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Experimental Brain Research

Erschienen in:

01.07.2005 | Research Article

Decreased anxiety levels related to aging

verfasst von: Meritxell Torras-Garcia, David Costa-Miserachs, Margalida Coll-Andreu, Isabel Portell-Cortés

Erschienen in: Experimental Brain Research | Ausgabe 2/2005

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Abstract

The present experiment investigated the effects of aging on emotional behavior, without concomitant influences from any previous behavioral manipulation apart from weighing the rats. Anxiety-related behaviors were measured in the elevated plus-maze (EPM). Performance in the open field (OF) was also assessed to control for any effect of aging on exploratory behavior that could account for changes in emotional behavior. Fifty-two naïve male Wistar rats of 3 (3MO), 17 (17MO), or 24 (24MO) months, were submitted to two sessions (5 min each) of EPM, followed by two sessions (2 min each) of OF, on 4 consecutive days. The main emotional indices (open arm entries, ratio of open arm entries to total entries, time spent in open arms, ratio of time in open arms to time in four arms, open arm ends, and head dips) measured in the EPM indicated a lower level of anxiety in aged (24MO) than in young (3MO) rats, whereas middle-aged (17MO) rats showed intermediate values between those of 3MO and 24MO rats; 3MO rats showed higher general motor activity (number of rearings in closed arms of EPM and in OF, and higher number of areas crossed in OF) than 17MO and 24MO rats. We conclude that aging is associated with a decrease in anxiety and in general motor activity.

Adamec RE, Sayin U, Brown A (1991) The effects of corticotrophin releasing-factor (CRF) and handling stress on behavior in the elevated plus-maze test of anxiety. J Psychopharmacol 5:175–186

Aldavert-Vera L, Costa-Miserachs D, Massanés-Rotger E, Soriano-Mas C, Segura-Torres P, Morgado-Bernal I (1997) Facilitation of distributed shuttle-box conditioning with posttraining intracranial self-stimulation in old rats. Neurobiol Learn Mem 67:254–258

Bertoglio LJ, Carobrez AP (2002) Behavioral profile of rats submitted to session 1-session 2 in the elevated plus-maze during diurnal/nocturnal phases and under different illumination conditions. Behav Brain Res 132:135–143

Boguszewski P, Zagrodzka J (2002) Emotional changes related to age in rats—a behavioral analysis. Behav Brain Res 133:323–332

Brett RR, Pratt JA (1990) Chronic handling modifies the anxiolytic effect of diazepam in the elevated plus-maze. Eur J Pharmacol 178:135–138

Choleris E, Thomas AW, Kavaliers M, Prato FS (2001) A detailed ethological analysis of the mouse open field test: effect of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field. Neurosci Biobehav Rev 25:235–260

Cizza G, Pacak K, Kvetnansky R, Palkovits M, Goldstein DS, Brady LS, Fukuhara K, Bergamini E, Kopin IJ, Blackman MR, Chrousos GP, Gold PW (1995) Decreased stress responsivity of central and peripheral catecholaminergic systems in aged 344/N Fischer rats. J Clin Invest 95:1217–1224

Darwish M, Korányi L, Nyakas C, Almeida OFX (2001) Exposure to a novel stimulus reduces anxiety level in adult and aging rats. Physiol Behav 72:403–407

File SE, Zangrossi H Jr, Viana M, Graeff FG (1993) Trial 2 in the elevated plus-maze: a different form of fear? Psychopharmacology 111:491–494

Gage FH, Dunnett SB, Bjorklund A (1984) Spatial learning and motor deficits in aged rats. Neurobiol Aging 5:43–48

Genn RF, Tucci SA, Thomas A, Edwards JE, File SE (2003) Age-associated sex differences in response to food deprivation in two animal tests of anxiety. Neurosci Biobehav Rev 27:155–161

Gilad GM, Li R, Wyatt RJ, Tizabi Y (1993) Effects of genotype on age-related alterations in the concentrations of stress hormones in plasma and hypothalamic monoamines in rats. J Reprod Fertil Suppl 46:119–130

Hauger RL, Thrivikraman KV, Plotsky PM (1994) Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats. Endocrinology 134:1528–1536

Herman JP, Larson BR, Speert DB, Seasholtz AF (2001) Hypothalamo-pituitary-adrenocortical dysregulation in aging F344/Brown-Norway F1 hybrid rats. Neurobiol Aging 22:323–332

Homs-Ormo S, Coll-Andreu M, Satorra-Marín N, Arévalo-García R, Morgado-Bernal I (2003) Effects of pedunculopontine tegmental nucleus lesions on emotional reactivity and locomotion in rats. Brain Res Bull 59:495–503

