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European Radiology

Erschienen in:

29.09.2017 | Computed Tomography

Prognostic value of coronary atherosclerosis progression evaluated by coronary CT angiography in patients with stable angina

verfasst von: Hui Gu, Yang Gao, Zhihui Hou, U. Joseph Schoepf, Alan N. Snyder, Taylor M. Duguay, Ximing Wang, Bin Lu

Erschienen in: European Radiology | Ausgabe 3/2018

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Abstract

Objectives

To investigate the progression of coronary atherosclerosis burden by coronary CT angiography (CCTA) and to demonstrate its association with the incidence of major adverse cardiac events (MACE).

Methods

We retrospectively studied patients with stable angina who had undergone repeat CCTA due to recurrent or worsening symptoms. Lipid-rich, fibrous, calcified and total plaque burden as well as coronary diameter stenosis were quantitatively analysed. The incidence of MACE during follow-up was determined.

Results

The final cohort consisted of 268 patients (mean age 52.9 ± 9.8 years, 71 % male) with a mean follow-up period of 4.6 ± 0.9 years. Patients with lipid-rich, fibrous, calcified and total plaque burden (%) progression, as well as coronary diameter stenosis (%) progression had a significantly higher incidence of MACE than those without (all p < 0.05). The progression of lipid-rich plaque (HR = 1.601, p = 0.021), total plaque burden (HR = 2.979, p = 0.043) and coronary diameter stenosis (HR = 4.327, p <0.001) were independent predictors of MACE (all p < 0.05).

Conclusions

Patients presenting with recurrent or worsening symptoms associated with coronary artery disease who have coronary atherosclerosis progression on CCTA are at an increased risk of future MACE.

Key Points

• Repeat CCTA can provide information regarding the progression of coronary atherosclerosis.

• Coronary atherosclerosis progression at CCTA is independently associated with MACE.

• CCTA findings could serve as incremental predictors of MACE.

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Titel: Prognostic value of coronary atherosclerosis progression evaluated by coronary CT angiography in patients with stable angina
verfasst von: Hui Gu
Yang Gao
Zhihui Hou
U. Joseph Schoepf
Alan N. Snyder
Taylor M. Duguay
Ximing Wang
Bin Lu
Publikationsdatum: 29.09.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 3/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5073-8

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Prognostic value of coronary atherosclerosis progression evaluated by coronary CT angiography in patients with stable angina