomez LF, Torres IP, Jimenez AM, McEwen JG, de Bedout C, Pelaez CA, et al. Detection of Histoplasma capsulatum in organic fertilizers by Hc100 nested polymerase chain reaction and its correlation with the physicochemical and microbiological characteristics of the samples. Am J Trop Med Hyg. 2018;98(5):1303–12 Validation of a molecular assay for detection ofHistoplasmaDNA in environmental samples.PubMedPubMedCentral
24.
•• Gago S, Esteban C, Valero C, Zaragoza O, de la Bellacasa JP, Buitrago MJ. A multiplex real-time PCR assay for identification of pneumocystis jirovecii, Histoplasma capsulatum, and Cryptococcus neoformans/Cryptococcus gattii in samples from AIDS patients with opportunistic pneumonia. J Clin Microbiol. 2014;52(4):1168–76 Validation of a molecular assay for the diagnosis of multiple opportunistic pathogens.PubMedPubMedCentral
25.
Zatti MDS, Arantes TD, Fernandes JAL, Bay MB, Milan EP, Naliato GFS, et al. Loop-mediated isothermal amplification and nested PCR of the internal transcribed spacer (ITS) for Histoplasma capsulatum detection. PLoS Negl Trop Dis. 2019;13(8):e0007692.PubMedPubMedCentral
26.
Muraosa Y, Toyotome T, Yahiro M, Watanabe A, Shikanai-Yasuda MA, Kamei K. Detection of Histoplasma capsulatum from clinical specimens by cycling probe-based real-time PCR and nested real-time PCR. Med Mycol. 2016;54(4):433–8.PubMed
27.
Deppen SA, Massion PP, Blume J, Walker RC, Antic S, Chen H, et al. Accuracy of a novel histoplasmosis enzyme immunoassay to evaluate suspicious lung nodules. Cancer Epidemiol Biomark Prev. 2019;28(2):321–6.
28.
McTaggart LR, Copeland JK, Surendra A, Wang PW, Husain S, Coburn B, et al. Mycobiome sequencing and analysis applied to fungal community profiling of the lower respiratory tract during fungal pathogenesis. Front Microbiol. 2019;10:512.PubMedPubMedCentral
29.
Scheel CM, Zhou Y, Theodoro RC, Abrams B, Balajee SA, Litvintseva AP. Development of a loop-mediated isothermal amplification method for detection of Histoplasma capsulatum DNA in clinical samples. J Clin Microbiol. 2014;52(2):483–8.PubMedPubMedCentral
30.
Valero C, Buitrago MJ, Gago S, Quiles-Melero I, Garcia-Rodriguez J. A matrix-assisted laser desorption/ionization time of flight mass spectrometry reference database for the identification of Histoplasma capsulatum. Med Mycol. 2018;56(3):307–14.PubMed
31.
Rubio-Carrasquilla M, Santa CD, Rendon JP, Botero-Garces J, Guimaraes AJ, Moreno E, et al. An interferon gamma release assay specific for Histoplasma capsulatum to detect asymptomatic infected individuals: a proof of concept study. Med Mycol. 2019;57:724–32.PubMed
32.
Frickmann H, Kunne C, Hagen RM, Podbielski A, Normann J, Poppert S, et al. Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment. BMC Microbiol. 2019;19(1):75.PubMedPubMedCentral
33.
da Silva RM Jr, da Silva Neto JR, Santos CS, Cruz KS, Frickmann H, Poppert S, et al. Fluorescent in situ hybridization of pre-incubated blood culture material for the rapid diagnosis of histoplasmosis. Med Mycol. 2015;53(2):160–4.PubMed
34.
Wheat LJ, Connolly-Stringfield P, Kohler RB, Frame PT, Gupta MR. Histoplasma capsulatum polysaccharide antigen detection in diagnosis and management of disseminated histoplasmosis in patients with acquired immunodeficiency syndrome. Am J Med. 1989;87(4):396–400.PubMed
35.
Metadaten
Titel
Innovative Approaches for Histoplasma Detection
verfasst von
Diego H. Caceres
Norma B. Fernandez
Shawn R. Lockhart
Publikationsdatum
06.06.2020
Verlag
Springer US
Erschienen in
Current Fungal Infection Reports / Ausgabe 3/2020
Print ISSN: 1936-3761
Elektronische ISSN: 1936-377X
DOI
https://doi.org/10.1007/s12281-020-00393-4

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