Skip to main content
Erschienen in: Social Psychiatry and Psychiatric Epidemiology 9/2017

26.07.2017 | Original Paper

Low emotion-oriented coping and informal help-seeking behaviour as major predictive factors for improvement in major depression at 5-year follow-up in the adult community

verfasst von: S. Rodgers, C. L. Vandeleur, M.-P. F. Strippoli, E. Castelao, A. Tesic, J. Glaus, A. M. Lasserre, M. Müller, W. Rössler, V. Ajdacic-Gross, M. Preisig

Erschienen in: Social Psychiatry and Psychiatric Epidemiology | Ausgabe 9/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Given the broad range of biopsychosocial difficulties resulting from major depressive disorder (MDD), reliable evidence for predictors of improved mental health is essential, particularly from unbiased prospective community samples. Consequently, a broad spectrum of potential clinical and non-clinical predictors of improved mental health, defined as an absence of current major depressive episode (MDE) at follow-up, were examined over a 5-year period in an adult community sample.

Methods

The longitudinal population-based PsyCoLaus study from the city of Lausanne, Switzerland, was used. Subjects having a lifetime MDD with a current MDE at baseline assessment were selected, resulting in a subsample of 210 subjects. Logistic regressions were applied to the data.

Results

Coping styles were the most important predictive factors in the present study. More specifically, low emotion-oriented coping and informal help-seeking behaviour at baseline were associated with the absence of an MDD diagnosis at follow-up. Surprisingly, neither formal help-seeking behaviour, nor psychopharmacological treatment, nor childhood adversities, nor depression subtypes turned out to be relevant predictors in the current study.

