nach oben

Erschienen in:

01.06.2012

Heme Oxygenase-1 Promoter Polymorphism is Associated with Risk of Malignant Mesothelioma

verfasst von: Aki Murakami, Yoshihiro Fujimori, Yoshie Yoshikawa, Shusai Yamada, Kunihiro Tamura, Noriko Hirayama, Takayuki Terada, Kozo Kuribayashi, Chiharu Tabata, Kazuya Fukuoka, Tomoko Tamaoki, Takashi Nakano

Erschienen in: Lung | Ausgabe 3/2012

Einloggen, um Zugang zu erhalten

Abstract

Background

Malignant mesothelioma is an aggressive tumor of serosal surfaces that is closely associated with asbestos exposure which induces oxidative stress. Heme oxygenase (HO)-1, a rate-limiting enzyme of heme degradation, plays a protective role against oxidative stress. The HO-1 gene promoter carries (GT)n repeats whose number is inversely related to transcriptional activity of the HO-1 gene.

Methods

To investigate the relationship between the length polymorphism of (GT)n repeats and mesothelioma susceptibility, we analyzed the HO-1 promoter in 44 asbestos-exposed subjects without mesothelioma and 78 asbestos-exposed subjects with mesothelioma using PCR-based genotyping.

Results

The number of repeats ranged from 16 to 38, with two peaks at 23 and 30 repeats. Polymorphisms of (GT)n repeats were grouped into two classes of alleles, short (S) (<24) and long (L) (≥24), and three genotypes: L/L, L/S, and S/S. The proportions of allele frequencies in class L as well as genotypic frequencies of L allele carriers (L/L and L/S) were significantly higher in the asbestos-exposed subjects with mesothelioma than in those without mesothelioma.

Conclusion

The findings of this study suggest that long (GT)n repeats in the HO-1 gene promoter are associated with a higher risk of malignant mesothelioma in the Japanese population.

Robinson BW, Musk AW, Lake RA (2005) Malignant mesothelioma. Lancet 366:397–408PubMedCrossRef

Nakano T (2008) Current therapies for malignant pleural mesothelioma. Environ Health Prev Med 13:75–83PubMedCrossRef

Baas P, Schouwink H, Zoetmulder FA (1998) Malignant pleural mesothelioma. Ann Oncol 9:139–149PubMedCrossRef

Shukla A, Gulumian M, Hei TK, Kamp D, Rahman Q, Mossman BT (2003) Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases. Free Radic Biol Med 34:1117–1129PubMedCrossRef

Dong H, Buard A, Renier A, Lévy F, Saint-Etienne L, Jaurand MC (1994) Role of oxygen derivatives in the cytotoxicity and DNA damage produced by asbestos on rat pleural mesothelial cells in vitro. Carcinogenesis 15:1251–1255PubMedCrossRef

Toyokuni S (2009) Mechanisms of asbestos-induced carcinogenesis. Nagoya J Med Sci 71:1–10PubMed

Otterbein LE, Choi AMK (2000) Heme oxygenase: colors of defense against cellular stress. Am J Physiol Lung Cell Mol Physiol 279:L1029–L1037PubMed

Okinaga S, Takahashi K, Takeda K, Yoshizawa M, Fujita H, Sasaki H, Shibahara S (1996) Regulation of human heme oxygenase-1 gene expression under thermal stress. Blood 87:5074–5084PubMed

Yamada N, Yamaya M, Okinaga S, Lie R, Suzuki T, Nakayama K, Takeda A, Yamaguchi T, Itoyama Y, Sekizawa K, Sasaki H (1999) Protective effects of heme oxygenase-1 against oxidant-induced injury in the cultured human tracheal epithelium. Am J Respir Cell Mol Biol 21:428–435PubMed

10.

Choi AM, Alam J (1996) Heme oxygenase-1: function, regulation and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 15:9–19PubMed

11.

Otterbein LE, Bach FH, Alam J, Soares M, Tao LuH, Wysk M, Davis RJ, Flavell RA, Choi AM (2000) Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 6:422–428PubMedCrossRef

12.

Exner M, Minar E, Wagner O, Schillinger M (2004) The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med 37:1097–1104PubMedCrossRef

13.

Shibahara S (2003) The heme oxygenase dilemma in cellular homeostasis: new insights for the feedback regulation of heme catabolism. Tohoku J Exp Med 200:167–186PubMedCrossRef

14.

Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, Shibahara S, Sasaki H (2000) Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 66:187–195PubMedCrossRef

15.

