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01.04.2009

Ebselen Improves Ischemia-Reperfusion Injury After Rat Lung Transplantation

verfasst von: Jürg Hamacher, Uz Stammberger, Elvira Weber, Rudolf Lucas, Albrecht Wendel

Erschienen in: Lung | Ausgabe 2/2009

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Abstract

The heterocyclic organic compound ebselen (2-phenyl-1,2-benizsoselenazol-3(2H)-one) is a glutathione peroxidase mimick with protective properties against oxidative injury. Ebselen also has anti-inflammatory activity, including attenuation of tumor necrosis factor release and increase of interleukin-10, as shown in vivo, in inflammatory and ischemia-reperfusion injuries, including those of the lung. This study was designed to assess its effect on severe ischemia-reperfusion injury in a model of left-sided rat lung isotransplantation. Orthotopic single left-sided lung allotransplantation (Wistar to Wistar) was performed in female rats after a total ischemic time of 18 h. In nine recipients given 500 mg/kg oral ebselen 1 h before transplantation, graft PaO₂/FiO₂ was improved 24 h after transplantation, as evidenced with a mean (standard deviation) PaO₂ of 139 (61) mmHg vs. eight controls with 65 (33) mmHg (p = 0.009). Bronchoalveolar PMN count was reduced to approximately 50% in the ebselen group compared with controls, whereas no difference in the tumor necrosis factor content was found. We conclude that the improvement of lung function in ebselen-treated transplanted rats is mainly the result of the anti-inflammatory activity of the drug during reperfusion.

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Titel: Ebselen Improves Ischemia-Reperfusion Injury After Rat Lung Transplantation
verfasst von: Jürg Hamacher
Uz Stammberger
Elvira Weber
Rudolf Lucas
Albrecht Wendel
Publikationsdatum: 01.04.2009
Verlag: Springer-Verlag
Erschienen in: Lung / Ausgabe 2/2009
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-009-9134-x

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