Conclusions

The paramount role of coping styles as predictors of improvement in depression found in the present study might be a valuable target for resource-oriented therapeutic models. On the one hand, the positive impact of low emotion-oriented coping highlights the utility of clinical interventions interrupting excessive mental ruminations during MDE. On the other hand, the importance of informal social networks raises questions regarding how to enlarge the personal network of affected subjects and on how to best support informal caregivers.
Literatur
1.
Zurück zum Zitat Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, Dodel R, Ekman M, Faravelli C, Fratiglioni L, Gannon B, Jones DH, Jennum P, Jordanova A, Jonsson L, Karampampa K, Knapp M, Kobelt G, Kurth T, Lieb R, Linde M, Ljungcrantz C, Maercker A, Melin B, Moscarelli M, Musayev A, Norwood F, Preisig M, Pugliatti M, Rehm J, Salvador-Carulla L, Schlehofer B, Simon R, Steinhausen HC, Stovner LJ, Vallat JM, Van den Bergh P, van Os J, Vos P, Xu W, Wittchen HU, Jonsson B, Olesen J (2011) Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21(10):718–779. doi:10.1016/j.euroneuro.2011.08.008 PubMedCrossRef Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, Dodel R, Ekman M, Faravelli C, Fratiglioni L, Gannon B, Jones DH, Jennum P, Jordanova A, Jonsson L, Karampampa K, Knapp M, Kobelt G, Kurth T, Lieb R, Linde M, Ljungcrantz C, Maercker A, Melin B, Moscarelli M, Musayev A, Norwood F, Preisig M, Pugliatti M, Rehm J, Salvador-Carulla L, Schlehofer B, Simon R, Steinhausen HC, Stovner LJ, Vallat JM, Van den Bergh P, van Os J, Vos P, Xu W, Wittchen HU, Jonsson B, Olesen J (2011) Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21(10):718–779. doi:10.​1016/​j.​euroneuro.​2011.​08.​008 PubMedCrossRef
2.
Zurück zum Zitat Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS (2003) The epidemiology of major depressive disorder: results from the national comorbidity survey replication (NCS-R). JAMA 289(23):3095–3105. doi:10.1001/jama.289.23.3095 PubMedCrossRef Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS (2003) The epidemiology of major depressive disorder: results from the national comorbidity survey replication (NCS-R). JAMA 289(23):3095–3105. doi:10.​1001/​jama.​289.​23.​3095 PubMedCrossRef
4.
Zurück zum Zitat Keller MB, Shapiro RW, Lavori PW, Wolfe N (1982) Relapse in major depressive disorder: analysis with the life table. Arch Gen Psychiatry 39(8):911–915PubMedCrossRef Keller MB, Shapiro RW, Lavori PW, Wolfe N (1982) Relapse in major depressive disorder: analysis with the life table. Arch Gen Psychiatry 39(8):911–915PubMedCrossRef
5.
Zurück zum Zitat Kanai T, Takeuchi H, Furukawa TA, Yoshimura R, Imaizumi T, Kitamura T, Takahashi K (2003) Time to recurrence after recovery from major depressive episodes and its predictors. Psychol Med 33(5):839–845PubMedCrossRef Kanai T, Takeuchi H, Furukawa TA, Yoshimura R, Imaizumi T, Kitamura T, Takahashi K (2003) Time to recurrence after recovery from major depressive episodes and its predictors. Psychol Med 33(5):839–845PubMedCrossRef
6.
Zurück zum Zitat Lin EH, Katon WJ, VonKorff M, Russo JE, Simon GE, Bush TM, Rutter CM, Walker EA, Ludman E (1998) Relapse of depression in primary care. Rate and clinical predictors. Arch Fam Med 7(5):443–449PubMedCrossRef Lin EH, Katon WJ, VonKorff M, Russo JE, Simon GE, Bush TM, Rutter CM, Walker EA, Ludman E (1998) Relapse of depression in primary care. Rate and clinical predictors. Arch Fam Med 7(5):443–449PubMedCrossRef
7.
Zurück zum Zitat Judd LL, Paulus MJ, Schettler PJ, Akiskal HS, Endicott J, Leon AC, Maser JD, Mueller T, Solomon DA, Keller MB (2000) Does incomplete recovery from first lifetime major depressive episode herald a chronic course of illness? Am J Psychiatry 157(9):1501–1504. doi:10.1176/appi.ajp.157.9.1501 PubMedCrossRef Judd LL, Paulus MJ, Schettler PJ, Akiskal HS, Endicott J, Leon AC, Maser JD, Mueller T, Solomon DA, Keller MB (2000) Does incomplete recovery from first lifetime major depressive episode herald a chronic course of illness? Am J Psychiatry 157(9):1501–1504. doi:10.​1176/​appi.​ajp.​157.​9.​1501 PubMedCrossRef
9.
Zurück zum Zitat Weissman MM, Kasl SV (1976) Help-seeking in depressed out-patients following maintenance therapy. Br J Psychiatry 129:252–260PubMedCrossRef Weissman MM, Kasl SV (1976) Help-seeking in depressed out-patients following maintenance therapy. Br J Psychiatry 129:252–260PubMedCrossRef
10.
Zurück zum Zitat Angst J (1986) The course of major depression, atypical bipolar disorder, and bipolar disorder. In: Hippius H, Klerman GL, Matussek N (eds) New results in depression research. Springer, Berlin/Heidelberg, pp 26–35CrossRef Angst J (1986) The course of major depression, atypical bipolar disorder, and bipolar disorder. In: Hippius H, Klerman GL, Matussek N (eds) New results in depression research. Springer, Berlin/Heidelberg, pp 26–35CrossRef
11.
Zurück zum Zitat Mueller TI, Leon AC, Keller MB, Solomon DA, Endicott J, Coryell W, Warshaw M, Maser JD (1999) Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. Am J Psychiatry 156(7):1000–1006. doi:10.1176/ajp.156.7.1000 PubMed Mueller TI, Leon AC, Keller MB, Solomon DA, Endicott J, Coryell W, Warshaw M, Maser JD (1999) Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. Am J Psychiatry 156(7):1000–1006. doi:10.​1176/​ajp.​156.​7.​1000 PubMed
12.
