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Erschienen in: Internal and Emergency Medicine 1/2021

02.05.2020 | IM - COMMENTARY

Interpreting procalcitonin in patients undergoing hemodialysis: a reliable or a misleading marker?

verfasst von: Marco Falcone, Giusy Tiseo, Francesco Menichetti

Erschienen in: Internal and Emergency Medicine | Ausgabe 1/2021

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Excerpt

Biomarkers are an essential tool for the identification and monitoring of patients developing an infection, to determine their clinical severity and to assess the response to antibiotic therapy [1]. However, the interpretation of procalcitonin (PCT) values may be challenging in subjects undergoing hemodialysis (HD), and several considerations about the use of PCT in HD patients should be done. …
Literatur
1.
Zurück zum Zitat Hamade B, Huang DT (2020) Procalcitonin: where are we now? Crit Care Clin 36:23–40CrossRef Hamade B, Huang DT (2020) Procalcitonin: where are we now? Crit Care Clin 36:23–40CrossRef
3.
Zurück zum Zitat Kofoed K, Andersen O, Kronborg G et al (2007) Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care 11:R38CrossRef Kofoed K, Andersen O, Kronborg G et al (2007) Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care 11:R38CrossRef
4.
Zurück zum Zitat Naeini AE, Montazerolghaem S (2006) Procalcitonin marker for sepsis diagnosis. Evaluating a rapid immuno-chromatografic test. Saudi Med J 27:422–424PubMed Naeini AE, Montazerolghaem S (2006) Procalcitonin marker for sepsis diagnosis. Evaluating a rapid immuno-chromatografic test. Saudi Med J 27:422–424PubMed
5.
Zurück zum Zitat Jimeno A, García-Velasco A, del Val O et al (2004) Assessment of procalcitonin as a diagnostic and prognostic marker in patients with solid tumors and febrile neutropenia. Cancer 100:2462–2469CrossRef Jimeno A, García-Velasco A, del Val O et al (2004) Assessment of procalcitonin as a diagnostic and prognostic marker in patients with solid tumors and febrile neutropenia. Cancer 100:2462–2469CrossRef
6.
Zurück zum Zitat Oshita H, Sakurai J, Kamitsuna M (2010) Semi-quantitative procalcitonin test for the diagnosis of bacterial infection: clinical use and experience in Japan. J Microbiol Immunol Infect 43:222–227CrossRef Oshita H, Sakurai J, Kamitsuna M (2010) Semi-quantitative procalcitonin test for the diagnosis of bacterial infection: clinical use and experience in Japan. J Microbiol Immunol Infect 43:222–227CrossRef
7.
Zurück zum Zitat Clec'h C, Fosse JP, Karoubi P et al (2006) Differential diagnostic value of procalcitonin in surgical and medical patients with septic shock. Crit Care Med 34:102–107CrossRef Clec'h C, Fosse JP, Karoubi P et al (2006) Differential diagnostic value of procalcitonin in surgical and medical patients with septic shock. Crit Care Med 34:102–107CrossRef
8.
Zurück zum Zitat Dorizzi RM, Polati E, Sette P, Ferrari A, Rizzotti P, Luzzani A (2006) Procalcitonin in the diagnosis of inflammation in intensive care units. Clin Biochem 39:1138–1143CrossRef Dorizzi RM, Polati E, Sette P, Ferrari A, Rizzotti P, Luzzani A (2006) Procalcitonin in the diagnosis of inflammation in intensive care units. Clin Biochem 39:1138–1143CrossRef
9.
Zurück zum Zitat Gaïni S, Koldkjaer OG, Pedersen C, Pedersen SS (2006) Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study. Crit Care 10:R53CrossRef Gaïni S, Koldkjaer OG, Pedersen C, Pedersen SS (2006) Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study. Crit Care 10:R53CrossRef
10.
Zurück zum Zitat Tsangaris I, Plachouras D, Kavatha D et al (2009) Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay. BMC Infect Dis 22(9):21 Tsangaris I, Plachouras D, Kavatha D et al (2009) Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay. BMC Infect Dis 22(9):21
11.
Zurück zum Zitat Brys ADH, Di Stasio E, Lenaert B et al (2020) Serum interleukin-6 and endotoxin levels and their relationship with fatigue and depressive symptoms in patients on chronic haemodialysis. Cytokine 125:154823CrossRef Brys ADH, Di Stasio E, Lenaert B et al (2020) Serum interleukin-6 and endotoxin levels and their relationship with fatigue and depressive symptoms in patients on chronic haemodialysis. Cytokine 125:154823CrossRef
12.
Zurück zum Zitat Nijsten MW, Olinga P, The TH et al (2000) Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro. Crit Care Med 28:458–461CrossRef Nijsten MW, Olinga P, The TH et al (2000) Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro. Crit Care Med 28:458–461CrossRef
