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06.06.2017 | Epidemiology

Lifetime moderate-to-vigorous physical activity and ER/PR/HER-defined post-menopausal breast cancer risk

verfasst von: Joy Shi, Lindsay C. Kobayashi, Anne Grundy, Harriet Richardson, Sandip K. SenGupta, Caroline A. Lohrisch, John J. Spinelli, Kristan J. Aronson

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 1/2017

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Abstract

Purpose

To assess the relationship of moderate-to-vigorous physical activity (MVPA) in leisure-time, household, and occupational domains across the total lifetime and in four age periods with breast cancer risk, as defined by estrogen receptor (ER)/progesterone receptor (PR) status and ER/PR/human epidermal growth factor-2 (HER2) status, among post-menopausal women.

Methods

Data were from 692 women with incident breast cancer and 644 controls in the Canadian Breast Cancer Study, a case–control study of women aged 40–80 years in British Columbia and Ontario. Mean metabolic equivalent (MET)-hours/week for questionnaire-assessed leisure-time, household, and occupational MVPA were calculated for the total lifetime and four age periods (12–17, 18–34, 45–49, and ≥50 years). Odds ratios (ORs) for the relationships between domain-specific MVPA at each lifetime period and risks of ER/PR-defined and ER/PR/HER2-defined breast cancers were estimated using polytomous logistic regression. Trend tests for dose–response relationships were calculated for the ORs across increasing tertiles of mean MET-hours/week of MVPA.

Results

Total lifetime leisure-time MVPA was associated with reduced risk of ER−/PR− breast cancer in a dose–response fashion (p _trend = 0.014). In contrast, total lifetime household MVPA was associated with reduced risk of ER+ and/or PR+ breast cancer (p _trend < 0.001). When further stratified by HER2 status, the effect of leisure-time MVPA appeared confined to HER2− breast cancers, and the effect of household MVPA did not differ according to HER2 status. Similar trends were observed when stratified by age period.

Conclusions

Lifetime leisure-time MVPA appeared to be associated with reduced risk of ER−/PR−/HER2− breast cancers and lifetime household MVPA was associated with reduced risk of ER+ and/or PR+ breast cancer, regardless of HER2 status.

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Yang XR, Chang-Claude J, Goode EL, Couch FJ, Nevanlinna H, Milne RL et al (2011) Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Ist 103:250–263. doi:10.1093/jnci/djq526 CrossRef

Boyle P (2012) Triple-negative breast cancer: epidemiological considerations and recommendations. Ann Oncol 23:vi7–vi12. doi:10.1093/annonc/mds187

Foulkes WD (2004) Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type. Clin Cancer Res 10:2029–2034CrossRefPubMed

Anderson WF, Chatterjee N, Ershler WB, Brawley OW (2002) Estrogen receptor breast cancer phenotypes in the surveillance, epidemiology, and end results database. Breast Cancer Res Treat 76:27–36. doi:10.1023/A:1020299707510 CrossRefPubMed

Trivers KF, Lund MJ, Porter P, Liff JM, Flagg EW, Coates RJ et al (2009) The epidemiology of triple-negative breast cancer, including race. Cancer Causes Control 20:1071–1082. doi:10.1007/s10552-009-9331-1 CrossRefPubMedPubMedCentral

Parise CA, Bauer KR, Brown MM, Caggiano V (2009) Breast cancer subtypes as defined by the estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2) among women with invasive breast cancer in California, 1999-2004. Breast J 15:593–602. doi:10.1111/j.1524-4741.2009.00822.x CrossRefPubMed

Ma H, Wang Y, Sullivan-Halley J (2010) Use of four biomarkers to evaluate the risk of breast cancer subtypes in the Women’s Contraceptive and Reproductive Experiences Study. Cancer Res 70:575–587. doi:10.1158/0008-5472.CAN-09-3460 CrossRefPubMedPubMedCentral

Peters TM, Moore SC, Gierach GL, Wareham NJ, Ekelund U, Hollenbeck AR et al (2009) Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study. BMC Cancer 9:1–14. doi:10.1186/1471-2407-9-349 CrossRef

Leitzmann MF, Moore SC, Peters TM, Lacey JV, Schatzkin A, Schairer C et al (2008) Prospective study of physical activity and risk of postmenopausal breast cancer. Breast Cancer Res 10(5):R92. doi:10.1186/bcr2190 CrossRefPubMedPubMedCentral

10.

Peplonska B, Lissowska J, Hartman TJ, Szeszenia-Dabrowska N, Blair A, Zatonski W et al (2008) Adulthood lifetime physical activity and breast cancer. Epidemiology 19:226–236. doi:10.1097/EDE.0b013e3181633bfb CrossRefPubMed

11.

