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Investigational New Drugs

Ausgabe 6/2022

Inhalt (23 Artikel)

Research

Ketamine promotes breast tumor growth in a mouse breast tumor model involving with high expression of miR-27b-3p and EGFR

Li-Kuei Chen, Chien-Hung Shih, Shiou-Sheng Chen, Zi-Xuan Huang, Yu-Jung Chang, Linyi Chen, Tsung-Hsien Chuang, Kuen-Bao Chen

Research

Analysis of melanoma tumor antigens and immune subtypes for the development of mRNA vaccine

Haiqin Ping, Wenjun Yu, Xiaoming Gong, Xin Tong, Cheyu Lin, Zhaojun Chen, Caiyun Cai, Kai Guo, Hengning Ke

Research

Two calix[4]pyrroles as potential therapeutics for castration-resistant prostate cancer

Imene Ben Toumia, Marco Ponassi, Paola Barboro, Erika Iervasi, Gabriela Coronel Vargas, Barbara Banelli, Stefano Fiordoro, Leila Chekir Ghedira, Franz Heinrich Kohnke, Alberto Izzotti, Camillo Rosano

Research

Combination of ruxolitinib with ABT-737 exhibits synergistic effects in cells carrying concurrent JAK2V617F and ASXL1 mutations

Jiajia Yuan, Junzhe Song, Chao Chen, Xue Lv, Jie Bai, Jing Yang, Yuan Zhou

Research

Comparison of dual mTORC1/2 inhibitor AZD8055 and mTORC1 inhibitor rapamycin on the metabolism of breast cancer cells using proton nuclear magnetic resonance spectroscopy metabolomics

Zhitao Ni, Shaolin Xu, Zheng Yu, Zhongjiang Ye, Rongqi Li, Chuang Chen, Jianhui Yang, Huamin Liu, Ziye Zhou, Xiuhua Zhang

Research

Carbidopa suppresses estrogen receptor-positive breast cancer via AhR-mediated proteasomal degradation of ERα

Zhiwei Chen, Xing Xia, Heyan Chen, Huirong Huang, Xingsi An, Meng Sun, Qing Yao, Kwonseop Kim, Hailin Zhang, Maoping Chu, Ruijie Chen, Yangzom D. Bhutia, Vadivel Ganapathy, Longfa Kou

Research

TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells’ killing

Xuejia Feng, Gui Yang, Litian Zhang, Shishi Tao, Joong Sup SHIM, Liang Chen, Qingxia Wu

Research

Effects of CYP3A4/5 and ABC transporter polymorphisms on osimertinib plasma concentrations in Japanese patients with non-small cell lung cancer

Hayato Yokota, Kazuhiro Sato, Sho Sakamoto, Yuji Okuda, Natsuki Fukuda, Mariko Asano, Masahide Takeda, Katsutoshi Nakayama, Masatomo Miura

Open Access Research

Phase I study of lurbinectedin in combination with weekly paclitaxel with or without bevacizumab in patients with advanced solid tumors

Emiliano Calvo, Cristiana Sessa, Guilherme Harada, Maria de Miguel, Carmen Kahatt, Xarles Erik Luepke-Estefan, Mariano Siguero, Carlos Fernandez-Teruel, Martin Cullell-Young, Anastasios Stathis, Alexander Drilon

Research

Optimal threshold of alpha-fetoprotein response in patients with unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab

Nobuharu Tamaki, Toshifumi Tada, Masayuki Kurosaki, Yutaka Yasui, Hironori Ochi, Toshie Mashiba, Azusa Sakamoto, Hiroyuki Marusawa, Ryoichi Narita, Yasushi Uchida, Takehiro Akahane, Masahiko Kondo, Nami Mori, Shintaro Takaki, Keiji Tsuji, Haruhiko Kobashi, Atsunori Kusakabe, Koichiro Furuta, Hirotaka Arai, Michiko Nonogi, Chikara Ogawa, Takashi Sato, Takashi Tamada, Shinichiro Nakamura, Chitomi Hasebe, Kaoru Tsuchiya, Namiki Izumi

Research

Risk factors for severe immune-related adverse events after first-line pembrolizumab monotherapy or combination chemotherapy for non-small-cell lung cancer

Toshiyuki Sumi, Yuta Koshshino, Motoki Sekikawa, Yuta Nagahisa, Keigo Matsuura, Naoki Shijubou, Koki Kamada, Hiroki Watanabe, Haruhiko Michimata, Daiki Nagayama, Yusuke Tanaka, Yuichi Yamada, Hirofumi Chiba

Research

A phase II study of sapanisertib (TAK-228) a mTORC1/2 inhibitor in rapalog-resistant advanced pancreatic neuroendocrine tumors (PNET): ECOG-ACRIN EA2161

Lakshmi Rajdev, Ju-Whei Lee, Steven K. Libutti, Al B. Benson, George A. Fisher Jr, Pamela L. Kunz, Andrew E. Hendifar, Paul Catalano, Peter J. O’Dwyer

Research

Relation of overall tumor burden with severe immune-related adverse events in nivolumab plus ipilimumab treatment for lung cancer

Toshiyuki Sumi, Motoki Sekikawa, Yuta Nagahisa, Keigo Matsuura, Naoki Shijubou, Koki Kamada, Hiroki Watanabe, Yuichi Yamada, Yusuke Tanaka, Hirofumi Chiba

Review

BMP2 as a promising anticancer approach: functions and molecular mechanisms

Tong-tong Li, Yong-wei Lai, Xu Han, Xin Niu, Peng-xia Zhang

SHORT REPORT

EGFR-TKI re-administration after osimertinib failure in T790M mutation loss cases with re-biopsy

Shinsuke Ogusu, Ryo Ariyasu, Takahiro Akita, Ayu Kiritani, Ryosuke Tsugitomi, Yoshiaki Amino, Ken Uchibori, Satoru Kitazono, Noriko Yanagitani, Makoto Nishio

Author Correction

Correction to: Analysis of melanoma tumor antigens and immune subtypes for the development of mRNA vaccine

Haiqin Ping, Wenjun Yu, Xiaoming Gong, Xin Tong, Cheyu Lin, Zhaojun Chen, Caiyun Cai, Kai Guo, Hengning Ke

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Update Onkologie

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