13.
Zurück zum Zitat Mori K, Noguchi M, Sumino Y, Sato F, Mimata H (2012) Use of procalcitonin in patients on chronic hemodialysis: procalcitonin is not related with increased serum calcitonin. ISRN Urol 2012:431859PubMedPubMedCentral Mori K, Noguchi M, Sumino Y, Sato F, Mimata H (2012) Use of procalcitonin in patients on chronic hemodialysis: procalcitonin is not related with increased serum calcitonin. ISRN Urol 2012:431859PubMedPubMedCentral
14.
Zurück zum Zitat Falcone M, Tiseo G, Dentali F et al (2018) Predicting resistant etiology in hospitalized patients with blood cultures positive for Gram-negative bacilli. Eur J Intern Med 53:21–28CrossRef Falcone M, Tiseo G, Dentali F et al (2018) Predicting resistant etiology in hospitalized patients with blood cultures positive for Gram-negative bacilli. Eur J Intern Med 53:21–28CrossRef
15.
Zurück zum Zitat Falcone M, Russo A, Iacovelli A et al (2016) Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Clin Microbiol Infect 22:444–450CrossRef Falcone M, Russo A, Iacovelli A et al (2016) Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Clin Microbiol Infect 22:444–450CrossRef
16.
Zurück zum Zitat Falcone M, Tiseo G, Gutiérrez-Gutiérrez B et al (2019) Impact of initial antifungal therapy on the outcome of patients with candidemia and septic shock admitted to medical wards: a Propensity Score-adjusted analysis. Open Forum Infect Dis 6:fz251CrossRef Falcone M, Tiseo G, Gutiérrez-Gutiérrez B et al (2019) Impact of initial antifungal therapy on the outcome of patients with candidemia and septic shock admitted to medical wards: a Propensity Score-adjusted analysis. Open Forum Infect Dis 6:fz251CrossRef
17.
Zurück zum Zitat Falcone M, Bassetti M, Tiseo G et al (2020) Time to appropriate antibiotic therapy is a predictor of outcome in patients with bloodstream infection caused by KPC-producing Klebsiella pneumoniae. Crit Care 24:29CrossRef Falcone M, Bassetti M, Tiseo G et al (2020) Time to appropriate antibiotic therapy is a predictor of outcome in patients with bloodstream infection caused by KPC-producing Klebsiella pneumoniae. Crit Care 24:29CrossRef
18.
Zurück zum Zitat Schuetz P, Maurer P, Punjabi V, Desai A, Amin DN, Gluck E (2013) Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients. Crit Care 17:R115CrossRef Schuetz P, Maurer P, Punjabi V, Desai A, Amin DN, Gluck E (2013) Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients. Crit Care 17:R115CrossRef
19.
Zurück zum Zitat Montagnana M, Lippi G, Tessitore N et al (2009) Procalcitonin values after dialysis is closely related to type of dialysis membrane. Scand J Clin Lab Invest 69:703–707CrossRef Montagnana M, Lippi G, Tessitore N et al (2009) Procalcitonin values after dialysis is closely related to type of dialysis membrane. Scand J Clin Lab Invest 69:703–707CrossRef
20.
Zurück zum Zitat Kubo S, Iwasaki M, Horie M et al (2019) Biological variation of procalcitonin levels in hemodialysis patients. Clin Exp Nephrol 23:402–408CrossRef Kubo S, Iwasaki M, Horie M et al (2019) Biological variation of procalcitonin levels in hemodialysis patients. Clin Exp Nephrol 23:402–408CrossRef
21.
Zurück zum Zitat Chastre J, Wolff M, Fagon JY et al (2003) Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 290:2588–2598CrossRef Chastre J, Wolff M, Fagon JY et al (2003) Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 290:2588–2598CrossRef
22.
Zurück zum Zitat Wirz Y, Meier MA, Bouadma L et al (2018) Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials. Crit Care 22:191CrossRef Wirz Y, Meier MA, Bouadma L et al (2018) Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials. Crit Care 22:191CrossRef
23.
Zurück zum Zitat Tiseo G, Mazzone A, Falcone M (2019) Identifying patients with acute bacterial skin and skin structure infection who need blood cultures. Intern Emerg Med 14:203–206CrossRef Tiseo G, Mazzone A, Falcone M (2019) Identifying patients with acute bacterial skin and skin structure infection who need blood cultures. Intern Emerg Med 14:203–206CrossRef
Metadaten
Titel
Interpreting procalcitonin in patients undergoing hemodialysis: a reliable or a misleading marker?
verfasst von
Marco Falcone
Giusy Tiseo
Francesco Menichetti
Publikationsdatum
02.05.2020
Verlag
Springer International Publishing
Erschienen in
Internal and Emergency Medicine / Ausgabe 1/2021
Print ISSN: 1828-0447
Elektronische ISSN: 1970-9366
DOI
https://doi.org/10.1007/s11739-020-02341-z

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