Slattery ML, Edwards S, Murtaugh MA, Sweeney C, Herrick J, Byers T et al (2007) Physical activity and breast cancer risk among women in the southwestern United States. Ann Epidemiol 17:342–353CrossRefPubMedPubMedCentral

12.

Bernstein L, Patel AV, Ursin G, Sullivan-Halley J, Press MF, Deapen D et al (2005) Lifetime recreational exercise activity and breast cancer risk among black women and white women. J Nat Cancer Inst 97:1671–1679CrossRefPubMed

13.

Adams SA, Matthews CE, Hebert JR, Moore CG, Cunningham JE, Shu X-O et al (2006) Association of physical activity with hormone receptor status: the Shanghai Breast Cancer Study. Cancer Epidemiol Biomark Prev 15:1170–1178CrossRef

14.

Enger SM, Ross RK, Paganini-hill A, Carpenter CL, Bernstein L (2000) Body size, physical activity, and breast cancer hormone receptor status: results from two case-control studies. Cancer Epidemiol Biomark Prev 9:681–687

15.

Suzuki R, Iwasaki M, Kasuga Y (2010) Leisure-time physical activity and breast cancer risk by hormone receptor status: effective life periods and exercise intensity. Cancer Causes Control 21:1787–1798. doi:10.1007/s10552-010-9605-7 CrossRefPubMed

16.

Eliassen A, Hankinson S, Rosner B, Holmes M, Willett W (2010) Physical activity and risk of breast cancer among postmenopausal women. Arch Intern Med 170:1758–1764. doi:10.1001/archinternmed.2010.363 CrossRefPubMedPubMedCentral

17.

Rosato V, Bertuccio P, Bosetti C, Negri E, Edefonti V, Ferraroni M (2013) Nutritional factors, physical activity, and breast cancer by hormone receptor status. Breast 22:887–893. doi:10.1016/j.breast.2013.04.004 CrossRefPubMed

18.

Schmidt ME, Steindorf K, Mutschelknauss E, Slanger T, Kropp S, Obi N et al (2008) Physical activity and postmenopausal breast cancer: effect modification by breast cancer subtypes and effective periods in life. Cancer Epidemiol Biomark Prev 17:3402–3410. doi:10.1158/1055-9965.EPI-08-0479 CrossRef

19.

Bardia A, Hartmann LC, Vachon CM, Vierkant RA, Wang AH, Olson JE et al (2006) Recreational physical activity and risk of postmenopausal breast cancer based on hormone receptor status. Arch Intern Med 166:2478–2483CrossRefPubMed

20.

Suzuki R, Iwasaki M, Yamamoto S, Inoue M, Sasazuki S (2011) Leisure-time physical activity and breast cancer risk defined by estrogen and progesterone receptor status—the Japan Public Health Center-based Prospective Study. Prev Med 52:227–233. doi:10.1016/j.ypmed.2011.01.016 PubMed

21.

Dallal CM, Sullivan-Halley J, Ross RK, Wang Y, Deapen D, Horn-ross PL et al (2007) Long-term recreational physical activity and risk of invasive and in situ breast cancer. Arch Intern Med 167:408–415CrossRefPubMed

22.

Wu Y, Zhang D, Kang S (2012) Physical activity and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat 137(3):869–882. doi:10.1007/s10549-012-2396-7 CrossRefPubMed

23.

Steindorf K, Ritte R, Eomois P, Lukanova A, Tjonneland A, Johnsen N et al (2012) Physical activity and risk of breast cancer overall and by hormone receptor status: the European prospective investigation into cancer and nutrition. Int J Cancer 132:1667–1678. doi:10.1002/ijc.27778 CrossRefPubMed

24.

Phipps AI, Chlebowski RT, Prentice R (2011) Body size, physical activity, and risk of triple-negative and estrogen receptor—positive breast cancer. Cancer Epidemiol Biomark Prev 20:454–463. doi:10.1158/1055-9965.EPI-0974 CrossRef

25.

Ma H, Xu X, Ursin G, Simon MS, Marchbanks PA, Malone KE et al (2015) Reduced risk of breast cancer associated with recreational physical activity varies by HER2 status. Cancer Med 4:1122–1135. doi:10.1002/cam4.465 CrossRefPubMedPubMedCentral

26.

Ma H, Xu X, Clague J, Lu Y, Togawa K, Wang SS et al (2016) Recreational physical activity and risk of triple negative breast cancer in the California Teachers Study. Breast Cancer Res Treat 18:62. doi:10.1186/s13058-016-0723-3 CrossRef

27.

Grundy A, Richardson H, Burstyn I, Lohrisch C, Sengupta SK, Lai AS et al (2013) Increased risk of breast cancer associated with long-term shift work in Canada. Occ Environ Med 70:831–838. doi:10.1136/oemed-2013-101482 CrossRef

28.

