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26.01.2022 | Review

Insights into the multifunctional roles of geminivirus-encoded proteins in pathogenesis

verfasst von: Ragunathan Devendran, Tsewang Namgial, Kishore Kumar Reddy, Manish Kumar, Fauzia Zarreen, Supriya Chakraborty

Erschienen in: Archives of Virology | Ausgabe 2/2022

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Abstract

Geminiviruses are a major threat to agriculture in tropical and subtropical regions of the world. Geminiviruses have small genome with limited coding capacity. Despite this limitation, these viruses have mastered hijacking the host cellular metabolism for their survival. To compensate for the small size of their genome, geminiviruses encode multifunctional proteins. In addition, geminiviruses associate themselves with satellite DNA molecules which also encode proteins that support the virus in establishing successful infection. Geminiviral proteins recruit multiple host factors, suppress the host defense, and manipulate host metabolism to establish infection. We have updated the knowledge accumulated about the proteins of geminiviruses and their satellites in the context of pathogenesis in a single review. We also discuss their interactions with host factors to provide a mechanistic understanding of the infection process.

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Titel: Insights into the multifunctional roles of geminivirus-encoded proteins in pathogenesis
verfasst von: Ragunathan Devendran
Tsewang Namgial
Kishore Kumar Reddy
Manish Kumar
Fauzia Zarreen
Supriya Chakraborty
Publikationsdatum: 26.01.2022
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 2/2022
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-021-05338-x

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