This MIB guide briefly summarizes the generation of patient-derived xenografts (PDXs) and highlights the importance of validating PDX models for the presence of B cell lymphoma of human origin before their use in radiotheranostic applications. The …
verfasst von:
Shayla Shmuel, Sébastien Monette, Dina Ibrahim, Patrícia M.R. Pereira
Acute myocardial infarction (AMI) is one of the leading causes of morbidity and mortality worldwide [ 1 ]. Escalated inflammatory cascade response is recognized as a major injury mechanism [ 2 , 3 ]. Anti-inflammatory strategies specific to the …
verfasst von:
Ping Wu, Li Xu, Qi Wang, Xiaofang Ma, Xinzhu Wang, Hongliang Wang, Sheng He, Huibin Ru, Yuting Zhao, Yuxin Xiao, Jingying Zhang, Xinchao Wang, Shaohui An, Marcus Hacker, Xiang Li, Xiaoli Zhang, Yuetao Wang, Minfu Yang, Zhifang Wu, Sijin Li
Nasopharyngeal carcinoma (NPC) is an epithelial cancer that occurs in the top and lateral walls of the nasopharyngeal cavity, commonly in the nasopharyngeal mucosa. It is a high-grade malignant tumor in China, and its incidence ranks first among …
verfasst von:
Mengna Liu, Xi Chen, Haoyuan Ding, Qiaoqiao Shu, Yun Zheng, Yue Chen, Liang Cai
Cancer metastasis is a leading cause of death in humans [ 1 ]. One of the main pathways of metastasis is via the blood circulatory system (“hematogenous metastasis”) wherein tumor cells intravasate into the vasculature from the primary tumor and …
verfasst von:
Joshua Pace, Jane J. Lee, Madduri Srinivasarao, Shivakrishna Kallepu, Philip S. Low, Mark Niedre
Alice Petty, Anna Garcia-Hidalgo, Els F. Halff, Sridhar Natesan, Dominic J. Withers, Elaine E. Irvine, Michelle Kokkinou, Lisa A. Wells, David R. Bonsall, Sac-Pham Tang, Mattia Veronese, Oliver D. Howes
Molecular oxygen and its thermodynamic transformation drive nearly all life processes. Quantitative measurement and imaging of oxygen in living systems is of fundamental importance for the study of life processes and their aberrations—disease– …
Melanoma incidence is continuously increasing over time with a worldwide total of 325.000 new cases in 2020 [ 1 , 2 ]. Skin melanomas detected at an early stage of development are easily cured by surgical resection with an excellent survival …
verfasst von:
Mohammad Wehbi, Lionel Mignion, Nicolas Joudiou, Evelyne Harkemanne, Bernard Gallez
Heart failure has become a global disease epidemic, particularly in the elderly [ 1 , 2 ]. Notwithstanding major advances in treatment, the exact molecular mechanisms underlying the pathogenesis of heart failure remain incompletely understood …
verfasst von:
Bibi S. van Thiel, Martine de Boer, Yanto Ridwan, Marion G. J. de Kleijnen, Nicole van Vliet, Janette van der Linden, Isa de Beer, Paula M. van Heijningen, Wilbert P. Vermeij, Jan H. J. Hoeijmakers, A. H. Jan Danser, Roland Kanaar, Dirk J. Duncker, Ingrid van der Pluijm, Jeroen Essers
In multiple myeloma (MM), a cancer of malignant bone marrow plasma cells, cluster of differentiation 38 (CD38) is overexpressed. Thus, CD38 has become a valuable therapeutic target, with CD38-targeted FDA approved antibodies, daratumumab and …
verfasst von:
Alexander Zheleznyak, Rui Tang, Kathleen Duncan, Brad Manion, Kexian Liang, Baogang Xu, Alexander Vanover, Anchal Ghai, Julie Prior, Stephen Lees, Samuel Achilefu, Kimberly Kelly, Monica Shokeen
The tumor microenvironment (TME) is a complex and dynamic system which interacts with tumor cells and defines the effects on tumor development and progression. TME differs significantly from healthy tissue microenvironment and, among others, is …
verfasst von:
Małgorzata Szczygieł, Barbara Kalinowska, Dariusz Szczygieł, Martyna Krzykawska-Serda, Leszek Fiedor, Aleksandra Anna Murzyn, Justyna Sopel, Zenon Matuszak, Martyna Elas
Within this special issue, many eminent investigators report on measurements of oxygen (O2) levels in tissues. Given the complexities of spatial and temporal heterogeneities of O2 in tissues and its many sources, this commentary draws attention to …
Bioprinting is an additive manufacturing technology intended for the engineering of functional human tissues and organs [ 1 , 2 ]. Human-relevant models are created that expand our knowledge of the underlying pathological mechanisms in diseases [ 3 …–
verfasst von:
Sajad Sarvari, Duncan McGee, Ryan O’Connell, Oxana Tseytlin, Andrey A. Bobko, Mark Tseytlin
Oxygen is at the center of the oxidative metabolism of aerobic living organisms for their energy production. A healthy human adult consumes ~ 3 mL O 2 kg −1 .min −1 (~ 300 L per day for a 70 kg adult) [ 1 ]. An imbalance between oxygen supply and …
verfasst von:
Misa A. Shaw, Martin Poncelet, Navin Viswakarma, Gian Paolo Vallerini, Safa Hameed, Teresa D. Gluth, Werner J. Geldenhuys, Emily H. Hoblitzell, Timothy D. Eubank, Boris Epel, Mrignayani Kotecha, Benoit Driesschaert
Low oxygen (hypoxia) is a hallmark of rapidly growing solid tumors. Hypoxia has been indicated in a number of disease states, including anemia, renal failure, and cardiovascular disease, in addition to its central role in carcinogenesis. The …
verfasst von:
Rhia M. Martin, Samantha Diaz, Martin Poncelet, Benoit Driesschaert, Eugene Barth, Mrignayani Kotecha, Boris Epel, Gareth R. Eaton, Joshua R. Biller
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), is a principal cause of life-threatening illness in adults and children [ 1 – 3 ]. There is evidence that oxidative stress is critical in pathogenesis of …
verfasst von:
Hanan B. Elajaili, Lukas B. Woodcock, Tanden A. Hovey, George A. Rinard, Samuel DeGraw, Autumn Canny, Nathan M. Dee, Joseph P. Y. Kao, Eva S. Nozik, Sandra S. Eaton, Gareth R. Eaton
Low tissue oxygenation and hypoxic conditions, that develop during growth of solid tumors, favor the formation of an aggressive tumor phenotype, which has a negative impact on almost all anticancer therapies used to date [ 1 ]. Therefore …
verfasst von:
Gabriela Dziurman, Agnieszka Drzał, Aleksandra Anna Murzyn, Maciej Mikolaj Kmiec, Martyna Elas, Martyna Krzykawska-Serda
Tumor hypoxia is associated with worse prognosis, decreased local tumor control and more aggressive phenotypes; it also decreases radiation sensitivity by 3- to 5-fold [ 1 , 2 ]. Over the last 50+ years, researchers have attempted to ameliorate …
verfasst von:
Ashlyn G. Rickard, Yvonne M. Mowery, Alex Bassil, Douglas C. Rouse, Nerissa T. Williams, Theresa Charity, Rafaela Belloni, Brian Crouch, Nimmi Ramanujam, Daniel Stevenson, Rico Castillo, Stephanie Blocker, Boris Epel, Mrignayani Kotecha, Gregory M. Palmer
Cancer is a major public health problem worldwide and is the second leading cause of death in the USA [ 1 ]. According to government statistics, approximately 38.4% of men and women are diagnosed with cancer during their lifespans [ 2 ]. About …
verfasst von:
Boris Epel, Navin Viswakarma, Subramanian V. Sundramoorthy, Nitin J. Pawar, Mrignayani Kotecha
In recent decades, the tumor microenvironment (TME) has been recognized as a key factor in cancer progression and therapy [ 1 ]. TME includes both the physical components, such as extracellular matrix, and physiological molecular components such as …
verfasst von:
Timothy D. Eubank, Andrey A. Bobko, E. Hannah Hoblitzell, Marieta Gencheva, Benoit Driesschaert, Valery V. Khramtsov