Zurück zum Zitat Spijker J, de Graaf R, Bijl RV, Beekman AT, Ormel J, Nolen WA (2004) Determinants of persistence of major depressive episodes in the general population. Results from the Netherlands mental health survey and incidence study (NEMESIS). J Affect Disord 81(3):231–240. doi:10.1016/j.jad.2003.08.005 PubMedCrossRef Spijker J, de Graaf R, Bijl RV, Beekman AT, Ormel J, Nolen WA (2004) Determinants of persistence of major depressive episodes in the general population. Results from the Netherlands mental health survey and incidence study (NEMESIS). J Affect Disord 81(3):231–240. doi:10.​1016/​j.​jad.​2003.​08.​005 PubMedCrossRef
13.
Zurück zum Zitat Sargeant JK, Bruce ML, Florio LP, Weissman MM (1990) Factors associated with 1-year outcome of major depression in the community. Arch Gen Psychiatry 47(6):519–526PubMedCrossRef Sargeant JK, Bruce ML, Florio LP, Weissman MM (1990) Factors associated with 1-year outcome of major depression in the community. Arch Gen Psychiatry 47(6):519–526PubMedCrossRef
14.
Zurück zum Zitat Furukawa TA, Kitamura T, Takahashi K (2000) Time to recovery of an inception cohort with hitherto untreated unipolar major depressive episodes. Br J Psychiatry 177:331–335PubMedCrossRef Furukawa TA, Kitamura T, Takahashi K (2000) Time to recovery of an inception cohort with hitherto untreated unipolar major depressive episodes. Br J Psychiatry 177:331–335PubMedCrossRef
15.
Zurück zum Zitat De Raedt R, Koster EH (2010) Understanding vulnerability for depression from a cognitive neuroscience perspective: a reappraisal of attentional factors and a new conceptual framework. Cogn Affect Behav Neurosci 10(1):50–70. doi:10.3758/CABN.10.1.50 PubMedCrossRef De Raedt R, Koster EH (2010) Understanding vulnerability for depression from a cognitive neuroscience perspective: a reappraisal of attentional factors and a new conceptual framework. Cogn Affect Behav Neurosci 10(1):50–70. doi:10.​3758/​CABN.​10.​1.​50 PubMedCrossRef
17.
18.
20.
21.
Zurück zum Zitat Sotsky SM, Glass DR, Shea MT, Pilkonis PA, Collins JF, Elkin I, Watkins JT, Imber SD, Leber WR, Moyer J et al (1991) Patient predictors of response to psychotherapy and pharmacotherapy: findings in the NIMH treatment of depression collaborative research program. Am J Psychiatry 148(8):997–1008. doi:10.1176/ajp.148.8.997 PubMedCrossRef Sotsky SM, Glass DR, Shea MT, Pilkonis PA, Collins JF, Elkin I, Watkins JT, Imber SD, Leber WR, Moyer J et al (1991) Patient predictors of response to psychotherapy and pharmacotherapy: findings in the NIMH treatment of depression collaborative research program. Am J Psychiatry 148(8):997–1008. doi:10.​1176/​ajp.​148.​8.​997 PubMedCrossRef
22.
Zurück zum Zitat DeRubeis RJ, Gelfand LA, Tang TZ, Simons AD (1999) Medications versus cognitive behavior therapy for severely depressed outpatients: mega-analysis of four randomized comparisons. Am J Psychiatry 156(7):1007–1013. doi:10.1176/ajp.156.7.1007 PubMed DeRubeis RJ, Gelfand LA, Tang TZ, Simons AD (1999) Medications versus cognitive behavior therapy for severely depressed outpatients: mega-analysis of four randomized comparisons. Am J Psychiatry 156(7):1007–1013. doi:10.​1176/​ajp.​156.​7.​1007 PubMed
24.
Zurück zum Zitat Kendler KS, Eaves LJ, Walters EE, Neale MC, Heath AC, Kessler RC (1996) The identification and validation of distinct depressive syndromes in a population-based sample of female twins. Arch Gen Psychiatry 53(5):391–399PubMedCrossRef Kendler KS, Eaves LJ, Walters EE, Neale MC, Heath AC, Kessler RC (1996) The identification and validation of distinct depressive syndromes in a population-based sample of female twins. Arch Gen Psychiatry 53(5):391–399PubMedCrossRef
26.
Zurück zum Zitat Fuller-Thomson E, Battiston M, Gadalla TM, Brennenstuhl S (2014) Bouncing back: remission from depression in a 12-year panel study of a representative Canadian community sample. Soc Psychiatry Psychiatr Epidemiol 49(6):903–910. doi:10.1007/s00127-013-0814-8 PubMedCrossRef Fuller-Thomson E, Battiston M, Gadalla TM, Brennenstuhl S (2014) Bouncing back: remission from depression in a 12-year panel study of a representative Canadian community sample. Soc Psychiatry Psychiatr Epidemiol 49(6):903–910. doi:10.​1007/​s00127-013-0814-8 PubMedCrossRef
27.
Zurück zum Zitat Keller MB, Klerman GL, Lavori PW, Coryell W, Endicott J, Taylor J (1984) Long-term outcome of episodes of major depression. Clinical and public health significance. JAMA 252(6):788–792PubMedCrossRef Keller MB, Klerman GL, Lavori PW, Coryell W, Endicott J, Taylor J (1984) Long-term outcome of episodes of major depression. Clinical and public health significance. JAMA 252(6):788–792PubMedCrossRef
29.
30.
Zurück zum Zitat Garnefski N, Kraaij V, Spinhoven P (2001) Negative life events, cognitive emotion regulation and emotional problems. Personal Individ Differ 30:1311–1327CrossRef Garnefski N, Kraaij V, Spinhoven P (2001) Negative life events, cognitive emotion regulation and emotional problems. Personal Individ Differ 30:1311–1327CrossRef
31.
Zurück zum Zitat Ravindran AV, Griffiths J, Waddell C, Anisman H (1995) Stressful life events and coping styles in relation to dysthymia and major depressive disorder: variations associated with alleviation of symptoms following pharmacotherapy. Prog Neuropsychopharmacol Biol Psychiatry 19(4):637–653PubMedCrossRef Ravindran AV, Griffiths J, Waddell C, Anisman H (1995) Stressful life events and coping styles in relation to dysthymia and major depressive disorder: variations associated with alleviation of symptoms following pharmacotherapy. Prog Neuropsychopharmacol Biol Psychiatry 19(4):637–653PubMedCrossRef
32.
