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12.04.2019 | Osteocytes (J Klein Nulend, Section editor) | Ausgabe 3/2019

Current Osteoporosis Reports 3/2019

Inter-site Variability of the Human Osteocyte Lacunar Network: Implications for Bone Quality

Current Osteoporosis Reports > Ausgabe 3/2019
Petar Milovanovic, Björn Busse
Wichtige Hinweise
This article is part of the Topical Collection on Osteocytes

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Purpose of Review

This article provides a review on the variability of the osteocyte lacunar network in the human skeleton. It highlights characteristics of the osteocyte lacunar network in relation to different skeletal sites and fracture susceptibility.

Recent Findings

Application of 2D analyses (quantitative backscattered electron microscopy, histology, confocal laser scanning microscopy) and 3D reconstructions (microcomputed tomography and synchrotron radiation microcomputed tomography) provides extended high-resolution information on osteocyte lacunar properties in individuals of various age (fetal, children’s growth, elderly), sex, and disease states with increased fracture risk.


Recent findings on the distribution of osteocytes in the human skeleton are reviewed. Quantitative data highlighting the variability of the osteocyte lacunar network is presented with special emphasis on site specificity and maintenance of bone health. The causes and consequences of heterogeneous distribution of osteocyte lacunae both within specific regions of interest and on the skeletal level are reviewed and linked to differential bone quality factors and fracture susceptibility.

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