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Erschienen in: InFo Hämatologie + Onkologie 6/2020

25.06.2020 | Kolorektales Karzinom | Zertifizierte Fortbildung

Kolorektales Karzinom, Mammakarzinom und andere Entitäten

Lebermetastasen - interdisziplinäre Therapie

verfasst von: Dr. med. Marcella Steffani, PD Dr. med. Daniel Hartmann, Prof. Dr. med. Marc Martignoni, Michael W. Müller, Prof. Dr. Alexander Novotny, Prof. Dr. med. Helmut Friess

Erschienen in: InFo Hämatologie + Onkologie | Ausgabe 6/2020

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Chirurgie, Systemtherapie, Bestrahlung sowie lokale und vaskuläre Behandlungskonzepte - für die Therapie von Lebermetastasen stehen eine ganze Reihe von unterschiedlichen Ansätzen zur Verfügung. Lesen Sie in der folgenden Übersicht, wann welches Verfahren zum Einsatz kommen sollte, was es jeweils zu beachten gilt und warum eine erfolgreiche Therapie nur in interdisziplinärer Abstimmung gelingen kann.
Literatur
1.
Zurück zum Zitat Abdalla EK et al. Improving resectability of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol. 2006;13(10):1271-80 Abdalla EK et al. Improving resectability of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol. 2006;13(10):1271-80
2.
Zurück zum Zitat Hoffmann K et al. Liver resection for multimodal treatment of breast cancer metastases: identification of prognostic factors. Ann Surg Oncol. 2010;17(6):1546-54 Hoffmann K et al. Liver resection for multimodal treatment of breast cancer metastases: identification of prognostic factors. Ann Surg Oncol. 2010;17(6):1546-54
3.
Zurück zum Zitat Frilling A et al. Recommendations for management of patients with neuroendocrine liver metastases. Lancet Oncol. 2014;15(1):e8-21 Frilling A et al. Recommendations for management of patients with neuroendocrine liver metastases. Lancet Oncol. 2014;15(1):e8-21
4.
Zurück zum Zitat Kassahun WT. Controversies in defining prognostic relevant selection criteria that determine long-term effectiveness of liver resection for noncolorectal nonneuroendocrine liver metastasis. Int J Surg. 2015;24(Pt A):85-90 Kassahun WT. Controversies in defining prognostic relevant selection criteria that determine long-term effectiveness of liver resection for noncolorectal nonneuroendocrine liver metastasis. Int J Surg. 2015;24(Pt A):85-90
5.
Zurück zum Zitat Luedde T et al. Interdisziplinäre Therapie kolorektaler Lebermetastasen. Gastroenterologe. 2016;11(6):479-88 Luedde T et al. Interdisziplinäre Therapie kolorektaler Lebermetastasen. Gastroenterologe. 2016;11(6):479-88
6.
Zurück zum Zitat Jara M et al. Reductions in post-hepatectomy liver failure and related mortality after implementation of the LiMAx algorithm in preoperative work-up: a single-centre analysis of 1170 hepatectomies of one or more segments. HPB (Oxford). 2015;17(7):651-8 Jara M et al. Reductions in post-hepatectomy liver failure and related mortality after implementation of the LiMAx algorithm in preoperative work-up: a single-centre analysis of 1170 hepatectomies of one or more segments. HPB (Oxford). 2015;17(7):651-8
7.
Zurück zum Zitat Ribero D et al. Standardized liver volumetry for portal vein embolization. Semin Intervent Radiol. 2008;25(2):104-9 Ribero D et al. Standardized liver volumetry for portal vein embolization. Semin Intervent Radiol. 2008;25(2):104-9
8.
Zurück zum Zitat Angelsen JH et al. Surgery for colorectal liver metastases: the impact of resection margins on recurrence and overall survival. World J Surg Oncol. 2014;12:127 Angelsen JH et al. Surgery for colorectal liver metastases: the impact of resection margins on recurrence and overall survival. World J Surg Oncol. 2014;12:127
9.