Zurück zum Zitat Endler NS, Parker JDA (1990) State and trait anxiety, depression and coping styles. Aust J Psychol 42(2):207–220CrossRef Endler NS, Parker JDA (1990) State and trait anxiety, depression and coping styles. Aust J Psychol 42(2):207–220CrossRef
33.
Zurück zum Zitat O’Brien TB, DeLongis A (1996) The interactional context of problem-, emotion-, and relationship-focused coping: the role of the big five personality factors. J Pers 64(4):775–813PubMedCrossRef O’Brien TB, DeLongis A (1996) The interactional context of problem-, emotion-, and relationship-focused coping: the role of the big five personality factors. J Pers 64(4):775–813PubMedCrossRef
34.
Zurück zum Zitat Rosenbaum S, Tiedemann A, Sherrington C, Curtis J, Ward PB (2014) Physical activity interventions for people with mental illness: a systematic review and meta-analysis. J Clin Psychiatry 75(9):964–974. doi:10.4088/JCP.13r08765 PubMedCrossRef Rosenbaum S, Tiedemann A, Sherrington C, Curtis J, Ward PB (2014) Physical activity interventions for people with mental illness: a systematic review and meta-analysis. J Clin Psychiatry 75(9):964–974. doi:10.​4088/​JCP.​13r08765 PubMedCrossRef
35.
Zurück zum Zitat Kaniasty K, Norris FH (2000) Help-seeking comfort and receiving social support: the role of ethnicity and context of need. Am J Community Psychol 28(4):545–581PubMedCrossRef Kaniasty K, Norris FH (2000) Help-seeking comfort and receiving social support: the role of ethnicity and context of need. Am J Community Psychol 28(4):545–581PubMedCrossRef
36.
Zurück zum Zitat Schomerus G, Matschinger H, Angermeyer MC (2009) Attitudes that determine willingness to seek psychiatric help for depression: a representative population survey applying the theory of planned behaviour. Psychol Med 39(11):1855–1865. doi:10.1017/S0033291709005832 PubMedCrossRef Schomerus G, Matschinger H, Angermeyer MC (2009) Attitudes that determine willingness to seek psychiatric help for depression: a representative population survey applying the theory of planned behaviour. Psychol Med 39(11):1855–1865. doi:10.​1017/​S003329170900583​2 PubMedCrossRef
37.
Zurück zum Zitat Wang PS, Angermeyer M, Borges G, Bruffaerts R, Tat Chiu W, Girolamo DEG, Fayyad J, Gureje O, Haro JM, Huang Y, Kessler RC, Kovess V, Levinson D, Nakane Y, Oakley Brown MA, Ormel JH, Posada-Villa J, Aguilar-Gaxiola S, Alonso J, Lee S, Heeringa S, Pennell BE, Chatterji S, Ustun TB (2007) Delay and failure in treatment seeking after first onset of mental disorders in the World Health Organization’s World mental health survey initiative. World Psychiatry 6(3):177–185PubMedPubMedCentral Wang PS, Angermeyer M, Borges G, Bruffaerts R, Tat Chiu W, Girolamo DEG, Fayyad J, Gureje O, Haro JM, Huang Y, Kessler RC, Kovess V, Levinson D, Nakane Y, Oakley Brown MA, Ormel JH, Posada-Villa J, Aguilar-Gaxiola S, Alonso J, Lee S, Heeringa S, Pennell BE, Chatterji S, Ustun TB (2007) Delay and failure in treatment seeking after first onset of mental disorders in the World Health Organization’s World mental health survey initiative. World Psychiatry 6(3):177–185PubMedPubMedCentral
38.
Zurück zum Zitat Andrews G, Sanderson K, Slade T, Issakidis C (2000) Why does the burden of disease persist? Relating the burden of anxiety and depression to effectiveness of treatment. Bull World Health Organ 78(4):446–454PubMedPubMedCentral Andrews G, Sanderson K, Slade T, Issakidis C (2000) Why does the burden of disease persist? Relating the burden of anxiety and depression to effectiveness of treatment. Bull World Health Organ 78(4):446–454PubMedPubMedCentral
41.
Zurück zum Zitat Brown J, Evans-Lacko S, Aschan L, Henderson MJ, Hatch SL, Hotopf M (2014) Seeking informal and formal help for mental health problems in the community: a secondary analysis from a psychiatric morbidity survey in South London. BMC Psychiatry 14(1):275PubMedPubMedCentralCrossRef Brown J, Evans-Lacko S, Aschan L, Henderson MJ, Hatch SL, Hotopf M (2014) Seeking informal and formal help for mental health problems in the community: a secondary analysis from a psychiatric morbidity survey in South London. BMC Psychiatry 14(1):275PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Bebbington PE, Meltzer H, Brugha TS, Farrell M, Jenkins R, Ceresa C, Lewis G (2000) Unequal access and unmet need: neurotic disorders and the use of primary care services. Psychol Med 30(6):1359–1367PubMedCrossRef Bebbington PE, Meltzer H, Brugha TS, Farrell M, Jenkins R, Ceresa C, Lewis G (2000) Unequal access and unmet need: neurotic disorders and the use of primary care services. Psychol Med 30(6):1359–1367PubMedCrossRef
43.
Zurück zum Zitat Mojtabai R, Olfson M, Sampson NA, Jin R, Druss B, Wang PS, Wells KB, Pincus HA, Kessler RC (2011) Barriers to mental health treatment: results from the national comorbidity survey replication. Psychol Med 41(8):1751–1761PubMedCrossRef Mojtabai R, Olfson M, Sampson NA, Jin R, Druss B, Wang PS, Wells KB, Pincus HA, Kessler RC (2011) Barriers to mental health treatment: results from the national comorbidity survey replication. Psychol Med 41(8):1751–1761PubMedCrossRef
44.
Zurück zum Zitat Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62(6):617–627PubMedPubMedCentralCrossRef Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62(6):617–627PubMedPubMedCentralCrossRef
45.
Zurück zum Zitat Baumeister H, Parker G (2012) Meta-review of depressive subtyping models. J Affect Disord 139:126–140CrossRef Baumeister H, Parker G (2012) Meta-review of depressive subtyping models. J Affect Disord 139:126–140CrossRef
46.
47.
