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Pediatric Surgery International

Erschienen in:

31.03.2016 | Review Article

Intestinal transplantation in children: current status

verfasst von: Andrea Martinez Rivera, Paul W. Wales

Erschienen in: Pediatric Surgery International | Ausgabe 6/2016

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Abstract

Intestinal transplantation (IT) is the least common form of organ transplantation; however, it has shown exceptional growth and improvement in graft survival rates over the past two decades mainly due to better outcomes achieved during the first year of transplantation (76 % at 1 year), due to improvement in surgical techniques and the development of better immunosupressive therapies as we understand more about the relationship between the recipient and host immune system. There are still ongoing issues with chronic rejection and long-term survival. Intestinal transplantation is still an acceptable therapy for patients with intestinal failure (IF), but it is generally reserved for patients who develop severe and life-threatening complications despite standard therapies, or those who are not able to maintain a good quality of life. The purpose of this review is to describe the current status, indications, outcomes and advances in the field of intestinal transplantation.

Grant D, Abu-Elmagd K, Mazariegos G, Vianna R, Langnas A, Mangus R, Farmer DG, Lacaille F, Iyer K, Fishbein T (2015) Intestinal transplant registry report: global activity and trends. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 15(1):210–219CrossRef

Reyes JD (2014) Intestinal transplantation: an unexpected journey. Robert E. Gross lecture. J Pediatr Surg 49(1):13–18CrossRefPubMed

Boluda ER (2015) Pediatric small bowel transplantation. Current Opin Organ Transpl 20(5):550–556CrossRef

Squires RH, Duggan C, Teitelbaum DH, Wales PW, Balint J, Venick R, Rhee S, Sudan D, Mercer D, Martinez JA et al (2012) Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium. J Pediatr 161(4):723–728 (e722) CrossRefPubMedPubMedCentral

Goulet O, Ruemmele F, Lacaille F, Colomb V (2004) Irreversible intestinal failure. J Pediatr Gastroenterol Nutr 38(3):250–269CrossRefPubMed

Stanger JD, Oliveira C, Blackmore C, Avitzur Y, Wales PW (2013) The impact of multi-disciplinary intestinal rehabilitation programs on the outcome of pediatric patients with intestinal failure: a systematic review and meta-analysis. J Pediatr Surg 48(5):983–992CrossRefPubMed

Thaker K, Avitzur Y (2013) Intestine transplantation in children. In: Sukhotnik I (ed) Short bowel Syndrome in Children, vol 1. Nova Biomedical Publishers, Inc, New York, pp 159–185

Grant D (1996) Current results of intestinal transplantation. The International Intestinal Transplant Registry. Lancet, 347(9018):1801–1803CrossRefPubMed

Grant D, Abu-Elmagd K, Reyes J, Tzakis A, Langnas A, Fishbein T, Goulet O, Farmer D (2005) 2003 report of the intestine transplant registry: a new era has dawned. Ann Surg 241(4):607–613CrossRefPubMedPubMedCentral

10.

Avitzur Y, Wang JY, de Silva NT, Burghardt KM, DeAngelis M, Grant D, Ng VL, Jones N, Wales PW (2015) Impact of intestinal rehabilitation program and its innovative therapies on the outcome of intestinal transplant candidates. J Pediatr Gastroenterol Nutr 61(1):18–23PubMed

11.

Calkins KL, Dunn JCY, Shew SB, Reyen L, Farmer D, Devaskar SU, Venick RS (2014) Pediatric intestinal failure associated liver disease is reversed with 6 months of intravenous fish oil. JPEN J Parenter Enteral Nutr 38(6):682–692CrossRefPubMedPubMedCentral

12.

Chan CF, Wu TC (2014) Recent advances in the management of pediatric intestinal failure. Pediatr Neonatol 55(6):426–430CrossRefPubMed

13.

