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Erschienen in: Endocrine 2/2015

01.06.2015 | Position Statement/Guideline

Italian Association of Clinical Endocrinologists (AME) & Italian Association of Clinical Diabetologists (AMD) Position Statement

Diabetes mellitus and thyroid disorders: recommendations for clinical practice

verfasst von: Edoardo Guastamacchia, Vincenzo Triggiani, Alberto Aglialoro, Antimo Aiello, Lucia Ianni, Mauro Maccario, Michele Zini, Carlo Giorda, Rinaldo Guglielmi, Corrado Betterle, Roberto Attanasio, Giorgio Borretta, Piernicola Garofalo, Enrico Papini, Roberto Castello, Antonio Ceriello

Erschienen in: Endocrine | Ausgabe 2/2015

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Abstract

Thyroid disease and diabetes mellitus, the most common disorders in endocrine practice, are not infrequently associated in the same subject. An altered thyroid function may affect glucose tolerance and worsen metabolic control in patients with diabetes. Thyrotoxicosis increases the risk of hyperglycemic emergencies, while a clinically relevant hypothyroidism may have a detrimental effect on glycemic control in diabetic patients. The association of alterations in thyroid function with diabetes mellitus may adversely affect the risk of cardiovascular and microvascular complications resulting from diabetes. Moreover, the treatments used for both diabetes and thyroid disease, respectively, can impact one other. Finally, multinodular goiter, but not thyroid carcinoma, was shown to be more prevalent in type 2 diabetes mellitus. Aim of the present Position Statement is to focus on the evidence concerning the association of thyroid disease and diabetes mellitus and to provide some practical suggestions for an updated clinical management.
Literatur
2.
Zurück zum Zitat D. Atkins, D. Best, P.A. Briss, M. Eccles, Y. Falck-Ytter, S. Flottorp, G.H. Guyatt, R.T. Harbour, M.C. Haugh, D. Henry, S. Hill, R. Jaeschke, G. Leng, A. Liberati, N. Magrini, J. Mason, P. Middleton, J. Mrukowicz, D. O’Connell, A.D. Oxman, B. Phillips, H.J. Schünemann, T. Edejer, H. Varonen, G.E. Vist, J.W. Williams Jr, S. Zaza, GRADE Working Group, Grading quality of evidence and strength of recommendations. BMJ 328(7454), 1490 (2004). (no LoE)PubMed D. Atkins, D. Best, P.A. Briss, M. Eccles, Y. Falck-Ytter, S. Flottorp, G.H. Guyatt, R.T. Harbour, M.C. Haugh, D. Henry, S. Hill, R. Jaeschke, G. Leng, A. Liberati, N. Magrini, J. Mason, P. Middleton, J. Mrukowicz, D. O’Connell, A.D. Oxman, B. Phillips, H.J. Schünemann, T. Edejer, H. Varonen, G.E. Vist, J.W. Williams Jr, S. Zaza, GRADE Working Group, Grading quality of evidence and strength of recommendations. BMJ 328(7454), 1490 (2004). (no LoE)PubMed
3.
Zurück zum Zitat B.A. Swiglo, M.H. Murad, H.J. Schünemann, R. Kunz, R.A. Vigersky, G.H. Guyatt, V.M. Montori, A case for clarity, consistency, and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system. J. Clin. Endocrinol. Metab. 93(3), 666–673 (2008). doi:10.1210/jc.2007-1907. (no LoE)PubMed B.A. Swiglo, M.H. Murad, H.J. Schünemann, R. Kunz, R.A. Vigersky, G.H. Guyatt, V.M. Montori, A case for clarity, consistency, and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system. J. Clin. Endocrinol. Metab. 93(3), 666–673 (2008). doi:10.​1210/​jc.​2007-1907. (no LoE)PubMed
4.
Zurück zum Zitat G.H. Guyatt, A.D. Oxman, G.E. Vist, R. Kunz, Y. Falck-Ytter, P. Alonso-Coello, H.J. Schünemann, GRADE Working Group, GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336(7650), 924–926 (2008). doi:10.1136/bmj.39489.470347.AD. (no LoE)PubMedCentralPubMed G.H. Guyatt, A.D. Oxman, G.E. Vist, R. Kunz, Y. Falck-Ytter, P. Alonso-Coello, H.J. Schünemann, GRADE Working Group, GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336(7650), 924–926 (2008). doi:10.​1136/​bmj.​39489.​470347.​AD. (no LoE)PubMedCentralPubMed
5.
Zurück zum Zitat J.I. Mechanick, P.M. Camacho, R.H. Cobin, A.J. Garber, J.R. Garber, H. Gharib, S.M. Petak, H.W. Rodbard, D.L. Trence, American Association of Clinical Endocrinologists, Protocol for standardized production of clinical practice guidelines-2010 update. Endocr. Pract. 16(2), 270–283 (2010). (no LoE)PubMed J.I. Mechanick, P.M. Camacho, R.H. Cobin, A.J. Garber, J.R. Garber, H. Gharib, S.M. Petak, H.W. Rodbard, D.L. Trence, American Association of Clinical Endocrinologists, Protocol for standardized production of clinical practice guidelines-2010 update. Endocr. Pract. 16(2), 270–283 (2010). (no LoE)PubMed
6.
Zurück zum Zitat M.P.J. Vanderpump, The epidemiology of thyroid diseases, in Werner and Ingbar’s the thryoid: a fundamental and clinical text, ed. by L.E. Braverman, R.D. Utiger (J.B. Lippicott-Raven, Philadelphia, 2005), pp. 398–496 M.P.J. Vanderpump, The epidemiology of thyroid diseases, in Werner and Ingbar’s the thryoid: a fundamental and clinical text, ed. by L.E. Braverman, R.D. Utiger (J.B. Lippicott-Raven, Philadelphia, 2005), pp. 398–496
7.
Zurück zum Zitat F. Aghini-Lombardi, L. Antonangeli, E. Martino, P. Vitti, D. Maccherini, F. Leoli, T. Rago, L. Grasso, R. Valeriano, A. Balestrieri, A. Pinchera, The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. J Clin. Endocrinol. Metab. 84(2), 561–566 (1999). (LoE )PubMed F. Aghini-Lombardi, L. Antonangeli, E. Martino, P. Vitti, D. Maccherini, F. Leoli, T. Rago, L. Grasso, R. Valeriano, A. Balestrieri, A. Pinchera, The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. J Clin. Endocrinol. Metab. 84(2), 561–566 (1999). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
8.
Zurück zum Zitat W.M. Tunbridge, D.C. Evered, R. Hall, D. Appleton, M. Brewis, F. Clark, J.G. Evans, E. Young, T. Bird, P.A. Smith, The spectrum of thyroid disease in a community: the Whickham survey. Clin. Endocrinol. (Oxford) 7(6), 481–493 (1977). (LoE ) W.M. Tunbridge, D.C. Evered, R. Hall, D. Appleton, M. Brewis, F. Clark, J.G. Evans, E. Young, T. Bird, P.A. Smith, The spectrum of thyroid disease in a community: the Whickham survey. Clin. Endocrinol. (Oxford) 7(6), 481–493 (1977). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
9.
Zurück zum Zitat M.P. Vanderpump, W.M. Tunbridge, J.M. French, D. Appleton, D. Bates, F. Clark, J. Grimley Evans, D.M. Hasan, H. Rodgers, F. Tunbridge, E.T. Young, The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin. Endocrinol. (Oxford) 43(1), 55–68 (1995). (LoE ) M.P. Vanderpump, W.M. Tunbridge, J.M. French, D. Appleton, D. Bates, F. Clark, J. Grimley Evans, D.M. Hasan, H. Rodgers, F. Tunbridge, E.T. Young, The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin. Endocrinol. (Oxford) 43(1), 55–68 (1995). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
10.
Zurück zum Zitat J.V. Parle, J.A. Franklyn, K.W. Cross, S.C. Jones, M.C. Sheppard, Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin. Endocrinol. (Oxford) 34(1), 77–83 (1991). (LoE ) J.V. Parle, J.A. Franklyn, K.W. Cross, S.C. Jones, M.C. Sheppard, Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin. Endocrinol. (Oxford) 34(1), 77–83 (1991). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
12.
Zurück zum Zitat M. Mouradian, N. Abourizk, Diabetes mellitus and thyroid disease. Diabetes Care 6(5), 512–520 (1983). (no LoE)PubMed M. Mouradian, N. Abourizk, Diabetes mellitus and thyroid disease. Diabetes Care 6(5), 512–520 (1983). (no LoE)PubMed
13.
Zurück zum Zitat R.S. Gray, W.J. Irvine, B.F. Clarke, Screening for thyroid dysfunction in diabetics. Br. Med. J. 2(6202), 1439 (1979). (no LoE)PubMedCentralPubMed R.S. Gray, W.J. Irvine, B.F. Clarke, Screening for thyroid dysfunction in diabetics. Br. Med. J. 2(6202), 1439 (1979). (no LoE)PubMedCentralPubMed
16.
Zurück zum Zitat P. Perros, R.J. McCrimmon, G. Shaw, B.M. Frier, Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet. Med. 12(7), 622–627 (1995)PubMed P. Perros, R.J. McCrimmon, G. Shaw, B.M. Frier, Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet. Med. 12(7), 622–627 (1995)PubMed
17.
Zurück zum Zitat G.E. Umpierrez, K.A. Latif, M.B. Murphy, H.C. Lambeth, F. Stentz, A. Bush, A.E. Kitabch, Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study. Diabetes Care 26(4), 1181–1185 (2003). (LoE )PubMed G.E. Umpierrez, K.A. Latif, M.B. Murphy, H.C. Lambeth, F. Stentz, A. Bush, A.E. Kitabch, Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study. Diabetes Care 26(4), 1181–1185 (2003). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
18.
Zurück zum Zitat L.C. de Graaff, J.W. Smit, J.K. Radder, Prevalence and clinical significance of organ-specific autoantibodies in type 1 diabetes mellitus. Neth. J. Med. 65(7), 235–247 (2007). (no LoE)PubMed L.C. de Graaff, J.W. Smit, J.K. Radder, Prevalence and clinical significance of organ-specific autoantibodies in type 1 diabetes mellitus. Neth. J. Med. 65(7), 235–247 (2007). (no LoE)PubMed
19.
Zurück zum Zitat J.M. Moore, J.M. Neilson, Antibodies to gastric mucosa and thyroid in diabetes mellitus. Lancet. 2(7309), 645–647 (1963). (LoE )PubMed J.M. Moore, J.M. Neilson, Antibodies to gastric mucosa and thyroid in diabetes mellitus. Lancet. 2(7309), 645–647 (1963). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
20.
Zurück zum Zitat D.E. Goldstein, A. Drasch, J. Gibbs, R.M. Blizzard, Diabetes mellitus: the incidence of circulating antibodies against thyroid, gastric, and adrenal tissue. J. Pediatr. 77(2), 304–306 (1970). (LoE )PubMed D.E. Goldstein, A. Drasch, J. Gibbs, R.M. Blizzard, Diabetes mellitus: the incidence of circulating antibodies against thyroid, gastric, and adrenal tissue. J. Pediatr. 77(2), 304–306 (1970). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
21.
