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Erschienen in: European Radiology 7/2016

01.10.2015 | Interventional

Safety and Clinical Effectiveness of Percutaneous Vertebroplasty in the Elderly (≥80 years)

verfasst von: Frédéric Clarençon, Robert Fahed, Joseph Gabrieli, Yessine Guermazi, Evelyne Cormier, Luc Molet-Benhamou, Betty Jean, Sabrina Dadoun, Michèle Rose, Lise Le Jean, Jacques Chiras

Erschienen in: European Radiology | Ausgabe 7/2016

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Abstract

Purpose

To evaluate the safety and clinical effectiveness of percutaneous vertebroplasty (PVP) in patients aged 80 and over.

Methods

One hundred and seventy-three patients (127 women, 46 men; mean age = 84.2y) underwent 201 PVP procedures (391 vertebrae) in our institution from June 2008 to March 2012. One hundred and twenty-six patients (73 %) had osteoporotic vertebral compression fractures (VCF), 36 (20.5 %) were treated for tumour lesions, and the remaining 11 (6.5 %) for lesions from another cause. Comorbidities and American Society of Anesthesiologists (ASA) scores were assessed before treatment. Periprocedural and delayed complications were systematically recorded. A qualitative scale was used to evaluate pain relief at 1-month follow-up, ranging from significant pain worsening to marked improvement or disappearance. New fracture occurrence was assessed on follow-up imaging.

Results

Forty-five percent of patients had pretreatment ASA class scores ≥3. No major complication occurred. Pain was unchanged in 16.9 % of cases, mildly improved in 31.5 %, and disappeared in 47.8 %. We identified 27 (11 %) symptomatic new VCFs in patients with osteoporosis on follow-up imaging. The mean delay in diagnosis of new fractures was 5 ± 8.7 months.

Conclusions

Even in the elderly, PVP remains a safe and effective technique for pain relief, independently of the underlying disease.