Zurück zum Zitat Arnow BA, Blasey C, Williams LM, Palmer DM, Rekshan W, Schatzberg AF, Etkin A, Kulkarni J, Luther JF, Rush AJ (2015) Depression subtypes in predicting antidepressant response: a report from the iSPOT-D trial. Am J Psychiatry 172(8):743–750. doi:10.1176/appi.ajp.2015.14020181 PubMedCrossRef Arnow BA, Blasey C, Williams LM, Palmer DM, Rekshan W, Schatzberg AF, Etkin A, Kulkarni J, Luther JF, Rush AJ (2015) Depression subtypes in predicting antidepressant response: a report from the iSPOT-D trial. Am J Psychiatry 172(8):743–750. doi:10.​1176/​appi.​ajp.​2015.​14020181 PubMedCrossRef
48.
Zurück zum Zitat Uher R, Dernovsek MZ, Mors O, Hauser J, Souery D, Zobel A, Maier W, Henigsberg N, Kalember P, Rietschel M, Placentino A, Mendlewicz J, Aitchison KJ, McGuffin P, Farmer A (2011) Melancholic, atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline. J Affect Disord 132(1–2):112–120. doi:10.1016/j.jad.2011.02.014 PubMedCrossRef Uher R, Dernovsek MZ, Mors O, Hauser J, Souery D, Zobel A, Maier W, Henigsberg N, Kalember P, Rietschel M, Placentino A, Mendlewicz J, Aitchison KJ, McGuffin P, Farmer A (2011) Melancholic, atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline. J Affect Disord 132(1–2):112–120. doi:10.​1016/​j.​jad.​2011.​02.​014 PubMedCrossRef
51.
Zurück zum Zitat Firmann M, Mayor V, Vidal PM, Bochud M, Pecoud A, Hayoz D, Paccaud F, Preisig M, Song KS, Yuan X, Danoff TM, Stirnadel HA, Waterworth D, Mooser V, Waeber G, Vollenweider P (2008) The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord 8:6. doi:10.1186/1471-2261-8-6 PubMedPubMedCentralCrossRef Firmann M, Mayor V, Vidal PM, Bochud M, Pecoud A, Hayoz D, Paccaud F, Preisig M, Song KS, Yuan X, Danoff TM, Stirnadel HA, Waterworth D, Mooser V, Waeber G, Vollenweider P (2008) The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord 8:6. doi:10.​1186/​1471-2261-8-6 PubMedPubMedCentralCrossRef
52.
Zurück zum Zitat Preisig M, Waeber G, Vollenweider P, Bovet P, Rothen S, Vandeleur C, Guex P, Middleton L, Waterworth D, Mooser V, Tozzi F, Muglia P (2009) The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors. BMC Psychiatry 9:9. doi:10.1186/1471-244X-9-9 PubMedPubMedCentralCrossRef Preisig M, Waeber G, Vollenweider P, Bovet P, Rothen S, Vandeleur C, Guex P, Middleton L, Waterworth D, Mooser V, Tozzi F, Muglia P (2009) The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors. BMC Psychiatry 9:9. doi:10.​1186/​1471-244X-9-9 PubMedPubMedCentralCrossRef
53.
Zurück zum Zitat Preisig M, Fenton BT, Matthey ML, Berney A, Ferrero F (1999) Diagnostic interview for genetic studies (DIGS): inter-rater and test–retest reliability of the French version. Eur Arch Psychiatry Clin Neurosci 249(4):174–179PubMedCrossRef Preisig M, Fenton BT, Matthey ML, Berney A, Ferrero F (1999) Diagnostic interview for genetic studies (DIGS): inter-rater and test–retest reliability of the French version. Eur Arch Psychiatry Clin Neurosci 249(4):174–179PubMedCrossRef
54.
Zurück zum Zitat Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T (1994) Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH genetics initiative. Arch Gen Psychiatry 51(11):849–859 (discussion 863–844) PubMedCrossRef Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T (1994) Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH genetics initiative. Arch Gen Psychiatry 51(11):849–859 (discussion 863–844) PubMedCrossRef
55.
Zurück zum Zitat APA (2000) Diagnostic and statistical manual of mental disorders (text revision), 4th edn. American Psychiatric Association, Washington, DC APA (2000) Diagnostic and statistical manual of mental disorders (text revision), 4th edn. American Psychiatric Association, Washington, DC
56.
Zurück zum Zitat Endicott J, Spitzer RL (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35(7):837–844PubMedCrossRef Endicott J, Spitzer RL (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35(7):837–844PubMedCrossRef
57.
Zurück zum Zitat Leboyer M, Barbe B, Gorwood P, Teherani M, Allilaire JF, Preisig M, Matthey ML, Poyetton V, Ferrero F (1995) Interview diagnostique pour les etudes génétiques. INSERM, Paris Leboyer M, Barbe B, Gorwood P, Teherani M, Allilaire JF, Preisig M, Matthey ML, Poyetton V, Ferrero F (1995) Interview diagnostique pour les etudes génétiques. INSERM, Paris
58.
Zurück zum Zitat Berney A, Preisig M, Matthey ML, Ferrero F, Fenton BT (2002) Diagnostic interview for genetic studies (DIGS): inter-rater and test–retest reliability of alcohol and drug diagnoses. Drug Alcohol Depend 65(2):149–158PubMedCrossRef Berney A, Preisig M, Matthey ML, Ferrero F, Fenton BT (2002) Diagnostic interview for genetic studies (DIGS): inter-rater and test–retest reliability of alcohol and drug diagnoses. Drug Alcohol Depend 65(2):149–158PubMedCrossRef
59.
Zurück zum Zitat Rougemont-Buecking A, Rothen S, Jeanpretre N, Lustenberger Y, Vandeleur CL, Ferrero F, Preisig M (2008) Inter-informant agreement on diagnoses and prevalence estimates of anxiety disorders: direct interview versus family history method. Psychiatry Res 157(1–3):211–223. doi:10.1016/j.psychres.2006.04.022 PubMedCrossRef Rougemont-Buecking A, Rothen S, Jeanpretre N, Lustenberger Y, Vandeleur CL, Ferrero F, Preisig M (2008) Inter-informant agreement on diagnoses and prevalence estimates of anxiety disorders: direct interview versus family history method. Psychiatry Res 157(1–3):211–223. doi:10.​1016/​j.​psychres.​2006.​04.​022 PubMedCrossRef
60.