Zurück zum Zitat W.J. Irvine, B.F. Clarke, L. Scarth, D.R. Cullen, L.J. Duncan, Thyroid and gastric autoimmunity in patients with diabetes mellitus. Lancet 2(7665), 163–168 (1970)PubMed W.J. Irvine, B.F. Clarke, L. Scarth, D.R. Cullen, L.J. Duncan, Thyroid and gastric autoimmunity in patients with diabetes mellitus. Lancet 2(7665), 163–168 (1970)PubMed
22.
Zurück zum Zitat J. Nerup, C. Binder, Thyroid, gastric and adrenal auto-immunity in diabetes mellitus. Acta. Endocrinol. (Copenh) 72(2), 279–286 (1973). (LoE ) J. Nerup, C. Binder, Thyroid, gastric and adrenal auto-immunity in diabetes mellitus. Acta. Endocrinol. (Copenh) 72(2), 279–286 (1973). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
23.
Zurück zum Zitat M. Neufeld, N.K. Maclaren, W.J. Riley, D. Lezotte, J.V. McLaughlin, J. Silverstein, A.L. Rosenbloom, Islet cell and other organ-specific antibodies in U.S. Caucasians and Blacks with insulin-dependent diabetes mellitus. Diabetes 29(8), 589–592 (1980). (LoE )PubMed M. Neufeld, N.K. Maclaren, W.J. Riley, D. Lezotte, J.V. McLaughlin, J. Silverstein, A.L. Rosenbloom, Islet cell and other organ-specific antibodies in U.S. Caucasians and Blacks with insulin-dependent diabetes mellitus. Diabetes 29(8), 589–592 (1980). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
24.
Zurück zum Zitat W.J. Riley, N.K. Maclaren, D.C. Lezotte, R.P. Spillar, A.L. Rosenbloom, Thyroid autoimmunity in insulin-dependent diabetes mellitus: the case for routine screening. J. Pediatr. 99(3), 350–354 (1981). (LoE )PubMed W.J. Riley, N.K. Maclaren, D.C. Lezotte, R.P. Spillar, A.L. Rosenbloom, Thyroid autoimmunity in insulin-dependent diabetes mellitus: the case for routine screening. J. Pediatr. 99(3), 350–354 (1981). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
25.
Zurück zum Zitat S. Court, J.M. Parkin, Hypothyroidism and growth failure in diabetes mellitus. Arch. Dis. Child. 57, 622–624 (1982). (LoE )PubMedCentralPubMed S. Court, J.M. Parkin, Hypothyroidism and growth failure in diabetes mellitus. Arch. Dis. Child. 57, 622–624 (1982). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMedCentralPubMed
26.
Zurück zum Zitat J. Kokkonen, J. Kiuttu, A. Mustonen, O. Räsänen, Organ-specific antibodies in healthy and diabetic children and young adults. Acta. Pediatr. Scand. 71(2), 223–226 (1982). (LoE ) J. Kokkonen, J. Kiuttu, A. Mustonen, O. Räsänen, Organ-specific antibodies in healthy and diabetic children and young adults. Acta. Pediatr. Scand. 71(2), 223–226 (1982). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
27.
Zurück zum Zitat B.B. Gilani, M.H. MacGillivray, M.L. Voorhess, B.J. Mills, W.J. Riley, N.K. MacLaren, Thyroid hormone abnormalities at diagnosis of insulin-dependent diabetes mellitus in children. J. Pediatr. 105(2), 218–222 (1984). (LoE )PubMed B.B. Gilani, M.H. MacGillivray, M.L. Voorhess, B.J. Mills, W.J. Riley, N.K. MacLaren, Thyroid hormone abnormalities at diagnosis of insulin-dependent diabetes mellitus in children. J. Pediatr. 105(2), 218–222 (1984). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
28.
Zurück zum Zitat N.K. Maclaren, W.J. Riley, Thyroid, gastric, and adrenal autoimmunities associated with insulin-dependent diabetes mellitus. Diabetes Care 8(Suppl 1), 34–38 (1985). (LoE )PubMed N.K. Maclaren, W.J. Riley, Thyroid, gastric, and adrenal autoimmunities associated with insulin-dependent diabetes mellitus. Diabetes Care 8(Suppl 1), 34–38 (1985). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
29.
Zurück zum Zitat D.W. Drell, A.L. Notkins, Multiple immunological abnormalities in patients with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 30(3), 132–143 (1987). (no LoE)PubMed D.W. Drell, A.L. Notkins, Multiple immunological abnormalities in patients with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 30(3), 132–143 (1987). (no LoE)PubMed
30.
Zurück zum Zitat S. Kontiainen, A. Schlenzka, S. Koskimies, A. Rilva, J. Mäenpää, Autoantibodies and autoimmune diseases in young diabetics. Diabetes Res. 13(4), 151–156 (1990). (LoE )PubMed S. Kontiainen, A. Schlenzka, S. Koskimies, A. Rilva, J. Mäenpää, Autoantibodies and autoimmune diseases in young diabetics. Diabetes Res. 13(4), 151–156 (1990). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
31.
Zurück zum Zitat M. Landin-Olsson, F.A. Karlsson, A. Lernmark, G. Sundkvist, Islet cell and thyrogastric antibodies in 633 consecutive 15- to 34-yr-old patients in the diabetes incidence study in Sweden. Diabetes 41(8), 1022–1027 (1992). (LoE )PubMed M. Landin-Olsson, F.A. Karlsson, A. Lernmark, G. Sundkvist, Islet cell and thyrogastric antibodies in 633 consecutive 15- to 34-yr-old patients in the diabetes incidence study in Sweden. Diabetes 41(8), 1022–1027 (1992). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
32.
Zurück zum Zitat G. Radetti, C. Paganini, L. Gentili, S. Bernasconi, C. Betterle, M. Borkenstein, K. Cvijovic, M. Kadrnka-Lovrencic, C. Krzisnik, T. Battelino, R. Lorini, S. Marinoni, F. Rigon, L. Tatò, L. Pinelli, G. Tonini, Frequency of Hashimoto’s thyroiditis in children with type 1 diabetes mellitus. Acta Diabetol. 32(2), 121–124 (1995). (Loe ) doi:10.1007/BF00569570 PubMed G. Radetti, C. Paganini, L. Gentili, S. Bernasconi, C. Betterle, M. Borkenstein, K. Cvijovic, M. Kadrnka-Lovrencic, C. Krzisnik, T. Battelino, R. Lorini, S. Marinoni, F. Rigon, L. Tatò, L. Pinelli, G. Tonini, Frequency of Hashimoto’s thyroiditis in children with type 1 diabetes mellitus. Acta Diabetol. 32(2), 121–124 (1995). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif ) doi:10.​1007/​BF00569570 PubMed
33.
Zurück zum Zitat P. Abrams, I. De Leeuw, J. Vertommen, In new-onset insulin-dependent diabetic patients the presence of anti-thyroid peroxidase antibodies is associated with islet cell autoimmunity and the high risk haplotype HLA DQA1*0301-DQB1*0302. Belgian Diabetes Registry. Diabet. Med. 13(5), 415–419 (1996). (LoE )PubMed P. Abrams, I. De Leeuw, J. Vertommen, In new-onset insulin-dependent diabetic patients the presence of anti-thyroid peroxidase antibodies is associated with islet cell autoimmunity and the high risk haplotype HLA DQA1*0301-DQB1*0302. Belgian Diabetes Registry. Diabet. Med. 13(5), 415–419 (1996). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
34.
Zurück zum Zitat I.G. Jefferson, The clinical approach to thyroid disorders associated with childhood insulin dependent diabetes mellitus. J. Pediatr. Endocrinol. Metab. 9(Suppl 1), 95–100 (1996). (no LoE)PubMed I.G. Jefferson, The clinical approach to thyroid disorders associated with childhood insulin dependent diabetes mellitus. J. Pediatr. Endocrinol. Metab. 9(Suppl 1), 95–100 (1996). (no LoE)PubMed
35.
Zurück zum Zitat R. Lorini, G. d’Annunzio, L. Vitali, A. Scaramuzza, IDDM and autoimmune thyroid disease in the pediatric age group. J. Pediatr. Endocrinol. Metab. 9(Suppl 1), 89–94 (1996). (LoE )PubMed R. Lorini, G. d’Annunzio, L. Vitali, A. Scaramuzza, IDDM and autoimmune thyroid disease in the pediatric age group. J. Pediatr. Endocrinol. Metab. 9(Suppl 1), 89–94 (1996). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
36.
Zurück zum Zitat F. Presotto, C. Betterle, Insulin-dependent diabetes mellitus: a constellation of autoimmune diseases. J. Pediatr. Endocrinol. Metab. 10(5), 455–469 (1997). (no LoE)PubMed F. Presotto, C. Betterle, Insulin-dependent diabetes mellitus: a constellation of autoimmune diseases. J. Pediatr. Endocrinol. Metab. 10(5), 455–469 (1997). (no LoE)PubMed
37.
Zurück zum Zitat E. McCanlies, L.A. O’Leary, T.P. Foley, M.K. Kramer, J.P. Burke, A. Libman, J.S. Swan, A.R. Steenkiste, B.J. Mccarthy, M. Trucco, J.S. Dorman, Hashimoto’s thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function. J. Clin. Endocrinol. Metab. 83(5), 1548–1551 (1998). (LoE )PubMed E. McCanlies, L.A. O’Leary, T.P. Foley, M.K. Kramer, J.P. Burke, A. Libman, J.S. Swan, A.R. Steenkiste, B.J. Mccarthy, M. Trucco, J.S. Dorman, Hashimoto’s thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function. J. Clin. Endocrinol. Metab. 83(5), 1548–1551 (1998). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
38.
Zurück zum Zitat C.C. Chang, C.N. Huang, L.M. Chuang, Autoantibodies to thyroid peroxidase in patients with type 1 diabetes in Taiwan. Eur. J. Endocrinol. 139(1), 44–48 (1998). (LoE )PubMed C.C. Chang, C.N. Huang, L.M. Chuang, Autoantibodies to thyroid peroxidase in patients with type 1 diabetes in Taiwan. Eur. J. Endocrinol. 139(1), 44–48 (1998). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
39.
Zurück zum Zitat D. Hansen, F.N. Bennedbaek, L.K. Hansen, M. Hoier-Madsen, B.B. Jacobsen, L. Hegedüs, Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus. Eur. J. Endocrinol. 140(6), 512–518 (1999). (Loe )PubMed D. Hansen, F.N. Bennedbaek, L.K. Hansen, M. Hoier-Madsen, B.B. Jacobsen, L. Hegedüs, Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus. Eur. J. Endocrinol. 140(6), 512–518 (1999). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )PubMed
40.
Zurück zum Zitat M.B. Roldán, M. Alonso, R. Barrio, Thyroid autoimmunity in children and adolescents with Type 1 diabetes mellitus. Diabetes Nutr. Metab. 12(1), 27–31 (1999). (LoE )PubMed M.B. Roldán, M. Alonso, R. Barrio, Thyroid autoimmunity in children and adolescents with Type 1 diabetes mellitus. Diabetes Nutr. Metab. 12(1), 27–31 (1999). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
41.
