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Erschienen in: Clinical Research in Cardiology 4/2017

25.11.2016 | Original Paper

The wearable cardioverter-defibrillator in a real-world clinical setting: experience in 102 consecutive patients

verfasst von: Julia W. Erath, Mate Vamos, Abdul Sami Sirat, Stefan H. Hohnloser

Erschienen in: Clinical Research in Cardiology | Ausgabe 4/2017

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Abstract

Background

The wearable cardioverter-defibrillator (WCD) is used for temporary protection of patients deemed to be at high risk for sudden death (SCD) not yet meeting indications for the implantable defibrillator (ICD).

Objectives

To evaluate the efficacy, safety, and compliance of/to WCD use and subsequent medium-term outcome of patients in a single-center observational study.

Methods

A total of 102 consecutive patients were fitted with the WCD from 2012 to 2015 and followed for a mean of 11 months (±8 months).

Results

The most common clinical indication for WCD-prescription (63%) was a new diagnosis of severely impaired LV function (LVEF ≤35%). The median wear time of the WCD was 54 days with a daily use of 23 h. Appropriate WCD therapy occurred in four patients (seven shocks for VF, one shock for VT). An ICD was finally implanted in 56 patients (55%). Improvement in LV function was the most common reason not to implant an ICD (HR 0.37; 95% CI 0.19–0.73; p = 0.004). Two patients had inappropriate shocks from their WCD due to atrial fibrillation/flutter. Five patients fitted with an ICD after the end of WCD therapy suffered VT/VF episodes. After wearing the WCD, six patients died (five ICD recipients and one non-ICD recipient).