Zurück zum Zitat Leboyer M, Maier W, Teherani M, Lichtermann D, D’Amato T, Franke P, Lepine JP, Minges J, McGuffin P (1991) The reliability of the SADS-LA in a family study setting. Eur Arch Psychiatry Clin Neurosci 241(3):165–169PubMedCrossRef Leboyer M, Maier W, Teherani M, Lichtermann D, D’Amato T, Franke P, Lepine JP, Minges J, McGuffin P (1991) The reliability of the SADS-LA in a family study setting. Eur Arch Psychiatry Clin Neurosci 241(3):165–169PubMedCrossRef
61.
Zurück zum Zitat APA (2000) Practice guideline for the treatment of patients with major depressive disorder (revision). Am J Psychiatry 157:1–45CrossRef APA (2000) Practice guideline for the treatment of patients with major depressive disorder (revision). Am J Psychiatry 157:1–45CrossRef
62.
Zurück zum Zitat Glaus J, Vandeleur C, Gholam-Rezaee M, Castelao E, Perrin M, Rothen S, Bovet P, Marques-Vidal P, von Kanel R, Merikangas K, Mooser V, Waterworth DM, Waeber G, Vollenweider P, Preisig M (2013) Atypical depression and alcohol misuse are related to the cardiovascular risk in the general population. Acta Psychiatr Scand 128(4):282–293. doi:10.1111/acps.12057 PubMed Glaus J, Vandeleur C, Gholam-Rezaee M, Castelao E, Perrin M, Rothen S, Bovet P, Marques-Vidal P, von Kanel R, Merikangas K, Mooser V, Waterworth DM, Waeber G, Vollenweider P, Preisig M (2013) Atypical depression and alcohol misuse are related to the cardiovascular risk in the general population. Acta Psychiatr Scand 128(4):282–293. doi:10.​1111/​acps.​12057 PubMed
63.
Zurück zum Zitat Hollingshead AB (1975) Four factor index of social status. Yale University Press, New Haven Hollingshead AB (1975) Four factor index of social status. Yale University Press, New Haven
64.
Zurück zum Zitat Grob A, Bodmer N, Flammer A (1993) Living conditions and the development of adolescents in Europe: the case of Switzerland. Research Report (Nr. 5). Institute of Psychology. University of Berne, Switzerland Grob A, Bodmer N, Flammer A (1993) Living conditions and the development of adolescents in Europe: the case of Switzerland. Research Report (Nr. 5). Institute of Psychology. University of Berne, Switzerland
65.
Zurück zum Zitat Bodmer NM, Grob A (1996) Bien-être et contraintes d’adolescents: une comparaison entre adolescents de familles monoparentales et de familles biparentales. Int J Psychol 31:39–48CrossRef Bodmer NM, Grob A (1996) Bien-être et contraintes d’adolescents: une comparaison entre adolescents de familles monoparentales et de familles biparentales. Int J Psychol 31:39–48CrossRef
66.
Zurück zum Zitat Perrin M, Vandeleur CL, Castelao E, Rothen S, Glaus J, Vollenweider P, Preisig M (2014) Determinants of the development of post-traumatic stress disorder, in the general population. Soc Psychiatry Psychiatr Epidemiol 49(3):447–457. doi:10.1007/s00127-013-0762-3 PubMedCrossRef Perrin M, Vandeleur CL, Castelao E, Rothen S, Glaus J, Vollenweider P, Preisig M (2014) Determinants of the development of post-traumatic stress disorder, in the general population. Soc Psychiatry Psychiatr Epidemiol 49(3):447–457. doi:10.​1007/​s00127-013-0762-3 PubMedCrossRef
67.
Zurück zum Zitat Nelder JA, Wedderburn RWM (1972) Generalized linear models. J R Stat Soc Series A (General) 135(3):370–384CrossRef Nelder JA, Wedderburn RWM (1972) Generalized linear models. J R Stat Soc Series A (General) 135(3):370–384CrossRef
68.
Zurück zum Zitat Budtz-Jorgensen E, Keiding N, Grandjean P, Weihe P (2007) Confounder selection in environmental epidemiology: assessment of health effects of prenatal mercury exposure. Ann Epidemiol 17(1):27–35PubMedCrossRef Budtz-Jorgensen E, Keiding N, Grandjean P, Weihe P (2007) Confounder selection in environmental epidemiology: assessment of health effects of prenatal mercury exposure. Ann Epidemiol 17(1):27–35PubMedCrossRef
69.
Zurück zum Zitat Hosmer DW, Lemeshow S (2000) Applied logistic regression. Wiley, New YorkCrossRef Hosmer DW, Lemeshow S (2000) Applied logistic regression. Wiley, New YorkCrossRef
70.
Zurück zum Zitat Bhopal RS (2016) Concepts of epidemiology: integrating the ideas, theories, principles, and methods of epidemiology, 3rd edn. Oxford University Press, New YorkCrossRef Bhopal RS (2016) Concepts of epidemiology: integrating the ideas, theories, principles, and methods of epidemiology, 3rd edn. Oxford University Press, New YorkCrossRef
71.
Zurück zum Zitat Rothman KJ, Greenland S, Lash TL (2008) Modern epidemiology, 3rd edn. Lippincott Williams & Wilkins, Philadelphia Rothman KJ, Greenland S, Lash TL (2008) Modern epidemiology, 3rd edn. Lippincott Williams & Wilkins, Philadelphia
72.
Zurück zum Zitat Lorant V, Deliege D, Eaton W, Robert A, Philippot P, Ansseau M (2003) Socioeconomic inequalities in depression: a meta-analysis. Am J Epidemiol 157(2):98–112PubMedCrossRef Lorant V, Deliege D, Eaton W, Robert A, Philippot P, Ansseau M (2003) Socioeconomic inequalities in depression: a meta-analysis. Am J Epidemiol 157(2):98–112PubMedCrossRef
74.
Zurück zum Zitat Nolen-Hoeksema S, Morrow J (1993) Effects of rumination and distraction on naturally occurring depressed mood. Cogn Emot 7:561–570CrossRef Nolen-Hoeksema S, Morrow J (1993) Effects of rumination and distraction on naturally occurring depressed mood. Cogn Emot 7:561–570CrossRef
75.
Zurück zum Zitat Nolen-Hoeksema S (2000) The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. J Abnorm Psychol 109(3):504–511PubMedCrossRef Nolen-Hoeksema S (2000) The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. J Abnorm Psychol 109(3):504–511PubMedCrossRef
76.
Zurück zum Zitat Lyubomirsky S, Nolen-Hoeksema S (1993) Self-perpetuating properties of dysphoric rumination. J Pers Soc Psychol 65(2):339–349PubMedCrossRef Lyubomirsky S, Nolen-Hoeksema S (1993) Self-perpetuating properties of dysphoric rumination. J Pers Soc Psychol 65(2):339–349PubMedCrossRef
