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Investigational New Drugs

Ausgabe 3/2005

Inhalt (10 Artikel)

A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug

Carmela Fimognari, Luca Sangiorgi, Silvia Capponcelli, Michael Nüsse, Silvia Fontanesi, Fausto Berti, Silvia Soddu, Giorgio Cantelli-Forti, Patrizia Hrelia

Induction of apoptosis by flavopiridol unrelated to cell cycle arrest in germ cell tumour derived cell lines

Frank Mayer, Sandra Mueller, Elke Malenke, M. Kuczyk, Jörg T. Hartmann, Carsten Bokemeyer

Cryptophycins-309, 249 and other cryptophycin analogs: Preclinical efficacy studies with mouse and human tumors

Jian Liang, Richard E. Moore, Eric D. Moher, John E. Munroe, Rima S. Al-awar, David A. Hay, David L. Varie, Tony Y. Zhang, James A. Aikins, Michael J. Martinelli, Chuan Shih, James E. Ray, Lowell L. Gibson, Vasu Vasudevan, Lisa Polin, Kathryn White, Juiwanna Kushner, Chiab Simpson, Susan Pugh, Thomas H. Corbett

Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam

Charlotte van Kesteren, Anthe S. Zandvliet, Mats O. Karlsson, Ron A. A. Mathôt, Cornelis J. A. Punt, Jean-Pierre Armand, Eric Raymond, Alwin D. R. Huitema, Christian Dittrich, Herlinde Dumez, Henri H. Roché, Jean-Pierre Droz, Miroslav Ravic, S. Murray Yule, Jantien Wanders, Jos H. Beijnen, Pierre Fumoleau, Jan H. M. Schellens

Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy

Dean Lim, Robert J. Morgan Jr., Steven Akman, Kim Margolin, Brian I. Carr, Lucille Leong, Oluwole Odujinrin, James H. Doroshow

Weekly irinotecan plus UFT and leucovorin as first-line chemotherapy of patients with advanced colorectal cancer

M. Méndez, P. G. Alfonso, E. Pujol, E. González, C. Castañon, P. Cerezuela, Y. López-Mateos, J. J. Cruz

Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma

Michael J. Millward, Anthony Joshua, Rick Kefford, Steinar Aamdal, Damien Thomson, Peter Hersey, Guy Toner, Kevin Lynch

Phase II trial of dolastatin-10 in patients with advanced breast cancer

Edith A. Perez, David W. Hillman, Paul A. Fishkin, James E. Krook, Winston W. Tan, Phillip A. Kuriakose, Steven R. Alberts, Shaker R. Dakhil

Randomized phase II evaluation of aprinocarsen in combination with gemcitabine and cisplatin for patients with advanced/metastatic non-small cell lung cancer

Johan Vansteenkiste, Jean-Luc Canon, Henrik Riska, Robert Pirker, Patrick Peterson, William John, Pekka Mali, Michael Lahn

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