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Clinical Rheumatology

Erschienen in:

09.11.2019 | Review Article

Leptin: an unappreciated key player in SLE

verfasst von: Qihang Yuan, Haifeng Chen, Xia Li, Jing Wei

Erschienen in: Clinical Rheumatology | Ausgabe 2/2020

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Abstract

Leptin is the forerunner of the adipokine superfamily and plays a key role in regulating energy expenditure and neuroendocrine function. Researches into leptin put emphasize not only on the metabolic role but also its immunoregulatory effect on immune response through immunocyte activation and cytokine secretion. Leptin acts on receptors that are widespread throughout the body and that are expressed across many tissue types. As a consequence, the abnormal expression of leptin has been found to correlate with a number of diseases, including cancers, autoimmune diseases, and cardiovascular diseases. The significance of leptin in the development of autoimmune diseases is becoming increasingly prominent. Systemic lupus erythematosus (SLE) is a severe atypical autoimmune disease that causes damage to multiple organ systems. It is characterised by the following: impaired clearance of apoptotic cells, loss of tolerance to self-antigens, aberrant activation of T cells and B cells, and chronic inflammation. The heightened immunocyte response in SLE means that these physiological systems are particularly vulnerable to regulation by leptin in addition to being of great significance to the research field. Our current review provides insight into the regulatory roles that leptin plays on immune effector cells in SLE.

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Titel: Leptin: an unappreciated key player in SLE
verfasst von: Qihang Yuan
Haifeng Chen
Xia Li
Jing Wei
Publikationsdatum: 09.11.2019
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 2/2020
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-019-04831-8

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