79.
Zurück zum Zitat Roy-Byrne PP, Vitaliano PP, Cowley DS, Luciano G, Zheng Y, Dunner DL (1992) Coping in panic and major depressive disorder. Relative effects of symptom severity and diagnostic comorbidity. J Nerv Ment Dis 180(3):179–183PubMedCrossRef Roy-Byrne PP, Vitaliano PP, Cowley DS, Luciano G, Zheng Y, Dunner DL (1992) Coping in panic and major depressive disorder. Relative effects of symptom severity and diagnostic comorbidity. J Nerv Ment Dis 180(3):179–183PubMedCrossRef
80.
Zurück zum Zitat Beck AT (1967) Depression: clinical, experimental, and theoretical aspects. Harper & Row, New York Beck AT (1967) Depression: clinical, experimental, and theoretical aspects. Harper & Row, New York
82.
Zurück zum Zitat Jorm AF, Griffiths KM (2006) Population promotion of informal self-help strategies for early intervention against depression and anxiety. Psychol Med 36(1):3–6PubMedCrossRef Jorm AF, Griffiths KM (2006) Population promotion of informal self-help strategies for early intervention against depression and anxiety. Psychol Med 36(1):3–6PubMedCrossRef
83.
Zurück zum Zitat Jorm AF, Griffiths KM, Christensen H, Parslow RA, Rogers B (2004) Actions taken to cope with depression at different levels of severity: a community survey. Psychol Med 34(2):293–299PubMedCrossRef Jorm AF, Griffiths KM, Christensen H, Parslow RA, Rogers B (2004) Actions taken to cope with depression at different levels of severity: a community survey. Psychol Med 34(2):293–299PubMedCrossRef
84.
Zurück zum Zitat Barker C, Pistrang N, Shapiro DA, Shaw I (1990) Coping and help-seeking in the UK adult population. Br J Clin Psychol 29(Pt 3):271–285PubMedCrossRef Barker C, Pistrang N, Shapiro DA, Shaw I (1990) Coping and help-seeking in the UK adult population. Br J Clin Psychol 29(Pt 3):271–285PubMedCrossRef
86.
Zurück zum Zitat Clement S, Schauman O, Graham T, Maggioni F, Evans-Lacko S, Bezborodovs N, Morgan C, Rusch N, Brown JS, Thornicroft G (2015) What is the impact of mental health-related stigma on help-seeking? A systematic review of quantitative and qualitative studies. Psychol Med 45(1):11–27. doi:10.1017/S0033291714000129 PubMedCrossRef Clement S, Schauman O, Graham T, Maggioni F, Evans-Lacko S, Bezborodovs N, Morgan C, Rusch N, Brown JS, Thornicroft G (2015) What is the impact of mental health-related stigma on help-seeking? A systematic review of quantitative and qualitative studies. Psychol Med 45(1):11–27. doi:10.​1017/​S003329171400012​9 PubMedCrossRef
89.
Zurück zum Zitat Kleinman A, Eisenberg L, Good B (1978) Culture, illness, and care: clinical lessons from anthropologic and cross-cultural research. Ann Intern Med 88(2):251–258PubMedCrossRef Kleinman A, Eisenberg L, Good B (1978) Culture, illness, and care: clinical lessons from anthropologic and cross-cultural research. Ann Intern Med 88(2):251–258PubMedCrossRef
91.
Zurück zum Zitat Kirsch I (1990) Changing expectations: a keyto effectivepsychotherapy. Brooks/Cole, Pacific Grove Kirsch I (1990) Changing expectations: a keyto effectivepsychotherapy. Brooks/Cole, Pacific Grove
92.
Zurück zum Zitat Kirsch IE (1999) How expectancies shape experience. American Psychological Association, Washington, DCCrossRef Kirsch IE (1999) How expectancies shape experience. American Psychological Association, Washington, DCCrossRef
93.
Zurück zum Zitat Mischel W, Shoda Y (1994) Personality psychology has two goals: must it be two fields? Psychol Inquiry 5:156–158CrossRef Mischel W, Shoda Y (1994) Personality psychology has two goals: must it be two fields? Psychol Inquiry 5:156–158CrossRef
94.
Zurück zum Zitat Catanzaro SJ, Wasch HH, Kirsch I, Mearns J (2000) Coping-related expectancies and dispositions as prospective predictors of coping responses and symptoms. J Pers 68(4):757–788PubMedCrossRef Catanzaro SJ, Wasch HH, Kirsch I, Mearns J (2000) Coping-related expectancies and dispositions as prospective predictors of coping responses and symptoms. J Pers 68(4):757–788PubMedCrossRef
97.
Zurück zum Zitat Fox KR (1999) The influence of physical activity on mental well-being. Public Health Nutr 2(3A):411–418PubMedCrossRef Fox KR (1999) The influence of physical activity on mental well-being. Public Health Nutr 2(3A):411–418PubMedCrossRef
101.
Zurück zum Zitat Krogh J, Nordentoft M, Sterne JA, Lawlor DA (2011) The effect of exercise in clinically depressed adults: systematic review and meta-analysis of randomized controlled trials. J Clin Psychiatry 72(4):529–538. doi:10.4088/JCP.08r04913blu PubMedCrossRef Krogh J, Nordentoft M, Sterne JA, Lawlor DA (2011) The effect of exercise in clinically depressed adults: systematic review and meta-analysis of randomized controlled trials. J Clin Psychiatry 72(4):529–538. doi:10.​4088/​JCP.​08r04913blu PubMedCrossRef
102.
Zurück zum Zitat Angst J, Gamma A, Benazzi F, Ajdacic V, Rossler W (2007) Melancholia and atypical depression in the Zurich study: epidemiology, clinical characteristics, course, comorbidity and personality. Acta Psychiatr Scand 115(Suppl 433):72–84. doi:10.1111/j.1600-0447.2007.00965.x CrossRef Angst J, Gamma A, Benazzi F, Ajdacic V, Rossler W (2007) Melancholia and atypical depression in the Zurich study: epidemiology, clinical characteristics, course, comorbidity and personality. Acta Psychiatr Scand 115(Suppl 433):72–84. doi:10.​1111/​j.​1600-0447.​2007.​00965.​x CrossRef
103.