Zurück zum Zitat G. Gambelunghe, F. Forini, S. Laureti, G. Murdolo, G. Toraldo, F. Santeusanio, P. Brunetti, C.B. Sanjeevi, A. Falorni, Increased risk for endocrine autoimmunity in Italian type 2 diabetic patients with GAD65 autoantibodies. Clin. Endocrinol. (Oxford) 52(5), 565–573 (2000). (LoE ) G. Gambelunghe, F. Forini, S. Laureti, G. Murdolo, G. Toraldo, F. Santeusanio, P. Brunetti, C.B. Sanjeevi, A. Falorni, Increased risk for endocrine autoimmunity in Italian type 2 diabetic patients with GAD65 autoantibodies. Clin. Endocrinol. (Oxford) 52(5), 565–573 (2000). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
42.
Zurück zum Zitat C. Rattarasarn, M.A. Diosdado, J. Ortego, R. Leelawattana, S. Soonthornpun, W. Setasuban, S. Jaruratanasirikul, N. Patarakijvanich, Thyroid autoantibodies in Thai type 1 diabetic patients: clinical significance and their relationship with glutamic acid decarboxylase antibodies. Diabetes Res. Clin. Pract. 49(2–3), 107–111 (2000). (LoE )PubMed C. Rattarasarn, M.A. Diosdado, J. Ortego, R. Leelawattana, S. Soonthornpun, W. Setasuban, S. Jaruratanasirikul, N. Patarakijvanich, Thyroid autoantibodies in Thai type 1 diabetic patients: clinical significance and their relationship with glutamic acid decarboxylase antibodies. Diabetes Res. Clin. Pract. 49(2–3), 107–111 (2000). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
43.
Zurück zum Zitat C.E. De Block, I.H. De Leeuw, J.J. Vertommen, R.P. Rooman, M.V. Du Caju, C.M. Van Campenhout, J.J. Weyler, F. Winnock, J. Van Autreve, F.K. Gorus, Belgian Diabetes Registry, Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes. Clin. Exp. Immunol. 126(2), 236–241 (2001). (LoE )PubMed C.E. De Block, I.H. De Leeuw, J.J. Vertommen, R.P. Rooman, M.V. Du Caju, C.M. Van Campenhout, J.J. Weyler, F. Winnock, J. Van Autreve, F.K. Gorus, Belgian Diabetes Registry, Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes. Clin. Exp. Immunol. 126(2), 236–241 (2001). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
44.
Zurück zum Zitat O. Kordonouri, A. Klinghammer, E.B. Lang, A. Grüters-Kieslich, M. Grabert, R.W. Holl, Thyroid autoimmunity in children and adolescents with type 1 diabetes: a multicenter survey. Diabetes Care 25(8), 1346–1350 (2002). (Loe )PubMed O. Kordonouri, A. Klinghammer, E.B. Lang, A. Grüters-Kieslich, M. Grabert, R.W. Holl, Thyroid autoimmunity in children and adolescents with type 1 diabetes: a multicenter survey. Diabetes Care 25(8), 1346–1350 (2002). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )PubMed
45.
Zurück zum Zitat H. Bárová, J. Perusicová, M. Hill, I. Sterzl, K. Vondra, Z. Masek, Anti-GAD-positive patients with type 1 diabetes mellitus have higher prevalence of autoimmune thyroiditis than anti-GAD-negative patients with type 1 and type 2 diabetes mellitus. Physiol. Res. 53(3), 279–286 (2004). (LoE )PubMed H. Bárová, J. Perusicová, M. Hill, I. Sterzl, K. Vondra, Z. Masek, Anti-GAD-positive patients with type 1 diabetes mellitus have higher prevalence of autoimmune thyroiditis than anti-GAD-negative patients with type 1 and type 2 diabetes mellitus. Physiol. Res. 53(3), 279–286 (2004). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
46.
Zurück zum Zitat M. Prázný, J. Skrha, Z. Límanová, Z. Vanícková, J. Hilgertová, J. Prázná, M. Jaresová, I. Stríz, Screening for associated autoimmunity in type 1 diabetes mellitus with respect to diabetes control. Physiol. Res. 54(1), 41–48 (2005). (LoE )PubMed M. Prázný, J. Skrha, Z. Límanová, Z. Vanícková, J. Hilgertová, J. Prázná, M. Jaresová, I. Stríz, Screening for associated autoimmunity in type 1 diabetes mellitus with respect to diabetes control. Physiol. Res. 54(1), 41–48 (2005). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
47.
Zurück zum Zitat K. Vondra, J. Vrbíková, B. Bendlová, K. Dvorakova, I. Sterzl, M. Vondrova, Differences in type I diabetes mellitus of young adults with and without thyroid autoimmunity. Exp. Clin. Endocrinol. Diabetes 113(7), 404–408 (2005). (LoE )PubMed K. Vondra, J. Vrbíková, B. Bendlová, K. Dvorakova, I. Sterzl, M. Vondrova, Differences in type I diabetes mellitus of young adults with and without thyroid autoimmunity. Exp. Clin. Endocrinol. Diabetes 113(7), 404–408 (2005). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
48.
Zurück zum Zitat J.M. Barker, J. Yu, L. Yu, J. Wang, D. Miao, F. Bao, E. Hoffenberg, J.C. Nelson, P.A. Gottlieb, M. Rewers, G.S. Eisenbarth, Autoantibody “subspecificity” in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups. Diabetes Care 28(4), 850–855 (2005). (LoE )PubMed J.M. Barker, J. Yu, L. Yu, J. Wang, D. Miao, F. Bao, E. Hoffenberg, J.C. Nelson, P.A. Gottlieb, M. Rewers, G.S. Eisenbarth, Autoantibody “subspecificity” in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups. Diabetes Care 28(4), 850–855 (2005). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
49.
Zurück zum Zitat H. Völzke, U. Krohn, H. Wallaschofski, J. Lüdemann, U. John, W. Kerner, The spectrum of thyroid disorders in adult type 1 diabetes mellitus. Diabetes Metab. Res. Rev. 23(3), 227–233 (2007). (LoE )PubMed H. Völzke, U. Krohn, H. Wallaschofski, J. Lüdemann, U. John, W. Kerner, The spectrum of thyroid disorders in adult type 1 diabetes mellitus. Diabetes Metab. Res. Rev. 23(3), 227–233 (2007). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
50.
Zurück zum Zitat R.M. Mantovani, L.M. Mantovani, V.M. Dias, Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus: prevalence and risk factors. J. Pediatr. Endocrinol. Metab. 20(6), 669–675 (2007). (LoE )PubMed R.M. Mantovani, L.M. Mantovani, V.M. Dias, Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus: prevalence and risk factors. J. Pediatr. Endocrinol. Metab. 20(6), 669–675 (2007). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
51.
Zurück zum Zitat K. Warncke, E.E. Fröhlich-Reiterer, A. Thon, S.E. Hofer, D. Wiemann, R.W. Holl, DPV Initiative of the German Working Group for Pediatric Diabetology, German BMBF Competence Network for Diabetes Mellitus, DPV Initiative of the German Working Group for Pediatric Diabetology, German BMBF Competence Network for Diabetes Mellitus, Polyendocrinopathy in children, adolescents, and young adults with type 1 diabetes: a multicenter analysis of 28,671 patients from the German/Austrian DPV-Wiss database. Diabetes Care 33(9), 2010–2012 (2010). doi:10.2337/dc10-0404 PubMedCentralPubMed K. Warncke, E.E. Fröhlich-Reiterer, A. Thon, S.E. Hofer, D. Wiemann, R.W. Holl, DPV Initiative of the German Working Group for Pediatric Diabetology, German BMBF Competence Network for Diabetes Mellitus, DPV Initiative of the German Working Group for Pediatric Diabetology, German BMBF Competence Network for Diabetes Mellitus, Polyendocrinopathy in children, adolescents, and young adults with type 1 diabetes: a multicenter analysis of 28,671 patients from the German/Austrian DPV-Wiss database. Diabetes Care 33(9), 2010–2012 (2010). doi:10.​2337/​dc10-0404 PubMedCentralPubMed
52.
Zurück zum Zitat R. Volpé, Autoimmunity in the Endocrine System, in Monographs on Endocrinology (Springer-Verlag, Berlin-Heidelberg-New York, (1981)), pp. 19–111. (no LoE) R. Volpé, Autoimmunity in the Endocrine System, in Monographs on Endocrinology (Springer-Verlag, Berlin-Heidelberg-New York, (1981)), pp. 19–111. (no LoE)
53.
Zurück zum Zitat D. Maugendre, F. Vérité, I. Guilhem, B. Genetet, H. Allannic, M. Delamaire, Anti-pancreatic autoimmunity and Graves’ disease: study of a cohort of 600 Caucasian patients. Eur. J. Endocrinol. 137(5), 503–510 (1997). (LoE )PubMed D. Maugendre, F. Vérité, I. Guilhem, B. Genetet, H. Allannic, M. Delamaire, Anti-pancreatic autoimmunity and Graves’ disease: study of a cohort of 600 Caucasian patients. Eur. J. Endocrinol. 137(5), 503–510 (1997). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
54.
Zurück zum Zitat R. Kalmann, M.P. Mourits, Diabetes mellitus: a risk factor in patients with Graves’ orbitopathy. Br. J. Ophthalmol. 83(4), 463–465 (1999). (LoE )PubMedCentralPubMed R. Kalmann, M.P. Mourits, Diabetes mellitus: a risk factor in patients with Graves’ orbitopathy. Br. J. Ophthalmol. 83(4), 463–465 (1999). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMedCentralPubMed
55.
Zurück zum Zitat W.J. Irvine, C.J. McCallum, R.S. Gray, C.J. Campbell, L.J. Duncan, J.W. Farquhar, H. Vaughan, P.J. Morris, Pancreatic islet-cell antibodies in diabetes mellitus correlated with the duration and type of diabetes coexistent autoimmune disease, and HLA type. Diabetes 26(2), 138–147 (1977). (LoE )PubMed W.J. Irvine, C.J. McCallum, R.S. Gray, C.J. Campbell, L.J. Duncan, J.W. Farquhar, H. Vaughan, P.J. Morris, Pancreatic islet-cell antibodies in diabetes mellitus correlated with the duration and type of diabetes coexistent autoimmune disease, and HLA type. Diabetes 26(2), 138–147 (1977). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
56.
Zurück zum Zitat G.M. Bright, R.M. Blizzard, D.L. Kaiser, W.L. Clarke, Organ-specific autoantibodies in children with common endocrine diseases. J. Pediatr. 100(1), 8–14 (1982). (LoE )PubMed G.M. Bright, R.M. Blizzard, D.L. Kaiser, W.L. Clarke, Organ-specific autoantibodies in children with common endocrine diseases. J. Pediatr. 100(1), 8–14 (1982). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
57.
Zurück zum Zitat C. Betterle, F. Presotto, B. Pedini, L. Moro, R.S. Slack, F. Zanette, R. Zanchetta, Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value in the development of type 1 (insulin-dependent) diabetes mellitus. A ten year follow-up study. Diabetologia 30(5), 292–297 (1987). (LoE )PubMed C. Betterle, F. Presotto, B. Pedini, L. Moro, R.S. Slack, F. Zanette, R. Zanchetta, Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value in the development of type 1 (insulin-dependent) diabetes mellitus. A ten year follow-up study. Diabetologia 30(5), 292–297 (1987). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
58.
