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CardioVascular and Interventional Radiology

Erschienen in:

01.04.2012 | Laboratory Investigation

Angiography in the Isolated Perfused Kidney: Radiological Evaluation of Vascular Protection in Tissue Ablation by Nonthermal Irreversible Electroporation

verfasst von: Johann Jakob Wendler, Maciej Pech, Simon Blaschke, Markus Porsch, Andreas Janitzky, Matthias Ulrich, Oliver Dudeck, Jens Ricke, Uwe-Bernd Liehr

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 2/2012

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Abstract

Purpose

The nonthermal irreversible electroporation (NTIRE) is a novel nonthermal tissue ablation technique by local application of high-voltage current within microseconds leading to a delayed apoptosis. The purpose of this experimental study was the first angiographic evaluation of the acute damage of renal vascular structure in NTIRE.

Methods

Results of conventional dynamic digital substraction angiography (DSA) and visualization of the terminal vascular bed of renal parenchyma by high-resolution X-ray in mammography technique were evaluated before, during, and after NTIRE of three isolated perfused porcine ex vivo kidneys.

Results

In the dedicated investigation, no acute vascular destruction of the renal parenchyma and no dysfunction of the kidney perfusion model were observed during or after NTIRE. Conspicuous were concentric wave-like fluctuations of the DSA contrast agent simultaneous to the NTIRE pulses resulting from NTIRE pulse shock wave.

Conclusion

The NTIRE offers an ablation method with no acute collateral vascular damage in angiographic evaluation.

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Titel: Angiography in the Isolated Perfused Kidney: Radiological Evaluation of Vascular Protection in Tissue Ablation by Nonthermal Irreversible Electroporation
verfasst von: Johann Jakob Wendler
Maciej Pech
Simon Blaschke
Markus Porsch
Andreas Janitzky
Matthias Ulrich
Oliver Dudeck
Jens Ricke
Uwe-Bernd Liehr
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: CardioVascular and Interventional Radiology / Ausgabe 2/2012
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-011-0187-x

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Angiography in the Isolated Perfused Kidney: Radiological Evaluation of Vascular Protection in Tissue Ablation by Nonthermal Irreversible Electroporation