Zurück zum Zitat Qadan M, D'Angelica MI. Extending the Limits of Resection for Colorectal Liver Metastases: Positive Resection Margin and Outcome After Resection of Colorectal Cancer Liver Metastases. J Gastrointest Surg. 2017;21(1):196-8 Qadan M, D'Angelica MI. Extending the Limits of Resection for Colorectal Liver Metastases: Positive Resection Margin and Outcome After Resection of Colorectal Cancer Liver Metastases. J Gastrointest Surg. 2017;21(1):196-8
10.
Zurück zum Zitat Abdalla EK et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004;239(6):818-25; discussion 825-7 Abdalla EK et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004;239(6):818-25; discussion 825-7
11.
Zurück zum Zitat Adam R et al. Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev. 2015;41(9):729-41 Adam R et al. Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev. 2015;41(9):729-41
12.
Zurück zum Zitat van der Poel MJ et al. Multicentre propensity score-matched study of laparoscopic versus open repeat liver resection for colorectal liver metastases. Br J Surg. 2019;106(6):783-9 van der Poel MJ et al. Multicentre propensity score-matched study of laparoscopic versus open repeat liver resection for colorectal liver metastases. Br J Surg. 2019;106(6):783-9
13.
Zurück zum Zitat Martínez-Cecilia D et al. Laparoscopic Versus Open Liver Resection for Colorectal Metastases in Elderly and Octogenarian Patients: A Multicenter Propensity Score Based Analysis of Short- and Long-term Outcomes. Ann Surg. 2017;265(6):1192-1200 Martínez-Cecilia D et al. Laparoscopic Versus Open Liver Resection for Colorectal Metastases in Elderly and Octogenarian Patients: A Multicenter Propensity Score Based Analysis of Short- and Long-term Outcomes. Ann Surg. 2017;265(6):1192-1200
14.
Zurück zum Zitat Sandström P et al. ALPPS Improves Resectability Compared With Conventional Two-stage Hepatectomy in Patients With Advanced Colorectal Liver Metastasis: Results From a Scandinavian Multicenter Randomized Controlled Trial (LIGRO Trial). Ann Surg. 2018;267(5):833-40 Sandström P et al. ALPPS Improves Resectability Compared With Conventional Two-stage Hepatectomy in Patients With Advanced Colorectal Liver Metastasis: Results From a Scandinavian Multicenter Randomized Controlled Trial (LIGRO Trial). Ann Surg. 2018;267(5):833-40
15.
Zurück zum Zitat Madoff DC et al. Portal vein embolization in preparation for major hepatic resection: evolution of a new standard of care. J Vasc Interv Radiol. 2005;16(6):779-90 Madoff DC et al. Portal vein embolization in preparation for major hepatic resection: evolution of a new standard of care. J Vasc Interv Radiol. 2005;16(6):779-90
16.
Zurück zum Zitat van Lienden KP et al. Portal vein embolization before liver resection: a systematic review. Cardiovasc Intervent Radiol. 2013;36(1):25-34 van Lienden KP et al. Portal vein embolization before liver resection: a systematic review. Cardiovasc Intervent Radiol. 2013;36(1):25-34
17.
Zurück zum Zitat Abulkhir A et al. Preoperative portal vein embolization for major liver resection: a meta-analysis. Ann Surg. 2008;247(1):49-57 Abulkhir A et al. Preoperative portal vein embolization for major liver resection: a meta-analysis. Ann Surg. 2008;247(1):49-57
18.
Zurück zum Zitat Strasberg SM, Phillips C. Use and dissemination of the brisbane 2000 nomenclature of liver anatomy and resections. Ann Surg. 2013;257(3):377-82 Strasberg SM, Phillips C. Use and dissemination of the brisbane 2000 nomenclature of liver anatomy and resections. Ann Surg. 2013;257(3):377-82
19.
Zurück zum Zitat Nordlinger B et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013;14(12):1208-15 Nordlinger B et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013;14(12):1208-15
20.
Zurück zum Zitat Van Cutsem E et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360(14):1408-17 Van Cutsem E et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360(14):1408-17
21.