Zurück zum Zitat Y. Yamaguchi, N. Chikuba, Y. Ueda, H. Yamamoto, H. Yamasaki, T. Nakanishi, S. Akazawa, S. Nagataki, Islet cell antibodies in patients with autoimmune thyroid diseases. Diabetes 40(3), 319–322 (1991). (LoE )PubMed Y. Yamaguchi, N. Chikuba, Y. Ueda, H. Yamamoto, H. Yamasaki, T. Nakanishi, S. Akazawa, S. Nagataki, Islet cell antibodies in patients with autoimmune thyroid diseases. Diabetes 40(3), 319–322 (1991). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
59.
Zurück zum Zitat C. Betterle, F. Presotto, L. Magrin, B. Pedini, L. Moro, A. Caretto, R. Zanchetta, The natural history of pre-type 1 (insulin-dependent) diabetes mellitus in patients with autoimmune endocrine diseases. Diabetologia 37(1), 95–103 (1994). (Loe )PubMed C. Betterle, F. Presotto, L. Magrin, B. Pedini, L. Moro, A. Caretto, R. Zanchetta, The natural history of pre-type 1 (insulin-dependent) diabetes mellitus in patients with autoimmune endocrine diseases. Diabetologia 37(1), 95–103 (1994). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )PubMed
60.
Zurück zum Zitat B. Hallengren, A. Falorni, M. Landin-Olsson, A. Lernmark, K.I. Papadopoulos, G. Sundkvist, Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients at diagnosis and following treatment. J. Intern. Med. 239(1), 63–68 (1996). (LoE )PubMed B. Hallengren, A. Falorni, M. Landin-Olsson, A. Lernmark, K.I. Papadopoulos, G. Sundkvist, Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients at diagnosis and following treatment. J. Intern. Med. 239(1), 63–68 (1996). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
61.
Zurück zum Zitat E. Kawasaki, N. Abiru, M. Yano, S. Uotani, K. Matsumoto, H. Matsuo, H. Yamasaki, H. Yamamoto, Y. Yamaguchi, S. Akazawa, Autoantibodies in patients with autoimmune thyroid disease: relation to competitive insulin antibodies. J. Autoimmun. 8(5), 633–643 (1995). (LoE ) doi:10.1006/jaut.1995.0047 PubMed E. Kawasaki, N. Abiru, M. Yano, S. Uotani, K. Matsumoto, H. Matsuo, H. Yamasaki, H. Yamamoto, Y. Yamaguchi, S. Akazawa, Autoantibodies in patients with autoimmune thyroid disease: relation to competitive insulin antibodies. J. Autoimmun. 8(5), 633–643 (1995). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1006/​jaut.​1995.​0047 PubMed
62.
Zurück zum Zitat D.Y. Aksoy, B.P. Yürekli, B.O. Yildiz, O. Gedik, Prevalence of glutamic acid decarboxylase antibody positivity and its association with insulin secretion and sensitivity in autoimmune thyroid disease: a pilot study. Exp. Clin. Endocrinol. Diabetes 114(8), 412–416 (2006). (LoE )PubMed D.Y. Aksoy, B.P. Yürekli, B.O. Yildiz, O. Gedik, Prevalence of glutamic acid decarboxylase antibody positivity and its association with insulin secretion and sensitivity in autoimmune thyroid disease: a pilot study. Exp. Clin. Endocrinol. Diabetes 114(8), 412–416 (2006). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
63.
Zurück zum Zitat M. Pietropaolo, J.C. Hutton, G.S. Eisenbarth, Protein thyrosine phoshatase-like proteins: link with IDDM. Diabetes Care 20(2), 208–214 (1997). (no LoE)PubMed M. Pietropaolo, J.C. Hutton, G.S. Eisenbarth, Protein thyrosine phoshatase-like proteins: link with IDDM. Diabetes Care 20(2), 208–214 (1997). (no LoE)PubMed
64.
Zurück zum Zitat N.G. Morgenthaler, J. Seissler, P. Achenbach, D. Glawe, M. Payton, H.M. Meinck, M.R. Christie, W.A. Scherbaum, Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or Stiff man syndrome. Autoimmunity 25(4), 203–211 (1997). (LoE )PubMed N.G. Morgenthaler, J. Seissler, P. Achenbach, D. Glawe, M. Payton, H.M. Meinck, M.R. Christie, W.A. Scherbaum, Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or Stiff man syndrome. Autoimmunity 25(4), 203–211 (1997). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
65.
Zurück zum Zitat E. Bosi, F. Becker, E. Bonifacio, R. Wagner, P. Collins, E.A. Gale, G. Bottazzo, Progression to type 1 diabetes in autoimmune endocrine patients with islet cell antibodies. Diabetes. 40(8), 977–984 (1991). (Loe )PubMed E. Bosi, F. Becker, E. Bonifacio, R. Wagner, P. Collins, E.A. Gale, G. Bottazzo, Progression to type 1 diabetes in autoimmune endocrine patients with islet cell antibodies. Diabetes. 40(8), 977–984 (1991). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )PubMed
66.
Zurück zum Zitat C.M. Tudela, B.M. Casey, D.D. McIntire, F.G. Cunningham, Relationship of subclinical thyroid disease to the incidence of gestational diabetes. Obstet. Gynecol. 119(5), 983–988 (2012). (LoE ) doi:10.1097/AOG.0b013e318250aeeb PubMed C.M. Tudela, B.M. Casey, D.D. McIntire, F.G. Cunningham, Relationship of subclinical thyroid disease to the incidence of gestational diabetes. Obstet. Gynecol. 119(5), 983–988 (2012). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1097/​AOG.​0b013e318250aeeb​ PubMed
67.
Zurück zum Zitat C. Betterle, A.C. Spadaccino, F. Presotto, R. Zanchetta, B. Pedini, M. Lai, N.A. Greggio, G.F. Bottazzo, The number of markers of pancreatic autoimmunity increases the risk for type 1 diabetes mellitus (DM) in Italian and English patients with organ-specific autoimmune diseases (OSAD). Ann. N. Y. Acad. Sci. 958, 276–280 (2002). (LoE )PubMed C. Betterle, A.C. Spadaccino, F. Presotto, R. Zanchetta, B. Pedini, M. Lai, N.A. Greggio, G.F. Bottazzo, The number of markers of pancreatic autoimmunity increases the risk for type 1 diabetes mellitus (DM) in Italian and English patients with organ-specific autoimmune diseases (OSAD). Ann. N. Y. Acad. Sci. 958, 276–280 (2002). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
68.
Zurück zum Zitat A.R. Radaideh, M.K. Nusier, F.L. Amari, A.E. Bateiha, M.S. El-Khateeb, A.S. Naser, K.M. Ajlouni, Thyroid dysfunction in patients with type 2 diabetes mellitus in Jordan. Saudi Med. J. 25(8), 1046–1050 (2004). (LoE )PubMed A.R. Radaideh, M.K. Nusier, F.L. Amari, A.E. Bateiha, M.S. El-Khateeb, A.S. Naser, K.M. Ajlouni, Thyroid dysfunction in patients with type 2 diabetes mellitus in Jordan. Saudi Med. J. 25(8), 1046–1050 (2004). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
69.
Zurück zum Zitat S.A.P. Chubb, W.A. Davis, Z. Inman, T.M. Davis, Prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes: the Fremantle Diabetes Study. Clin. Endocrinol. (Oxford) 62(4), 480–486 (2005). (Loe ) S.A.P. Chubb, W.A. Davis, Z. Inman, T.M. Davis, Prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes: the Fremantle Diabetes Study. Clin. Endocrinol. (Oxford) 62(4), 480–486 (2005). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )
70.
Zurück zum Zitat A. Mohn, S. Di Michele, R. Di Luzio, S. Tumini, F. Chiarelli, The effect of subclinical hypothyroidism on metabolic control in children and adolescents with type 1 diabetes mellitus. Diabet. Med. 19(1), 70–73 (2002). (LoE )PubMed A. Mohn, S. Di Michele, R. Di Luzio, S. Tumini, F. Chiarelli, The effect of subclinical hypothyroidism on metabolic control in children and adolescents with type 1 diabetes mellitus. Diabet. Med. 19(1), 70–73 (2002). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
73.
Zurück zum Zitat B. Gopinath, J.J. Wang, A. Kifley, J.R. Wall, S.R. Leeder, P. Mitchell, Type 2 diabetes does not predict incident thyroid dysfunction in the elderly. Diabetes Res. Clin. Pract. 82(3), e11–e13 (2008). (LoE ) doi:10.1016/j.diabres.2008.08.017 PubMed B. Gopinath, J.J. Wang, A. Kifley, J.R. Wall, S.R. Leeder, P. Mitchell, Type 2 diabetes does not predict incident thyroid dysfunction in the elderly. Diabetes Res. Clin. Pract. 82(3), e11–e13 (2008). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1016/​j.​diabres.​2008.​08.​017 PubMed
74.
Zurück zum Zitat J.J. Díez, P. Sánchez, P. Iglesias, Prevalence of thyroid dysfunction in patients with type 2 diabetes. Exp. Clin. Endocrinol. Diabetes 119(4), 201–207 (2011). (LoE ) doi:10.1055/s-0031-1271691 PubMed J.J. Díez, P. Sánchez, P. Iglesias, Prevalence of thyroid dysfunction in patients with type 2 diabetes. Exp. Clin. Endocrinol. Diabetes 119(4), 201–207 (2011). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1055/​s-0031-1271691 PubMed
75.
Zurück zum Zitat A. Huber, F. Menconi, S. Corathers, E.M. Jacobson, Y. Tomer, Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr. Rev. 29(6), 697–725 (2008). doi:10.1210/er.2008-0015. (no LoE)PubMedCentralPubMed A. Huber, F. Menconi, S. Corathers, E.M. Jacobson, Y. Tomer, Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr. Rev. 29(6), 697–725 (2008). doi:10.​1210/​er.​2008-0015. (no LoE)PubMedCentralPubMed
76.
Zurück zum Zitat E.C. Somers, S.L. Thomas, L. Smeeth, A.J. Hall, Autoimmune diseases co-occurring within individuals and within families: a systematic review. Epidemiology 17(2), 202–217 (2006). (Loe )PubMed E.C. Somers, S.L. Thomas, L. Smeeth, A.J. Hall, Autoimmune diseases co-occurring within individuals and within families: a systematic review. Epidemiology 17(2), 202–217 (2006). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )PubMed
77.
Zurück zum Zitat P.R. Gallas, R.P. Stolk, K. Bakker, E. Endert, W.M. Wiersinga, Thyroid dysfunction during pregnancy and in the first postpartum year in women with diabetes mellitus type 1. Eur. J. Endocrinol. 147(4), 443–451 (2002). (LoE )PubMed P.R. Gallas, R.P. Stolk, K. Bakker, E. Endert, W.M. Wiersinga, Thyroid dysfunction during pregnancy and in the first postpartum year in women with diabetes mellitus type 1. Eur. J. Endocrinol. 147(4), 443–451 (2002). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
78.