Islam T, McConnell R, Gauderman WJ, Avol E, Peters JM, Gilliland FD (2008) Ozone, oxidant defense genes, and risk of asthma during adolescence. Am J Respir Crit Care Med 177:388–395PubMedCrossRef

16.

Song F, Li X, Zhang M, Yao P, Yang N, Sun X, Hu FB, Liu L (2009) Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes in a Chinese population. Am J Epidemiol 170:747–756PubMedCrossRef

17.

Chen YH, Lin SJ, Lin MW, Tsai HL, Kuo SS, Chen JW, Charng MJ, Wu TC, Chen LC, Ding YA, Pan WH, Jou YS, Chau LY (2002) Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet 111:1–8PubMedCrossRef

18.

Hu JL, Li ZY, Liu W, Zhang RG, Li GL, Wang T, Ren JH, Wu G (2010) Polymorphism in heme oxygenase-1 (HO-1) promoter and alcohol are related to the risk of esophageal squamous cell carcinoma on Chinese males. Neoplasma 57:86–92PubMedCrossRef

19.

Huang SK, Chiu AW, Pu YS, Huang YK, Chung CJ, Tsai HJ, Yang MH, Chen CJ, Hsueh YM (2008) Arsenic methylation capability, heme oxygenase-1 and NADPH quinone oxidoreductase-1 genetic polymorphisms and the stage and grade of urothelial carcinomas. Urol Int 80:405–412PubMedCrossRef

20.

Sawa T, Mounawar M, Tatemichi M, Gilibert I, Katoh T, Ohshima H (2008) Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. Cancer Lett 269:78–84PubMedCrossRef

21.

Kikuchi A, Yamaya M, Suzuki S, Yasuda H, Kubo H, Nakayama K, Handa M, Sasaki T, Shibahara S, Sekizawa K, Sasaki H (2005) Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. Hum Genet 116:354–360PubMedCrossRef

22.

Chang KW, Lee TC, Yeh WI, Chung MY, Liu CJ, Chi LY, Lin SC (2004) Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. Br J Cancer 91:1551–1555PubMedCrossRef

23.

Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, Nanjo K, Sasaki A, Seino Y, Ito C, Shima K, Nonaka K, Kadowaki T, Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus (2002) Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. Diabetes Res Clin Pract 55:65–85

24.

Alderman MH (1993) A review of the Joint National Committee on detection, evaluation, and treatment of high blood pressure. The fifth report, 1993. Am J Hypertens 6:896–898PubMed

25.

Landi S, Gemignani F, Neri M, Barale R, Bonassi S, Bottari F, Canessa PA, Canzian F, Ceppi M, Filiberti R, Ivaldi GP, Mencoboni M, Scaruffi P, Tonini GP, Mutti L, Puntoni R (2007) Polymorphisms of glutathione-S-transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma. Int J Cancer 120:2739–2743PubMedCrossRef

26.

Janssen YM, Marsh JP, Absher MP, Gabrielson E, Borm PJ, Driscoll K, Mossman BT (1994) Oxidant stress responses in human pleural mesothelial cells exposed to asbestos. Am J Respir Crit Care Med 149:795–802PubMed

27.

Nagatomo H, Morimoto Y, Oyabu T, Hirohashi M, Ogami A, Yamato H, Kuroda K, Higashi T, Tanaka I (2005) Expression of heme oxygenase-1 in the lungs of rats exposed to crocidolite asbestos. Inhal Toxicol 17:293–296PubMedCrossRef

28.

Hirai H, Kubo H, Yamaya M, Nakayama K, Numasaki M, Kobayashi S, Suzuki S, Shibahara S, Sasaki H (2003) Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood 102:1619–1621PubMedCrossRef

Titel: Heme Oxygenase-1 Promoter Polymorphism is Associated with Risk of Malignant Mesothelioma
verfasst von: Aki Murakami
Yoshihiro Fujimori
Yoshie Yoshikawa
Shusai Yamada
Kunihiro Tamura
Noriko Hirayama
Takayuki Terada
Kozo Kuribayashi
Chiharu Tabata
Kazuya Fukuoka
Tomoko Tamaoki
Takashi Nakano
Publikationsdatum: 01.06.2012
Verlag: Springer-Verlag
Erschienen in: Lung / Ausgabe 3/2012
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-012-9371-2

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Heme Oxygenase-1 Promoter Polymorphism is Associated with Risk of Malignant Mesothelioma