Key Points

Post-PVP pain improvement was observed in 79.3 % of elderly patients.
PVP remains a safe technique in elderly patients.
No decompensation of comorbidity was observed in our series.
Literatur
1.
Zurück zum Zitat Galibert P, Deramond H, Rosat P, Le Gars D (1987) Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 33:166–168PubMed Galibert P, Deramond H, Rosat P, Le Gars D (1987) Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 33:166–168PubMed
2.
Zurück zum Zitat Kallmes DF, Comstock BA, Heagerty PJ et al (2009) A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med 361:569–579CrossRefPubMedPubMedCentral Kallmes DF, Comstock BA, Heagerty PJ et al (2009) A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med 361:569–579CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat McGirt MJ, Parker SL, Wolinsky JP, Witham TF, Bydon A, Gokaslan ZL (2009) Vertebroplasty and kyphoplasty for the treatment of vertebral compression fractures: an evidenced-based review of the literature. Spine J 9:501–508CrossRefPubMed McGirt MJ, Parker SL, Wolinsky JP, Witham TF, Bydon A, Gokaslan ZL (2009) Vertebroplasty and kyphoplasty for the treatment of vertebral compression fractures: an evidenced-based review of the literature. Spine J 9:501–508CrossRefPubMed
4.
Zurück zum Zitat Klazen CA, Lohle PN, de Vries J et al (2010) Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet 376:1085–1092CrossRefPubMed Klazen CA, Lohle PN, de Vries J et al (2010) Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet 376:1085–1092CrossRefPubMed
5.
Zurück zum Zitat Masala S, Mammucari M, Angelopoulos G et al (2009) Percutaneous vertebroplasty in the management of vertebral osteoporotic fractures. Short-term, mid-term and long-term follow-up of 285 patients. Skelet Radiol 38:863–869CrossRef Masala S, Mammucari M, Angelopoulos G et al (2009) Percutaneous vertebroplasty in the management of vertebral osteoporotic fractures. Short-term, mid-term and long-term follow-up of 285 patients. Skelet Radiol 38:863–869CrossRef
6.
Zurück zum Zitat Weill A, Chiras J, Simon JM, Rose M, Sola-Martinez T, Enkaoua E (1996) Spinal metastases: indications for and results of percutaneous injection of acrylic surgical cement. Radiology 199:241–247CrossRefPubMed Weill A, Chiras J, Simon JM, Rose M, Sola-Martinez T, Enkaoua E (1996) Spinal metastases: indications for and results of percutaneous injection of acrylic surgical cement. Radiology 199:241–247CrossRefPubMed
7.
Zurück zum Zitat Cotten A, Dewatre F, Cortet B et al (1996) Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up. Radiology 200:525–530CrossRefPubMed Cotten A, Dewatre F, Cortet B et al (1996) Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up. Radiology 200:525–530CrossRefPubMed
8.
Zurück zum Zitat Brodano GB, Amendola L, Martikos K et al (2011) Vertebroplasty: benefits are more than risks in selected and evidence-based informed patients. A retrospective study of 59 cases. Eur Spine J 20:1265–1271CrossRefPubMedPubMedCentral Brodano GB, Amendola L, Martikos K et al (2011) Vertebroplasty: benefits are more than risks in selected and evidence-based informed patients. A retrospective study of 59 cases. Eur Spine J 20:1265–1271CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Mont'Alverne F, Vallee JN, Cormier E et al (2005) Percutaneous vertebroplasty for metastatic involvement of the axis. AJNR Am J Neuroradiol 26:1641–1645PubMed Mont'Alverne F, Vallee JN, Cormier E et al (2005) Percutaneous vertebroplasty for metastatic involvement of the axis. AJNR Am J Neuroradiol 26:1641–1645PubMed
10.
Zurück zum Zitat Martin JB, Wetzel SG, Seium Y et al (2003) Percutaneous vertebroplasty in metastatic disease: transpedicular access and treatment of lysed pedicles--initial experience. Radiology 229:593–597CrossRefPubMed Martin JB, Wetzel SG, Seium Y et al (2003) Percutaneous vertebroplasty in metastatic disease: transpedicular access and treatment of lysed pedicles--initial experience. Radiology 229:593–597CrossRefPubMed
11.
Zurück zum Zitat Fourney DR, Schomer DF, Nader R et al (2003) Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg 98:21–30CrossRefPubMed Fourney DR, Schomer DF, Nader R et al (2003) Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg 98:21–30CrossRefPubMed