Conclusion

WCD therapy was well accepted by patients and provided temporary protection against ventricular tachyarrhythmias in patients at risk for SCD. The WCD may help to avoid unnecessary ICD implantations in a significant proportion of patients.
Literatur
1.
Zurück zum Zitat Martens E, Sinner MF, Siebermair J, Raufhake C, Beckmann BM, Veith S, Düvel D, Steinbeck G, Kääb S (2014) Incidence of sudden cardiac death in Germany. Results from an emergency medical service registry in Lower Saxony. Europace 12:369–381 Martens E, Sinner MF, Siebermair J, Raufhake C, Beckmann BM, Veith S, Düvel D, Steinbeck G, Kääb S (2014) Incidence of sudden cardiac death in Germany. Results from an emergency medical service registry in Lower Saxony. Europace 12:369–381
2.
Zurück zum Zitat Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, Daubert JP, Higgins SL, Brown MW, Andrews ML, Multicenter Automatic Defibrillator Implantation Trail II Investigators (2002) Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 346:877–883CrossRefPubMed Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, Daubert JP, Higgins SL, Brown MW, Andrews ML, Multicenter Automatic Defibrillator Implantation Trail II Investigators (2002) Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 346:877–883CrossRefPubMed
3.
Zurück zum Zitat Moss AJ, Brown MW, Cannom DS, Daubert JP, Estes M, Foster E, Greenberg HM, Hall WJ, Higgins SL, Klein H, Pfeffer M, Wilber D, Zareba W (2005) Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol. Ann Noninvasive Electrocardiol 10:34–43CrossRefPubMed Moss AJ, Brown MW, Cannom DS, Daubert JP, Estes M, Foster E, Greenberg HM, Hall WJ, Higgins SL, Klein H, Pfeffer M, Wilber D, Zareba W (2005) Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol. Ann Noninvasive Electrocardiol 10:34–43CrossRefPubMed
4.
Zurück zum Zitat Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, Domanski M, Troutman C, Anderson J, Johnson G, McNulty SE, Clapp-Channing N, Davidson-Ray LD, Fraulo ES, Fishbein DP, Luceri RM, Sudden Ip JH, Death in Heart Failure Trail (SCD-HeFT) Investigators (2005) Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352:225–237CrossRefPubMed Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, Domanski M, Troutman C, Anderson J, Johnson G, McNulty SE, Clapp-Channing N, Davidson-Ray LD, Fraulo ES, Fishbein DP, Luceri RM, Sudden Ip JH, Death in Heart Failure Trail (SCD-HeFT) Investigators (2005) Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352:225–237CrossRefPubMed
5.
Zurück zum Zitat Moss AJ, Schuger C, Beck C, Brown MW, Cannom DS, Daubert JP, Estes NA 3rd, Greenberg H, Hall WJ, Huang DT, Kautzner J, Klein H, McNitt S, Olshansky B, Shoda M, Wilber D, Zareba W, MADIT-RIT Trial Investigators (2012) Reduction in appropriate therapy and mortality through ICD programming. N Engl J Med 367:2275–2283CrossRefPubMed Moss AJ, Schuger C, Beck C, Brown MW, Cannom DS, Daubert JP, Estes NA 3rd, Greenberg H, Hall WJ, Huang DT, Kautzner J, Klein H, McNitt S, Olshansky B, Shoda M, Wilber D, Zareba W, MADIT-RIT Trial Investigators (2012) Reduction in appropriate therapy and mortality through ICD programming. N Engl J Med 367:2275–2283CrossRefPubMed
6.
Zurück zum Zitat Klein HU, Goldenberg I, Moss AJ (2013) Risk stratification for implantable cardioverter defibrillator therapy: the role of the wearable cardioverter-defibrillator. Eur Heart J 34:2230–2242CrossRefPubMed Klein HU, Goldenberg I, Moss AJ (2013) Risk stratification for implantable cardioverter defibrillator therapy: the role of the wearable cardioverter-defibrillator. Eur Heart J 34:2230–2242CrossRefPubMed
7.
Zurück zum Zitat Chung MK, Szymkiewicz SJ, Shao M, Zishiri E, Niebauer MJ, Lindsay BD, Tchou PJ (2010) Aggregate national experience with the wearable cardioverter-defibrillator: event rates, compliance, and survival. JACC 56(3):194–203CrossRefPubMedPubMedCentral Chung MK, Szymkiewicz SJ, Shao M, Zishiri E, Niebauer MJ, Lindsay BD, Tchou PJ (2010) Aggregate national experience with the wearable cardioverter-defibrillator: event rates, compliance, and survival. JACC 56(3):194–203CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Kutiyfa V, Moss AJ, Klein H, Biton Y, McNitt S, MacKecknie B, Zareba W, Goldenberg I (2015) Use of the wearable cardioverter defibrillator in high-risk cardiac patients. Data from the prospective registry of patients using the wearable cardioverter defibrillator (WEARIT-II Registry). Circulation 132:1613–1619CrossRef Kutiyfa V, Moss AJ, Klein H, Biton Y, McNitt S, MacKecknie B, Zareba W, Goldenberg I (2015) Use of the wearable cardioverter defibrillator in high-risk cardiac patients. Data from the prospective registry of patients using the wearable cardioverter defibrillator (WEARIT-II Registry). Circulation 132:1613–1619CrossRef