Diamond IR, Pencharz PB, Feldman BM, Ling SC, Moore AM, Wales PW (2012) Novel lipid-based approaches to pediatric intestinal failure-associated liver disease. Arch Pediatr Adolesc Med 166(5):473–478CrossRefPubMed

14.

Diamond IR, Sterescu A, Pencharz PB, Kim JH, Wales PW (2009) Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr 48(2):209–215CrossRefPubMed

15.

Kaufman SS, Matsumoto CS (2015) Management of pediatric intestinal failure. Minerva Pediatr 67(4):321–340PubMed

16.

Lee S, Park HJ, Yoon J, Hong SH, Oh CY, Lee SK, Seo JM (2016) Reversal of intestinal failure-associated liver disease by switching from a combination lipid emulsion containing fish oil to fish oil monotherapy. J Parenter Enter Nutr 40(3):437–440 CrossRef

17.

Oliveira C, Nasr A, Brindle M, Wales PW (2012) Ethanol locks to prevent catheter-related bloodstream infections in parenteral nutrition: a meta-analysis. Pediatrics 129(2):318–329CrossRefPubMed

18.

Piper HG, Wales PW (2013) Prevention of catheter-related blood stream infections in children with intestinal failure. Current Opin Gastroenterol 29(1):1–6CrossRef

19.

Wales PW, Allen N, Worthington P, George D, Compher C, Teitelbaum D (2014) ASPEN clinical guidelines: support of pediatric patients with intestinal failure at risk of parenteral nutrition-associated liver disease. JPEN J Parenter Enteral Nutr 38(5):538–557CrossRefPubMed

20.

Wales PW, Jancelewicz T, Romao RL, Piper HG, de Silva NT, Avitzur Y (2013) Delayed primary serial transverse enteroplasty as a novel management strategy for infants with congenital ultra-short bowel syndrome. J Pediatr Surg 48(5):993–999CrossRefPubMed

21.

Oliveira C, de Silva N, Wales PW (2012) Five-year outcomes after serial transverse enteroplasty in children with short bowel syndrome. J Pediatr Surg 47(5):931–937CrossRefPubMed

22.

Kaufman SS, Atkinson JB, Bianchi A, Goulet OJ, Grant D, Langnas AN, McDiarmid SV, Mittal N, Reyes J, Tzakis AG (2001) Indications for pediatric intestinal transplantation: a position paper of the American Society of Transplantation. Pediatr Transplant 5(2):80–87CrossRefPubMed

23.

Report of Intestine Transplant Registry (2009) 25 years of pediatric follow-up. In: Intestinal Transplant Association online report

24.

Burghardt KM, Wales PW, de Silva N, Stephens D, Yap J, Grant D, Avitzur Y (2015) Pediatric intestinal transplant listing criteria—a call for a change in the new era of intestinal failure outcomes. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 15(6):1674–1681CrossRef

25.

Mazariegos GV, Steffick DE, Horslen S, Farmer D, Fryer J, Grant D, Langnas A, Magee JC (2010) Intestine transplantation in the United States, 1999–2008. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 10(4 Pt 2):1020–1034CrossRef

26.

Sudan D (2014) The current state of intestine transplantation: indications, techniques, outcomes and challenges. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 14(9):1976–1984CrossRef

27.

Grant D, Wall W, Mimeault R, Zhong R, Ghent C, Garcia B, Stiller C, Duff J (1990) Successful small-bowel/liver transplantation. Lancet (London, England) 335(8683):181–184CrossRef

28.

Sudan DL, Iyer KR, Deroover A, Chinnakotla S, Fox IJ Jr, Shaw BW Jr, Langnas AN (2001) A new technique for combined liver/small intestinal transplantation. Transplantation 72(11):1846–1848CrossRefPubMed

29.

Fishbein T, Florman S, Gondolesi G, Decker R (2003) Noncomposite simultaneous liver and intestinal transplantation. Transplantation 75(4):564–565CrossRefPubMed

30.

