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01.05.2020 | COVID-19 | Editorial Zur Zeit gratis

COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?

verfasst von: Paola Rizzo, Francesco Vieceli Dalla Sega, Francesca Fortini, Luisa Marracino, Claudio Rapezzi, Roberto Ferrari

Erschienen in: Basic Research in Cardiology | Ausgabe 3/2020

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Abstract

From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease.

Agata J, Ura N, Yoshida H, Shinshi Y, Sasaki H, Hyakkoku M, Taniguchi S, Shimamoto K (2006) Olmesartan is an angiotensin II receptor blocker with an inhibitory effect on angiotensin-converting enzyme. Hypertens Res 29:865–874. https://doi.org/10.1291/hypres.29.865 CrossRefPubMed

Aquila G, Kostina A, Vieceli Dalla Sega F, Shlyakhto E, Kostareva A, Marracino L, Ferrari R, Rizzo P, Malaschicheva A (2019) The Notch pathway: a novel therapeutic target for cardiovascular diseases? Expert Opin Ther Targets 23:695–710. https://doi.org/10.1080/14728222.2019.1641198 CrossRefPubMed

Benvenuto D, Giovanetti M, Ciccozzi A, Spoto S, Angeletti S, Ciccozzi M (2020) The 2019-new coronavirus epidemic: evidence for virus evolution. J Med Virol 92:455–459. https://doi.org/10.1002/jmv.25688 CrossRefPubMedPubMedCentral

Boucher JM, Peterson SM, Urs S, Zhang C, Liaw L (2011) The miR-143/145 cluster is a novel transcriptional target of Jagged-1/Notch signaling in vascular smooth muscle cells. J Biol Chem 286:28312–28321. https://doi.org/10.1074/jbc.M111.221945 CrossRefPubMedPubMedCentral

Caolo V, Schulten HM, Zhuang ZW, Murakami M, Wagenaar A, Verbruggen S, Molin DG, Post MJ (2011) Soluble Jagged-1 inhibits neointima formation by attenuating Notch-Herp2 signaling. Arterioscler Thromb Vasc Biol 31:1059–1065. https://doi.org/10.1161/ATVBAHA.110.217935 CrossRefPubMed

Carbone M, Green JB, Bucci EM, Lednicky JJ (2020) Editorial: Coronaviruses: Facts, Myths and Hypotheses. J Thorac Oncol. https://doi.org/10.1016/j.jtho.2020.02.024 CrossRefPubMedPubMedCentral

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395:507–513. https://doi.org/10.1016/S0140-6736(20)30211-7 CrossRefPubMedPubMedCentral

Cheng J, Koenig SN, Kuivaniemi HS, Garg V, Hans CP (2014) Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model. J Am Heart Assoc 3:e001064. https://doi.org/10.1161/JAHA.114.001064 CrossRefPubMedPubMedCentral

AaRPaMFaTM C (2015) Roles of dysregulated Notch pathway and small DNA tumor viruses in cancer initiation and progression. J Cancer Metastasis Treat. https://doi.org/10.4103/2394-4722.171982 CrossRef

10.

Collins SD (1932) Excess mortality from causes other than influenza and pneumonia during influenza epidemics. Public Health Rep 47:2159–2179. https://doi.org/10.2307/4580606 CrossRef

11.

Corrales-Medina VF, Madjid M, Musher DM (2010) Role of acute infection in triggering acute coronary syndromes. Lancet Infect Dis 10:83–92. https://doi.org/10.1016/S1473-3099(09)70331-7 CrossRefPubMed

12.

Danahay H, Pessotti AD, Coote J, Montgomery BE, Xia D, Wilson A, Yang H, Wang Z, Bevan L, Thomas C, Petit S, London A, LeMotte P, Doelemeyer A, Vélez-Reyes GL, Bernasconi P, Fryer CJ, Edwards M, Capodieci P, Chen A, Hild M, Jaffe AB (2015) Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. Cell Rep 10:239–252. https://doi.org/10.1016/j.celrep.2014.12.017 CrossRefPubMed

13.

