TLE rats at week 13 after SE induction were used to detect the influence of AMPARs in learning and memory ability. Treatment of 0.1 µg/µl (
S)-AMPA did not significantly alter the escape latency, the time spent in the target quadrant, and the step-through latency of the TLE (Fig.
4a–c). The escape latency of the TLE rats was decreased by 10.64%, 14.98% and 28.56% by 0.4 µg/µl (
S)-AMPA on day 3, 4 and 5 of that week as compared to the 0.1 µg/µl (
S)-AMPA group (ANOVA,
p < 0.05, Fig.
4a). The time spent in the target quadrant was increased by 25.88% after injection of 0.4 µg/µl (
S)-AMPA compared with 0.1 µg/µl (
S)-AMPA group (ANOVA,
p < 0.05, Fig.
4b). The step-through latency was increased by 31.52% after injection of 0.4 µg/µl (
S)-AMPA compared with the 0.1 µg/µl (
S)-AMPA group (ANOVA,
p < 0.05, Fig.
4c). The escape latency was decreased by 15.48%, 27.90% and 32.35% on day 3, 4 and 5, respectively, after injection of 0.8 µg/µl (
S)-AMPA, compared to the 0.4 µg/µl (
S)-AMPA group (ANOVA,
p < 0.05, Fig.
4a). The time spent in the target quadrant was increased by 35.73% after injection of 0.8 µg/µl (
S)-AMPA compared to the 0.4 µg/µl (
S)-AMPA group (ANOVA,
p < 0.05, Fig.
4b). The step-through latency was increased by 33.94% after injection of 0.8 µg/µl (
S)-AMPA compared to the 0.4 µg/µl (
S)-AMPA group (ANOVA,
p < 0.05, Fig.
4c). These data demonstrated that the intra-hippocampal injection of the AMPARs agonist ameliorated the cognitive impairment of TLE rats in a dose-dependent manner.