Zurück zum Zitat A. Hanukoglu, A. Mizrachi, I. Dalal, O. Admoni, Y. Rakover, Z. Bistritzer, A. Levine, E. Somekh, D. Lehmann, M. Tuval, M. Boaz, A. Golander, Extrapancreatic autoimmune manifestations in type 1 diabetes patients and their first-degree relatives: a multicenter study. Diabetes Care. 26(4), 1235–1240 (2003). (LoE )PubMed A. Hanukoglu, A. Mizrachi, I. Dalal, O. Admoni, Y. Rakover, Z. Bistritzer, A. Levine, E. Somekh, D. Lehmann, M. Tuval, M. Boaz, A. Golander, Extrapancreatic autoimmune manifestations in type 1 diabetes patients and their first-degree relatives: a multicenter study. Diabetes Care. 26(4), 1235–1240 (2003). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
79.
Zurück zum Zitat G.C. Gonzàles, I. Capel, J. Rodríguez-Espinosa, D. Mauricio, A. de Leiva, A. Pérez, Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction. Diabetes Care 30(6), 1611–1612 (2007). (LoE ) G.C. Gonzàles, I. Capel, J. Rodríguez-Espinosa, D. Mauricio, A. de Leiva, A. Pérez, Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction. Diabetes Care 30(6), 1611–1612 (2007). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
80.
Zurück zum Zitat O. Kordonouri, D. Deiss, T. Danne, A. Dorow, C. Bassir, A. Grüters-Kieslich, Predictivity of thyroid autoantibodies for the development of thyroid disorders in children and adolescents with type 1 diabetes. Diabet. Med. 19(6), 518–521 (2002). (LoE )PubMed O. Kordonouri, D. Deiss, T. Danne, A. Dorow, C. Bassir, A. Grüters-Kieslich, Predictivity of thyroid autoantibodies for the development of thyroid disorders in children and adolescents with type 1 diabetes. Diabet. Med. 19(6), 518–521 (2002). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
81.
Zurück zum Zitat O. Kordonouri, R. Hartmann, D. Deiss, M. Wilms, A. Grüters-Kieslich, Natural course of autoimmune thyroiditis in type 1 diabetes: association with gender, age, diabetes duration, and puberty. Arch. Dis. Child. 90(4), 411–414 (2005). (LoE )PubMedCentralPubMed O. Kordonouri, R. Hartmann, D. Deiss, M. Wilms, A. Grüters-Kieslich, Natural course of autoimmune thyroiditis in type 1 diabetes: association with gender, age, diabetes duration, and puberty. Arch. Dis. Child. 90(4), 411–414 (2005). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMedCentralPubMed
82.
Zurück zum Zitat B. Lindberg, U.B. Ericsson, R. Ljung, S.A. Ivarsson, High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children. J. Lab. Clin. Med. 130(6), 585–589 (1997). (LoE )PubMed B. Lindberg, U.B. Ericsson, R. Ljung, S.A. Ivarsson, High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children. J. Lab. Clin. Med. 130(6), 585–589 (1997). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
83.
Zurück zum Zitat M.J.B. Villano, A.K. Huber, D.A. Greenberg, B.K. Golden, E. Concepcion, Y. Tomer, Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families. J. Clin. Endocrinol. Metab. 94(4), 1458–1466 (2009). (Loe ) doi:10.1210/jc.2008-2193 PubMedCentralPubMed M.J.B. Villano, A.K. Huber, D.A. Greenberg, B.K. Golden, E. Concepcion, Y. Tomer, Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families. J. Clin. Endocrinol. Metab. 94(4), 1458–1466 (2009). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif ) doi:10.​1210/​jc.​2008-2193 PubMedCentralPubMed
85.
Zurück zum Zitat A. Van den Driessche, V. Eenkhoorn, L. Van Gaal, C. De Block, Type 1 diabetes and autoimmune polyglandular syndrome: a clinical review. Neth. J. Med. 67(11), 376–387 (2009). (no LoE)PubMed A. Van den Driessche, V. Eenkhoorn, L. Van Gaal, C. De Block, Type 1 diabetes and autoimmune polyglandular syndrome: a clinical review. Neth. J. Med. 67(11), 376–387 (2009). (no LoE)PubMed
86.
Zurück zum Zitat J.M. Barker, Clinical review: type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening. J. Clin. Endocrinol. Metab. 91(4), 1210–1217 (2006). (no LoE)PubMed J.M. Barker, Clinical review: type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening. J. Clin. Endocrinol. Metab. 91(4), 1210–1217 (2006). (no LoE)PubMed
87.
Zurück zum Zitat G.S. Eisenbarth, P.A. Gottlieb, Autoimmune polyendocrine syndromes. N. Engl. J. Med. 350(20), 2068–2079 (2004). (no LoE)PubMed G.S. Eisenbarth, P.A. Gottlieb, Autoimmune polyendocrine syndromes. N. Engl. J. Med. 350(20), 2068–2079 (2004). (no LoE)PubMed
88.
Zurück zum Zitat American Diabetes Association, Standards of Medical Care in Diabetes 2012. Diabetes Care 35(Suppl 1), S11–S63 (2012). doi:10.2337/dc12-s011. (no LoE) American Diabetes Association, Standards of Medical Care in Diabetes 2012. Diabetes Care 35(Suppl 1), S11–S63 (2012). doi:10.​2337/​dc12-s011. (no LoE)
89.
Zurück zum Zitat Canadian Diabetes Association Clinical Practice Guidelines Expert Committee, Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Can. J. Diabetes 37(suppl 1), S1–S212 (2013). doi:10.1016/j.jcjd.2013.01.009. (no LoE) Canadian Diabetes Association Clinical Practice Guidelines Expert Committee, Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Can. J. Diabetes 37(suppl 1), S1–S212 (2013). doi:10.​1016/​j.​jcjd.​2013.​01.​009. (no LoE)
90.
Zurück zum Zitat J.M. Dora, W.E. Machado, J. Rheinheimer, D. Crispim, A.L. Maia, Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis. Eur. J. Endocrinol. 163(3), 427–434 (2010). (LoE ) doi:10.1530/EJE-10-0419 PubMed J.M. Dora, W.E. Machado, J. Rheinheimer, D. Crispim, A.L. Maia, Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis. Eur. J. Endocrinol. 163(3), 427–434 (2010). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1530/​EJE-10-0419 PubMed
91.
Zurück zum Zitat H.R. Maxon, K.W. Kreines, R.E. Goldsmith, H.C. Knowles Jr, Long-term observations of glucose tolerance in thyrotoxic patients. Arch. Intern. Med. 135(11), 1477–1480 (1975). (LoE )PubMed H.R. Maxon, K.W. Kreines, R.E. Goldsmith, H.C. Knowles Jr, Long-term observations of glucose tolerance in thyrotoxic patients. Arch. Intern. Med. 135(11), 1477–1480 (1975). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
93.
Zurück zum Zitat P. Cavallo-Perin, A. Bruno, L. Boine, M. Cassader, G. Lenti, G. Pagano, Insulin resistance in Graves’ disease: a quantitative in vivo evaluation. Eur. J. Clin. Invest. 18(6), 607–613 (1988). (LoE )PubMed P. Cavallo-Perin, A. Bruno, L. Boine, M. Cassader, G. Lenti, G. Pagano, Insulin resistance in Graves’ disease: a quantitative in vivo evaluation. Eur. J. Clin. Invest. 18(6), 607–613 (1988). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
94.
Zurück zum Zitat E. Maratou, D.J. Hadjidakis, M. Peppa, M. Alevizaki, K. Tsegka, V. Lambadiari, P. Mitrou, E. Boutati, A. Kollias, T. Economopoulos, S.A. Raptis, G. Dimitriadis, Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism. Eur. J. Endocrinol. 163(4), 625–630 (2010). (LoE )doi:10.1530/EJE-10-0246 PubMed E. Maratou, D.J. Hadjidakis, M. Peppa, M. Alevizaki, K. Tsegka, V. Lambadiari, P. Mitrou, E. Boutati, A. Kollias, T. Economopoulos, S.A. Raptis, G. Dimitriadis, Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism. Eur. J. Endocrinol. 163(4), 625–630 (2010). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )doi:10.​1530/​EJE-10-0246 PubMed
95.
Zurück zum Zitat P. Mitrou, E. Boutati, V. Lambadiari, A. Tsegka, A.E. Raptis, N. Tountas, T. Economopoulos, S.A. Raptis, G. Dimitriadis, Insulin resistance in hyperthyroidism: the role of IL6 and TNF alpha. Eur. J. Endocrinol. 162(1), 121–126 (2010). (LoE ) doi:10.1530/EJE-09-0622 PubMed P. Mitrou, E. Boutati, V. Lambadiari, A. Tsegka, A.E. Raptis, N. Tountas, T. Economopoulos, S.A. Raptis, G. Dimitriadis, Insulin resistance in hyperthyroidism: the role of IL6 and TNF alpha. Eur. J. Endocrinol. 162(1), 121–126 (2010). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1530/​EJE-09-0622 PubMed
96.
Zurück zum Zitat A. Bhattacharyya, P.G. Wiles, Diabetic ketoacidosis precipitated by thyrotoxicosis. Postgrad. Med. J. 75(883), 291–292 (1999). (LoE )PubMedCentralPubMed A. Bhattacharyya, P.G. Wiles, Diabetic ketoacidosis precipitated by thyrotoxicosis. Postgrad. Med. J. 75(883), 291–292 (1999). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMedCentralPubMed
97.
Zurück zum Zitat K.A. Al-Shoumer, B.A. Vasanthy, M.M. Al-Zaid, Effects of treatment of hyperthyroidism on glucose homeostasis, insulin secretion, and markers of bone turnover. Endocr. Pract. 12(2), 121–130 (2006). (LoE )PubMed K.A. Al-Shoumer, B.A. Vasanthy, M.M. Al-Zaid, Effects of treatment of hyperthyroidism on glucose homeostasis, insulin secretion, and markers of bone turnover. Endocr. Pract. 12(2), 121–130 (2006). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
98.
Zurück zum Zitat E. Solà, C. Morillas, S. Garzón, M. Gómez-Balaguer, A. Hernández-Mijares, Association between diabetic ketoacidosis and thyrotoxicosis. Acta. Diabetol. 39(4), 235–237 (2002). (LoE )PubMed E. Solà, C. Morillas, S. Garzón, M. Gómez-Balaguer, A. Hernández-Mijares, Association between diabetic ketoacidosis and thyrotoxicosis. Acta. Diabetol. 39(4), 235–237 (2002). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMed
99.
Zurück zum Zitat M. Kunishige, E. Sekimoto, M. Komatsu, Y. Bando, H. Uehara, K. Izumi, Thyrotoxicosis masked by diabetic ketoacidosis: a fatal complication. Diabetes Care 24(1), 171 (2001). (LoE )PubMed M. Kunishige, E. Sekimoto, M. Komatsu, Y. Bando, H. Uehara, K. Izumi, Thyrotoxicosis masked by diabetic ketoacidosis: a fatal complication. Diabetes Care 24(1), 171 (2001). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMed
100.