Kato T, Selvaggi G, Gaynor JJ, Takahashi H, Nishida S, Moon J, Levi D, Smith L, Hernandez E, Ruiz P et al (2008) Inclusion of donor colon and ileocecal valve in intestinal transplantation. Transplantation 86(2):293–297CrossRefPubMed

31.

Matsumoto CS, Kaufman SS, Fishbein TM (2011) Inclusion of the colon in intestinal transplantation. Current Opin Organ Transpl 16(3):312–315CrossRef

32.

Horslen SP (2006) Optimal management of the post-intestinal transplant patient. Gastroenterology 130(2 Suppl 1):S163–S169CrossRefPubMed

33.

Lacaille F, Vass N, Sauvat F, Canioni D, Colomb V, Talbotec C, De Serre NP, Salomon J, Hugot JP, Cezard JP et al (2008) Long-term outcome, growth and digestive function in children 2–18 years after intestinal transplantation. Gut 57(4):455–461CrossRefPubMed

34.

Venick RS, Wozniak LJ, Colangelo J, Beckwith P, Reyen L, Esmailian YA, McDiarmid SV, Vargas JH, Ament ME, Busuttil RW et al (2011) Long-term nutrition and predictors of growth and weight gain following pediatric intestinal transplantation. Transplantation 92(9):1058–1062PubMed

35.

Fishbein TM (2009) Intestinal transplantation. New Engl J Med 361(10):998–1008CrossRefPubMed

36.

Ningappa M, Ashokkumar C, Ranganathan S, Schmitt L, Higgs BW, Sun Q, Branca M, Mazariegos G, Zeevi A, Abu-Elmagd K et al (2012) Mucosal plasma cell barrier disruption during intestine transplant rejection. Transplantation 94(12):1236–1242CrossRefPubMed

37.

Ruiz P, Bagni A, Brown R, Cortina G, Harpaz N, Magid MS, Reyes J (2004) Histological criteria for the identification of acute cellular rejection in human small bowel allografts: results of the pathology workshop at the VIII International Small Bowel Transplant Symposium. Transpl Proc 36(2):335–337CrossRef

38.

Gondolesi G, Ghirardo S, Raymond K, Hoppenhauer L, Surillo D, Rumbo C, Fishbein T, Sansaricq C, Sauter B (2006) The value of plasma citrulline to predict mucosal injury in intestinal allografts. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 6(11):2786–2790CrossRef

39.

Hibi T, Nishida S, Garcia J, Tryphonopoulos P, Tekin A, Selvaggi G, Weppler D, Levi DM, Ruiz P, Tzakis AG (2012) Citrulline level is a potent indicator of acute rejection in the long term following pediatric intestinal/multivisceral transplantation. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 12(Suppl 4):S27–S32CrossRef

40.

Mercer DF, Vargas L, Sun Y, Moreno AM, Grant WJ, Botha JF, Langnas AN, Sudan DL (2011) Stool calprotectin monitoring after small intestine transplantation. Transplantation 91(10):1166–1171CrossRefPubMed

41.

De Greef E, Avitzur Y, Grant D, De-Angelis M, Ng V, Jones N, Ngan B, Shapiro R, Steinberg R, Gana JC (2012) Infliximab as salvage therapy in paediatric intestinal transplant with steroid- and thymoglobulin-resistant late acute rejection. J Pediatr Gastroenterol Nutr 54(4):565–567CrossRefPubMed

42.

Farmer DG, Venick RS, Colangelo J, Esmailian Y, Yersiz H, Duffy JP, Cortina GR, Artavia K, Ngo K, McDiarmid SV et al (2010) Pretransplant predictors of survival after intestinal transplantation: analysis of a single-center experience of more than 100 transplants. Transplantation 90(12):1574–1580CrossRefPubMed

43.

