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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.12.2012 | Original Article

Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus ¹⁸F-FDG PET

verfasst von: Tobias A. Fuchs, Jelena R. Ghadri, Julia Stehli, Catherine Gebhard, Egle Kazakauskaite, Bernd Klaeser, Oliver Gaemperli, Michael Fiechter, Philipp A. Kaufmann

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 12/2012

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Abstract

Purpose

The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue.

Methods

Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, apical, septal, lateral and inferior myocardium and CT density was measured in Hounsfield units (HU). Findings were compared to ¹⁸F-fluorodeoxyglucose uptake by positron emission tomography (FDG PET), which served as the standard of reference to distinguish scar (<50 % FDG uptake) from viable tissue (≥50 % uptake).

Results

Visually detected hypodense regions demonstrated a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 74, 97, 84 and 94 %, respectively. A receiver-operating characteristic (ROC) curve analysis revealed a cutoff value of mean HU at <28.8 for predicting scar tissue with an area under the curve of 0.93 yielding a sensitivity, specificity, PPV and NPV of 94, 90, 67 and 99 %, respectively.

Conclusion

Hypodense regions in unenhanced cardiac CT scans allow accurate identification of nonviable myocardial scar tissue.

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Titel: Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET
verfasst von: Tobias A. Fuchs
Jelena R. Ghadri
Julia Stehli
Catherine Gebhard
Egle Kazakauskaite
Bernd Klaeser
Oliver Gaemperli
Michael Fiechter
Philipp A. Kaufmann
Publikationsdatum: 01.12.2012
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 12/2012
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2212-y

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Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus ¹⁸F-FDG PET

Abstract

Purpose

Methods

Results

Conclusion

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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