Zurück zum Zitat Folprecht G et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol. 2010;11(1):38-47 Folprecht G et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol. 2010;11(1):38-47
22.
Zurück zum Zitat Khoo E et al. Systematic review of systemic adjuvant, neoadjuvant and perioperative chemotherapy for resectable colorectal-liver metastases. HPB (Oxford). 2016;18(6):485-93 Khoo E et al. Systematic review of systemic adjuvant, neoadjuvant and perioperative chemotherapy for resectable colorectal-liver metastases. HPB (Oxford). 2016;18(6):485-93
23.
Zurück zum Zitat Maher B et al. The management of colorectal liver metastases. Clin Radiol. 2017;72(8):617-25 Maher B et al. The management of colorectal liver metastases. Clin Radiol. 2017;72(8):617-25
24.
Zurück zum Zitat Folprecht G et al. Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates. Ann Oncol. 2005;16(8):1311-9 Folprecht G et al. Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates. Ann Oncol. 2005;16(8):1311-9
25.
Zurück zum Zitat Ychou M et al. A randomized phase II trial of three intensified chemotherapy regimens in first-line treatment of colorectal cancer patients with initially unresectable or not optimally resectable liver metastases. The METHEP trial. Ann Surg Oncol. 2013;20(13):4289-97 Ychou M et al. A randomized phase II trial of three intensified chemotherapy regimens in first-line treatment of colorectal cancer patients with initially unresectable or not optimally resectable liver metastases. The METHEP trial. Ann Surg Oncol. 2013;20(13):4289-97
26.
Zurück zum Zitat Zorzi D et al. Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg. 2007;94(3):274-86 Zorzi D et al. Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg. 2007;94(3):274-86
27.
Zurück zum Zitat Ye LC et al. Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol. 2013;31(16):1931-8 Ye LC et al. Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol. 2013;31(16):1931-8
28.
Zurück zum Zitat Carrato A et al. First-line panitumumab plus FOLFOX4 or FOLFIRI in colorectal cancer with multiple or unresectable liver metastases: A randomised, phase II trial (PLANET-TTD). Eur J Cancer. 2017;81:191-202 Carrato A et al. First-line panitumumab plus FOLFOX4 or FOLFIRI in colorectal cancer with multiple or unresectable liver metastases: A randomised, phase II trial (PLANET-TTD). Eur J Cancer. 2017;81:191-202
29.
Zurück zum Zitat Geissler M et al. mFOLFOXIRI + Panitumumab versus FOLFOXIRI as first-line treatment in patients with RAS wild- type metastatic colorectal cancer m(CRC): a randomized phase II VOLFI trial of the AIO (AIO- KRK0109). Ann Oncol. 2018;29(Suppl_5):v108 Geissler M et al. mFOLFOXIRI + Panitumumab versus FOLFOXIRI as first-line treatment in patients with RAS wild- type metastatic colorectal cancer m(CRC): a randomized phase II VOLFI trial of the AIO (AIO- KRK0109). Ann Oncol. 2018;29(Suppl_5):v108
30.
Zurück zum Zitat Schwartzberg LS et al. PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol. 2014;32(21):2240-7 Schwartzberg LS et al. PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol. 2014;32(21):2240-7
31.
Zurück zum Zitat Gruenberger T et al. Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: the OLIVIA multinational randomised phase II trial. Ann Oncol. 2015;26(4):702-8 Gruenberger T et al. Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: the OLIVIA multinational randomised phase II trial. Ann Oncol. 2015;26(4):702-8
32.
Zurück zum Zitat Rusthoven KE et al. Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases. J Clin Oncol. 2009;27(10):1572-8 Rusthoven KE et al. Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases. J Clin Oncol. 2009;27(10):1572-8
33.
Zurück zum Zitat Scorsetti M et al. Stereotactic body radiation therapy for liver metastases. J Gastrointest Oncol. 2014;5(3):190-7 Scorsetti M et al. Stereotactic body radiation therapy for liver metastases. J Gastrointest Oncol. 2014;5(3):190-7
34.