David EG, Gwendolyn MJ, Mehdi B, Jiewei X, Kirsten O et al (2020) A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. BioRxiv. https://doi.org/10.1101/2020.03.22.002386 CrossRefPubMedPubMedCentral

14.

Doberstein K, Steinmeyer N, Hartmetz AK, Eberhardt W, Mittelbronn M, Harter PN, Juengel E, Blaheta R, Pfeilschifter J, Gutwein P (2013) MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients. Neoplasia 15:218–230. https://doi.org/10.1593/neo.121222 CrossRefPubMedPubMedCentral

15.

Fang L, Karakiulakis G, Roth M (2020) Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. https://doi.org/10.1016/S2213-2600(20)30116-8 CrossRefPubMedPubMedCentral

16.

Ferrari R, Di Pasquale G, Rapezzi C (2020) 2019 CORONAVIRUS: which implications for cardiology? Eur J Prev Cardiol. https://doi.org/10.1177/2047487320918102

17.

Ferrari R, Rizzo P (2014) The Notch pathway: a novel target for myocardial remodelling therapy? Eur Heart J 35:2140–2145. https://doi.org/10.1093/eurheartj/ehu244 CrossRefPubMed

18.

Fortini F, Vieceli Dalla Sega F, Caliceti C, Lambertini E, Pannuti A, Peiffer DS, Balla C, Rizzo P (2019) Estrogen-mediated protection against coronary heart disease: the role of the Notch pathway. J Steroid Biochem Mol Biol 189:87–100. https://doi.org/10.1016/j.jsbmb.2019.02.008 CrossRefPubMed

19.

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS, Covid-19 CMTEGf, (2020) Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. https://doi.org/10.1056/NEJMoa2002032 CrossRefPubMedPubMedCentral

20.

Gude N, Joyo E, Toko H, Quijada P, Villanueva M, Hariharan N, Sacchi V, Truffa S, Joyo A, Voelkers M, Alvarez R, Sussman MA (2015) Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells. Basic Res Cardiol 110:29. https://doi.org/10.1007/s00395-015-0488-3 CrossRefPubMedPubMedCentral

21.

Hildebrand D, Uhle F, Sahin D, Krauser U, Weigand MA, Heeg K (2018) The interplay of notch signaling and STAT3 in TLR-activated human primary monocytes. Front Cell Infect Microbiol 8:241. https://doi.org/10.3389/fcimb.2018.00241 CrossRefPubMedPubMedCentral

22.

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and Is blocked by a clinically proven protease inhibitor. Cell. https://doi.org/10.1016/j.cell.2020.02.052 CrossRefPubMedPubMedCentral

23.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395:497–506. https://doi.org/10.1016/S0140-6736(20)30183-5 CrossRefPubMedPubMedCentral

24.

Ito T, Allen RM, Carson WF, Schaller M, Cavassani KA, Hogaboam CM, Lukacs NW, Matsukawa A, Kunkel SL (2011) The critical role of Notch ligand Delta-like 1 in the pathogenesis of influenza A virus (H1N1) infection. PLoS Pathog 7:e1002341. https://doi.org/10.1371/journal.ppat.1002341 CrossRefPubMedPubMedCentral

25.

Kyula JN, Van Schaeybroeck S, Doherty J, Fenning CS, Longley DB, Johnston PG (2010) Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer. Clin Cancer Res 16:3378–3389. https://doi.org/10.1158/1078-0432.CCR-10-0014 CrossRefPubMedPubMedCentral

26.

Lambert DW, Yarski M, Warner FJ, Thornhill P, Parkin ET, Smith AI, Hooper NM, Turner AJ (2005) Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem 280:30113–30119. https://doi.org/10.1074/jbc.M505111200 CrossRefPubMed

27.