Kobayashi LC, Janssen I, Richardson H, Lai AS, Spinelli JJ, Aronson KJ (2013) Moderate-to-vigorous intensity physical activity across the life course and risk of pre- and post-menopausal breast cancer. Breast Cancer Res Treat 139:851–861. doi:10.1007/s10549-013-2569-9 CrossRefPubMed

29.

Friedenreich C, Courneya K, Bryant H (1998) The lifetime total physical activity questionnaire: development and reliability. Med Sci Sport Exerc 30:266–274CrossRef

30.

Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz ANNM, Strath SJ et al (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sport Exerc 32:S498–S516CrossRef

31.

Harris L, Fritsche H, Mennel R, Norton L, Ravdin P, Taube S et al (2007) American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol 25:5287–5312CrossRefPubMed

32.

Smigal C, Jemal A, Ward E, Cokkinides V, Smith R, Howe HL et al (2006) Trends in breast cancer by race and ethnicity: update 2006. CA Cancer J Clin 56:168–183CrossRefPubMed

33.

Mcpherson K, Steel CM, Dixon JM (2000) Breast cancer—epidemiology, risk factors, and genetics. BMJ 321:624–628CrossRefPubMedPubMedCentral

34.

Friedenreich CM (2011) Physical activity and breast cancer: review of the epidemiologic evidence and biological mechanisms. In: Senn H-J, Otto F (eds) Clinical cancer prevention. Springer, Berlin, pp 125–139

35.

Friedenreich CM, Neilson HK, Woolcott CG, Wang Q, Yasui Y, Brant RF et al (2011) Mediators and moderators of the effects of a year-long exercise intervention on endogenous sex hormones in postmenopausal women. Cancer Causes Control 11:1365–1373. doi:10.1007/s10552-011-9809-5 CrossRef

36.

Friedenreich C, Woolcott C, McTiernan A, Ballard-Barbash R, Brant R, Stanczyk F et al (2010) Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol 28:1458–1466. doi:10.1200/JCO.2009.24.9557 CrossRefPubMedPubMedCentral

37.

Friedenreich CM, Neilson HK, Woolcott CG, Wang Q, Stanczyk FZ, McTiernan A et al (2011) Inflammatory marker changes in a yearlong randomized exercise intervention trial among postmenopausal women. Cancer Prev Res 5:98–108. doi:10.1158/1940-6207.CAPR-11-0369 CrossRef

38.

Lynch BM, Friedenreich CM, Vallance JK, Eakin EG, Owen N (2011) Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003–2006). Breast Cancer Res Treat 130:183–194. doi:10.1007/s10549-011-1559-2 CrossRefPubMed

39.

Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB (2003) Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obesity 11:1055–1064CrossRef

40.

Friedenreich CM, Neilson HK, Woolcott CG, Mctiernan A, Wang Q, Ballard-Barbash R et al (2011) Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocr Relat Cancer 18:357–369. doi:10.1530/ERC-10-0303 CrossRefPubMedPubMedCentral

41.

Vona-Davis L, Rose DP (2007) Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer 14:189–206CrossRefPubMed

42.

Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436–444. doi:10.1038/nature07205 CrossRefPubMed

43.

Bruning PF, Bonfrèr JMG, van Noord PAH, Hart AAM, de Jong-Bakker M, Nooijen WJ (1992) Insulin resistance and breast cancer risk. Int J Cancer 52:511–516CrossRefPubMed

44.

Jin Q, Esteva F (2008) Cross-talk between the ErbB/HER family and the type i insulin-like growth factor receptor signaling pathway in breast cancer. J Mammary Gland Biol Neoplasia 13(4):485–498CrossRefPubMed

45.

Allen NE, Appleby PN, Kaaks R, Rinaldi S, Davey GK, Key TJ (2003) Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women. Cancer Causes Control 14:65–74CrossRefPubMed

46.

McTiernan A, Sorensen B, Yasui Y, Tworoger SS, Ulrich CM, Irwin ML et al (2005) No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol Biomark Prev 14:1020–1021CrossRef

47.

Ridley K, Olds T (2008) Assigning energy costs to activities in children: a review and synthesis. Med Sci Sports Exerc 40(8):1439CrossRefPubMed

Titel: Lifetime moderate-to-vigorous physical activity and ER/PR/HER-defined post-menopausal breast cancer risk
verfasst von: Joy Shi
Lindsay C. Kobayashi
Anne Grundy
Harriet Richardson
Sandip K. SenGupta
Caroline A. Lohrisch
John J. Spinelli
Kristan J. Aronson
Publikationsdatum: 06.06.2017
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 1/2017
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-017-4323-4

Springer Medizin

Lifetime moderate-to-vigorous physical activity and ER/PR/HER-defined post-menopausal breast cancer risk