Zurück zum Zitat R. Naeije, J. Golstein, N. Clumeck, H. Meinhold, K.W. Wenzel, L. Vanhaelst, A low T3 syndrome in diabetic ketoacidosis. Clin. Endocrinol. (Oxford) 8(6), 467–472 (1978). (LoE ) R. Naeije, J. Golstein, N. Clumeck, H. Meinhold, K.W. Wenzel, L. Vanhaelst, A low T3 syndrome in diabetic ketoacidosis. Clin. Endocrinol. (Oxford) 8(6), 467–472 (1978). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
101.
Zurück zum Zitat K.K. Boelaert, J.A. Franklyn, Thyroid hormone in health and disease. J. Endocrinol. 187(1), 1–15 (2005). (LoE )PubMed K.K. Boelaert, J.A. Franklyn, Thyroid hormone in health and disease. J. Endocrinol. 187(1), 1–15 (2005). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
102.
Zurück zum Zitat J.A. Franklin, P. Maisonneuve, M.C. Sheppard, J. Betteridge, P. Boyle, Mortality after the treatment of hyperthyroidism with radioactive iodine. N. Engl. J. Med. 338(11), 712–718 (1998). (LoE ) J.A. Franklin, P. Maisonneuve, M.C. Sheppard, J. Betteridge, P. Boyle, Mortality after the treatment of hyperthyroidism with radioactive iodine. N. Engl. J. Med. 338(11), 712–718 (1998). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
103.
Zurück zum Zitat S.W. Moon, J.R. Hahm, G.W. Lee, M.Y. Kang, J.H. Jung, T.S. Jung, K.W. Lee, K.A. Jung, Y.J. Ahn, S. Kim, M.A. Kim, D.R. Kim, S.I. Chung, M.H. Park, A case of hyperglycemic hyperosmolar state associated with Graves’ hyperthyroidism: a case report. J. Korean Med. Sci. 21(4), 765–767 (2006). (LoE )PubMedCentralPubMed S.W. Moon, J.R. Hahm, G.W. Lee, M.Y. Kang, J.H. Jung, T.S. Jung, K.W. Lee, K.A. Jung, Y.J. Ahn, S. Kim, M.A. Kim, D.R. Kim, S.I. Chung, M.H. Park, A case of hyperglycemic hyperosmolar state associated with Graves’ hyperthyroidism: a case report. J. Korean Med. Sci. 21(4), 765–767 (2006). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMedCentralPubMed
104.
Zurück zum Zitat M.F. Celani, M.E. Bonati, N. Stucci, Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus. Diabetes Res. 27(1), 15–25 (1994). (LoE )PubMed M.F. Celani, M.E. Bonati, N. Stucci, Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus. Diabetes Res. 27(1), 15–25 (1994). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
105.
Zurück zum Zitat E. Maratou, D.J. Hadjidakis, A. Kollias, K. Tsegka, M. Peppa, M. Alevizaki, P. Mitrou, V. Lambadiari, E. Boutati, D. Nikzas, N. Tountas, T. Economopoulos, S.A. Raptis, G. Dimitriadis, Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur. J. Endocrinol. 160(5), 785–790 (2009). (LoE ) doi:10.1530/EJE-08-0797 PubMed E. Maratou, D.J. Hadjidakis, A. Kollias, K. Tsegka, M. Peppa, M. Alevizaki, P. Mitrou, V. Lambadiari, E. Boutati, D. Nikzas, N. Tountas, T. Economopoulos, S.A. Raptis, G. Dimitriadis, Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur. J. Endocrinol. 160(5), 785–790 (2009). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1530/​EJE-08-0797 PubMed
106.
107.
Zurück zum Zitat H. Debiec, H.S. Cross, M. Peterlik, d-glucose uptake is increased in jejunal brush-border membrane vesicles from hyperthyroid chicks. Acta. Endocrinol. (Copenh) 120(4), 435–441 (1989). (no LoE) H. Debiec, H.S. Cross, M. Peterlik, d-glucose uptake is increased in jejunal brush-border membrane vesicles from hyperthyroid chicks. Acta. Endocrinol. (Copenh) 120(4), 435–441 (1989). (no LoE)
108.
Zurück zum Zitat A.R. Cappola, P.W. Ladenson, Hypothyroidism and atherosclerosis. J. Clin. Endocrinol. Metab. 88(6), 2438–2444 (2003). (no LoE)PubMed A.R. Cappola, P.W. Ladenson, Hypothyroidism and atherosclerosis. J. Clin. Endocrinol. Metab. 88(6), 2438–2444 (2003). (no LoE)PubMed
109.
Zurück zum Zitat L. Duntas, G. Kolovou, Options for the treatment of hyperlipidemia in type 2 diabetes mellitus and hypothyroidism: lowering the cardiovascular risk. Future Cardiol. 7(2), 137–144 (2011). doi:10.2217/fca.10.126. (no LoE)PubMed L. Duntas, G. Kolovou, Options for the treatment of hyperlipidemia in type 2 diabetes mellitus and hypothyroidism: lowering the cardiovascular risk. Future Cardiol. 7(2), 137–144 (2011). doi:10.​2217/​fca.​10.​126. (no LoE)PubMed
110.
Zurück zum Zitat E. Yeter, T. Keles, T. Durmaz, E. Bozkurt, Rhabdomyolysis due to the additive effect of statin therapy and hypothyroidism: a case report. J. Med. Case Rep. 1, 130 (2007). (LoE )PubMedCentralPubMed E. Yeter, T. Keles, T. Durmaz, E. Bozkurt, Rhabdomyolysis due to the additive effect of statin therapy and hypothyroidism: a case report. J. Med. Case Rep. 1, 130 (2007). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMedCentralPubMed
111.
Zurück zum Zitat K. Tokinaga, T. Oeda, Y. Suzuki, Y. Matsushima, HMG-CoA reductase inhibitors (statins) might cause high elevations of creatine phosphokinase (CK) in patients with unnoticed hypothyroidism. Endocr. J. 53(3), 401–405 (2006). (LoE )PubMed K. Tokinaga, T. Oeda, Y. Suzuki, Y. Matsushima, HMG-CoA reductase inhibitors (statins) might cause high elevations of creatine phosphokinase (CK) in patients with unnoticed hypothyroidism. Endocr. J. 53(3), 401–405 (2006). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
112.
Zurück zum Zitat M.P. Vanderpump, W.M. Tunbridge, J.M. French, D. Appleton, D. Bates, F. Clark, J. Grimley Evans, H. Rodgers, F. Tunbridge, E.T. Youn, The development of ischemic heart disease in relation to autoimmune thyroid disease in a 20-year follow-up study of an English community. Thyroid 6(3), 155–160 (1996). (LoE )PubMed M.P. Vanderpump, W.M. Tunbridge, J.M. French, D. Appleton, D. Bates, F. Clark, J. Grimley Evans, H. Rodgers, F. Tunbridge, E.T. Youn, The development of ischemic heart disease in relation to autoimmune thyroid disease in a 20-year follow-up study of an English community. Thyroid 6(3), 155–160 (1996). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
113.
Zurück zum Zitat S.A. Chubb, W.A. Davis, T.M. Davis, Interactions among thyroid function, insulin sensitivity, and serum lipid concentrations: the Fremantle diabetes study. J. Clin. Endocrinol. Metab. 90(9), 5317–5320 (2005). (Loe )PubMed S.A. Chubb, W.A. Davis, T.M. Davis, Interactions among thyroid function, insulin sensitivity, and serum lipid concentrations: the Fremantle diabetes study. J. Clin. Endocrinol. Metab. 90(9), 5317–5320 (2005). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )PubMed
115.
Zurück zum Zitat N. Knudsen, P. Laurberg, L.B. Rasmussen, I. Bülow, H. Perrild, L. Ovesen, T. Jørgensen, Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J. Clin. Endocrinol. Metab. 90(7), 4019–4024 (2005). (LoE )PubMed N. Knudsen, P. Laurberg, L.B. Rasmussen, I. Bülow, H. Perrild, L. Ovesen, T. Jørgensen, Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J. Clin. Endocrinol. Metab. 90(7), 4019–4024 (2005). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
116.
Zurück zum Zitat N. Manji, K. Boelaert, M.C. Sheppard, R.L. Holder, S.C. Gough, J.A. Franklyn, Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects. Clin. Endocrinol. (Oxford) 64(2), 125–128 (2006). (LoE ) N. Manji, K. Boelaert, M.C. Sheppard, R.L. Holder, S.C. Gough, J.A. Franklyn, Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects. Clin. Endocrinol. (Oxford) 64(2), 125–128 (2006). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
117.
Zurück zum Zitat K. Oboubie, J. Smith, L.M. Evans, R. John, J.S. Davies, J.H. Lazarus, Increased central arterial stiffness in hypothyroidism. J. Clin. Endocrinol. Metab. 87(10), 4662–4666 (2002). (LoE ) K. Oboubie, J. Smith, L.M. Evans, R. John, J.S. Davies, J.H. Lazarus, Increased central arterial stiffness in hypothyroidism. J. Clin. Endocrinol. Metab. 87(10), 4662–4666 (2002). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
118.
Zurück zum Zitat P.J. Owen, R. Sabit, J.H. Lazarus, Thyroid disease and vascular function. Thyroid 17, 519–524 (2007)PubMed P.J. Owen, R. Sabit, J.H. Lazarus, Thyroid disease and vascular function. Thyroid 17, 519–524 (2007)PubMed
119.
Zurück zum Zitat R.S. Gray, D.Q. Borsey, W.J. Irvine, J. Seth, B.F. Clarke, Natural history of thyroid function in diabetics with impaired thyroid reserve: a four year controlled study. Clin. Endocrinol. (Oxford) 19(4), 445–451 (1983). (Loe ) R.S. Gray, D.Q. Borsey, W.J. Irvine, J. Seth, B.F. Clarke, Natural history of thyroid function in diabetics with impaired thyroid reserve: a four year controlled study. Clin. Endocrinol. (Oxford) 19(4), 445–451 (1983). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )
120.
Zurück zum Zitat A. Franzese, P. Buono, M. Mascolo, A.L. Leo, G. Valerio, Thyroid autoimmunity starting during the course of type 1 diabetes denotes a subgroup of children with more severe diabetes. Diabetes Care 23(8), 1201–1202 (2000). (LoE )PubMed A. Franzese, P. Buono, M. Mascolo, A.L. Leo, G. Valerio, Thyroid autoimmunity starting during the course of type 1 diabetes denotes a subgroup of children with more severe diabetes. Diabetes Care 23(8), 1201–1202 (2000). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
121.
Zurück zum Zitat T. Sathyapalan, A.M. Manuchehri, A.S. Rigby, S.L. Atkin, Subclinical hypothyroidism is associated with reduced all-cause mortality in patients with type 2 diabetes. Diabetes Care 33(3), e37 (2010). (Loe ) doi:10.2337/dc09-1555 PubMed T. Sathyapalan, A.M. Manuchehri, A.S. Rigby, S.L. Atkin, Subclinical hypothyroidism is associated with reduced all-cause mortality in patients with type 2 diabetes. Diabetes Care 33(3), e37 (2010). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif ) doi:10.​2337/​dc09-1555 PubMed
122.
Zurück zum Zitat A.E. Hak, H.A. Pols, T.J. Visser, H.A. Drexhage, A. Hofman, J.C. Witteman, Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann. Intern. Med. 132(4), 270–278 (2000). (Loe )PubMed A.E. Hak, H.A. Pols, T.J. Visser, H.A. Drexhage, A. Hofman, J.C. Witteman, Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann. Intern. Med. 132(4), 270–278 (2000). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )PubMed
123.