Lei C, Fu W, Qian K, Li T, Zhang S, Ding M, Hu S (2020) Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig. Biorxiv. https://doi.org/10.1101/2020.02.01.929976 CrossRefPubMedPubMedCentral

28.

Lukacs NW, Smit JJ, Schaller MA, Lindell DM (2008) Regulation of immunity to respiratory syncytial virus by dendritic cells, toll-like receptors, and notch. Viral Immunol 21:115–122. https://doi.org/10.1089/vim.2007.0110 CrossRefPubMed

29.

Molano FD, Arevalo-Rodriguez I, Roqué i Figuls M, Montero Oleas N, Nuvials X, Zamora J (2020) Levels of interleukin-6 in identifying severely ill adult patients with sepsis. Cochrane. https://doi.org/10.1002/14651858.CD011811 CrossRef

30.

Osborne BA, Minter LM (2007) Notch signalling during peripheral T-cell activation and differentiation. Nat Rev Immunol 7:64–75. https://doi.org/10.1038/nri1998 CrossRefPubMed

31.

Park JS, Kim SH, Kim K, Jin CH, Choi KY, Jang J, Choi Y, Gwon AR, Baik SH, Yun UJ, Chae SY, Lee S, Kang YM, Lee KC, Arumugam TV, Mattson MP, Park JH, Jo DG (2015) Inhibition of notch signalling ameliorates experimental inflammatory arthritis. Ann Rheum Dis 74:267–274. https://doi.org/10.1136/annrheumdis-2013-203467 CrossRefPubMed

32.

Patel VB, Clarke N, Wang Z, Fan D, Parajuli N, Basu R, Putko B, Kassiri Z, Turner AJ, Oudit GY (2014) Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS. J Mol Cell Cardiol 66:167–176. https://doi.org/10.1016/j.yjmcc.2013.11.017 CrossRefPubMed

33.

Paules CI, Marston HD, Fauci AS (2020) Coronavirus infections-more than just the common cold. JAMA. https://doi.org/10.1001/jama.2020.0757 CrossRefPubMed

34.

Pei H, Yu Q, Xue Q, Guo Y, Sun L, Hong Z, Han H, Gao E, Qu Y, Tao L (2013) Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of oxidative/nitrative stress. Basic Res Cardiol 108:373. https://doi.org/10.1007/s00395-013-0373-x CrossRefPubMed

35.

Penninkilampi R, Brothers HM, Eslick GD (2016) Pharmacological agents targeting γ-secretase increase risk of cancer and cognitive decline in alzheimer's disease patients: a systematic review and meta-analysis. J Alzheimers Dis 53:1395–1404. https://doi.org/10.3233/JAD-160275 CrossRefPubMed

36.

Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, Xie C, Ma K, Shang K, Wang W, Tian DS (2020) Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. https://doi.org/10.1093/cid/ciaa248 CrossRefPubMedPubMedCentral

37.

Qin L, Qiu KZ, Hu CP, Wu GJ, Wang LL, Tan YR (2019) Bronchial epithelial cells promote the differentiation of Th2 lymphocytes in airway microenvironment through jagged/notch-1 signaling after RSV infection. Int Arch Allergy Immunol 179:43–52. https://doi.org/10.1159/000495581 CrossRefPubMed

38.

Qiu H, Tang X, Ma J, Shaverdashvili K, Zhang K, Bedogni B (2015) Notch1 autoactivation via transcriptional regulation of furin, which sustains notch1 signaling by processing notch1-activating proteases ADAM10 and membrane type 1 matrix metalloproteinase. Mol Cell Biol 35:3622–3632. https://doi.org/10.1128/MCB.00116-15 CrossRefPubMedPubMedCentral

39.

Radojcic V, Maillard I (2016) Notch signaling and alloreactivity. Transplantation 100:2593–2600. https://doi.org/10.1097/TP.0000000000001468 CrossRefPubMedPubMedCentral

40.

