Erschienen in:
01.12.2000 | Paper Report
Integrin aV?3 is important for bone resorption
verfasst von:
Willis Huang
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
Einloggen, um Zugang zu erhalten
Excerpt
Osteoclasts are the primary cells responsible for bone resorption. Dysregulation of osteoclast activity has been linked to major diseases such as arthritis, osteoporosis, osteopetrosis, and metastatic tumor invasion into bone. Osteoclasts derive from a monocyte/macrophage lineage, and acquire a multinucleated, bone-resorbing phenotype after stimulation by two essential molecules: osteoclast differentiation factor (ODF or OPGL/RANKL/TRANCE) and macrophage colony stimulating factor (M-CSF). With proper stimulation and contact with bone, these polykaryons undergo cytoskeletal changes directing their bone-resorptive organelle (the ruffled membrane) to the point of contact. Matrix attachment molecules may direct these cytoskeletal changes. Prior studies using peptide inhibitors of the aV?3 integrin showed that these peptides could inhibit the resorptive capacity of osteoclasts. It is possible that similar integrins such as aV?5 could also be involved in resorption or even have overlapping function with aV?3. To further explore the role of aV?3 in resorption, these investigators generated ?3-/- mice and examined them for defects in osteoclast function, bone structure, and bone metabolism. Regulation of aV?5, a closely related integrin, was also examined in the ?3-/- mice. …