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06.09.2016 | Original Paper

iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis

verfasst von: Nükhet Cavusoglu, Caroline Delattre, Mark Donovan, Sylvie Bourassa, Arnaud Droit, Charles El Rawadi, Roland Jourdain, Dominique Bernard

Erschienen in: Archives of Dermatological Research | Ausgabe 9/2016

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Abstract

The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological functions provided new insights into the affected metabolic pathways of a dandruff scalp. Dandruff scalp showed (1) profound changes in the expression and maturation of structural and epidermal differentiation related proteins, that are responsible for the integrity of the skin, (2) altered relevant factors that regulate skin hydration, and (3) an imbalanced physiological protease–protease inhibitor ratio. Stratum corneum proteins with antimicrobial activity, mainly those derived from sweat and sebaceous glands were also found modified. Comparing our data with those reported for atopic dermatitis revealed that about 50 % of the differentially expressed proteins in the superficial layers of the stratum corneum from dandruff and atopic dermatitis are identical.

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Titel: iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis
verfasst von: Nükhet Cavusoglu
Caroline Delattre
Mark Donovan
Sylvie Bourassa
Arnaud Droit
Charles El Rawadi
Roland Jourdain
Dominique Bernard
Publikationsdatum: 06.09.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Dermatological Research / Ausgabe 9/2016
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-016-1681-4

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