9.
Zurück zum Zitat Epstein AE, Abraham WT, Bianco NR, Kern KB, Mirro M, Rao SV, Rhee EK, Solomon SD, Szymkiewicz SJ (2013) Wearable cardioverter-defibrillator use in patients perceived to be at high risk early post-myocardial infarction. JACC 62:2000–2007CrossRefPubMed Epstein AE, Abraham WT, Bianco NR, Kern KB, Mirro M, Rao SV, Rhee EK, Solomon SD, Szymkiewicz SJ (2013) Wearable cardioverter-defibrillator use in patients perceived to be at high risk early post-myocardial infarction. JACC 62:2000–2007CrossRefPubMed
10.
Zurück zum Zitat Zishiri ET, Williams S, Cronin EM, Blackstone EH, Ellis SG, Roselli EE, Smedira NG, Gillinov AM, Glad JA, Tchou PJ, Szymkiewicz SJ, Chung MK (2013) Early risk of mortality after coronary artery revascularization in patients with left ventricular dysfunction and potential role of the wearable cardioverter-defibrillator. Circ Arrhythm Electrophysiol 6:117–128CrossRefPubMed Zishiri ET, Williams S, Cronin EM, Blackstone EH, Ellis SG, Roselli EE, Smedira NG, Gillinov AM, Glad JA, Tchou PJ, Szymkiewicz SJ, Chung MK (2013) Early risk of mortality after coronary artery revascularization in patients with left ventricular dysfunction and potential role of the wearable cardioverter-defibrillator. Circ Arrhythm Electrophysiol 6:117–128CrossRefPubMed
11.
Zurück zum Zitat Wäßnig NK, Günther M, Quick S, Pfluecke C, Rottstädt F, Szymkiewicz SJ, Ringquist S, Strasser RH, Speiser U (2016) Experience with the wearable cardioverter-defibrillator in patients at high risk for sudden cardiac death. Circulation 134:635–643CrossRefPubMedPubMedCentral Wäßnig NK, Günther M, Quick S, Pfluecke C, Rottstädt F, Szymkiewicz SJ, Ringquist S, Strasser RH, Speiser U (2016) Experience with the wearable cardioverter-defibrillator in patients at high risk for sudden cardiac death. Circulation 134:635–643CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Prutkin JM, Bao H, Curtis JP, Al-Khatib SM, Aggarwal S, Uslan DZ (2014) Factors associated with infection in 200.909 Medicare implantable cardioverter defibrillator implants: results from the National Cardiovascular Registry. Circulation 130:1037–1043CrossRefPubMed Prutkin JM, Bao H, Curtis JP, Al-Khatib SM, Aggarwal S, Uslan DZ (2014) Factors associated with infection in 200.909 Medicare implantable cardioverter defibrillator implants: results from the National Cardiovascular Registry. Circulation 130:1037–1043CrossRefPubMed
13.
Zurück zum Zitat Auricchio A, Klein H, Geller CJ, Reek S, Heilman MS, Szymkiewicz SJ (1998) Clinical efficacy of the wearable cardioverter-defibrillator in acutely terminating episodes of ventricular fibrillation. Am J Cardiol 81:1253–1256CrossRefPubMed Auricchio A, Klein H, Geller CJ, Reek S, Heilman MS, Szymkiewicz SJ (1998) Clinical efficacy of the wearable cardioverter-defibrillator in acutely terminating episodes of ventricular fibrillation. Am J Cardiol 81:1253–1256CrossRefPubMed
14.
Zurück zum Zitat Feldman AM, Klein H, Tchou P, Murali S, Hall WJ, Mancini D, Boehmer J, Harvey M, Heilman MS, Szymkiewicz SJ, Moss AJ, WEARIT Investigators and Coordinators, BIROAD Investigators and Coordinators (2004) Use of a wearable defibrillator in terminating tachyarrhythmias in patients at high risk for sudden death: results of the WEARIT/BIROAD. Pacing Clin Electrophysiol 27:4–9CrossRefPubMed Feldman AM, Klein H, Tchou P, Murali S, Hall WJ, Mancini D, Boehmer J, Harvey M, Heilman MS, Szymkiewicz SJ, Moss AJ, WEARIT Investigators and Coordinators, BIROAD Investigators and Coordinators (2004) Use of a wearable defibrillator in terminating tachyarrhythmias in patients at high risk for sudden death: results of the WEARIT/BIROAD. Pacing Clin Electrophysiol 27:4–9CrossRefPubMed
