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World Journal of Urology
Erschienen in: World Journal of Urology 10/2019

22.11.2018 | Topic Paper

Diagnostic biomarkers in non-muscle invasive bladder cancer

verfasst von: Izak Faiena, Charles J. Rosser, Karim Chamie, Hideki Furuya

Erschienen in: World Journal of Urology | Ausgabe 10/2019

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Abstract

Successful treatment of non-muscle invasive bladder cancer (NMIBC) relies heavily on our ability to accurately detect disease typically in the presence of hematuria as well as to detect the early recurrent tumors in patients with a history of NMIBC. Unfortunately, the current biomarker landscape for NMIBC is a work in progress. Cystoscopy continues to be the gold standard, but can still miss 10% of tumors. Therefore, physicians frequently use additional tools to aid in the diagnosis of bladder cancer, such as urinary cytology. The urinary cytology is a good option for high-grade disease; however, it is limited by low sensitivity in detecting low-grade disease, as well as variable interpretation among cytopathologists. Thus, the limitations of cystoscopy and urinary cytology have brought to light the need for more robust diagnostic assays. In this non-systematic review, we discuss the performance, potential advantages or disadvantages of these tests, and the future direction of biomarkers in NMIBC.
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Metadaten
Titel
Diagnostic biomarkers in non-muscle invasive bladder cancer
verfasst von
Izak Faiena
Charles J. Rosser
Karim Chamie
Hideki Furuya
Publikationsdatum
22.11.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
World Journal of Urology / Ausgabe 10/2019
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-018-2567-1

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