Erschienen in:
01.01.2015 | Correspondence
Oligoastrocytomas: throwing the baby out with the bathwater?
verfasst von:
Paul Wilcox, Cheryl C. Y. Li, Maggie Lee, Brindha Shivalingam, Jeffrey Brennan, Catherine M. Suter, Kimberley Kaufman, Trina Lum, Michael E. Buckland
Erschienen in:
Acta Neuropathologica
|
Ausgabe 1/2015
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Excerpt
Recently in this journal, Sahm and colleagues advised “parting with the diagnosis of OA (
oligoastrocytoma)”, based on genetic analyses of 43 putative OA tumours [
4]. Here we present our viewpoint that the majority of tumours tested by Sahm et al. were not true OAs, and that the entity of OA, whilst uncommon, remains a valuable diagnosis. We describe two cases of OA that exhibit lineage-associated molecular alterations restricted to only a proportion of tumour cells. These cases demonstrate that molecular heterogeneity in a subset of OAs is real, with important implications for our understanding of fundamental glioma biology, clinical trial design, and future treatment decisions. OA should not be ignored in the proposed new classification guidelines [
2]. …