Zurück zum Zitat M.D. Danese, P.W. Ladenson, C.L. Meinert, N.R. Powe, Clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. J. Clin. Endocrinol. Metab. 85(9), 2993–3001 (2000). (Loe )PubMed M.D. Danese, P.W. Ladenson, C.L. Meinert, N.R. Powe, Clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. J. Clin. Endocrinol. Metab. 85(9), 2993–3001 (2000). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figd_HTML.gif )PubMed
124.
Zurück zum Zitat H.S. Chen, T.E. Wu, T.S. Jap, R.A. Lu, M.L. Wang, R.L. Chen, H.D. Lin, Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in type 2 diabetic patients. Diabet. Med. 24(12), 1336–1344 (2007). (LoE )PubMed H.S. Chen, T.E. Wu, T.S. Jap, R.A. Lu, M.L. Wang, R.L. Chen, H.D. Lin, Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in type 2 diabetic patients. Diabet. Med. 24(12), 1336–1344 (2007). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
125.
Zurück zum Zitat A.I. Katz, D.S. Emmanouel, M.D. Lindheimer, Thyroid hormone and the kidney. Nephron 15(3–5), 223–249 (1975). (no LoE)PubMed A.I. Katz, D.S. Emmanouel, M.D. Lindheimer, Thyroid hormone and the kidney. Nephron 15(3–5), 223–249 (1975). (no LoE)PubMed
126.
Zurück zum Zitat J.K. Yang, W. Liu, J. Shi, Y.B. Li, An association between subclinical hypothyroidism and sight-threatening diabetic retinopathy in type 2 diabetic patients. Diabetes Care 33(5), 1018–1020 (2010). (LoE ) doi:10.2337/dc09-1784 PubMedCentralPubMed J.K. Yang, W. Liu, J. Shi, Y.B. Li, An association between subclinical hypothyroidism and sight-threatening diabetic retinopathy in type 2 diabetic patients. Diabetes Care 33(5), 1018–1020 (2010). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​2337/​dc09-1784 PubMedCentralPubMed
127.
Zurück zum Zitat G.R. Yang, J.K. Yang, L. Zhang, Y.H. An, J.K. Lu, Association between subclinical hypothyroidism and proliferative diabetic retinopathy in type 2 diabetic patients: a case-control study. Tohoku J. Exp. Med. 222(4), 303–310 (2010). (Loe )PubMed G.R. Yang, J.K. Yang, L. Zhang, Y.H. An, J.K. Lu, Association between subclinical hypothyroidism and proliferative diabetic retinopathy in type 2 diabetic patients: a case-control study. Tohoku J. Exp. Med. 222(4), 303–310 (2010). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif )PubMed
128.
Zurück zum Zitat R.G. Tilton, G. Pugliese, K. Chang, A. Speedy, M.A. Province, C. Kilo, J.R. Williamson, Effects of hypothyroidism on vascular 125I-albumin permeation and blood flow in rats. Metabolism 38(5), 471–478 (1989). (LoE )PubMed R.G. Tilton, G. Pugliese, K. Chang, A. Speedy, M.A. Province, C. Kilo, J.R. Williamson, Effects of hypothyroidism on vascular 125I-albumin permeation and blood flow in rats. Metabolism 38(5), 471–478 (1989). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
129.
Zurück zum Zitat S. Taddei, N. Caraccio, A. Virdis, A. Dardano, D. Versari, L. Ghiadoni, A. Salvetti, E. Ferrannini, F. Monzani, Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J. Clin. Endocrinol. Metab. 88(8), 3731–3737 (2003). (LoE )PubMed S. Taddei, N. Caraccio, A. Virdis, A. Dardano, D. Versari, L. Ghiadoni, A. Salvetti, E. Ferrannini, F. Monzani, Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J. Clin. Endocrinol. Metab. 88(8), 3731–3737 (2003). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
130.
Zurück zum Zitat L. Mutapcic, S.M. Wren, D.A. Leske, M.P. Fautsch, J.M. Holmes, The effect of l-thyroxine supplementation on retinal vascular development in neonatal rats. Curr. Eye Res. 30(12), 1035–1040 (2005). (no LoE)PubMed L. Mutapcic, S.M. Wren, D.A. Leske, M.P. Fautsch, J.M. Holmes, The effect of l-thyroxine supplementation on retinal vascular development in neonatal rats. Curr. Eye Res. 30(12), 1035–1040 (2005). (no LoE)PubMed
131.
Zurück zum Zitat K.A. Toulis, A. Stagnaro-Green, R. Negro, Maternal subclinical hypothyroidism and gestational diabetes mellitus: a meta analysis. Endocr. Pract. 20(7), 703–714 (2014). (LoE ) doi:10.4158/EP13440.RA PubMed K.A. Toulis, A. Stagnaro-Green, R. Negro, Maternal subclinical hypothyroidism and gestational diabetes mellitus: a meta analysis. Endocr. Pract. 20(7), 703–714 (2014). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​4158/​EP13440.​RA PubMed
132.
Zurück zum Zitat H.C. Gerstein, Incidence of postpartum thyroid dysfunction in patients with type 1 diabetes mellitus. Ann. Intern. Med. 118(6), 419–423 (1993). (LoE )PubMed H.C. Gerstein, Incidence of postpartum thyroid dysfunction in patients with type 1 diabetes mellitus. Ann. Intern. Med. 118(6), 419–423 (1993). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
133.
Zurück zum Zitat M. Vestgaard, L.R. Nielsen, A.K. Rasmussen, P. Damm, E.R. Mathiesen, Thyroid peroxidase antibodies in pregnant women with type 1 diabetes: impact on thyroid function, metabolic control and pregnancy outcome. Acta Obstet. Gynecol. Scand. 87(12), 1336–1342 (2008). (LoE ) doi:10.1080/00016340802499261 PubMed M. Vestgaard, L.R. Nielsen, A.K. Rasmussen, P. Damm, E.R. Mathiesen, Thyroid peroxidase antibodies in pregnant women with type 1 diabetes: impact on thyroid function, metabolic control and pregnancy outcome. Acta Obstet. Gynecol. Scand. 87(12), 1336–1342 (2008). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1080/​0001634080249926​1 PubMed
134.
Zurück zum Zitat A. Stagnaro-Green, Clinical review 152: postpartum thyroiditis. J. Clin. Endocrinol. Metab. 87(9), 4042–4047 (2002). (no LoE)PubMed A. Stagnaro-Green, Clinical review 152: postpartum thyroiditis. J. Clin. Endocrinol. Metab. 87(9), 4042–4047 (2002). (no LoE)PubMed
135.
Zurück zum Zitat P. Karakosta, D. Alegakis, V. Georgiou, T. Roumeliotaki, E. Fthenou, M. Vassilaki, D. Boumpas, E. Castanas, M. Kogevinas, L. Chatzi, Thyroid dysfunction and autoantibodies in early pregnancy are associated with increased risk of gestational diabetes and adverse birth outcomes. J. Clin. Endocrinol. Metab. 97(12), 4464–4472 (2012). (Loe ) doi:10.1210/jc.2012-2540 PubMed P. Karakosta, D. Alegakis, V. Georgiou, T. Roumeliotaki, E. Fthenou, M. Vassilaki, D. Boumpas, E. Castanas, M. Kogevinas, L. Chatzi, Thyroid dysfunction and autoantibodies in early pregnancy are associated with increased risk of gestational diabetes and adverse birth outcomes. J. Clin. Endocrinol. Metab. 97(12), 4464–4472 (2012). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif ) doi:10.​1210/​jc.​2012-2540 PubMed
136.
Zurück zum Zitat L. De Groot, M. Abalovich, E.K. Alexander, N. Amino, L. Barbour, R.H. Cobin, C.J. Eastman, J.H. Lazarus, D. Luton, S.J. Mandel, J. Mestman, J. Rovet, S. Sullivan, Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 97(8), 2543–2565 (2012). doi:10.1210/jc.2011-2803. (no LoE)PubMed L. De Groot, M. Abalovich, E.K. Alexander, N. Amino, L. Barbour, R.H. Cobin, C.J. Eastman, J.H. Lazarus, D. Luton, S.J. Mandel, J. Mestman, J. Rovet, S. Sullivan, Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 97(8), 2543–2565 (2012). doi:10.​1210/​jc.​2011-2803. (no LoE)PubMed
137.
Zurück zum Zitat M.J. McKenna, R. Herskowitz, J.I. Wolfsdorf, Screening for thyroid disease in children with IDDM. Diabetes Care 13(7), 801–803 (1990). (LoE )PubMed M.J. McKenna, R. Herskowitz, J.I. Wolfsdorf, Screening for thyroid disease in children with IDDM. Diabetes Care 13(7), 801–803 (1990). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
138.
Zurück zum Zitat R. Junik, M. Kozinski, K. Debska-Kozinska, Thyroid ultrasound in diabetic patients without overt thyroid disease. Acta. Radiol. 47(7), 687–691 (2006). (LoE )PubMed R. Junik, M. Kozinski, K. Debska-Kozinska, Thyroid ultrasound in diabetic patients without overt thyroid disease. Acta. Radiol. 47(7), 687–691 (2006). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
139.
Zurück zum Zitat J.J. Díez, P. Iglesias, An analysis of the relative risk for goitre in euthyroid patients with type 2 diabetes. Clin. Endocrinol. (Oxford) 80(3), 356–361 (2014). (LoE ) doi:10.1111/cen.12169 J.J. Díez, P. Iglesias, An analysis of the relative risk for goitre in euthyroid patients with type 2 diabetes. Clin. Endocrinol. (Oxford) 80(3), 356–361 (2014). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1111/​cen.​12169
140.
Zurück zum Zitat C.M. Kitahara, E.A. Platz, L.E. Beane Freeman, A. Black, A.W. Hsing, M.S. Linet, Y. Park, C. Schairer, A. Berrington de González, Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies (2012). Cancer Causes Control 23, 463–471 (2012). (Loe ) doi:10.1007/s10552-012-9896-y C.M. Kitahara, E.A. Platz, L.E. Beane Freeman, A. Black, A.W. Hsing, M.S. Linet, Y. Park, C. Schairer, A. Berrington de González, Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies (2012). Cancer Causes Control 23, 463–471 (2012). (Loe https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figc_HTML.gif ) doi:10.​1007/​s10552-012-9896-y
143.
Zurück zum Zitat D.M. Nathan, J.B. Buse, M.B. Davidson, E. Ferrannini, R.R. Holman, R. Sherwin, B. Zinman, American Diabetes Association, European Association for the Study of Diabetes, Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 52(1), 17–30 (2009). doi:10.1007/s00125-008-1157-y PubMed D.M. Nathan, J.B. Buse, M.B. Davidson, E. Ferrannini, R.R. Holman, R. Sherwin, B. Zinman, American Diabetes Association, European Association for the Study of Diabetes, Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 52(1), 17–30 (2009). doi:10.​1007/​s00125-008-1157-y PubMed
144.