12.
Zurück zum Zitat Chow E, Holden L, Danjoux C et al (2004) Successful salvage using percutaneous vertebroplasty in cancer patients with painful spinal metastases or osteoporotic compression fractures. Radiother Oncol 70:265–267CrossRefPubMed Chow E, Holden L, Danjoux C et al (2004) Successful salvage using percutaneous vertebroplasty in cancer patients with painful spinal metastases or osteoporotic compression fractures. Radiother Oncol 70:265–267CrossRefPubMed
13.
Zurück zum Zitat Cohen JE, Lylyk P, Ceratto R, Kaplan L, Umanskyt F, Gomori JM (2004) Percutaneous vertebroplasty: technique and results in 192 procedures. Neurol Res 26:41–49CrossRefPubMed Cohen JE, Lylyk P, Ceratto R, Kaplan L, Umanskyt F, Gomori JM (2004) Percutaneous vertebroplasty: technique and results in 192 procedures. Neurol Res 26:41–49CrossRefPubMed
14.
Zurück zum Zitat Pereira LP, Clarencon F, Cormier E et al (2013) Safety and effectiveness of percutaneous sacroplasty: a single-centre experience in 58 consecutive patients with tumours or osteoporotic insufficient fractures treated under fluoroscopic guidance. Eur Radiol 23:2764–2772CrossRefPubMed Pereira LP, Clarencon F, Cormier E et al (2013) Safety and effectiveness of percutaneous sacroplasty: a single-centre experience in 58 consecutive patients with tumours or osteoporotic insufficient fractures treated under fluoroscopic guidance. Eur Radiol 23:2764–2772CrossRefPubMed
15.
Zurück zum Zitat Freitas SS, Barrett-Connor E, Ensrud KE et al (2008) Rate and circumstances of clinical vertebral fractures in older men. Osteoporos Int 19:615–623CrossRefPubMed Freitas SS, Barrett-Connor E, Ensrud KE et al (2008) Rate and circumstances of clinical vertebral fractures in older men. Osteoporos Int 19:615–623CrossRefPubMed
16.
Zurück zum Zitat Anselmetti GC, Marcia S, Saba L et al (2012) Percutaneous vertebroplasty: multi-centric results from EVEREST experience in large cohort of patients. Eur J Radiol 81:4083–4086CrossRefPubMed Anselmetti GC, Marcia S, Saba L et al (2012) Percutaneous vertebroplasty: multi-centric results from EVEREST experience in large cohort of patients. Eur J Radiol 81:4083–4086CrossRefPubMed
17.
Zurück zum Zitat Wilson DJ, Owen S, Corkill RA (2013) Coblation vertebroplasty for complex vertebral insufficiency fractures. Eur Radiol 23:1785–1790CrossRefPubMed Wilson DJ, Owen S, Corkill RA (2013) Coblation vertebroplasty for complex vertebral insufficiency fractures. Eur Radiol 23:1785–1790CrossRefPubMed
18.
Zurück zum Zitat Liu XW, Jin P, Wang LJ, Li M, Sun G (2013) Vertebroplasty in the treatment of symptomatic vertebral haemangiomas without neurological deficit. Eur Radiol 23:2575–2581CrossRefPubMed Liu XW, Jin P, Wang LJ, Li M, Sun G (2013) Vertebroplasty in the treatment of symptomatic vertebral haemangiomas without neurological deficit. Eur Radiol 23:2575–2581CrossRefPubMed
19.
Zurück zum Zitat Fahed R, Clarencon F, Riouallon G et al (2014) Just a drop of cement: a case of cervical spine bone aneurysmal cyst successfully treated by percutaneous injection of a small amount of polymethyl-methacrylate cement. J Neurointerv Surg. doi:10.1136/neurintsurg-2014-011541.rep Fahed R, Clarencon F, Riouallon G et al (2014) Just a drop of cement: a case of cervical spine bone aneurysmal cyst successfully treated by percutaneous injection of a small amount of polymethyl-methacrylate cement. J Neurointerv Surg. doi:10.​1136/​neurintsurg-2014-011541.​rep
20.
Zurück zum Zitat DePalma MJ, Ketchum JM, Frankel BM, Frey ME (2011) Percutaneous vertebroplasty for osteoporotic vertebral compression fractures in the nonagenarians: a prospective study evaluating pain reduction and new symptomatic fracture rate. Spine (Phila Pa 1976) 36:277–282CrossRef DePalma MJ, Ketchum JM, Frankel BM, Frey ME (2011) Percutaneous vertebroplasty for osteoporotic vertebral compression fractures in the nonagenarians: a prospective study evaluating pain reduction and new symptomatic fracture rate. Spine (Phila Pa 1976) 36:277–282CrossRef
21.
Zurück zum Zitat Cahana A, Seium Y, Diby M, Martin JB, Ruefenacht D, Dietrich PY (2005) Percutaneous vertebroplasty in octogenarians: results and follow-up. Pain Pract 5:316–323CrossRefPubMed Cahana A, Seium Y, Diby M, Martin JB, Ruefenacht D, Dietrich PY (2005) Percutaneous vertebroplasty in octogenarians: results and follow-up. Pain Pract 5:316–323CrossRefPubMed