15.
Zurück zum Zitat Klein HU, Meltendorf U, Reek S, Smid J, Kuss S, Cygankiewicz I, Jons C, Szymkiewicz S, Buhtz F, Wollbrueck A, Zareba W, Moss AJ (2010) Bridging a temporary high risk of sudden arrhythmic death. Experience with the wearable cardioverter-defibrillator (WCD). Pacing Clin Electrophysiol 33:353–367CrossRefPubMed Klein HU, Meltendorf U, Reek S, Smid J, Kuss S, Cygankiewicz I, Jons C, Szymkiewicz S, Buhtz F, Wollbrueck A, Zareba W, Moss AJ (2010) Bridging a temporary high risk of sudden arrhythmic death. Experience with the wearable cardioverter-defibrillator (WCD). Pacing Clin Electrophysiol 33:353–367CrossRefPubMed
16.
Zurück zum Zitat Rao M, Goldenberg I, Moss AJ, Klein H, Huang DT, Bianco NR, Szymkiewicz SJ, Zareba W, Brenyo A, Buber J, Barsheshet A (2011) Wearable defibrillator in congenital structural heart disease and inherited arrhythmias. Am J Cardiol 108:1632–1638CrossRefPubMed Rao M, Goldenberg I, Moss AJ, Klein H, Huang DT, Bianco NR, Szymkiewicz SJ, Zareba W, Brenyo A, Buber J, Barsheshet A (2011) Wearable defibrillator in congenital structural heart disease and inherited arrhythmias. Am J Cardiol 108:1632–1638CrossRefPubMed
17.
Zurück zum Zitat Reek S, Geller JC, Meltendorf U, Wollbrueck A, Szymkiewicz SJ, Klein HU (2003) Clinical efficacy of a wearable defibrillator in acutely terminating episodes of ventricular fibrillation using biphasic shocks. Pacing Clin Electrophysiol 26:2016–2022CrossRefPubMed Reek S, Geller JC, Meltendorf U, Wollbrueck A, Szymkiewicz SJ, Klein HU (2003) Clinical efficacy of a wearable defibrillator in acutely terminating episodes of ventricular fibrillation using biphasic shocks. Pacing Clin Electrophysiol 26:2016–2022CrossRefPubMed
18.
Zurück zum Zitat Epstein AE, Dimarco JP, Ellenbogen KA, Estes NA 3rd, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO (2008) ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalities. Heart Rhythm 5:e1–e62CrossRefPubMed Epstein AE, Dimarco JP, Ellenbogen KA, Estes NA 3rd, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO (2008) ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalities. Heart Rhythm 5:e1–e62CrossRefPubMed
19.
Zurück zum Zitat Priori SG, Blomström-Lundquist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliot PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekval TM, Spaulding C, Van Veldhuisen DJ (2015) 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J 36:2793–2867CrossRefPubMed Priori SG, Blomström-Lundquist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliot PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekval TM, Spaulding C, Van Veldhuisen DJ (2015) 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J 36:2793–2867CrossRefPubMed
20.
Zurück zum Zitat Kusumoto FM, Calkins H, Boehmer J, Buxton AE, Chung MK, Gold MR, Hohnloser SH, Indik J, Lee R, Mehra MR, Menon V, Page RL, Shen WK, Slotwiner DJ, Stevenson LW, Varosy PD, Welikovitch L (2014) HRS/ACC/AHA expert consensus statement on the use of implantable cardioverter-defibrillator therapy in patients who are not included or well represented in clinical trials. JACC 64:1143–1177CrossRefPubMed Kusumoto FM, Calkins H, Boehmer J, Buxton AE, Chung MK, Gold MR, Hohnloser SH, Indik J, Lee R, Mehra MR, Menon V, Page RL, Shen WK, Slotwiner DJ, Stevenson LW, Varosy PD, Welikovitch L (2014) HRS/ACC/AHA expert consensus statement on the use of implantable cardioverter-defibrillator therapy in patients who are not included or well represented in clinical trials. JACC 64:1143–1177CrossRefPubMed
21.
Zurück zum Zitat Hinkle LE Jr, Thaler HAT (1982) Clinical classification of cardiac deaths. Circulation 65:457–464CrossRefPubMed Hinkle LE Jr, Thaler HAT (1982) Clinical classification of cardiac deaths. Circulation 65:457–464CrossRefPubMed
Metadaten
Titel
The wearable cardioverter-defibrillator in a real-world clinical setting: experience in 102 consecutive patients
verfasst von
Julia W. Erath
Mate Vamos
Abdul Sami Sirat
Stefan H. Hohnloser
Publikationsdatum
25.11.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Research in Cardiology / Ausgabe 4/2017
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-016-1054-1

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