Hawksworth JS, Rosen-Bronson S, Island E, Girlanda R, Guerra JF, Valdiconza C, Kishiyama K, Christensen KD, Kozlowski S, Kaufman S et al (2012) Successful isolated intestinal transplantation in sensitized recipients with the use of virtual crossmatching. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 12(Suppl 4):S33–S42CrossRef

44.

Fan J, Tryphonopoulos P, Tekin A, Nishida S, Selvaggi G, Amador A, Jebrock J, Weppler D, Levi D, Vianna R et al (2015) Eculizumab salvage therapy for antibody-mediated rejection in a desensitization-resistant intestinal re-transplant patient. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 15(7):1995–2000CrossRef

45.

Starzl TE, Todo S, Fung J, Demetris AJ, Venkataramman R, Jain A (1989) FK 506 for liver, kidney, and pancreas transplantation. Lancet (London, England) 2(8670):1000–1004CrossRef

46.

Trevizol AP, David AI, Dias ER, Mantovani D, Pecora R, D’Albuquerque LA (2012) Intestinal and multivisceral transplantation immunosuppression protocols–literature review. Transpl Proc 44(8):2445–2448CrossRef

47.

Kato T, Tzakis AG, Selvaggi G, Gaynor JJ, David AI, Bussotti A, Moon JI, Ueno T, DeFaria W, Santiago S et al (2006) Intestinal and multivisceral transplantation in children. Ann Surg 243(6):756–764 (discussion 764–756) CrossRefPubMedPubMedCentral

48.

Parizhskaya M, Redondo C, Demetris A, Jaffe R, Reyes J, Ruppert K, Martin L, Abu-Elmagd K (2003) Chronic rejection of small bowel grafts: pediatric and adult study of risk factors and morphologic progression. Pediatr Dev Pathol 6(3):240–250CrossRefPubMed

49.

Demetris AJ, Murase N, Lee RG, Randhawa P, Zeevi A, Pham S, Duquesnoy R, Fung JJ, Starzl TE (1997) Chronic rejection. A general overview of histopathology and pathophysiology with emphasis on liver, heart and intestinal allografts. Ann Transpl Q Polish Transpl Soc 2(2):27–44

50.

Florescu DF, Qiu F, Langnas AN, Mercer DF, Chambers H, Hill LA, Qaragholi N, Kalil AC (2012) Bloodstream infections during the first year after pediatric small bowel transplantation. Pediatr Infect Dis J 31(7):700–704CrossRefPubMed

51.

Avitzur Y, Grant D (2010) Intestine transplantation in children: update 2010. Pediatr Clin North Am 57(2):415–431 (table of contents) CrossRefPubMed

52.

Debray D, Baudouin V, Lacaille F, Charbit M, Rivet C, Harambat J, Iserin F, Di Filippo S, Guyot C (2009) De novo malignancy after solid organ transplantation in children. Transpl Proc 41(2):674–675CrossRef

53.

Pironi L, Baxter JP, Lauro A, Guidetti M, Agostini F, Zanfi C, Pinna AD (2012) Assessment of quality of life on home parenteral nutrition and after intestinal transplantation using treatment-specific questionnaires. Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg 12(Suppl 4):S60–S66CrossRef

54.

Andres AM, Alameda A, Mayoral O, Hernandez F, Dominguez E, Martinez Ojinaga E, Ramos E, Prieto G, Lopez Santamaria M, Tovar JA (2014) Health-related quality of life in pediatric intestinal transplantation. Pediatr Transplant 18(7):746–756CrossRefPubMed

55.

Sudan D (2006) Cost and quality of life after intestinal transplantation. Gastroenterology 130(2 Suppl 1):S158–S162CrossRefPubMed

56.

Struijs MC, Diamond IR, de Silva N, Wales PW (2009) Establishing norms for intestinal length in children. J Pediatr Surg 44(5):933–938CrossRefPubMed

Titel: Intestinal transplantation in children: current status
verfasst von: Andrea Martinez Rivera
Paul W. Wales
Publikationsdatum: 31.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 6/2016
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-016-3885-2

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