Kawano S, Ohmori S, Kambe F, Kanda K, Murata Y, Seo H (1995) Catecholamine response to stress: age related modifications in tail-suspended rats. Environ Med 39:107–111

Leal AMO, Moreira AC (1997) Daily variation of plasma testosterone, androsterone, and corticoesterone in rats under food restriction. Horm Behav 31:97–100

Lee JJ, Chang CK, Liu IM, Chi TC, Yu HJ, Cheng JT (2001) Changes in endogenous monoamines in aged rats. Clin Exp Pharmacol Physiol 28:285–289

Li S-C, Dinse HR (2002) Aging of the brain, sensoriomotor, and cognitive processes. Neurosci Biobehav Rev 26:729–732

Mabry TR, Gold PE, McCarty R (1995a) Age-related changes in plasma catecholamine responses to acute swim stress. Neurobiol Learn Mem 63:260–268

Mabry TR, Gold PE, McCarty R (1995b) Age-related changes in plasma catecholamine responses to chronic intermittent stress. Neurobiol Learn Mem 58:49–56

McCarty R, Pacak K, Goldstein DS, Eisenhofer, G (1997) Regulation of peripheral catecholamine response to acute stress in young adult and aged F-344 rats. Stress 2:113–122

Miyagawa H, Hasegawa M, Fukuta T, Amano M, Yamada K, Toshitaka N (1998) Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged rats. Behav Brain Res 91:73–81

Molon-Noblot S, Laroque P, Coleman JB, Hoe CM, Keenan KP (2003) The effects of ad libitum overfeeding and moderate and marked dietary restriction on age-related spontaneous pituitary gland pathology in Sprague-Dawley rats. Toxicol Pathol 31:310–320

Nagahara AH, Handa RJ (1997) Age-related changes in c-fos mRNA induction after open-field exposure in the rat brain. Neurobiol Aging 18:45–55

Pellow S, Chopin P, File SE, Briley M (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149–167

Pisarska M, Mulchahey JJ, Welge JA, Geracioti TD Jr, Kasckow JW (2000) Age-related alterations in emotional behaviors and amygdalar corticotrophin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats. Brain Res 877:184–190

Ramos A, Mormède P (1988) Stress and emotionality: a multidimensional and genetic approach. Neurosci Biobehav Rev 22:33–57

Rebouças RC, Schmidek WR (1997) Handling and isolation in three strains of rats affect open field, exploration, hoarding and predation. Physiol Behav 62:1159–1164

Rodgers RJ, Dalvi A (1997) Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev 21:801–810

Rowe WB, Steverman A, Walker M, Sharma S, Barden N, Seckl JR, Meany Mj (1997) Antidepressants restore hypothalamic-pituitary-adrenal feedback function in aged, cognitively-impaired rats. Neurobiol Aging 18: 527–533

Rowe WB, Spreekmeester E, Meaney MJ, Quirion R, Rochford J (1998) Reactivity to novelty in cognitively-impaired and cognitively-unimpaired aged rats and young rats. Neuroscience 83:669–680

Sprott RL (1997) Diet and calorie restriction. Exp Gerontol 32:205–214

Torras-Garcia M, Costa-Miserachs D, Morgado-Bernal I, Portell-Cortés I (2003) Improvement of shuttle-box performance by anterodorsal medial septal lesions in rats. Behav Brain Res 141:147–158

Treit D, Menard J, Royan C (1993) Anxiogenic stimuli in the elevated plus-maze. Pharmacol Biochem Behav 44:463–469

Van Eekelen JA, Rots NY, Sutanto W, de Kloet ER (1992) The effect of aging on stress responsiveness and central corticosteroid receptors in the Norway rat. Neurobiol Aging 13:159–170

Wall PM, Messier C (2001) Methodological and conceptual issues in the use of the elevated plus-maze as a psychological measurement instrument of animal anxiety-like behavior. Neurosci Biobehav Rev 25:275–286

Wang C, Weindruch R, Fernández JR, Coffey CS, Patel P, Allison DB (2004) Caloric restriction and body weight independently affect longevity in Wistar rats. Int J Obes 28:357–362

Titel: Decreased anxiety levels related to aging
verfasst von: Meritxell Torras-Garcia
David Costa-Miserachs
Margalida Coll-Andreu
Isabel Portell-Cortés
Publikationsdatum: 01.07.2005
Verlag: Springer-Verlag
Erschienen in: Experimental Brain Research / Ausgabe 2/2005
Print ISSN: 0014-4819
Elektronische ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-005-2240-y

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