22.
Zurück zum Zitat Potet J, Weber-Donat G, Curis E et al (2013) Incidence of pulmonary cement embolism after real-time CT fluoroscopy-guided vertebroplasty. J Vasc Interv Radiol 24:1853–1860CrossRefPubMed Potet J, Weber-Donat G, Curis E et al (2013) Incidence of pulmonary cement embolism after real-time CT fluoroscopy-guided vertebroplasty. J Vasc Interv Radiol 24:1853–1860CrossRefPubMed
23.
Zurück zum Zitat Cosar M, Sasani M, Oktenoglu T et al (2009) The major complications of transpedicular vertebroplasty. J Neurosurg Spine 11:607–613CrossRefPubMed Cosar M, Sasani M, Oktenoglu T et al (2009) The major complications of transpedicular vertebroplasty. J Neurosurg Spine 11:607–613CrossRefPubMed
24.
Zurück zum Zitat Monticelli F, Meyer HJ, Tutsch-Bauer E (2005) Fatal pulmonary cement embolism following percutaneous vertebroplasty (PVP). Forensic Sci Int 149:35–38CrossRefPubMed Monticelli F, Meyer HJ, Tutsch-Bauer E (2005) Fatal pulmonary cement embolism following percutaneous vertebroplasty (PVP). Forensic Sci Int 149:35–38CrossRefPubMed
25.
Zurück zum Zitat Syed MI, Jan S, Patel NA, Shaikh A, Marsh RA, Stewart RV (2006) Fatal fat embolism after vertebroplasty: identification of the high-risk patient. AJNR Am J Neuroradiol 27:343–345PubMed Syed MI, Jan S, Patel NA, Shaikh A, Marsh RA, Stewart RV (2006) Fatal fat embolism after vertebroplasty: identification of the high-risk patient. AJNR Am J Neuroradiol 27:343–345PubMed
26.
Zurück zum Zitat Syed MI, Patel NA, Jan S, Harron MS, Morar K, Shaikh A (2005) New symptomatic vertebral compression fractures within a year following vertebroplasty in osteoporotic women. AJNR Am J Neuroradiol 26:1601–1604PubMed Syed MI, Patel NA, Jan S, Harron MS, Morar K, Shaikh A (2005) New symptomatic vertebral compression fractures within a year following vertebroplasty in osteoporotic women. AJNR Am J Neuroradiol 26:1601–1604PubMed
27.
Zurück zum Zitat Ahrar K (2004) The role and limitations of radiofrequency ablation in treatment of bone and soft tissue tumors. Curr Oncol Rep 6:315–320CrossRefPubMed Ahrar K (2004) The role and limitations of radiofrequency ablation in treatment of bone and soft tissue tumors. Curr Oncol Rep 6:315–320CrossRefPubMed
28.
Zurück zum Zitat Klazen CA, Venmans A, de Vries J et al (2010) Percutaneous vertebroplasty is not a risk factor for new osteoporotic compression fractures: results from VERTOS II. AJNR Am J Neuroradiol 31:1447–1450CrossRefPubMed Klazen CA, Venmans A, de Vries J et al (2010) Percutaneous vertebroplasty is not a risk factor for new osteoporotic compression fractures: results from VERTOS II. AJNR Am J Neuroradiol 31:1447–1450CrossRefPubMed
29.
Zurück zum Zitat Anselmetti GC, Manca A, Hirsch J et al (2011) Percutaneous vertebroplasty in osteoporotic patients: an institutional experience of 1,634 patients with long-term follow-up. J Vasc Interv Radiol 22:1714–1720CrossRefPubMed Anselmetti GC, Manca A, Hirsch J et al (2011) Percutaneous vertebroplasty in osteoporotic patients: an institutional experience of 1,634 patients with long-term follow-up. J Vasc Interv Radiol 22:1714–1720CrossRefPubMed
30.
Zurück zum Zitat Masala S, Magrini A, Taglieri A et al (2014) Chronic obstructive pulmonary disease (COPD) patients with osteoporotic vertebral compression fractures (OVCFs): improvement of pulmonary function after percutaneous vertebroplasty (VTP). Eur Radiol 24:1577–1585CrossRefPubMed Masala S, Magrini A, Taglieri A et al (2014) Chronic obstructive pulmonary disease (COPD) patients with osteoporotic vertebral compression fractures (OVCFs): improvement of pulmonary function after percutaneous vertebroplasty (VTP). Eur Radiol 24:1577–1585CrossRefPubMed
Metadaten
Titel
Safety and Clinical Effectiveness of Percutaneous Vertebroplasty in the Elderly (≥80 years)
verfasst von
Frédéric Clarençon
Robert Fahed
Joseph Gabrieli
Yessine Guermazi
Evelyne Cormier
Luc Molet-Benhamou
Betty Jean
Sabrina Dadoun
Michèle Rose
Lise Le Jean
Jacques Chiras
Publikationsdatum
01.10.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 7/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-4035-2

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