Rapezzi C, Ferrari R (2020) The Cardiologist at the time of Coronavirus: a perfect storm. Eur Heart J 41:1320–1322. https://doi.org/10.1093/eurheartj/ehaa233 CrossRefPubMed

41.

Ren J, Nie Y, Lv M, Shen S, Tang R, Xu Y, Hou Y, Zhao S, Wang T (2015) Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17. Cell Mol Immunol 12:768–776. https://doi.org/10.1038/cmi.2014.101 CrossRefPubMed

42.

Rizzo P, Miele L, Ferrari R (2013) The notch pathway: a crossroad between the life and death of the endothelium. Eur Heart J 34:2504–2509. https://doi.org/10.1093/eurheartj/ehs141 CrossRefPubMed

43.

Ruan Q, Yang K, Wang W, Jiang L, Song J (2020) Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan China. Intensive Care Med. https://doi.org/10.1007/s00134-020-05991-x CrossRefPubMedPubMedCentral

44.

Schmieder RE (2005) Mechanisms for the clinical benefits of angiotensin II receptor blockers. Am J Hypertens 18:720–730. https://doi.org/10.1016/j.amjhyper.2004.11.032 CrossRefPubMed

45.

Schneider CS, Xu Q, Boylan NJ, Chisholm J, Tang BC, Schuster BS, Henning A, Ensign LM, Lee E, Adstamongkonkul P, Simons BW, Wang SS, Gong X, Yu T, Boyle MP, Suk JS, Hanes J (2017) Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation. Sci Adv 3:e1601556. https://doi.org/10.1126/sciadv.1601556 CrossRefPubMedPubMedCentral

46.

Schoeman D, Fielding BC (2019) Coronavirus envelope protein: current knowledge. Virol J 16:69. https://doi.org/10.1186/s12985-019-1182-0 CrossRefPubMedPubMedCentral

47.

Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem 282:20847–20853. https://doi.org/10.1074/jbc.M703847200 CrossRefPubMed

48.

Tian S, Hu W, Niu L, Liu H, Xu H, Xiao SY (2020) Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol. https://doi.org/10.1016/j.jtho.2020.02.010 CrossRefPubMedPubMedCentral

49.

Vieceli Dalla Sega F, Fortini F, Aquila G, Campo G, Vaccarezza M, Rizzo P (2019) Notch signaling regulates immune responses in atherosclerosis. Front Immunol 10:1130. https://doi.org/10.3389/fimmu.2019.01130 CrossRefPubMedPubMedCentral

50.

Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D (2020) Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. https://doi.org/10.1016/j.cell.2020.02.058 CrossRefPubMedPubMedCentral

51.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z (2020) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan. China. JAMA. https://doi.org/10.1001/jama.2020.1585 CrossRefPubMedPubMedCentral

52.

Wongchana W, Palaga T (2012) Direct regulation of interleukin-6 expression by Notch signaling in macrophages. Cell Mol Immunol 9:155–162. https://doi.org/10.1038/cmi.2011.36 CrossRefPubMed

53.

Zheng YY, Ma YT, Zhang JY, Xie X (2020) COVID-19 and the cardiovascular system. Nat Rev Cardiol. https://doi.org/10.1038/s41569-020-0360-5 CrossRefPubMedPubMedCentral

54.

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL (2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579:270–273. https://doi.org/10.1038/s41586-020-2012-7 CrossRefPubMedPubMedCentral

55.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W, Team CNCIaR (2020) A Novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382:727–733. https://doi.org/10.1056/NEJMoa2001017 CrossRefPubMedPubMedCentral

Titel: COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?
verfasst von: Paola Rizzo
Francesco Vieceli Dalla Sega
Francesca Fortini
Luisa Marracino
Claudio Rapezzi
Roberto Ferrari
Publikationsdatum: 01.05.2020
Verlag: Springer Berlin Heidelberg
Schlagwort: COVID-19
Erschienen in: Basic Research in Cardiology / Ausgabe 3/2020
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-020-0791-5

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