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Neuroscience Bulletin

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14.08.2023 | Original Article

Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer’s Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice

verfasst von: Yang Zhu, Hao Huang, Zhi Chen, Yong Tao, Ling-Yi Liao, Shi-Hao Gao, Yan-Jiang Wang, Chang-Yue Gao

Erschienen in: Neuroscience Bulletin | Ausgabe 2/2024

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Abstract

Intermittent theta burst stimulation (iTBS), a time-saving and cost-effective repetitive transcranial magnetic stimulation regime, has been shown to improve cognition in patients with Alzheimer’s disease (AD). However, the specific mechanism underlying iTBS-induced cognitive enhancement remains unknown. Previous studies suggested that mitochondrial functions are modulated by magnetic stimulation. Here, we showed that iTBS upregulates the expression of iron-sulfur cluster assembly 1 (ISCA1, an essential regulatory factor for mitochondrial respiration) in the brain of APP/PS1 mice. In vivo and in vitro studies revealed that iTBS modulates mitochondrial iron-sulfur cluster assembly to facilitate mitochondrial respiration and function, which is required for ISCA1. Moreover, iTBS rescues cognitive decline and attenuates AD-type pathologies in APP/PS1 mice. The present study uncovers a novel mechanism by which iTBS modulates mitochondrial respiration and function via ISCA1-mediated iron-sulfur cluster assembly to alleviate cognitive impairments and pathologies in AD. We provide the mechanistic target of iTBS that warrants its therapeutic potential for AD patients.

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Titel: Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer’s Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice
verfasst von: Yang Zhu
Hao Huang
Zhi Chen
Yong Tao
Ling-Yi Liao
Shi-Hao Gao
Yan-Jiang Wang
Chang-Yue Gao
Publikationsdatum: 14.08.2023
Verlag: Springer Nature Singapore
Erschienen in: Neuroscience Bulletin / Ausgabe 2/2024
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI: https://doi.org/10.1007/s12264-023-01098-7

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