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20.09.2018 | Epidemiology

Is the high proportion of young age at breast cancer onset a unique feature of Asian breast cancer?

verfasst von: Se Kyung Lee, Seok Won Kim, Jong-Han Yu, Jeong Eon Lee, Ji Young Kim, Joohyun Woo, Seokwon Lee, Eun-Kyu Kim, Hyeong-Gon Moon, Sung Sang Ko, Seok Jin Nam, Korean Breast Cancer Society

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 1/2019

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Abstract

Purpose

Women with breast cancer in Asian and Western countries are similar in many respects, but there are also differences, such as in the age at onset and the proportion of breast cancer occurring at younger ages. There is controversy as to whether these differences are due to inter-racial genetic differences or to environmental or other factors.

Methods

Using the Korean Breast Cancer Society’s large breast cancer registry, we investigated the causes of Koreans’ unique breast cancer characteristics by examining the changes in the incidence and proportion of young-onset breast cancer (YBC) in Korea over time. We analyzed data from 108,894 patients to compare characteristics between patients with YBC and non-YBC. For a subtype analysis, we analyzed data from 85,691 patients from 2000.

Results

Among the 108,894 patients, 17,877 (15.5%) had YBC. The tumors associated with YBC showed aggressive clinicopathologic features. The incidence of breast cancer in Korea has increased over time, and while both YBC and non-YBC increased each year, the increase in non-YBC was more pronounced; thus, the proportion of YBC has decreased over time. By 2020, it appears that the ratio of YBC in Korea will be similar to that in Western countries. The increase in YBC was mainly due to an increase in the luminal A subtype. The incidence of other YBC subtypes did not change over time.

Conclusions

Our data suggest that the current high proportion of YBC is probably not a unique feature of breast cancer in Asia but rather a transient phenomenon. Additionally, our results indirectly suggest that there were different causes for breast cancer in different age groups, suggesting the importance of using different approaches for different age groups to establish policies for preventing breast cancer.

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Titel: Is the high proportion of young age at breast cancer onset a unique feature of Asian breast cancer?
verfasst von: Se Kyung Lee
Seok Won Kim
Jong-Han Yu
Jeong Eon Lee
Ji Young Kim
Joohyun Woo
Seokwon Lee
Eun-Kyu Kim
Hyeong-Gon Moon
Sung Sang Ko
Seok Jin Nam
Korean Breast Cancer Society
Publikationsdatum: 20.09.2018
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 1/2019
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-018-4947-z

Springer Medizin

Is the high proportion of young age at breast cancer onset a unique feature of Asian breast cancer?