Zurück zum Zitat Scorsetti M et al. Phase II trial on SBRT for unresectable liver metastases: long-term outcome and prognostic factors of survival after 5 years of follow-up. Radiat Oncol. 2018;13(1):234 Scorsetti M et al. Phase II trial on SBRT for unresectable liver metastases: long-term outcome and prognostic factors of survival after 5 years of follow-up. Radiat Oncol. 2018;13(1):234
35.
Zurück zum Zitat Gillams A et al. Thermal ablation of colorectal liver metastases: a position paper by an international panel of ablation experts, The Interventional Oncology Sans Frontières meeting 2013. Eur Radiol. 2015;25(12):3438-54 Gillams A et al. Thermal ablation of colorectal liver metastases: a position paper by an international panel of ablation experts, The Interventional Oncology Sans Frontières meeting 2013. Eur Radiol. 2015;25(12):3438-54
36.
Zurück zum Zitat Nosher JL et al. Non-operative therapies for colorectal liver metastases. J Gastrointest Oncol. 2015;6(2):224-40 Nosher JL et al. Non-operative therapies for colorectal liver metastases. J Gastrointest Oncol. 2015;6(2):224-40
37.
Zurück zum Zitat Rempp H et al. The current role of minimally invasive therapies in the management of liver tumors. Abdom Imaging. 2011;36(6):635-47 Rempp H et al. The current role of minimally invasive therapies in the management of liver tumors. Abdom Imaging. 2011;36(6):635-47
38.
Zurück zum Zitat Wu YZ et al. Radiofrequency ablation vs hepatic resection for solitary colorectal liver metastasis: a meta-analysis. World J Gastroenterol. 2011;17(36):4143-8 Wu YZ et al. Radiofrequency ablation vs hepatic resection for solitary colorectal liver metastasis: a meta-analysis. World J Gastroenterol. 2011;17(36):4143-8
39.
Zurück zum Zitat Nielsen K et al. Incidence and treatment of local site recurrences following RFA of colorectal liver metastases. World J Surg. 2013;37(6):1340-7 Nielsen K et al. Incidence and treatment of local site recurrences following RFA of colorectal liver metastases. World J Surg. 2013;37(6):1340-7
40.
Zurück zum Zitat Solbiati L et al. Small liver colorectal metastases treated with percutaneous radiofrequency ablation: local response rate and long-term survival with up to 10-year follow-up. Radiology. 2012;265(3):958-68 Solbiati L et al. Small liver colorectal metastases treated with percutaneous radiofrequency ablation: local response rate and long-term survival with up to 10-year follow-up. Radiology. 2012;265(3):958-68
41.
Zurück zum Zitat Ruers T et al. Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004). Ann Oncol. 2012;23(10):2619-26 Ruers T et al. Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004). Ann Oncol. 2012;23(10):2619-26
42.
Zurück zum Zitat Jiao LR et al. Rapid Induction of Liver Regeneration for Major Hepatectomy (REBIRTH): A Randomized Controlled Trial of Portal Vein Embolisation versus ALPPS Assisted with Radiofrequency. Cancers (Basel). 2019;11(3). pii: E302 Jiao LR et al. Rapid Induction of Liver Regeneration for Major Hepatectomy (REBIRTH): A Randomized Controlled Trial of Portal Vein Embolisation versus ALPPS Assisted with Radiofrequency. Cancers (Basel). 2019;11(3). pii: E302
43.
Zurück zum Zitat Pillai K et al. Heat sink effect on tumor ablation characteristics as observed in monopolar radiofrequency, bipolar radiofrequency, and microwave, using ex vivo calf liver model. Medicine (Baltimore). 2015;94(9):e580 Pillai K et al. Heat sink effect on tumor ablation characteristics as observed in monopolar radiofrequency, bipolar radiofrequency, and microwave, using ex vivo calf liver model. Medicine (Baltimore). 2015;94(9):e580
44.
