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European Radiology

Erschienen in:

22.09.2015 | Head and Neck

Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours

verfasst von: Ji Xiong, Wenli Tan, Jianbo Wen, Jiawei Pan, Yin Wang, Jun Zhang, Daoying Geng

Erschienen in: European Radiology | Ausgabe 6/2016

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Abstract

Objectives

To explore the correlations of conventional MRI (cMRI) and diffusion tensor imaging (DTI) values with the 1p/19 codeletion and IDH mutations in oligodendroglial tumours (OTs).

Methods

Eighty-four patients with OTs who underwent cMRI and DTI were retrospectively reviewed. The maximal fractional anisotropy and minimal apparent diffusion coefficient (ADC) were measured and compared using the Mann-Whitney U test. Receiver operating characteristic curves, logistic regression analysis and four-table statistics analysis were performed to predict genotypings.

Results

OTs with 1p/19q codeletion or IDH mutations were prone to locate in frontal (P = 0.106 and 0.005, respectively) and insular lobes and were associated with absent or blurry contrast enhancement (P = 0.040 and 0.013, respectively). DTI values showed significant differences between OTs with and without IDH mutations (P < 0.05) but not in OTs with and without 1p/19q loss. The Ki-67 index significantly correlated with IDH mutations (P = 0.002) but not with 1p/19q codeletion. A combination of DTI and cMRI for the identification of IDH mutations resulted in sensitivity, specificity, positive and negative predictive values of 92.2 %, 75.8 %, 93.8 % and 71.1 %, respectively.

Conclusions

Combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in OTs.

Key Points

• OTs with 1p/19q codeletion were associated with absent or blurry contrast enhancement

• OTs with IDH mutations were also associated with absent or blurry contrast enhancement

• OTs with IDH mutations were prone to locate in frontal and insular lobes

• DTI values can provide a non-invasive method for assessing the IDH status of OTs

• A combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations

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Titel: Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours
verfasst von: Ji Xiong
Wenli Tan
Jianbo Wen
Jiawei Pan
Yin Wang
Jun Zhang
Daoying Geng
Publikationsdatum: 22.09.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-4025-4

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Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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