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Erschienen in:

01.12.2024 | Original Article

Is neurodevelopment impaired in Brazilian children with intestinal failure on prolonged parenteral nutrition? A single center study

verfasst von: Cristina Miller, Renata R. Kieling, Bruna Ziegler, Juliana M. Giesta, Alana V. Signorini, Giovana Q. Pires, Letícia Feldens, Marília R. Ceza, Marina R. Adami, Carlos O. Kieling, Helena A. S. Goldani

Erschienen in: Pediatric Surgery International | Ausgabe 1/2024

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Abstract

Purpose

To assess the neurodevelopment outcomes of children younger than 42 months of age with intestinal failure (IF) using prolonged parenteral nutrition (PN) followed by a Pediatric Multidisciplinary Intestinal Rehabilitation Program from a public tertiary hospital in Brazil.

Methods

Bayley III scale was administered in children aged 2 to 42 months with IF and receiving PN for more than 60 days. Composite scores in cognitive, motor, and language domains were analyzed. Developmental delay was defined as a performance 2 standard deviations (SD) below the average at the 3 domains. Association between Bayley III composite scores and clinical variables related to IF were tested.

Results

Twenty-four children with median (IQR) age of 17.5 months (9–28.5) were studied, 58.3% were male. Developmental delay was found in 34%, 33% and 27% of the patients in cognitive, motor, and language domains, respectively. There was no significant association between the Bayley-III composite scores and length of hospitalization, prematurity, and number of surgical procedures with anesthesia.

Conclusion

The study demonstrated impairments in the cognitive, motor and language domains in approximately one-third of young patients with IF on prolonged PN.

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Titel: Is neurodevelopment impaired in Brazilian children with intestinal failure on prolonged parenteral nutrition? A single center study
verfasst von: Cristina Miller
Renata R. Kieling
Bruna Ziegler
Juliana M. Giesta
Alana V. Signorini
Giovana Q. Pires
Letícia Feldens
Marília R. Ceza
Marina R. Adami
Carlos O. Kieling
Helena A. S. Goldani
Publikationsdatum: 01.12.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 1/2024
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-024-05694-0

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Is neurodevelopment impaired in Brazilian children with intestinal failure on prolonged parenteral nutrition? A single center study