Zurück zum Zitat Liang P et al. Malignant liver tumors: treatment with percutaneous microwave ablation--complications among cohort of 1136 patients. Radiology. 2009;251(3):933-40 Liang P et al. Malignant liver tumors: treatment with percutaneous microwave ablation--complications among cohort of 1136 patients. Radiology. 2009;251(3):933-40
45.
Zurück zum Zitat Pech M et al. MR-guided interstitial laser thermotherapy of colorectal liver metastases: efficiency, safety and patient survival. Eur J Med Res. 2007;12(4):161-8 Pech M et al. MR-guided interstitial laser thermotherapy of colorectal liver metastases: efficiency, safety and patient survival. Eur J Med Res. 2007;12(4):161-8
46.
Zurück zum Zitat Vogl TJ et al. Thermal ablation of liver metastases from colorectal cancer: radiofrequency, microwave and laser ablation therapies. Radiol Med. 2014;119(7):451-61 Vogl TJ et al. Thermal ablation of liver metastases from colorectal cancer: radiofrequency, microwave and laser ablation therapies. Radiol Med. 2014;119(7):451-61
47.
Zurück zum Zitat Scheffer HJ et al. Irreversible Electroporation for Colorectal Liver Metastases. Tech Vasc Interv Radiol. 2015;18(3):159-69 Scheffer HJ et al. Irreversible Electroporation for Colorectal Liver Metastases. Tech Vasc Interv Radiol. 2015;18(3):159-69
48.
Zurück zum Zitat Gruber-Rouh T et al. Transarterial chemoembolization of unresectable systemic chemotherapy-refractory liver metastases from colorectal cancer: long-term results over a 10-year period. Int J Cancer. 2014;134(5):1225-31 Gruber-Rouh T et al. Transarterial chemoembolization of unresectable systemic chemotherapy-refractory liver metastases from colorectal cancer: long-term results over a 10-year period. Int J Cancer. 2014;134(5):1225-31
49.
Zurück zum Zitat Martin RC 2nd et al. Randomized controlled trial of irinotecan drug-eluting beads with simultaneous FOLFOX and bevacizumab for patients with unresectable colorectal liver-limited metastasis. Cancer. 2015;121(20):3649-58 Martin RC 2nd et al. Randomized controlled trial of irinotecan drug-eluting beads with simultaneous FOLFOX and bevacizumab for patients with unresectable colorectal liver-limited metastasis. Cancer. 2015;121(20):3649-58
50.
Zurück zum Zitat Hendlisz A et al. Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin microspheres radioembolization for liver-limited metastatic colorectal cancer refractory to standard chemotherapy. J Clin Oncol. 2010;28(23):3687-94 Hendlisz A et al. Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin microspheres radioembolization for liver-limited metastatic colorectal cancer refractory to standard chemotherapy. J Clin Oncol. 2010;28(23):3687-94
51.
Zurück zum Zitat Wasan HS et al. First-line Selective Internal Radiotherapy Plus Chemotherapy Versus Chemotherapy Alone in Patients With Liver Metastases From Colorectal Cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): A Combined Analysis of Three Multicentre, Randomised, Phase 3 Trials. Lancet Oncol. 2017;18(9):1159-71 Wasan HS et al. First-line Selective Internal Radiotherapy Plus Chemotherapy Versus Chemotherapy Alone in Patients With Liver Metastases From Colorectal Cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): A Combined Analysis of Three Multicentre, Randomised, Phase 3 Trials. Lancet Oncol. 2017;18(9):1159-71
Metadaten
Titel
Kolorektales Karzinom, Mammakarzinom und andere Entitäten
Lebermetastasen - interdisziplinäre Therapie
verfasst von
Dr. med. Marcella Steffani
PD Dr. med. Daniel Hartmann
Prof. Dr. med. Marc Martignoni
Michael W. Müller
Prof. Dr. Alexander Novotny
Prof. Dr. med. Helmut Friess
Publikationsdatum
25.06.2020
Verlag
Springer Medizin
Erschienen in
InFo Hämatologie + Onkologie / Ausgabe 6/2020
Print ISSN: 2662-1754
Elektronische ISSN: 2662-1762
DOI
https://doi.org/10.1007/s15004-020-8132-2

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