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European Radiology

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01.08.2013 | Gastrointestinal

Liver fat volume fraction quantification with fat and water T₁ and T₂* estimation and accounting for NMR multiple components in patients with chronic liver disease at 1.5 and 3.0 T

verfasst von: Benjamin Leporq, Hélène Ratiney, Frank Pilleul, Olivier Beuf

Erschienen in: European Radiology | Ausgabe 8/2013

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Abstract

Objective

To validate a magnitude-based method for fat volume fraction (FVF) quantification in the liver without any dominant component ambiguity problems and with the aim of transferring this method to any imaging system (clinical fields of 1.5 and 3.0 T).

Methods

MR imaging was performed at 1.5 and 3.0 T using a multiple-angle multiple-gradient echo sequence. A quantification algorithm correcting for relaxation time effects using a disjointed estimation of T₁ and T₂* of fat and water and accounting for the NMR spectrum of fat was developed. Validations were performed on fat–water emulsion at 1.5 and 3.0 T and compared with ¹H-MRS. This was followed by a prospective in-vivo comparative study on 28 patients with chronic liver disease and included histology.

Results

Phantom study showed good agreement between MRI and MRS. MR-estimated FVF and histological results correlated strongly and FVF allowed the diagnosis of mild (cutoff = 5.5 %) and moderate steatosis (cutoff = 15.2 %) with a sensitivity/specificity of 100 %.

Conclusion

FVF calculation worked independently of the field strength. FVF may be a relevant biomarker for the clinical follow-up of patients (1) with or at risk of NAFLD (2) of steatosis in patients with other chronic liver diseases.

Key points

• Non-invasive techniques to diagnose non-alcoholic fatty liver diseases (NAFLD) are important.

• Liver fat volume fraction quantified using MRI correlates well with histology.

• Fat volume fraction could be a relevant marker for NAFLD clinical follow-up.

• Disjointed relaxation time estimation could potentially identify factors contributing to NAFLD.

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Titel: Liver fat volume fraction quantification with fat and water T1 and T2* estimation and accounting for NMR multiple components in patients with chronic liver disease at 1.5 and 3.0 T
verfasst von: Benjamin Leporq
Hélène Ratiney
Frank Pilleul
Olivier Beuf
Publikationsdatum: 01.08.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 8/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-013-2826-x

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Liver fat volume fraction quantification with fat and water T₁ and T₂* estimation and accounting for NMR multiple components in patients with chronic liver disease at 1.5 and 3.0 T

Abstract

Objective

Methods

Results

Conclusion

Key points

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