Zurück zum Zitat R.A. Vigersky, A. Filmore-Nassar, A.R. Glass, Thyrotropin suppression by metformin. J. Clin. Endocrinol. Metab. 91(1), 225–227 (2006). (LoE )PubMed R.A. Vigersky, A. Filmore-Nassar, A.R. Glass, Thyrotropin suppression by metformin. J. Clin. Endocrinol. Metab. 91(1), 225–227 (2006). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMed
145.
Zurück zum Zitat M.L. Isidro, M.A. Penín, R. Nemiña, F. Cordido, Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy. Endocrine 32(1), 79–82 (2007). (LoE )PubMed M.L. Isidro, M.A. Penín, R. Nemiña, F. Cordido, Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy. Endocrine 32(1), 79–82 (2007). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMed
146.
Zurück zum Zitat C. Cappelli, M. Rotondi, I. Pirola, B. Agosti, E. Gandossi, U. Valentini, E. De Martino, A. Cimino, L. Chiovato, E. Agabiti-Rosei, M. Castellano, TSH-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on l-T4 therapy patients. Diabetes Care 32(9), 1589–1590 (2009). (LoE ) doi:10.2337/dc09-0273 PubMedCentralPubMed C. Cappelli, M. Rotondi, I. Pirola, B. Agosti, E. Gandossi, U. Valentini, E. De Martino, A. Cimino, L. Chiovato, E. Agabiti-Rosei, M. Castellano, TSH-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on l-T4 therapy patients. Diabetes Care 32(9), 1589–1590 (2009). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​2337/​dc09-0273 PubMedCentralPubMed
147.
Zurück zum Zitat J.J. Díez, P. Iglesias, Relationship between serum thyrotropin concentrations and metformin therapy in euthyroid patients with type 2 diabetes. Clin. Endocrinol. (Oxford) 78(4), 505–511 (2013). (LoE ) doi:10.1111/j.1365-2265.2012.04468.x J.J. Díez, P. Iglesias, Relationship between serum thyrotropin concentrations and metformin therapy in euthyroid patients with type 2 diabetes. Clin. Endocrinol. (Oxford) 78(4), 505–511 (2013). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1111/​j.​1365-2265.​2012.​04468.​x
148.
Zurück zum Zitat J. Klubo-Gwiezdzinska, J. Costello Jr, A. Patel, A. Bauer, K. Jensen, M. Mete, K.D. Burman, L. Wartofsky, V. Vasko, Treatment with metformin is associated with higher remission rate in diabetic patients with thyroid cancer. J. Clin. Endocrinol. Metab. 98(8), 3269–3279 (2013). (LoE ) doi:10.1210/jc.2012-3799 PubMed J. Klubo-Gwiezdzinska, J. Costello Jr, A. Patel, A. Bauer, K. Jensen, M. Mete, K.D. Burman, L. Wartofsky, V. Vasko, Treatment with metformin is associated with higher remission rate in diabetic patients with thyroid cancer. J. Clin. Endocrinol. Metab. 98(8), 3269–3279 (2013). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif ) doi:10.​1210/​jc.​2012-3799 PubMed
149.
Zurück zum Zitat R.E. Tranquada, D.H. Solomon, J. Brown, R. Greene, The effect of oral hypoglycemic agents on thyroid function in the rat. Endocrinology. 67, 293–297 (1960). (no LoE)PubMed R.E. Tranquada, D.H. Solomon, J. Brown, R. Greene, The effect of oral hypoglycemic agents on thyroid function in the rat. Endocrinology. 67, 293–297 (1960). (no LoE)PubMed
150.
Zurück zum Zitat J.M. Hershman, T.J. Craane, J.A. Colwell, Effect of sulfonylurea drugs on the binding of triiodothyronine and thyroxine to thyroxine-binding globulin. J. Clin. Endocrinol. Metab. 28(11), 1605–1610 (1968). (LoE )PubMed J.M. Hershman, T.J. Craane, J.A. Colwell, Effect of sulfonylurea drugs on the binding of triiodothyronine and thyroxine to thyroxine-binding globulin. J. Clin. Endocrinol. Metab. 28(11), 1605–1610 (1968). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMed
151.
Zurück zum Zitat C. Kilo, J. Dudley, B. Kalb, Evaluation of the efficacy and safety of Diamicron in non-insulin-dependent diabetic patients. Diabetes Res. Clin. Pract. 14(Suppl 2), S79–S82 (1991). (LoE )PubMed C. Kilo, J. Dudley, B. Kalb, Evaluation of the efficacy and safety of Diamicron in non-insulin-dependent diabetic patients. Diabetes Res. Clin. Pract. 14(Suppl 2), S79–S82 (1991). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
152.
Zurück zum Zitat M.L. England, J.M. Hartnell, J.M. Hershman, S.R. Levin, Glyburide does not alter thyroid function. Diabetes Res. 3(9), 471–474 (1986). (LoE )PubMed M.L. England, J.M. Hartnell, J.M. Hershman, S.R. Levin, Glyburide does not alter thyroid function. Diabetes Res. 3(9), 471–474 (1986). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
153.
Zurück zum Zitat S.W. Shen, R. Bressler, Clinical pharmacology of oral antidiabetic agents (second of two parts). N. Engl. J. Med. 296(14), 787–793 (1977). (no LoE)PubMed S.W. Shen, R. Bressler, Clinical pharmacology of oral antidiabetic agents (second of two parts). N. Engl. J. Med. 296(14), 787–793 (1977). (no LoE)PubMed
154.
Zurück zum Zitat B. Efe, E. Entok, E. Güney, E. Erenoğlu, M. Kebapçı, Effects of second generation sulfonylureas on the thyroid. Turk J. Endocrinol. Metab. 4, 173–176 (1999). (no LoE) B. Efe, E. Entok, E. Güney, E. Erenoğlu, M. Kebapçı, Effects of second generation sulfonylureas on the thyroid. Turk J. Endocrinol. Metab. 4, 173–176 (1999). (no LoE)
155.
Zurück zum Zitat K. Starkey, A. Heufelder, G. Baker, W. Joba, M. Evans, S. Davies, M. Ludgate, Peroxisome proliferator-activated receptor-gamma in thyroid eye disease: contraindication for thiazolidinedione use? J. Clin. Endocrinol. Metab. 88(1), 55–59 (2003). (LoE )PubMed K. Starkey, A. Heufelder, G. Baker, W. Joba, M. Evans, S. Davies, M. Ludgate, Peroxisome proliferator-activated receptor-gamma in thyroid eye disease: contraindication for thiazolidinedione use? J. Clin. Endocrinol. Metab. 88(1), 55–59 (2003). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMed
156.
Zurück zum Zitat R. Menaka, M. Sehgal, M. Lakshmi, A. Bhattacharyya, Thiazolidinedione precipitated thyroid associated ophthalmopathy. J. Assoc. Physicians India 58, 255–257 (2010). (LoE )PubMed R. Menaka, M. Sehgal, M. Lakshmi, A. Bhattacharyya, Thiazolidinedione precipitated thyroid associated ophthalmopathy. J. Assoc. Physicians India 58, 255–257 (2010). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMed
157.
Zurück zum Zitat S. Lee, A. Tsirbas, R.A. Goldberg, J.D. McCann, Thiazolidinedione induced thyroid associated orbitopathy. BMC Ophthalmol. 7, 8 (2007). (LoE )PubMedCentralPubMed S. Lee, A. Tsirbas, R.A. Goldberg, J.D. McCann, Thiazolidinedione induced thyroid associated orbitopathy. BMC Ophthalmol. 7, 8 (2007). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figa_HTML.gif )PubMedCentralPubMed
158.
Zurück zum Zitat M. Dorkhan, M. Lantz, A. Frid, L. Groop, B. Hallengren, Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes. Clin. Endocrinol. (Oxford) 65(1), 35–39 (2006). (LoE ) M. Dorkhan, M. Lantz, A. Frid, L. Groop, B. Hallengren, Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes. Clin. Endocrinol. (Oxford) 65(1), 35–39 (2006). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )
160.
Zurück zum Zitat Byetta (Package insert) Amylin Pharmaceuticals Inc. San Diego (2007) (no LoE) Byetta (Package insert) Amylin Pharmaceuticals Inc. San Diego (2007) (no LoE)
162.
Zurück zum Zitat V.R. Aroda, R. Ratner, The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a review. Diabetes Metab. Res. Rev. 27(6), 528–542 (2011). doi:10.1002/dmrr.1202 PubMed V.R. Aroda, R. Ratner, The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a review. Diabetes Metab. Res. Rev. 27(6), 528–542 (2011). doi:10.​1002/​dmrr.​1202 PubMed
163.
Zurück zum Zitat D.J. Drucker, S.I. Sherman, R.M. Bergenstal, J.B. Buse, The safety of incretin-based therapies—review of the scientific evidence. J. Clin. Endocrinol. Metab. 96(7), 2027–2031 (2011). doi:10.1210/jc.2011-0599 PubMed D.J. Drucker, S.I. Sherman, R.M. Bergenstal, J.B. Buse, The safety of incretin-based therapies—review of the scientific evidence. J. Clin. Endocrinol. Metab. 96(7), 2027–2031 (2011). doi:10.​1210/​jc.​2011-0599 PubMed
164.
Zurück zum Zitat L. Hegedüs, A.C. Moses, M. Zdravkovic, T. Le Thi, G.H. Daniels, GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide. J. Clin. Endocrinol. Metab. 96(3), 853–860 (2011). (LoE )PubMed L. Hegedüs, A.C. Moses, M. Zdravkovic, T. Le Thi, G.H. Daniels, GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide. J. Clin. Endocrinol. Metab. 96(3), 853–860 (2011). (LoE https://static-content.springer.com/image/art%3A10.1007%2Fs12020-014-0474-9/MediaObjects/12020_2014_474_Figb_HTML.gif )PubMed
167.
Zurück zum Zitat M.H. Murad, F. Coto-Yglesias, A.T. Wang, N. Sheidaee, R.J. Mullan, M.B. Elamin, P.J. Erwin, V.M. Montori, Clinical review: drug-induced hypoglycemia: a systematic review. J. Clin. Endocrinol. Metab. 94(3), 741–745 (2009). doi:10.1210/jc.2008-1416 PubMed M.H. Murad, F. Coto-Yglesias, A.T. Wang, N. Sheidaee, R.J. Mullan, M.B. Elamin, P.J. Erwin, V.M. Montori, Clinical review: drug-induced hypoglycemia: a systematic review. J. Clin. Endocrinol. Metab. 94(3), 741–745 (2009). doi:10.​1210/​jc.​2008-1416 PubMed
Metadaten
Titel
Italian Association of Clinical Endocrinologists (AME) & Italian Association of Clinical Diabetologists (AMD) Position Statement
Diabetes mellitus and thyroid disorders: recommendations for clinical practice
verfasst von
Edoardo Guastamacchia
Vincenzo Triggiani
Alberto Aglialoro
Antimo Aiello
Lucia Ianni
Mauro Maccario
Michele Zini
Carlo Giorda
Rinaldo Guglielmi
Corrado Betterle
Roberto Attanasio
Giorgio Borretta
Piernicola Garofalo
Enrico Papini
Roberto Castello
Antonio Ceriello
Publikationsdatum
01.06.2015
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 2/2015
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-014-0474-9

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