Zurück zum Zitat Stewart JW, McGrath PJ, Fava M, Wisniewski SR, Zisook S, Cook I, Nierenberg AA, Trivedi MH, Balasubramani GK, Warden D, Lesser I, John Rush A (2010) Do atypical features affect outcome in depressed outpatients treated with citalopram? Int J Neuropsychopharmacol 13(1):15–30. doi:10.1017/S1461145709000182 PubMedCrossRef Stewart JW, McGrath PJ, Fava M, Wisniewski SR, Zisook S, Cook I, Nierenberg AA, Trivedi MH, Balasubramani GK, Warden D, Lesser I, John Rush A (2010) Do atypical features affect outcome in depressed outpatients treated with citalopram? Int J Neuropsychopharmacol 13(1):15–30. doi:10.​1017/​S146114570900018​2 PubMedCrossRef
104.
Zurück zum Zitat Lasserre AM, Glaus J, Vandeleur CL, Marques-Vidal P, Vaucher J, Bastardot F, Waeber G, Vollenweider P, Preisig M (2014) Depression with atypical features and increase in obesity, body mass index, waist circumference, and fat mass: a prospective, population-based study. JAMA Psychiatry 71(8):880–888. doi:10.1001/jamapsychiatry.2014.411 PubMedCrossRef Lasserre AM, Glaus J, Vandeleur CL, Marques-Vidal P, Vaucher J, Bastardot F, Waeber G, Vollenweider P, Preisig M (2014) Depression with atypical features and increase in obesity, body mass index, waist circumference, and fat mass: a prospective, population-based study. JAMA Psychiatry 71(8):880–888. doi:10.​1001/​jamapsychiatry.​2014.​411 PubMedCrossRef
105.
Zurück zum Zitat Lasserre AM, Strippoli MF, Glaus J, Gholam-Rezaee M, Vandeleur CL, Castelao E, Marques-Vidal P, Waeber G, Vollenweider P, Preisig M (2017) Prospective associations of depression subtypes with cardio-metabolic risk factors in the general population. Mol Psychiatry 22(7):1026–1034. doi:10.1038/mp.2016.178 PubMedCrossRef Lasserre AM, Strippoli MF, Glaus J, Gholam-Rezaee M, Vandeleur CL, Castelao E, Marques-Vidal P, Waeber G, Vollenweider P, Preisig M (2017) Prospective associations of depression subtypes with cardio-metabolic risk factors in the general population. Mol Psychiatry 22(7):1026–1034. doi:10.​1038/​mp.​2016.​178 PubMedCrossRef
106.
Zurück zum Zitat Undurraga J, Baldessarini RJ (2012) Randomized, placebo-controlled trials of antidepressants for acute major depression: thirty-year meta-analytic review. Neuropsychopharmacology 37(4):851–864PubMedCrossRef Undurraga J, Baldessarini RJ (2012) Randomized, placebo-controlled trials of antidepressants for acute major depression: thirty-year meta-analytic review. Neuropsychopharmacology 37(4):851–864PubMedCrossRef
107.
Zurück zum Zitat Frank E, Prien RF, Jarrett RB, Keller MB, Kupfer DJ, Lavori PW, Rush AJ, Weissman MM (1991) Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry 48(9):851–855PubMedCrossRef Frank E, Prien RF, Jarrett RB, Keller MB, Kupfer DJ, Lavori PW, Rush AJ, Weissman MM (1991) Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry 48(9):851–855PubMedCrossRef
108.
Zurück zum Zitat Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62(6):593–602. doi:10.1001/archpsyc.62.6.593 PubMedCrossRef Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62(6):593–602. doi:10.​1001/​archpsyc.​62.​6.​593 PubMedCrossRef
110.
Zurück zum Zitat Santini ZI, Koyanagi A, Tyrovolas S, Mason C, Haro JM (2015) The association between social relationships and depression: a systematic review. J Affect Disord 175:53–65PubMedCrossRef Santini ZI, Koyanagi A, Tyrovolas S, Mason C, Haro JM (2015) The association between social relationships and depression: a systematic review. J Affect Disord 175:53–65PubMedCrossRef
111.
Zurück zum Zitat Aldao A, Nolen-Hoeksema S (2010) Specificity of cognitive emotion regulation strategies: a transdiagnostic examination. Behav Res Ther 48(10):974–983PubMedCrossRef Aldao A, Nolen-Hoeksema S (2010) Specificity of cognitive emotion regulation strategies: a transdiagnostic examination. Behav Res Ther 48(10):974–983PubMedCrossRef
112.
Zurück zum Zitat Robinson MD, Clore GL (2002) Episodic and semantic knowledge in emotional self-report: evidence for two judgment processes. J Pers Soc Psychol 83(1):198–215PubMedCrossRef Robinson MD, Clore GL (2002) Episodic and semantic knowledge in emotional self-report: evidence for two judgment processes. J Pers Soc Psychol 83(1):198–215PubMedCrossRef
Metadaten
Titel
Low emotion-oriented coping and informal help-seeking behaviour as major predictive factors for improvement in major depression at 5-year follow-up in the adult community
verfasst von
S. Rodgers
C. L. Vandeleur
M.-P. F. Strippoli
E. Castelao
A. Tesic
J. Glaus
A. M. Lasserre
M. Müller
W. Rössler
V. Ajdacic-Gross
M. Preisig
Publikationsdatum
26.07.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Social Psychiatry and Psychiatric Epidemiology / Ausgabe 9/2017
Print ISSN: 0933-7954
Elektronische ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-017-1421-x

Weitere Artikel der Ausgabe 9/2017

Social Psychiatry and Psychiatric Epidemiology 9/2017 Zur Ausgabe

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

ADHS-Medikation erhöht das kardiovaskuläre Risiko

16.05.2024 Herzinsuffizienz Nachrichten

Erwachsene, die Medikamente gegen das Aufmerksamkeitsdefizit-Hyperaktivitätssyndrom einnehmen, laufen offenbar erhöhte Gefahr, an Herzschwäche zu erkranken oder einen Schlaganfall zu erleiden. Es scheint eine Dosis-Wirkungs-Beziehung zu bestehen.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Typ-2-Diabetes und Depression folgen oft aufeinander

14.05.2024 Typ-2-Diabetes Nachrichten

Menschen mit Typ-2-Diabetes sind überdurchschnittlich gefährdet, in den nächsten Jahren auch noch eine Depression zu entwickeln – und umgekehrt. Besonders ausgeprägt ist die Wechselbeziehung laut GKV-Daten bei jüngeren Erwachsenen.

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.