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Graefe's Archive for Clinical and Experimental Ophthalmology

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06.07.2018 | Pediatrics

Intravitreal bevacizumab treatment reduces ocular blood flow in retinopathy of prematurity: a four-case report

verfasst von: Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Masahiko Tomita, Kotaro Hine, Norio Mizukaki, Hitoshi Yoda, Yuichi Hori

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 11/2018

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Abstract

Purpose

To evaluate the relationship between ocular blood flow, expressed as mean blur rate (MBR) by laser speckle flowgraphy, and intravitreal bevacizumab (IVB) therapy in neonates with retinopathy of prematurity (ROP).

Methods

This was a case series study of 4 neonates with ROP under sedation before and after IVB and evaluated 8 eyes, in which the circulation could be measured three times consecutively. We performed optic nerve head blood flow measurement and fluorescein angiography (FA) before and 1 week after treatment. Blood flow was analyzed separately for MBR-A (mean of all values), MBR-V (vessel mean), and MBR-T (tissue mean). Comparisons between the MBR (-A, -V, -T), body weight, and other systemic and ocular parameters before and after treatment were performed using a paired t test.

Results

The MBR values after IVB were lower than the pre-treatment values in all cases. All eyes showed leakage at neovascularization on FA before treatment. Although leakage improved 1 week after treatment, the neovascularization did not completely regress.

Conclusions

IVB improves vein dilation and artery tortuosity, while reducing ocular blood flow in neonates with ROP. We suggest that neovascularization might not be involved in reducing ocular blood flow in the early stage of IVB treatment.

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Titel: Intravitreal bevacizumab treatment reduces ocular blood flow in retinopathy of prematurity: a four-case report
verfasst von: Tadashi Matsumoto
Takashi Itokawa
Tomoaki Shiba
Masahiko Tomita
Kotaro Hine
Norio Mizukaki
Hitoshi Yoda
Yuichi Hori
Publikationsdatum: 06.07.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 11/2018
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-4063-0

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Intravitreal bevacizumab treatment reduces ocular blood flow in retinopathy of prematurity: a four-case report

Abstract

Purpose

Methods

Results

Conclusions

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